FULCRUM THERAPEUTICS INC FULC
COM · Common Stock · CUSIP 359616109
Company in Cambridge, United States
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersCambridge, MA
- Founded2016
- Websitefulcrumtx.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($197.8k this quarter). Holder counts are more reliable. Shares outstanding: 61.8m as of 2023-03-02, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $2.85. Options: 7 managers hold calls ($2.0m notional), 4 hold puts ($137.5k).
Trends to Q1 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 106 |
| Q4 2022 | 111 |
| Q1 2023 | 117 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 65 | 43 |
| Q1 2023 | 79 | 43 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $5.2m | $312.0k | 0.06 |
| Q4 2022 | $4.2m | $379.7k | 0.09 |
| Q1 2023 | $2.0m | $137.5k | 0.07 |
Biggest buyers
| FMR LLC | Added | +7.1m |
| Point72 Asset Management, L.P. | New | +2.6m |
| RA CAPITAL MANAGEMENT, L.P. | Added | +2.1m |
| Cormorant Asset Management, LP | New | +1.1m |
| BlackRock Inc. | Added | +914.7k |
| MONTANOVA CAPITAL, LLC | Added | +902.9k |
| Venrock Adviser, LLC | Added | +859.8k |
| COWEN AND COMPANY, LLC | Added | +814.9k |
| VANGUARD GROUP INC | Added | +757.9k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Added | +686.4k |
Biggest sellers
| Logos Global Management LP | Sold out | -2.0m |
| TRV GP III, LLC | Sold out | -2.0m |
| Deep Track Capital, LP | Sold out | -768.6k |
| Sofinnova Investments, Inc. | Sold out | -631.4k |
| CITADEL ADVISORS LLC | Reduced | -606.8k |
| Nantahala Capital Management, LLC | Reduced | -478.6k |
| Alphabet Inc. | Reduced | -241.2k |
| Parkman Healthcare Partners LLC | Sold out | -206.9k |
| INTERNATIONAL BIOTECHNOLOGY TRUST PLC | Sold out | -193.7k |
| ACUTA CAPITAL PARTNERS, LLC | Sold out | -185.0k |
Biggest calls
| CITADEL ADVISORS LLC | Added | $991.2k347.8k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $849.3k298.0k shares |
| WOLVERINE TRADING, LLC | New | $50.0k17.6k shares |
| SIMPLEX TRADING, LLC | Added | $40.0k14.3k shares |
| JANE STREET GROUP, LLC | New | $35.6k12.5k shares |
| GROUP ONE TRADING LLC | Added | $9.7k3.4k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| CITADEL ADVISORS LLC | Added | $84.9k29.8k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $47.6k16.7k shares |
| SIMPLEX TRADING, LLC | Reduced | $5.0k2.0k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| TANG CAPITAL MANAGEMENT LLC 13G · passive investor +2.2 pts · filed 2026-07-15 | 10.4% |
| EcoR1 Capital, LLC 13G · institution no change · filed 2026-06-25 | 9.0% |
| Nantahala Capital Management, LLC 13G · institution +3.6 pts · filed 2026-08-14 | 8.2% |
| BlackRock Portfolio Management LLC 13G · institution +2.1 pts · filed 2026-10-27 | 8.1% |
| BlackRock, Inc. 13G · institution +1.2 pts · filed 2026-07-28 | 7.2% |
| MONTANOVA CAPITAL, LLC 13G · institution -3.9 pts · filed 2026-08-14 | 5.5% |
Fell to 5% or below in the last year: BANK OF AMERICA CORP /DE/ (1.5%, 2026-10-28), RA CAPITAL MANAGEMENT, L.P. (0.0%, 2026-08-14), TCG Crossover GP II, LLC (0.0%, 2026-08-14), VANGUARD GROUP INC (0.0%, 2026-03-26)
Insider purchases and sales in Q1 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2021 | 0 | — | 0 | — | — |
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 0 | — | 0 | — | — |
| Q1 2022 | 0 | — | 0 | — | — |
| Q2 2022 | 0 | — | 1 | $3.5m | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 0 | — | — |
| Q1 2023 | 0 | — | 1 | $101.5k | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2023-01-20 | RA Capital Healthcare Fund LP +3 10% owner · See Footnotes | Bought | $25.0m1.9m shares |
| 2023-01-13 | Gould Robert J Interim President & CEO, director | Sold | $101.5k6.8k shares |
| 2023-01-04 | RA Capital Healthcare Fund LP +3 10% owner · See Footnotes | Bought | $1.3m180.7k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2023
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.00% of their portfolio | 12.3m $35.1m | Added +7.1m |
| RA CAPITAL MANAGEMENT, L.P. 0.75% of their portfolio | 11.6m $33.1m | Added +2.1m |
| RTW INVESTMENTS, LP 0.33% of their portfolio | 5.5m $15.7m | Added +518.6k |
| MONTANOVA CAPITAL, LLC 0.71% of their portfolio | 5.2m $14.8m | Added +902.9k |
| BlackRock Inc. 0.00% of their portfolio | 4.2m $11.9m | Added +914.7k |
| VANGUARD GROUP INC 0.00% of their portfolio | 2.9m $8.2m | Added +757.9k |
| Point72 Asset Management, L.P. 0.03% of their portfolio | 2.6m $7.5m | New |
| TRV GP IV, LLC 4.77% of their portfolio | 2.3m $6.7m | Unchanged |
| COWEN AND COMPANY, LLC 0.73% of their portfolio | 2.2m $6.2m | Added +814.9k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.01% of their portfolio | 1.8m $5.1m | Added +686.4k |
| Venrock Adviser, LLC 0.73% of their portfolio | 1.3m $3.7m | Added +859.8k |
| MORGAN STANLEY 0.00% of their portfolio | 1.2m $3.3m | Reduced -11.2k |
| Cormorant Asset Management, LP 0.20% of their portfolio | 1.1m $3.1m | New |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.1m $3.0m | Added +206.8k |
| STATE STREET CORP 0.00% of their portfolio | 965.6k $2.8m | Added +185.2k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 754.9k $2.2m | Added +368.1k |
| Rock Springs Capital Management LP 0.05% of their portfolio | 727.7k $2.1m | Added +343.1k |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 649.8k $1.9m | Added +516.8k |
| Simplify Asset Management Inc. 0.33% of their portfolio | 639.1k $1.8m | New |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 620.6k $1.8m | New |
| Vivo Capital, LLC 0.11% of their portfolio | 550.0k $1.6m | New |
| NORTHERN TRUST CORP 0.00% of their portfolio | 452.0k $1.3m | Added +61.5k |
| HARVARD MANAGEMENT CO INC 0.12% of their portfolio | 410.7k $1.2m | Unchanged |
| NORGES BANK 0.00% of their portfolio | 410.5k $1.2m | Added +53.9k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 390.1k $1.1m | New |
| Squarepoint Ops LLC 0.01% of their portfolio | 319.7k $911.2k | New |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 297.8k $848.8k | Reduced -17.6k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 288.7k $823.0k | Added +35.0k |
| BESSEMER GROUP INC 0.00% of their portfolio | 287.0k $818.0k | Unchanged |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 262.6k $748.4k | Added +198.6k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 212.2k $604.8k | Added +14.3k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 209.5k $597.0k | Reduced -606.8k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 190.3k $543.0k | Added +5.6k |
| Alyeska Investment Group, L.P. 0.00% of their portfolio | 152.1k $433.6k | New |
| Graham Capital Management, L.P. 0.01% of their portfolio | 147.0k $418.9k | Added +125.6k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 141.3k $402.7k | Added +26.4k |
| Fiduciary Trust Co 0.01% of their portfolio | 136.6k $389.2k | Unchanged |
| XTX Topco Ltd 0.07% of their portfolio | 123.8k $352.7k | Added +88.9k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 121.0k $344.9k | Added +105.5k |
| Candriam S.C.A. 0.00% of their portfolio | 101.3k $265.8k | New |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 94.8k $270.1k | Reduced -31.2k |
| Swiss National Bank 0.00% of their portfolio | 86.5k $246.5k | Reduced -3.1k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 75.5k $215.0k | Added +15.8k |
| Cubist Systematic Strategies, LLC 0.00% of their portfolio | 65.1k $185.5k | Added +34.4k |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.00% of their portfolio | 62.3k $177.5k | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 59.1k $168.3k | New |
| Tekla Capital Management LLC 0.01% of their portfolio | 58.5k $166.8k | Unchanged |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 55.9k $159.3k | Added +13.1k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 54.3k $154.8k | Added +4.0k |
| CREDIT SUISSE AG/ 0.00% of their portfolio | 52.1k $148.4k | Added +8.2k |
| CORNERCAP INVESTMENT COUNSEL INC 0.02% of their portfolio | 44.1k $125.6k | Added +9.2k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 43.3k $123.4k | Added +8.4k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 42.4k $120.8k | Reduced -15.3k |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC 0.00% of their portfolio | 41.5k $118.4k | Reduced -43.0k |
| ALPS ADVISORS INC 0.00% of their portfolio | 40.7k $116.0k | Added +5.3k |
| OCCUDO QUANTITATIVE STRATEGIES LP 0.01% of their portfolio | 39.2k $111.8k | Added +13.2k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 36.5k $104.0k | Reduced -114.0k |
| Old Well Partners, LLC 0.04% of their portfolio | 34.6k $98.6k | Added +17.3k |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 34.1k $97.2k | Reduced -200 |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 32.3k $92.0k | Added +18.7k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 31.7k $90.4k | Added +13.0k |
| Virtu Financial LLC 0.01% of their portfolio | 31.1k $89.0k | New |
| COUNTRY TRUST BANK 0.00% of their portfolio | 30.2k $86.0k | Unchanged |
| Engineers Gate Manager LP 0.00% of their portfolio | 29.8k $85.0k | New |
| Y-Intercept (Hong Kong) Ltd 0.01% of their portfolio | 29.7k $84.5k | New |
| PDT Partners, LLC 0.01% of their portfolio | 28.6k $81.5k | Reduced -12.8k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 27.7k $78.9k | Added +8.8k |
| BARCLAYS PLC 0.00% of their portfolio | 27.3k $77.7k | Added +15.6k |
| BRANDYWINE MANAGERS, LLC 0.05% of their portfolio | 26.1k $74.5k | Unchanged |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 25.7k $73.2k | Added +10.9k |
| SG Americas Securities, LLC 0.00% of their portfolio | 25.0k $71.0k | Added +8.9k |
| AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio | 24.9k $71.0k | Added +4.3k |
| PANAGORA ASSET MANAGEMENT INC 0.00% of their portfolio | 22.3k $63.6k | Reduced -937 |
| Nantahala Capital Management, LLC 0.01% of their portfolio | 21.4k $60.9k | Reduced -478.6k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 20.2k $57.2k | New |
| Blackstone Inc. 0.00% of their portfolio | 19.2k $54.8k | Unchanged |
| JANUS HENDERSON GROUP PLC 0.00% of their portfolio | 19.0k $54.0k | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 17.0k $48.5k | Unchanged |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 15.8k $45.2k | Reduced -2.8k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 15.3k $43.7k | Reduced -160.8k |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 15.3k $43.6k | Added +2.5k |
| Alphabet Inc. 0.00% of their portfolio | 14.3k $40.6k | Reduced -241.2k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 14.3k $40.6k | Added +2.6k |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. 0.01% of their portfolio | 13.7k $39.2k | Added +2.6k |
| Corton Capital Inc. 0.03% of their portfolio | 13.4k $38.3k | Added +1.9k |
| Invesco Ltd. 0.00% of their portfolio | 12.5k $35.5k | Reduced -509 |
| TEACHER RETIREMENT SYSTEM OF TEXAS 0.00% of their portfolio | 12.3k $35.0k | New |
| Quantamental Technologies LLC 0.02% of their portfolio | 12.2k $34.6k | New |
| Verition Fund Management LLC 0.00% of their portfolio | 11.8k $33.5k | New |
| ARIZONA STATE RETIREMENT SYSTEM 0.00% of their portfolio | 11.6k $33.1k | Added +906 |
| Delphia (USA) Inc. 0.04% of their portfolio | 10.9k $31.1k | Added +270 |
| Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio | 10.4k $29.8k | Added +7.8k |
| ProShare Advisors LLC 0.00% of their portfolio | 10.3k $29.5k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 9.8k $27.8k | Added +6.6k |
| Legal & General Group Plc 0.00% of their portfolio | 9.5k $27.1k | Reduced -4.4k |
| Bank Julius Baer & Co. Ltd, Zurich 0.00% of their portfolio | 8.5k $24.0k | Unchanged |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 5.9k $17.0k | Added +4.1k |
| AMALGAMATED BANK 0.00% of their portfolio | 5.1k $14.0k | Reduced -670 |
| Point72 Middle East FZE 0.00% of their portfolio | 4.3k $12.3k | New |
| PrairieView Partners, LLC 0.00% of their portfolio | 3.6k $10.0k | Unchanged |