EXELIXIS INC EXEL
COM · Common Stock · CUSIP 30161Q104 · ISIN US30161Q1040
American biotechnology company
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersAlameda, CA
- Founded1994
- Websiteexelixis.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($89.0m this quarter). Holder counts are more reliable. Shares outstanding: 247.8m as of 2026-07-27, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $54.37. Options: 13 managers hold calls ($63.2m notional), 10 hold puts ($45.0m).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 401 |
| Q4 2022 | 387 |
| Q1 2023 | 366 |
| Q2 2023 | 380 |
| Q3 2023 | 401 |
| Q4 2023 | 427 |
| Q1 2024 | 422 |
| Q2 2024 | 416 |
| Q3 2024 | 454 |
| Q4 2024 | 519 |
| Q1 2025 | 560 |
| Q2 2025 | 636 |
| Q3 2025 | 622 |
| Q4 2025 | 685 |
| Q1 2026 | 701 |
| Q2 2026 | 756 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 219 | 203 |
| Q4 2024 | 264 | 211 |
| Q1 2025 | 306 | 226 |
| Q2 2025 | 352 | 258 |
| Q3 2025 | 297 | 326 |
| Q4 2025 | 326 | 301 |
| Q1 2026 | 333 | 343 |
| Q2 2026 | 377 | 346 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $81.6m | $79.0m | 0.97 |
| Q4 2025 | $58.9m | $39.2m | 0.67 |
| Q1 2026 | $40.8m | $45.0m | 1.10 |
| Q2 2026 | $63.2m | $45.0m | 0.71 |
Biggest buyers
| TWO SIGMA INVESTMENTS, LP | Added | +2.0m |
| D. E. Shaw & Co., Inc. | Added | +1.9m |
| UBS Group AG | Added | +774.4k |
| Assenagon Asset Management S.A. | Added | +720.3k |
| ENVESTNET ASSET MANAGEMENT INC | Added | +644.2k |
| Capital Impact Advisors, LLC | Added | +583.2k |
| GOLDMAN SACHS GROUP INC | Added | +571.9k |
| MARSHALL WACE, LLP | Added | +531.5k |
| AMERICAN CENTURY COMPANIES INC | Added | +519.4k |
| BANK OF AMERICA CORP /DE/ | Added | +504.7k |
Biggest sellers
| AQR CAPITAL MANAGEMENT LLC | Reduced | -2.1m |
| LOS ANGELES CAPITAL MANAGEMENT LLC | Reduced | -1.9m |
| BlackRock, Inc. | Reduced | -1.7m |
| FMR LLC | Reduced | -1.2m |
| JUPITER ASSET MANAGEMENT LTD | Reduced | -963.5k |
| FEDERATED HERMES, INC. | Reduced | -868.7k |
| CITADEL ADVISORS LLC | Reduced | -741.3k |
| FRANKLIN RESOURCES INC | Reduced | -561.2k |
| Nuveen, LLC | Reduced | -505.8k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | Reduced | -468.7k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $23.3m429.1k shares |
| MILLENNIUM MANAGEMENT LLC | Added | $12.0m221.2k shares |
| GROUP ONE TRADING LLC | Added | $8.9m162.9k shares |
| IMC-Chicago, LLC | Reduced | $3.9m71.1k shares |
| CITADEL ADVISORS LLC | Added | $3.6m66.5k shares |
| Twin Tree Management, LP | New | $3.5m64.5k shares |
| Caption Management, LLC | Added | $3.3m60.0k shares |
| JANE STREET GROUP, LLC | Reduced | $2.0m35.9k shares |
| Walleye Capital LLC | Added | $1.3m24.3k shares |
| SIMPLEX TRADING, LLC | Added | $516.9k9.5k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $16.5m303.8k shares |
| Sofinnova Investments, Inc. | Added | $13.8m254.2k shares |
| CITADEL ADVISORS LLC | Reduced | $4.7m86.3k shares |
| Caption Management, LLC | Added | $3.3m60.0k shares |
| IMC-Chicago, LLC | Added | $2.8m52.0k shares |
| Twin Tree Management, LP | New | $1.3m23.8k shares |
| JANE STREET GROUP, LLC | Reduced | $979.4k18.0k shares |
| GROUP ONE TRADING LLC | Added | $843.4k15.5k shares |
| SIMPLEX TRADING, LLC | Added | $516.9k9.5k shares |
| Walleye Capital LLC | Reduced | $244.8k4.5k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution filed 2025-04-28 | 10.2% |
| Farallon Capital Partners, L.P. 13D · may seek influence -0.9 pts · filed 2026-01-05 | 5.9% |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 13D · may seek influence filed 2026-08-14 | 5.6% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-29 | 5.1% |
Fell to 5% or below in the last year: AQR CAPITAL MANAGEMENT LLC (4.4%, 2026-08-12), VANGUARD GROUP INC (0.0%, 2026-03-26; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 4 | $10.8m | $7.6m |
| Q1 2025 | 0 | — | 10 | $11.1m | $1.1m |
| Q2 2025 | 0 | — | 10 | $21.0m | $7.7m |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 1 | $1.2m | 4 | $10.5m | — |
| Q1 2026 | 0 | — | 8 | $20.6m | $5.4m |
| Q2 2026 | 0 | — | 9 | $10.6m | $1.0m |
| Q3 2026 | 0 | — | 1 | $526.5k | $526.5k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-08-10 | Beckerle Mary C Director | Sold plan | $526.5k9.8k shares |
| 2026-06-01 | Eckhardt Sue Gail Director | Sold plan | $492.0k9.8k shares |
| 2026-06-01 | WYSZOMIERSKI JACK L Director | Sold plan | $198.4k3.9k shares |
| 2026-05-26 | Aftab Dana EVP, Research and Development | Sold | $2.2m43.5k shares |
| 2026-05-20 | Haley Patrick J. EVP, Commercial | Sold | $1.6m32.1k shares |
| 2026-05-18 | Senner Christopher J. EVP and CFO | Sold | $1.7m34.9k shares |
| 2026-05-18 | Hefti Brenda SVP and General Counsel | Sold plan | $332.6k6.6k shares |
| 2026-05-07 | POSTE GEORGE Director | Sold | $2.7m60.0k shares |
| 2026-05-07 | Freire Maria C Director | Sold | $949.2k20.6k shares |
| 2026-05-07 | Beckerle Mary C Director | Sold | $373.6k7.7k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.02% of their portfolio | 29.1m $1.6bn | Reduced -1.7m |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 4.29% of their portfolio | 13.5m $732.8m | Added +357.0k |
| RENAISSANCE TECHNOLOGIES LLC 1.01% of their portfolio | 13.4m $730.6m | Reduced -299.0k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.03% of their portfolio | 12.0m $655.3m | Reduced -42.2k |
| AQR CAPITAL MANAGEMENT LLC 0.21% of their portfolio | 11.0m $598.6m | Reduced -2.1m |
| VANGUARD CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 11.0m $595.8m | Reduced -308.0k |
| STATE STREET CORP 0.02% of their portfolio | 10.0m $542.5m | Reduced -328.4k |
| FULLER & THALER ASSET MANAGEMENT, INC. 1.32% of their portfolio | 8.9m $485.8m | Added +387.2k |
| LSV ASSET MANAGEMENT 0.80% of their portfolio | 8.1m $443.2m | Added +400.8k |
| GEODE CAPITAL MANAGEMENT, LLC 0.02% of their portfolio | 7.7m $416.3m | Reduced -145.3k |
| D. E. Shaw & Co., Inc. 0.19% of their portfolio | 5.6m $302.1m | Added +1.9m |
| MORGAN STANLEY 0.01% of their portfolio | 4.5m $245.9m | Added +341.4k |
| Invesco Ltd. 0.02% of their portfolio | 4.5m $244.6m | Added +181.3k |
| DIMENSIONAL FUND ADVISORS LP 0.04% of their portfolio | 4.4m $240.9m | Added +127.0k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.11% of their portfolio | 4.4m $237.6m | Reduced -468.7k |
| TWO SIGMA INVESTMENTS, LP 0.17% of their portfolio | 4.2m $229.1m | Added +2.0m |
| ASSETMARK, INC 0.32% of their portfolio | 3.4m $186.8m | Added +44.9k |
| Nuveen, LLC 0.04% of their portfolio | 3.3m $178.3m | Reduced -505.8k |
| UBS Group AG 0.03% of their portfolio | 3.2m $172.4m | Added +774.4k |
| Stephens Investment Management Group LLC 1.58% of their portfolio | 2.7m $147.5m | Added +185.5k |
| GOLDMAN SACHS GROUP INC 0.02% of their portfolio | 2.7m $146.4m | Added +571.9k |
| NORGES BANK 0.01% of their portfolio | 2.7m $146.3m | Not comparable |
| FIRST TRUST ADVISORS LP 0.08% of their portfolio | 2.5m $138.4m | Added +8.4k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.02% of their portfolio | 2.3m $123.1m | Reduced -56.4k |
| BANK OF AMERICA CORP /DE/ 0.01% of their portfolio | 2.1m $116.9m | Added +504.7k |
| NORTHERN TRUST CORP 0.01% of their portfolio | 2.1m $115.7m | Reduced -69.0k |
| Caisse de depot et placement du Quebec 0.16% of their portfolio | 2.1m $114.0m | Reduced -448.5k |
| Allspring Global Investments Holdings, LLC 0.17% of their portfolio | 2.0m $107.8m | Added +290.8k |
| Bank of New York Mellon Corp 0.02% of their portfolio | 2.0m $107.8m | Reduced -4.7k |
| AMERICAN CENTURY COMPANIES INC 0.04% of their portfolio | 1.8m $97.5m | Added +519.4k |
| Thrivent Financial for Lutherans 0.15% of their portfolio | 1.6m $88.2m | Added +52.1k |
| VANGUARD FIDUCIARY TRUST CO 0.02% of their portfolio | 1.6m $86.6m | Reduced -42.8k |
| Caligan Partners LP 4.08% of their portfolio | 1.6m $84.5m | Unchanged |
| JANE STREET GROUP, LLC 0.05% of their portfolio | 1.4m $76.3m | Added +315.4k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 1.3m $71.1m | Added +488.1k |
| Jupiter Topco LLC 0.03% of their portfolio | 1.2m $67.3m | First filing |
| MILLENNIUM MANAGEMENT LLC 0.04% of their portfolio | 1.2m $66.3m | Added +283.9k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio | 1.2m $65.4m | Reduced -90.7k |
| SEI INVESTMENTS CO 0.06% of their portfolio | 1.2m $63.5m | Reduced -463.0k |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.23% of their portfolio | 1.2m $63.1m | Reduced -1.9m |
| FMR LLC 0.00% of their portfolio | 1.1m $62.5m | Reduced -1.2m |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 1.1m $60.0m | Reduced -561.2k |
| Pacer Advisors, Inc. 0.15% of their portfolio | 1.1m $59.7m | Reduced -452.9k |
| AMERIPRISE FINANCIAL INC 0.01% of their portfolio | 1.0m $56.8m | Added +44.7k |
| Robeco Institutional Asset Management B.V. 0.07% of their portfolio | 1.0m $56.0m | Reduced -259.3k |
| ENVESTNET ASSET MANAGEMENT INC 0.01% of their portfolio | 949.7k $51.7m | Added +644.2k |
| RAYMOND JAMES FINANCIAL INC 0.01% of their portfolio | 941.6k $51.2m | Reduced -104.0k |
| HRT FINANCIAL LP 0.12% of their portfolio | 929.2k $50.6m | Added +468.7k |
| Gotham Asset Management, LLC 0.11% of their portfolio | 892.7k $48.6m | Reduced -27.2k |
| Assenagon Asset Management S.A. 0.03% of their portfolio | 857.3k $46.6m | Added +720.3k |
| Allianz Asset Management GmbH 0.04% of their portfolio | 853.1k $36.7m | Reduced -101.5k |
| Swedbank AB 0.04% of their portfolio | 841.8k $45.8m | Unchanged |
| MARSHALL WACE, LLP 0.04% of their portfolio | 831.5k $45.2m | Added +531.5k |
| Retirement Systems of Alabama 0.13% of their portfolio | 810.7k $44.1m | Reduced -58.4k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.82% of their portfolio | 804.1k $43.8m | Added +229 |
| Capital Impact Advisors, LLC 2.30% of their portfolio | 754.7k $41.1m | Added +583.2k |
| WELLS FARGO & COMPANY/MN 0.01% of their portfolio | 717.8k $39.1m | Added +30.5k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.03% of their portfolio | 669.0k $36.3m | Added +143.5k |
| RHUMBLINE ADVISERS 0.03% of their portfolio | 656.6k $35.7m | Reduced -67.4k |
| CANADA PENSION PLAN INVESTMENT BOARD 0.02% of their portfolio | 651.8k $35.5m | Added +135.9k |
| SYSTEMATIC FINANCIAL MANAGEMENT LP 0.70% of their portfolio | 650.0k $35.4m | Reduced -59.1k |
| PRINCIPAL FINANCIAL GROUP INC 0.02% of their portfolio | 631.1k $34.3m | Added +47.4k |
| BARCLAYS PLC 0.01% of their portfolio | 628.0k $34.2m | Added +123.7k |
| ROYAL BANK OF CANADA 0.01% of their portfolio | 620.2k $33.7m | Reduced -74.0k |
| Russell Investments Group, Ltd. 0.03% of their portfolio | 601.9k $32.8m | Reduced -22.1k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.13% of their portfolio | 578.9k $31.5m | Reduced -208.8k |
| Arbejdsmarkedets Tillaegspension 0.67% of their portfolio | 567.1k $30.9m | Reduced -42.4k |
| Pictet Asset Management Holding SA 0.03% of their portfolio | 555.4k $30.2m | Reduced -73.2k |
| California Public Employees Retirement System 0.02% of their portfolio | 539.7k $29.4m | Reduced -16.0k |
| CAPITAL FUND MANAGEMENT S.A. 0.21% of their portfolio | 527.2k $28.7m | Added +47.5k |
| BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio | 526.7k $28.7m | Reduced -446.5k |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.01% of their portfolio | 492.1k $26.8m | Added +8.9k |
| Woodline Partners LP 0.08% of their portfolio | 485.4k $26.4m | Unchanged |
| Driehaus Capital Management LLC 0.15% of their portfolio | 478.3k $26.0m | Added +141.6k |
| EULAV Asset Management 0.83% of their portfolio | 476.0k $25.9m | Reduced -16.0k |
| Squarepoint Ops LLC 0.05% of their portfolio | 473.7k $25.8m | Added +446.6k |
| Swiss National Bank 0.01% of their portfolio | 471.4k $25.6m | Reduced -32.9k |
| Man Group plc 0.05% of their portfolio | 456.8k $24.9m | Reduced -54.2k |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.04% of their portfolio | 452.1k $24.6m | Reduced -37.2k |
| IEQ CAPITAL, LLC 0.11% of their portfolio | 451.8k $24.6m | Reduced -127.8k |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.03% of their portfolio | 438.0k $23.8m | Unchanged |
| Baird Financial Group, Inc. 0.03% of their portfolio | 437.1k $23.8m | Added +431.4k |
| DekaBank Deutsche Girozentrale 0.03% of their portfolio | 429.7k $18.3m | Unchanged |
| ACADIAN ASSET MANAGEMENT LLC 0.03% of their portfolio | 421.4k $22.9m | Added +339.7k |
| BANK OF NOVA SCOTIA 0.03% of their portfolio | 419.7k $22.8m | New |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.08% of their portfolio | 415.6k $22.6m | Reduced -10.3k |
| South Street Advisors LLC 2.90% of their portfolio | 409.4k $22.3m | Added +5.5k |
| Bridgewater Associates, LP 0.09% of their portfolio | 400.9k $21.8m | Reduced -80.1k |
| VICTORY CAPITAL MANAGEMENT INC 0.01% of their portfolio | 394.8k $21.5m | Reduced -118.5k |
| Cerity Partners LLC 0.02% of their portfolio | 377.1k $20.5m | Added +63.2k |
| Tidal Investments LLC 0.05% of their portfolio | 375.3k $20.4m | Reduced -7.0k |
| Krensavage Asset Management, LLC 7.66% of their portfolio | 370.7k $20.2m | Reduced -45.0k |
| Legal & General Group Plc 0.00% of their portfolio | 359.5k $19.6m | Reduced -35.8k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 344.2k $14.8m | Added +19.6k |
| LAZARD ASSET MANAGEMENT LLC 0.03% of their portfolio | 343.0k $18.7m | Reduced -29.6k |
| NFJ INVESTMENT GROUP, LLC 0.62% of their portfolio | 338.0k $18.4m | Reduced -29.1k |
| HANCOCK WHITNEY CORP 0.30% of their portfolio | 330.8k $18.0m | Added +15.1k |
| SAWGRASS ASSET MANAGEMENT LLC 2.35% of their portfolio | 327.3k $17.8m | Added +35.5k |
| WORLDQUANT MILLENNIUM ADVISORS LLC 0.06% of their portfolio | 322.8k $17.6m | Added +86.5k |
| Mariner, LLC 0.02% of their portfolio | 313.1k $17.0m | Added +5.2k |