EDGEWISE THERAPEUTICS INC EWTX
COM · Common Stock · CUSIP 28036F105
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersBoulder, CO
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($88.5k this quarter). Holder counts are more reliable. Shares outstanding: 94.7m as of 2024-10-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $26.69. Options: 14 managers hold calls ($60.0m notional), 8 hold puts ($13.3m).
Trends to Q3 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 94 |
| Q4 2022 | 91 |
| Q1 2023 | 86 |
| Q2 2023 | 96 |
| Q3 2023 | 86 |
| Q4 2023 | 117 |
| Q1 2024 | 130 |
| Q2 2024 | 141 |
| Q3 2024 | 178 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 53 | 30 |
| Q1 2023 | 40 | 38 |
| Q2 2023 | 53 | 26 |
| Q3 2023 | 50 | 35 |
| Q4 2023 | 77 | 26 |
| Q1 2024 | 91 | 47 |
| Q2 2024 | 90 | 50 |
| Q3 2024 | 107 | 60 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q4 2023 | $362.9k | $72.2k | 0.20 |
| Q1 2024 | $407.9k | $270.0k | 0.66 |
| Q2 2024 | $1.1m | $139.7k | 0.13 |
| Q3 2024 | $60.0m | $13.3m | 0.22 |
Biggest buyers
| BRAIDWELL LP | New | +2.0m |
| JANUS HENDERSON GROUP PLC | Added | +2.0m |
| Artisan Partners Limited Partnership | New | +1.0m |
| Deep Track Capital, LP | Added | +914.1k |
| Driehaus Capital Management LLC | Added | +693.0k |
| PERCEPTIVE ADVISORS LLC | Added | +473.9k |
| Schonfeld Strategic Advisors LLC | Added | +467.4k |
| Paradigm Biocapital Advisors LP | Added | +463.7k |
| Logos Global Management LP | New | +450.0k |
| Cormorant Asset Management, LP | Added | +400.0k |
Biggest sellers
| FMR LLC | Reduced | -4.1m |
| CITADEL ADVISORS LLC | Reduced | -1.8m |
| GOLDMAN SACHS GROUP INC | Reduced | -1.1m |
| DEERFIELD MANAGEMENT COMPANY, L.P. | Reduced | -1.1m |
| Frazier Life Sciences Management, L.P. | Reduced | -898.2k |
| Venrock Adviser, LLC | Reduced | -818.2k |
| Artal Group S.A. | Sold out | -811.7k |
| NOVO HOLDINGS A/S | Reduced | -794.5k |
| Balyasny Asset Management L.P. | Sold out | -528.6k |
| ADAR1 Capital Management, LLC | Reduced | -418.4k |
Biggest calls
| Caption Management, LLC | New | $21.9m820.2k shares |
| Integral Health Asset Management, LLC | New | $13.3m500.0k shares |
| JANE STREET GROUP, LLC | New | $10.1m379.6k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $6.9m259.8k shares |
| CITADEL ADVISORS LLC | Added | $1.9m70.0k shares |
| SIMPLEX TRADING, LLC | Added | $1.8m68.7k shares |
| J. Goldman & Co LP | New | $1.3m47.2k shares |
| GROUP ONE TRADING LLC | Added | $864.8k32.4k shares |
| Cinctive Capital Management LP | New | $800.7k30.0k shares |
| MILLENNIUM MANAGEMENT LLC | New | $533.8k20.0k shares |
Biggest puts
| JANE STREET GROUP, LLC | New | $4.3m160.9k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $2.9m108.5k shares |
| MILLENNIUM MANAGEMENT LLC | New | $1.9m70.0k shares |
| SIMPLEX TRADING, LLC | Added | $1.9m69.9k shares |
| CITADEL ADVISORS LLC | Added | $1.7m62.8k shares |
| GROUP ONE TRADING LLC | Added | $539.1k20.2k shares |
| GTS SECURITIES LLC | New | $208.2k7.8k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
ORBIMED ADVISORS LLC
13D · may seek influence
filed 2025-05-12
Stated purposeThe Reporting Persons from time to time intend to review their investment in the Issuer on the basis of various factors, including the Issuer's business, financial condition, results of operations and prospects, general economic and industry conditions, the securities markets in general and those for the Issuer's Shares in particular, as well as other developments and other investment opportunities. Based upon such review, the Reporting Persons will take such actions in the future as the Reporting Persons may deem appropriate in light of the circumstances existing from time to time. If the Reporting Persons believe that further investment in the Issuer is attractive, whether because of the market price of Shares or otherwise, they may acquire Shares or other securities of the Issuer either… Full filing |
14.5% |
| Paradigm Biocapital Advisors LP 13G · passive investor +3.3 pts · filed 2026-08-14 | 9.5% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor -2.1 pts · filed 2026-08-14 | 7.8% |
| JANUS HENDERSON GROUP PLC 13G · institution +0.8 pts · filed 2026-05-15 | 5.5% |
| BlackRock, Inc. 13G · institution filed 2025-07-17 | 5.5% |
| FMR LLC 13G · institution new · filed 2026-08-06 | 5.1% |
Fell to 5% or below in the last year: BAKER BROS. ADVISORS LP (3.4%, 2026-08-14), Novo Holdings A/S (4.9%, 2026-04-27)
Insider purchases and sales in Q3 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2022 | 0 | — | 1 | $46.2k | — |
| Q1 2023 | 0 | — | 0 | — | — |
| Q2 2023 | 0 | — | 6 | $116.0k | — |
| Q3 2023 | 0 | — | 0 | — | — |
| Q4 2023 | 1 | $101.0k | 2 | $1.7m | — |
| Q1 2024 | 2 | $5.0m | 3 | $2.2m | $2.2m |
| Q2 2024 | 0 | — | 6 | $269.3k | — |
| Q3 2024 | 0 | — | 5 | $9.1m | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-09-23 | MOORE JOHN R General Counsel | Sold | $578.1k20.9k shares |
| 2024-09-20 | Carruthers R Michael Chief Financial Officer | Sold | $3.6m125.1k shares |
| 2024-09-20 | Russell Alan J Chief Scientific Officer, director | Sold | $2.1m75.0k shares |
| 2024-09-20 | MOORE JOHN R General Counsel | Sold | $1.4m50.0k shares |
| 2024-09-20 | Derakhshan Behrad Chief Business Officer | Sold | $1.2m42.1k shares |
| 2024-09-20 | Donovan Joanne M. CMO | Sold | $202.6k7.2k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q3 2024
| Manager | Shares | Change |
|---|---|---|
| ORBIMED ADVISORS LLC 7.34% of their portfolio | 15.0m $400.9m | Unchanged |
| RA CAPITAL MANAGEMENT, L.P. 2.74% of their portfolio | 8.9m $237.8m | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 6.4m $170.6m | First filing |
| BAKER BROS. ADVISORS LP 1.62% of their portfolio | 5.8m $155.9m | Unchanged |
| NOVO HOLDINGS A/S 7.36% of their portfolio | 5.5m $148.1m | Reduced -794.5k |
| JANUS HENDERSON GROUP PLC 0.06% of their portfolio | 4.6m $121.6m | Added +2.0m |
| VANGUARD GROUP INC 0.00% of their portfolio | 4.5m $120.5m | Added +7.9k |
| Cormorant Asset Management, LP 4.82% of their portfolio | 3.4m $90.9m | Added +400.0k |
| Frazier Life Sciences Management, L.P. 3.03% of their portfolio | 2.8m $75.6m | Reduced -898.2k |
| Paradigm Biocapital Advisors LP 2.61% of their portfolio | 2.8m $74.4m | Added +463.7k |
| PERCEPTIVE ADVISORS LLC 1.33% of their portfolio | 2.3m $62.2m | Added +473.9k |
| TCG Crossover Management, LLC 4.78% of their portfolio | 2.1m $56.4m | Reduced -159.7k |
| BRAIDWELL LP 1.48% of their portfolio | 2.0m $52.3m | New |
| Driehaus Capital Management LLC 0.45% of their portfolio | 2.0m $52.1m | Added +693.0k |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.71% of their portfolio | 1.8m $47.5m | Reduced -1.1m |
| STATE STREET CORP 0.00% of their portfolio | 1.7m $45.0m | Added +20.0k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.6m $42.7m | Reduced -73.1k |
| New Leaf Venture Partners, L.L.C. 42.62% of their portfolio | 1.6m $41.5m | Unchanged |
| VIKING GLOBAL INVESTORS LP 0.14% of their portfolio | 1.5m $39.5m | Unchanged |
| Bellevue Group AG 0.62% of their portfolio | 1.4m $38.1m | Unchanged |
| EcoR1 Capital, LLC 1.14% of their portfolio | 1.3m $33.4m | Unchanged |
| Deep Track Capital, LP 0.94% of their portfolio | 1.1m $29.4m | Added +914.1k |
| Artisan Partners Limited Partnership 0.04% of their portfolio | 1.0m $26.7m | New |
| Venrock Adviser, LLC 1.40% of their portfolio | 1.0m $26.7m | Reduced -818.2k |
| MILLENNIUM MANAGEMENT LLC 0.02% of their portfolio | 987.0k $26.3m | Reduced -158.5k |
| AMERICAN CENTURY COMPANIES INC 0.01% of their portfolio | 934.4k $24.9m | Added +74.3k |
| MPM BIOIMPACT LLC 3.67% of their portfolio | 917.2k $24.5m | Added +176.5k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 726.9k $19.4m | Added +259.4k |
| Parkman Healthcare Partners LLC 2.24% of their portfolio | 657.1k $17.5m | Added +82.6k |
| FMR LLC 0.00% of their portfolio | 653.2k $17.4m | Reduced -4.1m |
| MARSHALL WACE, LLP 0.02% of their portfolio | 577.6k $15.4m | Added +161.8k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 575.9k $15.4m | Added +67.2k |
| Schonfeld Strategic Advisors LLC 0.12% of their portfolio | 545.5k $14.6m | Added +467.4k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 538.2k $14.4m | Reduced -1.8m |
| Woodline Partners LP 0.12% of their portfolio | 527.8k $14.1m | Added +106.2k |
| Opaleye Management Inc. 2.33% of their portfolio | 522.5k $13.9m | Reduced -57.5k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 522.1k $13.9m | Reduced -49.1k |
| Granahan Investment Management, LLC 0.54% of their portfolio | 511.9k $13.7m | Reduced -198.8k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 482.2k $12.9m | Reduced -1.1m |
| D. E. Shaw & Co., Inc. 0.02% of their portfolio | 455.3k $12.2m | Added +143.9k |
| Logos Global Management LP 1.35% of their portfolio | 450.0k $12.0m | New |
| MORGAN STANLEY 0.00% of their portfolio | 418.1k $11.2m | Added +168.2k |
| Siren, L.L.C. 0.54% of their portfolio | 404.1k $10.8m | First filing |
| Sofinnova Investments, Inc. 0.85% of their portfolio | 384.8k $10.3m | Reduced -90.9k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 317.0k $8.5m | Added +188.3k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 308.1k $8.2m | Added +35.3k |
| VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 307.8k $8.2m | Added +283.5k |
| Candriam S.C.A. 0.05% of their portfolio | 294.6k $7.9m | Reduced -34.4k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 270.4k $7.2m | Added +27.3k |
| TWO SIGMA INVESTMENTS, LP 0.02% of their portfolio | 261.5k $7.0m | Reduced -101.1k |
| Aberdeen Group plc 0.01% of their portfolio | 256.6k $6.8m | New |
| Walleye Capital LLC 0.07% of their portfolio | 242.3k $6.5m | New |
| DAFNA Capital Management LLC 1.44% of their portfolio | 227.9k $6.1m | Reduced -62.3k |
| KENNEDY CAPITAL MANAGEMENT LLC 0.13% of their portfolio | 227.0k $6.1m | Reduced -45.0k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 217.9k $5.8m | Added +186.8k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 210.8k $5.6m | Reduced -57.9k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 205.3k $5.5m | Reduced -288.5k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio | 200.5k $5.4m | Added +183.7k |
| Ghost Tree Capital, LLC 1.89% of their portfolio | 195.0k $5.2m | New |
| Ally Bridge Group (NY) LLC 2.68% of their portfolio | 187.7k $5.0m | New |
| Polar Asset Management Partners Inc. 0.10% of their portfolio | 157.6k $4.2m | Reduced -29.9k |
| Moody Aldrich Partners LLC 0.73% of their portfolio | 151.2k $4.0m | New |
| Amundi 0.00% of their portfolio | 150.4k $4.3m | New |
| Qube Research & Technologies Ltd 0.01% of their portfolio | 131.9k $3.5m | Added +103.0k |
| Jump Financial, LLC 0.07% of their portfolio | 131.8k $3.5m | New |
| Informed Momentum Co LLC 0.50% of their portfolio | 125.2k $3.3m | New |
| Exome Asset Management LLC 1.09% of their portfolio | 119.8k $3.2m | New |
| BARCLAYS PLC 0.00% of their portfolio | 119.3k $3.2m | Added +88.8k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 100.9k $2.7m | Added +2.6k |
| HRT FINANCIAL LP 0.01% of their portfolio | 96.4k $2.6m | New |
| HighVista Strategies LLC 0.82% of their portfolio | 88.8k $2.4m | New |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 84.3k $2.2m | Added +4.4k |
| DekaBank Deutsche Girozentrale 0.00% of their portfolio | 80.0k $1.4m | Unchanged |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 76.0k $2.0m | Reduced -4.4k |
| CITIGROUP INC 0.00% of their portfolio | 75.8k $2.0m | Added +52.8k |
| UBS Group AG 0.00% of their portfolio | 75.3k $2.0m | Added +14.8k |
| Monashee Investment Management LLC 0.22% of their portfolio | 75.0k $2.0m | New |
| BRIDGER MANAGEMENT, LLC 1.00% of their portfolio | 74.7k $2.0m | New |
| SIMPLEX TRADING, LLC 0.07% of their portfolio | 74.0k $2.0m | Added +71.3k |
| Swiss National Bank 0.00% of their portfolio | 73.6k $2.0m | Unchanged |
| Quantum Private Wealth, LLC 0.66% of their portfolio | 73.4k $2.0m | Added +6.7k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 71.8k $1.9m | Added +20.4k |
| ALPS ADVISORS INC 0.01% of their portfolio | 68.9k $1.8m | Reduced -3.9k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 67.1k $1.8m | Added +37.2k |
| Invesco Ltd. 0.00% of their portfolio | 64.8k $1.7m | Added +42.5k |
| ACUTA CAPITAL PARTNERS, LLC 1.36% of their portfolio | 63.0k $1.7m | New |
| SEI INVESTMENTS CO 0.00% of their portfolio | 52.6k $1.4m | New |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 50.4k $1.3m | Reduced -14.1k |
| NORGES BANK 0.00% of their portfolio | 47.8k $1.3m | New |
| Cinctive Capital Management LP 0.07% of their portfolio | 46.2k $1.2m | New |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 45.4k $1.2m | Reduced -50.6k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 45.2k $1.4m | Added +20.7k |
| Legal & General Group Plc 0.00% of their portfolio | 43.7k $1.2m | Added +4.4k |
| MetLife Investment Management, LLC 0.01% of their portfolio | 42.3k $1.1m | Unchanged |
| Hudson Bay Capital Management LP 0.01% of their portfolio | 39.9k $1.1m | New |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 39.7k $1.1m | Added +10.4k |
| Corebridge Financial, Inc. 0.01% of their portfolio | 38.8k $1.0m | Reduced -240 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 38.4k $1.0m | Added +44 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 37.9k $1.0m | Reduced -1.2k |
| TUDOR INVESTMENT CORP ET AL 0.01% of their portfolio | 35.6k $950.5k | Added +9.2k |