DIANTHUS THERAPEUTICS INC DNTH
COM · Common Stock · CUSIP 252828108
Biotechnology company
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersNew York, NY
- Websitemagentatx.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.1m this quarter). Holder counts are more reliable. Shares outstanding: 32.2m as of 2025-08-06, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $18.63. Options: 5 managers hold calls ($2.7m notional), 3 hold puts ($571.8k).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2023 | 31 |
| Q4 2023 | 40 |
| Q1 2024 | 77 |
| Q2 2024 | 75 |
| Q3 2024 | 92 |
| Q4 2024 | 97 |
| Q1 2025 | 100 |
| Q2 2025 | 104 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2023 | 20 | 7 |
| Q1 2024 | 63 | 10 |
| Q2 2024 | 45 | 47 |
| Q3 2024 | 54 | 26 |
| Q4 2024 | 49 | 37 |
| Q1 2025 | 44 | 41 |
| Q2 2025 | 48 | 53 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $11.0k | $11.0k | 1.00 |
| Q4 2024 | $8.7k | $13.1k | 1.50 |
| Q1 2025 | $812.7k | $1.7m | 2.13 |
| Q2 2025 | $2.7m | $571.8k | 0.21 |
Biggest buyers
| Vestal Point Capital, LP | Added | +1.5m |
| BAKER BROS. ADVISORS LP | New | +789.8k |
| VANGUARD GROUP INC | Added | +337.2k |
| GOLDMAN SACHS GROUP INC | Added | +291.2k |
| MILLENNIUM MANAGEMENT LLC | New | +195.4k |
| CITADEL ADVISORS LLC | Added | +194.2k |
| Schonfeld Strategic Advisors LLC | New | +172.0k |
| ALLIANCEBERNSTEIN L.P. | Added | +149.2k |
| Ensign Peak Advisors, Inc | New | +134.4k |
| Sio Capital Management, LLC | Added | +119.1k |
Biggest sellers
| Venrock Adviser, LLC | Reduced | -744.4k |
| JANUS HENDERSON GROUP PLC | Sold out | -683.6k |
| BRAIDWELL LP | Sold out | -375.4k |
| GREAT POINT PARTNERS LLC | Sold out | -275.0k |
| BlackRock, Inc. | Reduced | -257.0k |
| Bain Capital Life Sciences Investors, LLC | Reduced | -207.5k |
| Deep Track Capital, LP | Reduced | -124.6k |
| SILVERARC CAPITAL MANAGEMENT, LLC | Reduced | -94.5k |
| Point72 Asset Management, L.P. | Reduced | -94.4k |
| Walleye Capital LLC | Reduced | -80.8k |
Biggest calls
| Caption Management, LLC | Added | $1.6m88.1k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $581.3k31.2k shares |
| GROUP ONE TRADING LLC | New | $460.2k24.7k shares |
| SIMPLEX TRADING, LLC | New | $1.0k100 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $478.8k25.7k shares |
| SIMPLEX TRADING, LLC | Added | $93.0k5.0k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution +1.0 pts · filed 2025-11-05 | 15.0% |
| T. Rowe Price Investment Management, Inc. 13G · institution +5.0 pts · filed 2026-08-07 | 12.1% |
| BlackRock, Inc. 13G · institution +1.3 pts · filed 2026-07-28 | 6.4% |
| WELLINGTON MANAGEMENT GROUP LLP 13G · institution +1.1 pts · filed 2026-08-13 | 5.9% |
Fell to 5% or below in the last year: Sirenia Capital Management LP (3.1%, 2026-08-14), Point72 Asset Management, L.P. (1.2%, 2026-05-15), RA CAPITAL MANAGEMENT, L.P. (4.8%, 2026-05-15), Octagon Capital Advisors LP (3.6%, 2026-05-14), Fairmount Funds Management LLC (4.9%, 2025-11-25), Avidity Partners Management LP (4.9%, 2025-11-19), Deep Track Capital, LP (0.0%, 2025-11-14), BCLS Fund III Investments, LP (3.1%, 2025-11-14), Vestal Point Capital, LP (3.0%, 2025-11-14)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 2 | $1.5m | 0 | — | — |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 0 | — | 0 | — | — |
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
None reported in Q2 2025.
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.00% of their portfolio | 4.5m $84.7m | Added +61.6k |
| Vestal Point Capital, LP 3.14% of their portfolio | 3.2m $59.6m | Added +1.5m |
| RA CAPITAL MANAGEMENT, L.P. 0.90% of their portfolio | 2.9m $53.4m | Unchanged |
| Fairmount Funds Management LLC 6.53% of their portfolio | 2.7m $50.4m | Added +6.5k |
| Bain Capital Life Sciences Investors, LLC 5.79% of their portfolio | 2.5m $46.2m | Reduced -207.5k |
| Octagon Capital Advisors LP 9.57% of their portfolio | 2.3m $43.6m | Unchanged |
| Deep Track Capital, LP 1.34% of their portfolio | 2.2m $41.6m | Reduced -124.6k |
| Avidity Partners Management LP 6.51% of their portfolio | 1.7m $32.5m | Added +22.0k |
| TCG Crossover Management, LLC 3.20% of their portfolio | 1.5m $28.0m | Unchanged |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.4m $26.9m | Added +337.2k |
| Point72 Asset Management, L.P. 0.06% of their portfolio | 1.4m $25.9m | Reduced -94.4k |
| BlackRock, Inc. 0.00% of their portfolio | 1.4m $25.3m | Reduced -257.0k |
| ALLIANCEBERNSTEIN L.P. 0.01% of their portfolio | 1.2m $21.9m | Added +149.2k |
| Venrock Adviser, LLC 1.40% of their portfolio | 1.0m $18.6m | Reduced -744.4k |
| 5AM Venture Management, LLC 7.05% of their portfolio | 984.7k $18.3m | Reduced -43.0k |
| STATE STREET CORP 0.00% of their portfolio | 820.1k $15.3m | Added +60.5k |
| BAKER BROS. ADVISORS LP 0.14% of their portfolio | 789.8k $14.7m | New |
| Catalio Capital Management, LP 2.92% of their portfolio | 746.5k $13.9m | Reduced -16.9k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 665.0k $12.4m | Added +194.2k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 484.9k $9.0m | Reduced -32.1k |
| Woodline Partners LP 0.04% of their portfolio | 400.5k $7.5m | Added +100.0k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 364.6k $6.8m | Added +291.2k |
| TANG CAPITAL MANAGEMENT LLC 0.25% of their portfolio | 264.7k $4.9m | Unchanged |
| Candriam S.C.A. 0.03% of their portfolio | 240.6k $4.5m | Reduced -8.0k |
| Sio Capital Management, LLC 1.76% of their portfolio | 236.1k $4.4m | Added +119.1k |
| Alphabet Inc. 0.18% of their portfolio | 208.7k $3.9m | Unchanged |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 195.4k $3.6m | New |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.01% of their portfolio | 185.0k $3.4m | Reduced -4.0k |
| Schonfeld Strategic Advisors LLC 0.02% of their portfolio | 172.0k $3.2m | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 165.1k $3.1m | Added +71.8k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 164.3k $3.1m | Reduced -3.8k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 160.3k $3.0m | Reduced -75.2k |
| MORGAN STANLEY 0.00% of their portfolio | 137.8k $2.6m | Added +58.7k |
| Ensign Peak Advisors, Inc 0.00% of their portfolio | 134.4k $2.5m | New |
| UBS Group AG 0.00% of their portfolio | 131.5k $2.4m | Added +84.1k |
| Rhenman & Partners Asset Management AB 0.30% of their portfolio | 126.6k $2.4m | Unchanged |
| Hudson Bay Capital Management LP 0.01% of their portfolio | 115.4k $2.2m | Added +40.4k |
| SILVERARC CAPITAL MANAGEMENT, LLC 0.37% of their portfolio | 95.8k $1.8m | Reduced -94.5k |
| ExodusPoint Capital Management, LP 0.02% of their portfolio | 75.1k $1.4m | New |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 74.4k $1.4m | Added +6.4k |
| Moody Aldrich Partners LLC 0.26% of their portfolio | 73.3k $1.4m | Reduced -1.1k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 66.7k $1.2m | Reduced -6.9k |
| BARCLAYS PLC 0.00% of their portfolio | 64.8k $1.2m | Added +33.7k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 56.3k $1.0m | New |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 54.1k $1.0m | Added +6.3k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 49.5k $922.8k | Added +48.2k |
| Nuveen, LLC 0.00% of their portfolio | 47.7k $888.5k | Reduced -16.7k |
| Cubist Systematic Strategies, LLC 0.01% of their portfolio | 43.4k $808.2k | Added +21.6k |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 37.1k $691.2k | Unchanged |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 31.5k $586.9k | Reduced -3.5k |
| Squarepoint Ops LLC 0.00% of their portfolio | 30.7k $572.1k | Added +19.7k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 30.1k $560.1k | Reduced -17.3k |
| Paloma Partners Management Co 0.12% of their portfolio | 29.2k $544.3k | New |
| Rafferty Asset Management, LLC 0.00% of their portfolio | 28.5k $531.4k | Added +4.7k |
| XTX Topco Ltd 0.02% of their portfolio | 27.0k $503.1k | New |
| Walleye Capital LLC 0.00% of their portfolio | 26.1k $486.9k | Reduced -80.8k |
| Verition Fund Management LLC 0.00% of their portfolio | 22.9k $427.5k | New |
| Invesco Ltd. 0.00% of their portfolio | 20.9k $390.1k | Added +5.0k |
| ArrowMark Colorado Holdings LLC 0.01% of their portfolio | 20.8k $387.3k | Unchanged |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 18.0k $335.5k | Added +5.3k |
| ALPS ADVISORS INC 0.00% of their portfolio | 17.4k $323.5k | Reduced -6.3k |
| HighVista Strategies LLC 0.11% of their portfolio | 15.9k $295.5k | Reduced -15.5k |
| BESSEMER GROUP INC 0.00% of their portfolio | 15.0k $279.0k | Added +135 |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 14.5k $269.9k | Reduced -3.4k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 14.1k $262.6k | Unchanged |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 13.0k $241.6k | Unchanged |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 12.3k $229.6k | Reduced -3.1k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 12.1k $223.9k | Reduced -3.2k |
| CITIGROUP INC 0.00% of their portfolio | 11.7k $217.4k | Reduced -23.1k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 10.7k $200.0k | Added +201 |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 9.4k $174.7k | Reduced -2.3k |
| Point72 (DIFC) Ltd 0.01% of their portfolio | 8.9k $166.0k | Reduced -7.8k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 8.1k $152.0k | Added +3.3k |
| AlphaQuest LLC 0.01% of their portfolio | 5.0k $93.7k | New |
| Virtus Investment Advisers, LLC 0.03% of their portfolio | 4.9k $90.8k | Reduced -2.1k |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 4.3k $80.5k | Added +3.3k |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 4.2k $78.8k | Reduced -1.5k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 4.1k $76.4k | Reduced -5.6k |
| Aquatic Capital Management LLC 0.00% of their portfolio | 3.2k $59.4k | New |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 2.3k $43.6k | Unchanged |
| Legal & General Group Plc 0.00% of their portfolio | 1.8k $34.1k | Reduced -2.1k |
| US BANCORP \DE\ 0.00% of their portfolio | 1.4k $26.8k | Reduced -144 |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 1.4k $26.6k | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 1.2k $22.7k | Reduced -513 |
| Point72 Asia (Singapore) Pte. Ltd. 0.00% of their portfolio | 1.0k $18.9k | New |
| AMALGAMATED BANK 0.00% of their portfolio | 827 $15.0k | Unchanged |
| Sterling Capital Management LLC 0.00% of their portfolio | 486 $9.1k | Added +102 |
| Parkside Financial Bank & Trust 0.00% of their portfolio | 410 $7.6k | Added +25 |
| Caitong International Asset Management Co., Ltd 0.00% of their portfolio | 356 $6.6k | New |
| CROWLEY WEALTH MANAGEMENT, INC. 0.00% of their portfolio | 221 $4.1k | Unchanged |
| Quarry LP 0.00% of their portfolio | 137 $2.6k | New |
| GAMMA Investing LLC 0.00% of their portfolio | 126 $2.3k | Reduced -88 |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 106 $1.0k | Reduced -5 |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 50 $932 | Reduced -40 |
| Riggs Asset Managment Co. Inc. 0.00% of their portfolio | 35 $653 | New |
| ROTHSCHILD INVESTMENT LLC 0.00% of their portfolio | 15 $279 | Reduced -30 |
| CWM, LLC 0.00% of their portfolio | 15 $0 | Reduced -2 |
| PRINCIPAL SECURITIES, INC. 0.00% of their portfolio | 11 $205 | New |
| SIGNATUREFD, LLC 0.00% of their portfolio | 8 $149 | New |
| Allworth Financial LP 0.00% of their portfolio | 8 $150 | Reduced -19 |