Vault-13

DAY ONE BIOPHARMACEUTICALS I

COM · Common Stock · CUSIP 23954D109 · ISIN US23954D1090

159 institutional holders +9 vs Q1 2024
74,795,74574.8m shares reported held*
$1.0bnreported value*
31 new 49 added 48 reduced 23 sold out net bought ≈ $20.1m (+1.5m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($160.0k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $13.78. Options: 9 managers hold calls ($3.5m notional), 10 hold puts ($4.9m).

Trends to Q2 2024

Institutional holders

Managers reporting a position, each quarter

0100200Q3 22: 93Q4 22: 110Q1 23: 127Q2 23: 141Q3 23: 132Q4 23: 142Q1 24: 150Q2 24: 159159Q3 22Q1 23Q3 23Q1 24Q2 24
Numbers
QuarterHolders
Q3 202293
Q4 2022110
Q1 2023127
Q2 2023141
Q3 2023132
Q4 2023142
Q1 2024150
Q2 2024159

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q4 22: 59 bought or addedQ4 22: 31 cut or sold outQ4 22Q1 23: 74 bought or addedQ1 23: 42 cut or sold outQ2 23: 98 bought or addedQ2 23: 47 cut or sold outQ2 23Q3 23: 69 bought or addedQ3 23: 56 cut or sold outQ4 23: 71 bought or addedQ4 23: 52 cut or sold outQ4 23Q1 24: 74 bought or addedQ1 24: 61 cut or sold outQ2 24: 80 bought or addedQ2 24: 71 cut or sold outQ2 24
Numbers
QuarterBought or addedCut or sold out
Q4 20225931
Q1 20237442
Q2 20239847
Q3 20236956
Q4 20237152
Q1 20247461
Q2 20248071

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$2m$4m$6mQ3 23 calls: $812.9kQ3 23 puts: $775.2kQ3 23P/C 0.95Q4 23 calls: $1.7mQ4 23 puts: $575.0kQ4 23P/C 0.35Q1 24 calls: $1.3mQ1 24 puts: $1.3mQ1 24P/C 0.99Q2 24 calls: $3.5mQ2 24 puts: $4.9mQ2 24P/C 1.40
Numbers
QuarterCallsPutsP/C
Q3 2023$812.9k$775.2k0.95
Q4 2023$1.7m$575.0k0.35
Q1 2024$1.3m$1.3m0.99
Q2 2024$3.5m$4.9m1.40

Biggest buyers

Vestal Point Capital, LP New +1,250,000+1.2m
DEERFIELD MANAGEMENT COMPANY, L.P. Added +1,157,825+1.2m
Estuary Capital Management LP Added +1,024,133+1.0m
BRAIDWELL LP Added +862,200+862.2k
Ally Bridge Group (NY) LLC New +536,095+536.1k
Pictet Asset Management Holding SA Added +476,437+476.4k
Point72 Asset Management, L.P. New +470,247+470.2k
Hudson Bay Capital Management LP Added +445,108+445.1k
Woodline Partners LP Added +434,993+435.0k
CITADEL ADVISORS LLC Added +322,343+322.3k

Biggest sellers

FMR LLC Reduced -1,742,897-1.7m
First Turn Management, LLC Sold out -1,318,207-1.3m
MORGAN STANLEY Reduced -530,404-530.4k
BlackRock Inc. Reduced -497,993-498.0k
Nicholas Investment Partners, LP Sold out -361,767-361.8k
SUPERSTRING CAPITAL MANAGEMENT LP Sold out -349,679-349.7k
Propel Bio Management, LLC Sold out -270,664-270.7k
Polar Capital Holdings Plc Reduced -250,000-250.0k
GOLDMAN SACHS GROUP INC Reduced -234,383-234.4k
Altitude Crest Partners Inc. Sold out -195,497-195.5k

Biggest calls

TORNO CAPITAL, LLC New $826.8k60.0k shares
GROUP ONE TRADING LLC Added $668.3k48.5k shares
BANK OF AMERICA CORP /DE/ Reduced $416.2k30.2k shares
CITIGROUP INC New $413.4k30.0k shares
CITADEL ADVISORS LLC Added $359.7k26.1k shares
Caption Management, LLC New $344.5k25.0k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP New $303.2k22.0k shares
SIMPLEX TRADING, LLC Reduced $147.0k10.7k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

GROUP ONE TRADING LLC Added $927.4k67.3k shares
TORNO CAPITAL, LLC New $826.8k60.0k shares
SIMPLEX TRADING, LLC Added $720.0k52.3k shares
CITADEL ADVISORS LLC Added $636.6k46.2k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $577.4k41.9k shares
CITIGROUP INC New $413.4k30.0k shares
Caption Management, LLC New $344.5k25.0k shares
JANE STREET GROUP, LLC New $275.6k20.0k shares
BANK OF AMERICA CORP /DE/ Unchanged $137.8k10.0k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
BlackRock, Inc. 13G · institution +1.1 pts · filed 2025-07-17 5.8% +1.1 pts 5.8m 2025-07-17
GLAZER CAPITAL, LLC 13G · passive investor new · filed 2026-03-19 5.4% new 5.6m 2026-03-19

Fell to 5% or below in the last year: Vestal Point Capital, LP (0.0%, 2026-05-15), Atlas Venture Fund XI, L.P. (0.0%, 2026-05-14), AI Day1 LLC (0.0%, 2026-04-27), FMR LLC (0.0%, 2026-04-07), VANGUARD GROUP INC (0.0%, 2026-03-26)

Holders, Q2 2024

#ManagerLocationShares Value% of their portfolioChangeShares change
1 RA CAPITAL MANAGEMENT, L.P. 1.43% of their portfolio BOSTON, MA 7,871,7217.9m $108.5m $108.5m 1.43% Added +61.9k +61,869
2 Atlas Venture Life Science Advisors, LLC 9.33% of their portfolio CAMBRIDGE, MA 6,430,2576.4m $88.6m $88.6m 9.33% Unchanged
3 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 4,623,2724.6m $63.7m $63.7m 0.00% Reduced -151.2k -151,211
4 BlackRock Inc. 0.00% of their portfolio New York, NY 4,533,4424.5m $62.5m $62.5m 0.00% Reduced -498.0k -497,993
5 FRANKLIN RESOURCES INC 0.02% of their portfolio San Mateo, CA 3,782,3703.8m $52.1m $52.1m 0.02% Reduced -24.4k -24,420
6 BRAIDWELL LP 1.31% of their portfolio STAMFORD, CT 3,035,9043.0m $41.8m $41.8m 1.31% Added +862.2k +862,200
7 DEERFIELD MANAGEMENT COMPANY, L.P. 0.67% of their portfolio New York, NY 2,923,1372.9m $40.3m $40.3m 0.67% Added +1.2m +1,157,825
8 Pictet Asset Management Holding SA 0.05% of their portfolio CAROUGE, V8 2,851,5742.9m $39.3m $39.3m 0.05% Added +476.4k +476,437
9 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 2,826,8202.8m $39.0m $39.0m 0.00% Reduced -68.1k -68,063
10 FMR LLC 0.00% of their portfolio BOSTON, MA 2,661,4442.7m $36.7m $36.7m 0.00% Reduced -1.7m -1,742,897
11 Estuary Capital Management LP 11.71% of their portfolio WAYZATA, MN 2,635,2702.6m $36.3m $36.3m 11.71% Added +1.0m +1,024,133
12 VIKING GLOBAL INVESTORS LP 0.14% of their portfolio STAMFORD, CT 2,558,5632.6m $35.3m $35.3m 0.14% Unchanged
13 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 2,350,8802.4m $32.4m $32.4m 0.00% Added +51.1k +51,116
14 GOLDMAN SACHS GROUP INC 0.01% of their portfolio NEW YORK, NY 1,903,1081.9m $26.2m $26.2m 0.01% Reduced -234.4k -234,383
15 JANUS HENDERSON GROUP PLC 0.01% of their portfolio LONDON, X0 1,839,2691.8m $25.4m $25.4m 0.01% Reduced -193.1k -193,115
16 TimesSquare Capital Management, LLC 0.37% of their portfolio NEW YORK, NY 1,688,5351.7m $23.3m $23.3m 0.37% Added +53.4k +53,390
17 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 1,296,2391.3m $17.9m $17.9m 0.00% Reduced -80.7k -80,722
18 Vestal Point Capital, LP 1.28% of their portfolio NEW YORK, NY 1,250,0001.2m $17.2m $17.2m 1.28% New
19 MAVERICK CAPITAL LTD 0.32% of their portfolio DALLAS, TX 1,211,1381.2m $16.7m $16.7m 0.32% Reduced -45.4k -45,432
20 Boxer Capital, LLC 0.86% of their portfolio San Diego, CA 1,189,9431.2m $16.4m $16.4m 0.86% Unchanged
21 Polar Capital Holdings Plc 0.08% of their portfolio London, X0 935,000935.0k $12.9m $12.9m 0.08% Reduced -250.0k -250,000
22 Parkman Healthcare Partners LLC 1.71% of their portfolio STAMFORD, CT 908,822908.8k $12.5m $12.5m 1.71% Added +217.0k +217,010
23 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 888,117888.1k $12.2m $12.2m 0.00% Reduced -93.5k -93,455
24 Woodline Partners LP 0.09% of their portfolio San Francisco, CA 707,531707.5k $9.7m $9.7m 0.09% Added +435.0k +434,993
25 Driehaus Capital Management LLC 0.09% of their portfolio Chicago, IL 706,446706.4k $9.7m $9.7m 0.09% Reduced -12.6k -12,565
26 DAFNA Capital Management LLC 2.19% of their portfolio LOS ANGELES, CA 666,463666.5k $9.2m $9.2m 2.19% Unchanged
27 Hudson Bay Capital Management LP 0.06% of their portfolio STAMFORD, CT 555,108555.1k $7.6m $7.6m 0.06% Added +445.1k +445,108
28 Ally Bridge Group (NY) LLC 4.40% of their portfolio NEW YORK, NY 536,095536.1k $7.4m $7.4m 4.40% New
29 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 533,039533.0k $7.3m $7.3m 0.00% Reduced -25.1k -25,106
30 Point72 Asset Management, L.P. 0.02% of their portfolio STAMFORD, CT 470,247470.2k $6.5m $6.5m 0.02% New
31 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 442,748442.7k $6.1m $6.1m 0.00% Reduced -14.9k -14,904
32 PFM Health Sciences, LP 0.30% of their portfolio SAN FRANCISCO, CA 396,644396.6k $5.5m $5.5m 0.30% Added +41.4k +41,393
33 CITADEL ADVISORS LLC 0.01% of their portfolio MIAMI, FL 369,608369.6k $5.1m $5.1m 0.01% Added +322.3k +322,343
34 SPHERA FUNDS MANAGEMENT LTD. 0.78% of their portfolio TEL AVIV, L3 347,627347.6k $4.8m $4.8m 0.78% Reduced -145.0k -145,000
35 TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio NEW YORK, NY 299,206299.2k $4.1m $4.1m 0.01% Added +278.8k +278,794
36 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 298,038298.0k $4.1m $4.1m 0.00% Added +25.9k +25,921
37 Candriam S.C.A. 0.02% of their portfolio STRASSEN, N4 290,014290.0k $4.0m $4.0m 0.02% Unchanged
38 Schonfeld Strategic Advisors LLC 0.03% of their portfolio NEW YORK, NY 244,957245.0k $3.4m $3.4m 0.03% Added +7.2k +7,209
39 D. E. Shaw & Co., Inc. 0.00% of their portfolio New York, NY 224,340224.3k $3.1m $3.1m 0.00% Added +121 +121
40 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 208,396208.4k $2.9m $2.9m 0.00% Reduced -7.0k -6,987
41 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 201,867201.9k $2.8m $2.8m 0.00% Added +23.7k +23,693
42 Monashee Investment Management LLC 0.36% of their portfolio Boston, MA 200,000200.0k $2.8m $2.8m 0.36% New
43 SAMSARA BIOCAPITAL, LLC 0.57% of their portfolio PALO ALTO, CA 196,425196.4k $2.7m $2.7m 0.57% Unchanged
44 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 190,906190.9k $2.6m $2.6m 0.00% Added +15.1k +15,131
45 Squarepoint Ops LLC 0.01% of their portfolio NEW YORK, NY 186,484186.5k $2.6m $2.6m 0.01% New
46 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 179,784179.8k $2.5m $2.5m 0.00% Added +123.0k +123,010
47 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 177,666177.7k $2.4m $2.4m 0.00% Added +50.1k +50,077
48 KENNEDY CAPITAL MANAGEMENT LLC 0.05% of their portfolio ST LOUIS, MO 173,738173.7k $2.4m $2.4m 0.05% New
49 Laurion Capital Management LP 0.08% of their portfolio NEW YORK, NY 171,887171.9k $2.4m $2.4m 0.08% Added +6.9k +6,904
50 NORGES BANK 0.00% of their portfolio OSLO, Q8 169,000169.0k $2.3m $2.3m 0.00% Unchanged
51 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 167,765167.8k $2.3m $2.3m 0.00% Added +138.8k +138,757
52 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 167,246167.2k $2.3m $2.3m 0.00% Reduced -530.4k -530,404
53 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 161,129161.1k $2.2m $2.2m 0.00% Added +27.0k +26,958
54 Rafferty Asset Management, LLC 0.01% of their portfolio New York, NY 149,655149.7k $2.1m $2.1m 0.01% Reduced -43.6k -43,569
55 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 120,906120.9k $1.7m $1.7m 0.00% Reduced -21.5k -21,512
56 AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio Greenwich, CT 113,020113.0k $1.6m $1.6m 0.00% Added +94.7k +94,703
57 MACQUARIE GROUP LTD 0.00% of their portfolio Sydney, NSW 2000, C3 110,603110.6k $1.5m $1.5m 0.00% Added +603 +603
58 BIT Capital GmbH 0.13% of their portfolio BERLIN, 2M 106,182106.2k $1.5m $1.5m 0.13% Unchanged
59 HRT FINANCIAL LP 0.01% of their portfolio NEW YORK, NY 98,62498.6k $1.4m $1.4m 0.01% New
60 Swiss National Bank 0.00% of their portfolio ZURICH, V8 95,40095.4k $1.3m $1.3m 0.00% Unchanged
61 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 91,09891.1k $1.3m $1.3m 0.00% Added +16.9k +16,944
62 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 85,43885.4k $1.2m $1.2m 0.00% Reduced -4.3k -4,289
63 TWO SIGMA ADVISERS, LP 0.00% of their portfolio NEW YORK, NY 84,30084.3k $1.2m $1.2m 0.00% New
64 Fisher Asset Management, LLC 0.00% of their portfolio PLANO, TX 73,30173.3k $1.0m $1.0m 0.00% Added +4.9k +4,890
65 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 72,14072.1k $994.1k $994.1k 0.00% New
66 UBS Group AG 0.00% of their portfolio ZURICH, V8 70,08370.1k $965.7k $965.7k 0.00% Reduced -93.9k -93,935
67 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 69,73069.7k $960.9k $960.9k 0.00% Added +31.9k +31,851
68 ALPS ADVISORS INC 0.01% of their portfolio Denver, CO 68,17068.2k $939.4k $939.4k 0.01% Added +6.5k +6,539
69 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 68,00068.0k $937.0k $937.0k 0.00% Unchanged
70 MARTINGALE ASSET MANAGEMENT L P 0.02% of their portfolio BOSTON, MA 65,08565.1k $896.9k $896.9k 0.02% Added +11.2k +11,204
71 NEOS Investment Management LLC 0.04% of their portfolio Westport, CT 64,85364.9k $893.7k $893.7k 0.04% Added +20.4k +20,430
72 Hennion & Walsh Asset Management, Inc. 0.05% of their portfolio Parsippany, NJ 64,35964.4k $886.9k $886.9k 0.05% Added +5.1k +5,070
73 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 56,93656.9k $784.6k $784.6k 0.00% Added +11.2k +11,175
74 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 55,59455.6k $766.1k $766.1k 0.00% Reduced -11.9k -11,872
75 Legal & General Group Plc 0.00% of their portfolio London, X0 55,17755.2k $760.3k $760.3k 0.00% Added +1.8k +1,753
76 TUDOR INVESTMENT CORP ET AL 0.01% of their portfolio STAMFORD, CT 51,89151.9k $715.1k $715.1k 0.01% Added +8.3k +8,301
77 Erste Asset Management GmbH 0.01% of their portfolio VIENNA, C4 51,20051.2k $708.1k $708.1k 0.01% Unchanged
78 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 48,27448.3k $665.2k $665.2k 0.00% Reduced -2.1k -2,094
79 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 47,38147.4k $652.9k $652.9k 0.00% Reduced -2.0k -1,959
80 Qube Research & Technologies Ltd 0.00% of their portfolio LONDON, X0 45,65245.7k $629.1k $629.1k 0.00% New
81 J. Goldman & Co LP 0.02% of their portfolio NEW YORK, NY 44,94344.9k $619.3k $619.3k 0.02% Reduced -16.4k -16,384
82 MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio CAUSEWAY BAY, K3 38,17438.2k $526.3k $526.3k 0.00% First filing
83 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 35,78935.8k $493.2k $493.2k 0.00% Reduced -2.4k -2,409
84 ADAR1 Capital Management, LLC 0.10% of their portfolio AUSTIN, TX 35,10035.1k $483.7k $483.7k 0.10% New
85 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 34,00534.0k $468.6k $468.6k 0.00% Reduced -137.0k -137,045
86 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 31,22431.2k $430.3k $430.3k 0.00% Reduced -419 -419
87 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 30,46730.5k $419.8k $419.8k 0.00% Reduced -3.0k -2,976
88 EntryPoint Capital, LLC 0.18% of their portfolio NEW YORK, NY 28,80328.8k $396.9k $396.9k 0.18% Added +28.2k +28,221
89 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 28,69328.7k $395.4k $395.4k 0.00% Reduced -1.6k -1,591
90 Corebridge Financial, Inc. 0.00% of their portfolio HOUSTON, TX 27,92427.9k $384.8k $384.8k 0.00% First filing
91 PROFUND ADVISORS LLC 0.01% of their portfolio BETHESDA, MD 27,60727.6k $380.4k $380.4k 0.01% Reduced -3.0k -3,005
92 TORNO CAPITAL, LLC 0.02% of their portfolio COHASSET, MA 26,07426.1k $359.3k $359.3k 0.02% New
93 Cetera Investment Advisers 0.00% of their portfolio SCHAUMBURG, IL 25,82925.8k $355.9k $355.9k 0.00% Reduced -1.3k -1,336
94 VIRTUS ADVISERS, LLC 0.17% of their portfolio HARTFORD, CT 25,49125.5k $351.3k $351.3k 0.17% Added +19.4k +19,413
95 Verition Fund Management LLC 0.00% of their portfolio GREENWICH, CT 23,65323.7k $325.9k $325.9k 0.00% New
96 Tower Research Capital LLC (TRC) 0.01% of their portfolio NEW YORK, NY 23,64923.6k $325.9k $325.9k 0.01% Added +21.9k +21,949
97 Handelsbanken Fonder AB 0.00% of their portfolio STOCKHOLM, V7 23,10023.1k $318.0k $318.0k 0.00% Added +5.7k +5,700
98 PRUDENTIAL FINANCIAL INC 0.00% of their portfolio NEWARK, NJ 22,59222.6k $311.3k $311.3k 0.00% Reduced -146.9k -146,930
99 ALGERT GLOBAL LLC 0.01% of their portfolio SAN FRANCISCO, CA 20,49720.5k $282.4k $282.4k 0.01% Reduced -4.5k -4,545
100 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 20,03220.0k $276.0k $276.0k 0.00% Reduced -46.2k -46,196