CENTURY THERAPEUTICS INC IPSC
COM · Common Stock · CUSIP 15673T100
Company in Philadelphia, United States
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersPhiladelphia, PA
- Founded2018
- Websitecenturytx.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 86.4m as of 2025-08-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $0.56. Options: 2 managers hold calls ($18.7k notional), 1 hold puts ($0).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 54 |
| Q4 2022 | 66 |
| Q1 2023 | 65 |
| Q2 2023 | 65 |
| Q3 2023 | 56 |
| Q4 2023 | 64 |
| Q1 2024 | 68 |
| Q2 2024 | 62 |
| Q3 2024 | 68 |
| Q4 2024 | 73 |
| Q1 2025 | 71 |
| Q2 2025 | 66 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 21 | 33 |
| Q4 2023 | 36 | 25 |
| Q1 2024 | 29 | 31 |
| Q2 2024 | 37 | 27 |
| Q3 2024 | 30 | 21 |
| Q4 2024 | 43 | 20 |
| Q1 2025 | 22 | 36 |
| Q2 2025 | 35 | 47 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $14.9k | $17.4k | 1.17 |
| Q4 2024 | $9.8k | $1.5k | 0.15 |
| Q1 2025 | $5.8k | $0 | 0.00 |
| Q2 2025 | $18.7k | $0 | 0.00 |
Biggest buyers
| RENAISSANCE TECHNOLOGIES LLC | Added | +837.2k |
| MILLENNIUM MANAGEMENT LLC | New | +812.2k |
| TWO SIGMA INVESTMENTS, LP | Added | +486.5k |
| GSA CAPITAL PARTNERS LLP | New | +466.6k |
| JANE STREET GROUP, LLC | New | +444.6k |
| TWO SIGMA ADVISERS, LP | Added | +290.2k |
| CITADEL ADVISORS LLC | Added | +177.4k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | +142.5k |
| MARSHALL WACE, LLP | New | +139.7k |
| HRT FINANCIAL LP | New | +111.1k |
Biggest sellers
| Venrock Adviser, LLC | Sold out | -2.5m |
| BlackRock, Inc. | Reduced | -2.1m |
| Casdin Capital, LLC | Reduced | -2.0m |
| FMR LLC | Reduced | -1.6m |
| STATE STREET CORP | Reduced | -718.8k |
| GEODE CAPITAL MANAGEMENT, LLC | Reduced | -590.0k |
| VANGUARD GROUP INC | Reduced | -267.4k |
| BAKER BROS. ADVISORS LP | Sold out | -241.7k |
| NORTHERN TRUST CORP | Reduced | -222.6k |
| Nuveen, LLC | Sold out | -157.3k |
Biggest calls
| CITADEL ADVISORS LLC | Added | $18.7k33.4k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor new · filed 2026-01-16 | 9.9% |
| TCG Crossover GP II, LLC 13G · passive investor new · filed 2026-01-15 | 9.9% |
| Deep Track Capital, LP 13G · passive investor new · filed 2026-01-15 | 7.3% |
| RTW INVESTMENTS, LP 13G · institution new · filed 2026-05-15 | 7.1% |
| Venrock Healthcare Capital Partners III, L.P. 13G · passive investor +2.4 pts · filed 2026-01-16 | 7.1% |
| Commodore Capital LP 13G · passive investor new · filed 2026-01-16 | 7.1% |
Fell to 5% or below in the last year: Point72 Asset Management, L.P. (3.3%, 2026-05-15), Bain Capital Life Sciences Opportunities III, LP (4.1%, 2025-11-14)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 0 | — | 0 | — | — |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 0 | — | 2 | $292.7k | — |
| Q2 2024 | 0 | — | 3 | $78.9k | $75.3k |
| Q3 2024 | 1 | $7.7k | 3 | $8.5k | $6.0k |
| Q4 2024 | 0 | — | 2 | $1.6k | — |
| Q1 2025 | 0 | — | 4 | $33.3k | — |
| Q2 2025 | 0 | — | 4 | $21.0k | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-06-09 | Carr Douglas SVP Finance & Operations | Sold | $3.0k4.9k shares |
| 2025-06-09 | Farid Adrienne Chief Operations Officer | Sold | $342552 shares |
| 2025-06-09 | Russotti Gregory Officer | Sold | $326526 shares |
| 2025-06-09 | Pfeiffenberger Brent President and CEO, director | Sold | $294475 shares |
| 2025-05-16 | Pfeiffenberger Brent President and CEO, director | Sold | $16.3k29.6k shares |
| 2025-05-05 | Farid Adrienne Chief Operations Officer | Sold | $5631.0k shares |
| 2025-05-05 | Carr Douglas SVP Finance & Operations | Sold | $162295 shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| Bain Capital Life Sciences Investors, LLC 0.38% of their portfolio | 5.4m $3.0m | Unchanged |
| VANGUARD GROUP INC 0.00% of their portfolio | 2.1m $1.2m | Reduced -267.4k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 2.0m $1.1m | Added +837.2k |
| DAFNA Capital Management LLC 0.26% of their portfolio | 1.7m $952.2k | Unchanged |
| Casdin Capital, LLC 0.06% of their portfolio | 1.2m $686.2k | Reduced -2.0m |
| Syncona Portfolio Ltd 1.76% of their portfolio | 1.2m $678.1k | Unchanged |
| FMR LLC 0.00% of their portfolio | 1.0m $570.2k | Reduced -1.6m |
| BlackRock, Inc. 0.00% of their portfolio | 924.7k $516.6k | Reduced -2.1m |
| TANG CAPITAL MANAGEMENT LLC 0.03% of their portfolio | 900.0k $502.8k | Unchanged |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 812.2k $453.8k | New |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 572.5k $319.9k | Added +486.5k |
| GSA CAPITAL PARTNERS LLP 0.02% of their portfolio | 466.6k $261.0k | New |
| SUPERSTRING CAPITAL MANAGEMENT LP 0.32% of their portfolio | 463.0k $258.7k | Unchanged |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 444.6k $248.4k | New |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 380.3k $212.5k | Reduced -590.0k |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 367.1k $205.1k | Added +290.2k |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 307.1k $170.0k | Added +22.9k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 276.0k $154.2k | Added +96.3k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 200.0k $111.7k | Added +142.5k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 186.5k $104.2k | Added +177.4k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 163.4k $91.3k | Reduced -107.4k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 147.2k $82.2k | Added +36.1k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 139.7k $78.2k | New |
| STATE STREET CORP 0.00% of their portfolio | 127.4k $71.2k | Reduced -718.8k |
| HRT FINANCIAL LP 0.00% of their portfolio | 111.1k $62.0k | New |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 91.3k $51.0k | New |
| Y-Intercept (Hong Kong) Ltd 0.00% of their portfolio | 90.0k $50.3k | New |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 0.00% of their portfolio | 81.2k $45.1k | Reduced -3.8k |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 67.7k $37.8k | New |
| NORTHERN TRUST CORP 0.00% of their portfolio | 67.0k $37.4k | Reduced -222.6k |
| LAZARD ASSET MANAGEMENT LLC 0.00% of their portfolio | 62.9k $35.0k | New |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 45.4k $25.4k | New |
| Squarepoint Ops LLC 0.00% of their portfolio | 40.5k $22.6k | Reduced -92.4k |
| Jain Global LLC 0.00% of their portfolio | 40.3k $22.5k | New |
| Point72 Asia (Singapore) Pte. Ltd. 0.00% of their portfolio | 36.9k $20.6k | New |
| HarbourVest Partners LLC 0.02% of their portfolio | 29.0k $16.2k | Unchanged |
| UBS Group AG 0.00% of their portfolio | 28.0k $15.7k | Added +8.5k |
| Parametrica Management Ltd 0.03% of their portfolio | 27.8k $15.6k | Unchanged |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 26.7k $14.9k | Reduced -93.8k |
| IEQ CAPITAL, LLC 0.00% of their portfolio | 22.4k $12.5k | Reduced -422 |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 22.4k $12.5k | Added +4.9k |
| Abel Hall, LLC 0.00% of their portfolio | 17.6k $9.8k | New |
| CITIGROUP INC 0.00% of their portfolio | 16.0k $8.9k | Reduced -16.9k |
| Quadrant Private Wealth Management, LLC 0.00% of their portfolio | 15.3k $8.5k | New |
| BARCLAYS PLC 0.00% of their portfolio | 12.2k $6.8k | Reduced -35.0k |
| TWO SIGMA SECURITIES, LLC 0.00% of their portfolio | 11.8k $6.6k | New |
| MORGAN STANLEY 0.00% of their portfolio | 11.3k $6.3k | Reduced -46.1k |
| Ground Swell Capital, LLC 0.01% of their portfolio | 10.2k $5.7k | New |
| Advisors Asset Management, Inc. 0.00% of their portfolio | 8.5k $4.7k | New |
| CWM, LLC 0.00% of their portfolio | 8.2k $5.0k | Added +1.3k |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 6.3k $3.5k | Reduced -753 |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 3.7k $2.1k | Reduced -601 |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 3.3k $1.8k | Reduced -25.6k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 2.6k $1.5k | Reduced -66.9k |
| Cubist Systematic Strategies, LLC 0.00% of their portfolio | 2.0k $1.1k | New |
| Point72 (DIFC) Ltd 0.00% of their portfolio | 1.7k $977 | New |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 1.5k $855 | Added +400 |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 1.3k $705 | Added +962 |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 861 $481 | Reduced -28.0k |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC 0.00% of their portfolio | 500 $279 | Unchanged |
| EverSource Wealth Advisors, LLC 0.00% of their portfolio | 455 $254 | Added +414 |
| True Wealth Design, LLC 0.00% of their portfolio | 266 $149 | Added +211 |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 198 $0 | Reduced -5.7k |
| Essential Partners LLC 0.00% of their portfolio | 119 $66 | First filing |
| IFP Advisors, Inc 0.00% of their portfolio | 6 $3 | New |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. — of their portfolio | 0 $0 | Unchanged |