Vault-13

CENTESSA PHARMACEUTICALS PLC

SPONSORED ADS · ADR · CUSIP 152309100

161 institutional holders +14 vs Q4 2025
148,637,227148.6m shares reported held*
$5.9bnreported value*
46 new 50 added 45 reduced 32 sold out net bought ≈ $165.8m (+4.4m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($622.5k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $39.67. Options: 10 managers hold calls ($31.9m notional), 10 hold puts ($23.2m).

Trends to Q1 2026

Institutional holders

Managers reporting a position, each quarter

0100200Q3 22: 45Q4 22: 45Q1 23: 45Q2 23: 46Q3 23: 50Q4 23: 59Q1 24: 71Q2 24: 81Q3 24: 104Q4 24: 115Q1 25: 131Q2 25: 118Q3 25: 126Q4 25: 147Q1 26: 161161Q3 22Q3 23Q3 24Q3 25Q1 26
Numbers
QuarterHolders
Q3 202245
Q4 202245
Q1 202345
Q2 202346
Q3 202350
Q4 202359
Q1 202471
Q2 202481
Q3 2024104
Q4 2024115
Q1 2025131
Q2 2025118
Q3 2025126
Q4 2025147
Q1 2026161

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q2 24: 44 bought or addedQ2 24: 26 cut or sold outQ3 24: 74 bought or addedQ3 24: 24 cut or sold outQ3 24Q4 24: 52 bought or addedQ4 24: 52 cut or sold outQ1 25: 74 bought or addedQ1 25: 51 cut or sold outQ1 25Q2 25: 63 bought or addedQ2 25: 67 cut or sold outQ3 25: 59 bought or addedQ3 25: 70 cut or sold outQ3 25Q4 25: 87 bought or addedQ4 25: 65 cut or sold outQ1 26: 96 bought or addedQ1 26: 77 cut or sold outQ1 26
Numbers
QuarterBought or addedCut or sold out
Q2 20244426
Q3 20247424
Q4 20245252
Q1 20257451
Q2 20256367
Q3 20255970
Q4 20258765
Q1 20269677

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$10m$20m$30m$40mQ2 25 calls: $8.5mQ2 25 puts: $2.0mQ2 25P/C 0.24Q3 25 calls: $33.2mQ3 25 puts: $22.6mQ3 25P/C 0.68Q4 25 calls: $10.4mQ4 25 puts: $6.5mQ4 25P/C 0.62Q1 26 calls: $31.9mQ1 26 puts: $23.2mQ1 26P/C 0.73
Numbers
QuarterCallsPutsP/C
Q2 2025$8.5m$2.0m0.24
Q3 2025$33.2m$22.6m0.68
Q4 2025$10.4m$6.5m0.62
Q1 2026$31.9m$23.2m0.73

Biggest buyers

Pentwater Capital Management LP New +8,170,000+8.2m
Capital World Investors Added +3,673,849+3.7m
Paradigm Biocapital Advisors LP New +3,574,048+3.6m
MORGAN STANLEY Added +3,159,255+3.2m
EcoR1 Capital, LLC Added +2,885,000+2.9m
PERCEPTIVE ADVISORS LLC Added +2,341,269+2.3m
Logos Global Management LP Added +1,925,000+1.9m
Deep Track Capital, LP Added +1,158,041+1.2m
BANK OF AMERICA CORP /DE/ Added +982,862+982.9k
ALPINE ASSOCIATES MANAGEMENT INC. New +865,500+865.5k

Biggest sellers

GENERAL ATLANTIC, L.P. Reduced -4,762,885-4.8m
PRICE T ROWE ASSOCIATES INC /MD/ Sold out -3,927,343-3.9m
Avoro Capital Advisors LLC Reduced -3,125,100-3.1m
Siren, L.L.C. Reduced -2,974,053-3.0m
ADAGE CAPITAL PARTNERS GP, L.L.C. Reduced -2,356,731-2.4m
FMR LLC Reduced -2,109,892-2.1m
FRANKLIN RESOURCES INC Reduced -1,683,899-1.7m
STEMPOINT CAPITAL LP Sold out -1,154,114-1.2m
MILLENNIUM MANAGEMENT LLC Reduced -1,148,550-1.1m
Sofinnova Investments, Inc. Sold out -1,104,274-1.1m

Biggest calls

EcoR1 Capital, LLC New $16.3m410.8k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $4.7m118.8k shares
CITADEL ADVISORS LLC Added $3.3m83.6k shares
CSS LLC/IL New $2.1m52.0k shares
SIMPLEX TRADING, LLC New $1.5m38.7k shares
GROUP ONE TRADING LLC Added $1.5m37.3k shares
GOLDMAN SACHS GROUP INC New $1.1m28.2k shares
JANE STREET GROUP, LLC Reduced $770.6k19.4k shares
Caption Management, LLC Reduced $317.8k8.0k shares
Point72 Asset Management, L.P. New $234.3k5.9k shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $6.9m173.4k shares
JANE STREET GROUP, LLC Added $4.5m114.1k shares
MILLENNIUM MANAGEMENT LLC New $2.7m69.0k shares
CITADEL ADVISORS LLC Added $1.9m48.2k shares
WATER ISLAND CAPITAL LLC New $1.6m41.0k shares
J. Goldman & Co LP New $1.6m40.5k shares
SIMPLEX TRADING, LLC New $1.6m39.1k shares
Exome Asset Management LLC New $1.4m34.7k shares
GROUP ONE TRADING LLC Reduced $544.2k13.7k shares
CSS LLC/IL New $393.2k9.9k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
Avoro Capital Advisors LLC 13G · institution -2.6 pts · filed 2026-05-15 7.4% -2.6 pts 11.4m 2026-05-15
General Atlantic Cooperatief U.A. 13D · may seek influence -1.6 pts · filed 2025-11-28 5.0% -1.6 pts 7.4m 2025-11-28

Fell to 5% or below in the last year: Pentwater Capital Management LP (0.0%, 2026-08-14), INDEX VENTURES LIFE VI (JERSEY) L.P. (0.0%, 2026-08-14), Adage Capital Management, L.P. (0.0%, 2026-08-12), Medicxi Growth I LP (0.0%, 2026-08-04), FMR LLC (0.0%, 2026-07-08), FARALLON CAPITAL MANAGEMENT, L.L.C. (0.0%, 2026-06-26)

Holders, Q1 2026

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Medicxi Ventures Management (Jersey) Ltd 80.76% of their portfolio ST. HELIER, Y9 19,963,15720.0m $792.9m $792.9m 80.76% Unchanged
2 Avoro Capital Advisors LLC 4.47% of their portfolio NEW YORK, NY 11,430,45511.4m $454.0m $454.0m 4.47% Reduced -3.1m -3,125,100
3 Index Venture Life Associates VI Ltd 100.00% of their portfolio ST. HELIER, Y9 9,961,78910.0m $395.7m $395.7m 100.00% Unchanged
4 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.55% of their portfolio Boston, MA 8,925,0108.9m $354.5m $354.5m 0.55% Reduced -2.4m -2,356,731
5 Pentwater Capital Management LP 2.31% of their portfolio Naples, FL 8,170,0008.2m $324.5m $324.5m 2.31% New
6 FMR LLC 0.01% of their portfolio BOSTON, MA 6,852,0476.9m $272.2m $272.2m 0.01% Reduced -2.1m -2,109,892
7 EcoR1 Capital, LLC 10.18% of their portfolio San Francisco, CA 6,000,0006.0m $238.3m $238.3m 10.18% Added +2.9m +2,885,000
8 PERCEPTIVE ADVISORS LLC 4.13% of their portfolio NEW YORK, NY 5,258,9035.3m $208.9m $208.9m 4.13% Added +2.3m +2,341,269
9 Capital World Investors 0.03% of their portfolio LOS ANGELES, CA 4,832,5484.8m $191.9m $191.9m 0.03% Added +3.7m +3,673,849
10 FARALLON CAPITAL MANAGEMENT, L.L.C. 1.13% of their portfolio SAN FRANCISCO, CA 4,809,0004.8m $191.0m $191.0m 1.13% Reduced -568.1k -568,068
11 TCG Crossover Management, LLC 4.87% of their portfolio PALO ALTO, CA 4,286,4804.3m $170.3m $170.3m 4.87% Unchanged
12 MORGAN STANLEY 0.01% of their portfolio NEW YORK, NY 4,268,3534.3m $169.5m $169.5m 0.01% Added +3.2m +3,159,255
13 Paradigm Biocapital Advisors LP 2.90% of their portfolio NEW YORK, NY 3,574,0483.6m $142.0m $142.0m 2.90% New
14 JANUS HENDERSON GROUP PLC 0.07% of their portfolio LONDON, X0 3,492,9773.5m $138.7m $138.7m 0.07% Reduced -600.6k -600,631
15 Deep Track Capital, LP 2.59% of their portfolio GREENWICH, CT 3,158,0413.2m $125.4m $125.4m 2.59% Added +1.2m +1,158,041
16 Logos Global Management LP 4.35% of their portfolio San Francisco, CA 2,125,0002.1m $84.4m $84.4m 4.35% Added +1.9m +1,925,000
17 RTW INVESTMENTS, LP 0.81% of their portfolio NEW YORK, NY 2,054,1752.1m $81.6m $81.6m 0.81% Added +263.3k +263,338
18 FEDERATED HERMES, INC. 0.13% of their portfolio PITTSBURGH, PA 2,049,4392.0m $81.4m $81.4m 0.13% Reduced -292.7k -292,700
19 BRAIDWELL LP 2.63% of their portfolio STAMFORD, CT 1,986,7682.0m $78.9m $78.9m 2.63% Reduced -201.6k -201,552
20 BANK OF AMERICA CORP /DE/ 0.01% of their portfolio CHARLOTTE, NC 1,932,4061.9m $76.8m $76.8m 0.01% Added +982.9k +982,862
21 MAVERICK CAPITAL LTD 0.86% of their portfolio DALLAS, TX 1,854,4881.9m $73.7m $73.7m 0.86% Added +210.8k +210,764
22 First Light Asset Management, LLC 5.56% of their portfolio Edina, MN 1,560,9911.6m $62.0m $62.0m 5.56% Reduced -717.9k -717,949
23 Affinity Asset Advisors, LLC 3.26% of their portfolio NEW YORK, NY 1,400,0001.4m $55.6m $55.6m 3.26% Added +799.4k +799,448
24 Foresite Capital Management VI LLC 11.77% of their portfolio WEST HOLLYWOOD, CA 1,364,0191.4m $54.2m $54.2m 11.77% Unchanged
25 GENERAL ATLANTIC, L.P. 2.50% of their portfolio New York, NY 1,354,8301.4m $53.8m $53.8m 2.50% Reduced -4.8m -4,762,885
26 GOLDMAN SACHS GROUP INC 0.01% of their portfolio NEW YORK, NY 1,144,5601.1m $45.5m $45.5m 0.01% Added +365.6k +365,559
27 Siren, L.L.C. 1.16% of their portfolio New York, NY 1,053,4641.1m $41.8m $41.8m 1.16% Reduced -3.0m -2,974,053
28 Cormorant Asset Management, LP 2.10% of their portfolio BOSTON, MA 1,050,0001.1m $41.7m $41.7m 2.10% Reduced -275.0k -275,000
29 ALPINE ASSOCIATES MANAGEMENT INC. 2.03% of their portfolio PALM BEACH, FL 865,500865.5k $34.4m $34.4m 2.03% New
30 Woodline Partners LP 0.13% of their portfolio San Francisco, CA 859,105859.1k $34.1m $34.1m 0.13% Added +280.9k +280,854
31 Balyasny Asset Management L.P. 0.07% of their portfolio Chicago, IL 852,828852.8k $33.9m $33.9m 0.07% Added +384.0k +384,013
32 Octagon Capital Advisors LP 3.30% of their portfolio NEW YORK, NY 750,000750.0k $29.8m $29.8m 3.30% Unchanged
33 MILLENNIUM MANAGEMENT LLC 0.02% of their portfolio NEW YORK, NY 722,121722.1k $28.7m $28.7m 0.02% Reduced -1.1m -1,148,550
34 BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.03% of their portfolio Paris, I0 702,254702.3k $27.9m $27.9m 0.03% New
35 AMERICAN CENTURY COMPANIES INC 0.01% of their portfolio KANSAS CITY, MO 687,427687.4k $27.3m $27.3m 0.01% Reduced -442.3k -442,331
36 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 684,482684.5k $27.2m $27.2m 0.01% Reduced -1.7m -1,683,899
37 BAKER BROS. ADVISORS LP 0.15% of their portfolio NEW YORK, NY 670,751670.8k $26.6m $26.6m 0.15% Unchanged
38 EVENTIDE ASSET MANAGEMENT, LLC 0.44% of their portfolio Boston, MA 668,142668.1k $26.5m $26.5m 0.44% New
39 TORONTO DOMINION BANK 0.05% of their portfolio TORONTO, ONTARIO, A6 654,850654.9k $26.0m $26.0m 0.05% New
40 TIG Advisors, LLC 1.23% of their portfolio New York, NY 648,326648.3k $25.8m $25.8m 1.23% New
41 D. E. Shaw & Co., Inc. 0.02% of their portfolio New York, NY 643,808643.8k $25.6m $25.6m 0.02% Reduced -187.8k -187,828
42 Bain Capital Life Sciences Investors, LLC 2.27% of their portfolio Boston, MA 635,000635.0k $25.2m $25.2m 2.27% New
43 Qube Research & Technologies Ltd 0.04% of their portfolio LONDON, X0 628,049628.0k $24.9m $24.9m 0.04% Added +249.3k +249,309
44 BlackRock, Inc. 0.00% of their portfolio New York, NY 625,420625.4k $24.8m $24.8m 0.00% Added +32.8k +32,816
45 CITADEL ADVISORS LLC 0.02% of their portfolio MIAMI, FL 598,197598.2k $23.8m $23.8m 0.02% Added +78.2k +78,235
46 5AM Venture Management, LLC 6.41% of their portfolio SAN FRANCISCO, CA 580,945580.9k $23.1m $23.1m 6.41% Unchanged
47 PFM Health Sciences, LP 2.21% of their portfolio SAN FRANCISCO, CA 528,224528.2k $21.0m $21.0m 2.21% Reduced -63.4k -63,377
48 Weiss Asset Management LP 0.37% of their portfolio BOSTON, MA 510,407510.4k $20.3m $20.3m 0.37% Not comparable
49 Spruce Street Capital LP 4.68% of their portfolio NEW YORK, NY 489,849489.8k $19.5m $19.5m 4.68% Added +411.9k +411,852
50 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 477,597477.6k $13.2m $13.2m 0.00% Added +396.1k +396,111
51 SILVERARC CAPITAL MANAGEMENT, LLC 2.18% of their portfolio BOSTON, MA 466,345466.3k $18.5m $18.5m 2.18% Added +8.1k +8,142
52 Trexquant Investment LP 0.11% of their portfolio STAMFORD, CT 390,951391.0k $15.5m $15.5m 0.11% Added +244.4k +244,428
53 UBS Group AG 0.00% of their portfolio ZURICH, V8 359,939359.9k $14.3m $14.3m 0.00% Reduced -177.6k -177,579
54 Rock Springs Capital Management LP 0.82% of their portfolio Baltimore, MD 351,828351.8k $14.0m $14.0m 0.82% Added +27.8k +27,813
55 GLAZER CAPITAL, LLC 0.27% of their portfolio New York, NY 325,001325.0k $12.9m $12.9m 0.27% New
56 Alyeska Investment Group, L.P. 0.04% of their portfolio CHICAGO, IL 320,430320.4k $12.7m $12.7m 0.04% New
57 Point72 Asset Management, L.P. 0.02% of their portfolio STAMFORD, CT 307,355307.4k $12.2m $12.2m 0.02% New
58 ROYCE & ASSOCIATES LP 0.11% of their portfolio New York, NY 278,064278.1k $11.0m $11.0m 0.11% Reduced -84.8k -84,809
59 Caption Management, LLC 0.52% of their portfolio OKLAHOMA CITY, OK 274,116274.1k $10.9m $10.9m 0.52% New
60 Nantahala Capital Management, LLC 0.63% of their portfolio NEW CANAAN, CT 254,803254.8k $10.1m $10.1m 0.63% Unchanged
61 TD Asset Management Inc 0.01% of their portfolio Toronto, A6 242,044242.0k $9.6m $9.6m 0.01% Reduced -134.3k -134,300
62 HighMark Wealth Management LLC 3.83% of their portfolio ST. PAUL, MN 236,785236.8k $9.4m $9.4m 3.83% Unchanged
63 Eagle Health Investments LP 1.79% of their portfolio Greenwich, CT 214,291214.3k $8.5m $8.5m 1.79% Added +111.2k +111,191
64 SummitTX Capital, L.P. 0.26% of their portfolio FORT WORTH, TX 206,847206.8k $8.2m $8.2m 0.26% Reduced -125.9k -125,861
65 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 189,961190.0k $7.5m $7.5m 0.00% Added +33.8k +33,756
66 RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio NEW YORK, NY 185,000185.0k $7.3m $7.3m 0.01% Reduced -94.3k -94,300
67 Schonfeld Strategic Advisors LLC 0.06% of their portfolio NEW YORK, NY 171,933171.9k $6.8m $6.8m 0.06% New
68 T. Rowe Price Investment Management, Inc. 0.00% of their portfolio BALTIMORE, MD 170,016170.0k $6.8m $6.8m 0.00% Added +166.9k +166,944
69 MARSHALL WACE, LLP 0.01% of their portfolio LONDON, X0 168,177168.2k $6.7m $6.7m 0.01% Reduced -48.0k -47,953
70 FRED ALGER MANAGEMENT, LLC 0.03% of their portfolio NEW YORK, NY 168,170168.2k $6.7m $6.7m 0.03% Added +6.0k +6,023
71 Holocene Advisors, LP 0.02% of their portfolio New York, NY 160,942160.9k $6.4m $6.4m 0.02% Added +59.3k +59,345
72 Atom Investors LP 0.45% of their portfolio AUSTIN, TX 158,509158.5k $6.3m $6.3m 0.45% Added +140.2k +140,162
73 Burkehill Global Management, LP 0.30% of their portfolio NEW YORK, NY 150,000150.0k $6.0m $6.0m 0.30% Unchanged
74 PLATINUM INVESTMENT MANAGEMENT LTD 1.38% of their portfolio SYDNEY AUSTRALIA 2000, C3 137,741137.7k $5.5m $5.5m 1.38% Reduced -17.4k -17,360
75 LMR Partners LLP 0.05% of their portfolio LONDON, X0 125,000125.0k $5.0m $5.0m 0.05% New
76 HRT FINANCIAL LP 0.02% of their portfolio NEW YORK, NY 116,992117.0k $4.6m $4.6m 0.02% Added +106.0k +105,972
77 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio JUPITER, FL 111,956112.0k $4.4m $4.4m 0.02% Reduced -236.3k -236,323
78 Legal & General Group Plc 0.00% of their portfolio London, X0 110,207110.2k $4.3m $4.3m 0.00% Added +4.8k +4,780
79 Freestone Grove Partners LP 0.03% of their portfolio San Francisco, CA 109,327109.3k $4.3m $4.3m 0.03% New
80 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 107,778107.8k $4.3m $4.3m 0.00% Added +20.2k +20,168
81 AQR Arbitrage LLC 0.06% of their portfolio Greenwich, CT 98,02898.0k $3.9m $3.9m 0.06% New
82 Pictet Asset Management Holding SA 0.00% of their portfolio CAROUGE, V8 96,91096.9k $2.7m $2.7m 0.00% New
83 Y-Intercept (Hong Kong) Ltd 0.07% of their portfolio HONG KONG, K3 96,36796.4k $3.8m $3.8m 0.07% Added +84.9k +84,926
84 Caitong International Asset Management Co., Ltd 0.69% of their portfolio HONG KONG, K3 93,68593.7k $3.7m $3.7m 0.69% Added +90.5k +90,467
85 HARVEST MANAGEMENT LLC 1.69% of their portfolio New York, NY 80,00080.0k $3.2m $3.2m 1.69% New
86 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 74,27674.3k $3.0m $3.0m 0.00% Added +71.6k +71,585
87 Jain Global LLC 0.04% of their portfolio NEW YORK, NY 71,51371.5k $2.8m $2.8m 0.04% Reduced -844.3k -844,290
88 Virtu Financial LLC 0.11% of their portfolio New York, NY 67,77567.8k $2.7m $2.7m 0.11% New
89 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 59,84459.8k $2.4m $2.4m 0.00% Added +2.4k +2,400
90 Squarepoint Ops LLC 0.00% of their portfolio NEW YORK, NY 50,60650.6k $2.0m $2.0m 0.00% Reduced -31.2k -31,206
91 WATER ISLAND CAPITAL LLC 0.22% of their portfolio NEW YORK, NY 41,00041.0k $1.6m $1.6m 0.22% New
92 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 40,96841.0k $1.6m $1.6m 0.00% Reduced -439.2k -439,236
93 TORNO CAPITAL, LLC 0.33% of their portfolio COHASSET, MA 40,00040.0k $1.6m $1.6m 0.33% Not comparable
94 BOOTHBAY FUND MANAGEMENT, LLC 0.04% of their portfolio NEW YORK, NY 39,65639.7k $1.6m $1.6m 0.04% Added +7.1k +7,148
95 Knott David M Jr 0.92% of their portfolio SYOSSET, NY 39,00039.0k $1.5m $1.5m 0.92% Added +35.0k +35,000
96 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 38,81238.8k $1.5m $1.5m 0.00% Reduced -36.0k -36,007
97 ADAR1 Capital Management, LLC 0.09% of their portfolio AUSTIN, TX 38,56638.6k $1.5m $1.5m 0.09% Unchanged
98 Candriam S.C.A. 0.01% of their portfolio STRASSEN, N4 36,25436.3k $1.4m $1.4m 0.01% Reduced -359.4k -359,369
99 Buckland Partners Management Co LLC 0.72% of their portfolio HARRISON, NY 30,00030.0k $1.2m $1.2m 0.72% New
100 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 29,67029.7k $1.2m $1.2m 0.00% Unchanged