Vault-13

CENTESSA PHARMACEUTICALS PLC

SPONSORED ADS · ADR · CUSIP 152309100

147 institutional holders +21 vs Q3 2025
143,759,797143.8m shares reported held*
$3.6bnreported value*
39 new 48 added 45 reduced 20 sold out net bought ≈ $379.8m (+15.2m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $25.01. Options: 9 managers hold calls ($10.4m notional), 5 hold puts ($6.5m).

Trends to Q4 2025

Institutional holders

Managers reporting a position, each quarter

050100150Q3 22: 45Q4 22: 45Q1 23: 45Q2 23: 46Q3 23: 50Q4 23: 59Q1 24: 71Q2 24: 81Q3 24: 104Q4 24: 115Q1 25: 131Q2 25: 118Q3 25: 126Q4 25: 147147Q3 22Q2 23Q1 24Q4 24Q4 25
Numbers
QuarterHolders
Q3 202245
Q4 202245
Q1 202345
Q2 202346
Q3 202350
Q4 202359
Q1 202471
Q2 202481
Q3 2024104
Q4 2024115
Q1 2025131
Q2 2025118
Q3 2025126
Q4 2025147

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q1 24: 45 bought or addedQ1 24: 13 cut or sold outQ2 24: 44 bought or addedQ2 24: 26 cut or sold outQ2 24Q3 24: 74 bought or addedQ3 24: 24 cut or sold outQ4 24: 52 bought or addedQ4 24: 52 cut or sold outQ4 24Q1 25: 74 bought or addedQ1 25: 51 cut or sold outQ2 25: 63 bought or addedQ2 25: 67 cut or sold outQ2 25Q3 25: 59 bought or addedQ3 25: 70 cut or sold outQ4 25: 87 bought or addedQ4 25: 65 cut or sold outQ4 25
Numbers
QuarterBought or addedCut or sold out
Q1 20244513
Q2 20244426
Q3 20247424
Q4 20245252
Q1 20257451
Q2 20256367
Q3 20255970
Q4 20258765

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$10m$20m$30m$40mQ1 25 calls: $2.4mQ1 25 puts: $11.7mQ1 25P/C 4.94Q2 25 calls: $8.5mQ2 25 puts: $2.0mQ2 25P/C 0.24Q3 25 calls: $33.2mQ3 25 puts: $22.6mQ3 25P/C 0.68Q4 25 calls: $10.4mQ4 25 puts: $6.5mQ4 25P/C 0.62
Numbers
QuarterCallsPutsP/C
Q1 2025$2.4m$11.7m4.94
Q2 2025$8.5m$2.0m0.24
Q3 2025$33.2m$22.6m0.68
Q4 2025$10.4m$6.5m0.62

Biggest buyers

Avoro Capital Advisors LLC Added +3,747,475+3.7m
FMR LLC Added +2,684,696+2.7m
EcoR1 Capital, LLC Added +2,565,000+2.6m
BRAIDWELL LP New +2,188,320+2.2m
Deep Track Capital, LP New +2,000,000+2.0m
MAVERICK CAPITAL LTD New +1,643,724+1.6m
ADAGE CAPITAL PARTNERS GP, L.L.C. Added +1,246,741+1.2m
TCG Crossover Management, LLC Added +1,150,000+1.1m
Sofinnova Investments, Inc. New +1,104,274+1.1m
FARALLON CAPITAL MANAGEMENT, L.L.C. Added +1,045,750+1.0m

Biggest sellers

GENERAL ATLANTIC, L.P. Reduced -3,564,103-3.6m
Commodore Capital LP Reduced -1,850,000-1.9m
First Light Asset Management, LLC Reduced -1,356,876-1.4m
JANUS HENDERSON GROUP PLC Reduced -1,314,591-1.3m
Point72 Asset Management, L.P. Sold out -1,072,665-1.1m
PRICE T ROWE ASSOCIATES INC /MD/ Reduced -876,713-876.7k
Cormorant Asset Management, LP Reduced -600,000-600.0k
Tanager Wealth Management LLP Sold out -598,044-598.0k
Ensign Peak Advisors, Inc Sold out -559,744-559.7k
Driehaus Capital Management LLC Sold out -515,979-516.0k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $4.0m160.5k shares
Caption Management, LLC Reduced $3.5m138.8k shares
UBS Group AG Reduced $882.9k35.3k shares
JANE STREET GROUP, LLC Reduced $580.2k23.2k shares
CITADEL ADVISORS LLC Reduced $562.7k22.5k shares
DIADEMA PARTNERS LP New $527.7k21.1k shares
GROUP ONE TRADING LLC Added $360.1k14.4k shares
STEMPOINT CAPITAL LP Reduced $26.2k75.0k shares
Persistent Asset Partners Ltd New $15.5k57 shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $2.4m96.7k shares
JANE STREET GROUP, LLC Added $1.8m73.3k shares
CITADEL ADVISORS LLC Reduced $935.4k37.4k shares
Caption Management, LLC Reduced $852.8k34.1k shares
GROUP ONE TRADING LLC Added $482.7k19.3k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
Avoro Capital Advisors LLC 13G · institution -2.6 pts · filed 2026-05-15 7.4% -2.6 pts 11.4m 2026-05-15
General Atlantic Cooperatief U.A. 13D · may seek influence -1.6 pts · filed 2025-11-28 5.0% -1.6 pts 7.4m 2025-11-28

Fell to 5% or below in the last year: Pentwater Capital Management LP (0.0%, 2026-08-14), INDEX VENTURES LIFE VI (JERSEY) L.P. (0.0%, 2026-08-14), Adage Capital Management, L.P. (0.0%, 2026-08-12), Medicxi Growth I LP (0.0%, 2026-08-04), FMR LLC (0.0%, 2026-07-08), FARALLON CAPITAL MANAGEMENT, L.L.C. (0.0%, 2026-06-26)

Holders, Q4 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Medicxi Ventures Management (Jersey) Ltd 59.80% of their portfolio ST. HELIER, Y9 19,963,15720.0m $499.3m $499.3m 59.80% Unchanged
2 Avoro Capital Advisors LLC 3.58% of their portfolio NEW YORK, NY 14,555,55514.6m $364.0m $364.0m 3.58% Added +3.7m +3,747,475
3 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.43% of their portfolio Boston, MA 11,281,74111.3m $282.2m $282.2m 0.43% Added +1.2m +1,246,741
4 Index Venture Life Associates VI Ltd 100.00% of their portfolio ST. HELIER, Y9 9,961,78910.0m $249.1m $249.1m 100.00% Unchanged
5 FMR LLC 0.01% of their portfolio BOSTON, MA 8,961,9399.0m $224.1m $224.1m 0.01% Added +2.7m +2,684,696
6 GENERAL ATLANTIC, L.P. 5.33% of their portfolio New York, NY 6,117,7156.1m $153.0m $153.0m 5.33% Reduced -3.6m -3,564,103
7 FARALLON CAPITAL MANAGEMENT, L.L.C. 0.70% of their portfolio SAN FRANCISCO, CA 5,377,0685.4m $134.5m $134.5m 0.70% Added +1.0m +1,045,750
8 TCG Crossover Management, LLC 3.55% of their portfolio PALO ALTO, CA 4,286,4804.3m $107.2m $107.2m 3.55% Added +1.1m +1,150,000
9 JANUS HENDERSON GROUP PLC 0.05% of their portfolio LONDON, X0 4,093,6084.1m $102.4m $102.4m 0.05% Reduced -1.3m -1,314,591
10 Siren, L.L.C. 3.00% of their portfolio New York, NY 4,027,5174.0m $100.7m $100.7m 3.00% Added +800.0k +800,000
11 PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio BALTIMORE, MD 3,927,3433.9m $98.2m $98.2m 0.01% Reduced -876.7k -876,713
12 EcoR1 Capital, LLC 3.56% of their portfolio San Francisco, CA 3,115,0003.1m $77.9m $77.9m 3.56% Added +2.6m +2,565,000
13 PERCEPTIVE ADVISORS LLC 1.34% of their portfolio NEW YORK, NY 2,917,6342.9m $73.0m $73.0m 1.34% Reduced -183.3k -183,268
14 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 2,368,3812.4m $59.2m $59.2m 0.01% Reduced -190.0k -190,033
15 FEDERATED HERMES, INC. 0.10% of their portfolio PITTSBURGH, PA 2,342,1392.3m $58.6m $58.6m 0.10% Added +592.5k +592,489
16 First Light Asset Management, LLC 4.36% of their portfolio Edina, MN 2,278,9402.3m $57.0m $57.0m 4.36% Reduced -1.4m -1,356,876
17 BRAIDWELL LP 1.75% of their portfolio STAMFORD, CT 2,188,3202.2m $54.7m $54.7m 1.75% New
18 Deep Track Capital, LP 1.14% of their portfolio GREENWICH, CT 2,000,0002.0m $50.0m $50.0m 1.14% New
19 MILLENNIUM MANAGEMENT LLC 0.03% of their portfolio NEW YORK, NY 1,870,6711.9m $46.8m $46.8m 0.03% Added +968.4k +968,403
20 RTW INVESTMENTS, LP 0.45% of their portfolio NEW YORK, NY 1,790,8371.8m $44.8m $44.8m 0.45% Reduced -500.9k -500,910
21 MAVERICK CAPITAL LTD 0.44% of their portfolio DALLAS, TX 1,643,7241.6m $41.1m $41.1m 0.44% New
22 Foresite Capital Management VI LLC 10.31% of their portfolio WEST HOLLYWOOD, CA 1,364,0191.4m $34.1m $34.1m 10.31% Added +50.0k +50,000
23 Cormorant Asset Management, LP 1.88% of their portfolio BOSTON, MA 1,325,0001.3m $33.1m $33.1m 1.88% Reduced -600.0k -600,000
24 Capital World Investors 0.00% of their portfolio LOS ANGELES, CA 1,158,6991.2m $29.0m $29.0m 0.00% Added +473.9k +473,894
25 STEMPOINT CAPITAL LP 4.95% of their portfolio NEW YORK, NY 1,154,1141.2m $28.9m $28.9m 4.95% Added +498.7k +498,729
26 AMERICAN CENTURY COMPANIES INC 0.01% of their portfolio KANSAS CITY, MO 1,129,7581.1m $28.3m $28.3m 0.01% Added +33.1k +33,054
27 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 1,109,0981.1m $27.7m $27.7m 0.00% Reduced -15.3k -15,347
28 Sofinnova Investments, Inc. 1.19% of their portfolio Menlo Park, CA 1,104,2741.1m $27.6m $27.6m 1.19% New
29 Commodore Capital LP 1.66% of their portfolio NEW YORK, NY 1,000,0001.0m $25.0m $25.0m 1.66% Reduced -1.9m -1,850,000
30 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 949,544949.5k $23.7m $23.7m 0.00% Added +396.5k +396,537
31 Jain Global LLC 0.22% of their portfolio NEW YORK, NY 915,803915.8k $22.9m $22.9m 0.22% Added +673.8k +673,828
32 D. E. Shaw & Co., Inc. 0.02% of their portfolio New York, NY 831,636831.6k $20.8m $20.8m 0.02% Added +767.2k +767,247
33 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 779,001779.0k $19.5m $19.5m 0.00% Added +531.4k +531,446
34 Octagon Capital Advisors LP 2.35% of their portfolio NEW YORK, NY 750,000750.0k $18.8m $18.8m 2.35% Reduced -80.0k -80,000
35 BAKER BROS. ADVISORS LP 0.10% of their portfolio NEW YORK, NY 670,751670.8k $16.8m $16.8m 0.10% New
36 Affinity Asset Advisors, LLC 1.08% of their portfolio NEW YORK, NY 600,552600.6k $15.0m $15.0m 1.08% Reduced -506.6k -506,610
37 BlackRock, Inc. 0.00% of their portfolio New York, NY 592,604592.6k $14.8m $14.8m 0.00% Added +184.2k +184,218
38 PFM Health Sciences, LP 1.50% of their portfolio SAN FRANCISCO, CA 591,601591.6k $14.8m $14.8m 1.50% Reduced -74.6k -74,595
39 5AM Venture Management, LLC 4.57% of their portfolio SAN FRANCISCO, CA 580,945580.9k $14.5m $14.5m 4.57% Reduced -100.0k -100,000
40 Woodline Partners LP 0.06% of their portfolio San Francisco, CA 578,251578.3k $14.5m $14.5m 0.06% Added +470.6k +470,580
41 UBS Group AG 0.00% of their portfolio ZURICH, V8 537,518537.5k $13.4m $13.4m 0.00% Added +452.3k +452,340
42 CITADEL ADVISORS LLC 0.01% of their portfolio MIAMI, FL 519,962520.0k $13.0m $13.0m 0.01% Added +382.8k +382,761
43 ARMISTICE CAPITAL, LLC 0.31% of their portfolio NEW YORK, NY 500,000500.0k $12.5m $12.5m 0.31% Added +122.0k +122,000
44 JANE STREET GROUP, LLC 0.01% of their portfolio NEW YORK, NY 480,204480.2k $12.0m $12.0m 0.01% Added +456.1k +456,113
45 Balyasny Asset Management L.P. 0.02% of their portfolio Chicago, IL 468,815468.8k $11.7m $11.7m 0.02% Reduced -336.8k -336,796
46 SILVERARC CAPITAL MANAGEMENT, LLC 1.66% of their portfolio BOSTON, MA 458,203458.2k $11.5m $11.5m 1.66% Added +317.0k +316,965
47 Walleye Capital LLC 0.06% of their portfolio NEW YORK, NY 441,160441.2k $11.0m $11.0m 0.06% New
48 Candriam S.C.A. 0.05% of their portfolio STRASSEN, N4 395,623395.6k $9.9m $9.9m 0.05% Added +52.4k +52,416
49 Qube Research & Technologies Ltd 0.01% of their portfolio LONDON, X0 378,740378.7k $9.5m $9.5m 0.01% New
50 TD Asset Management Inc 0.01% of their portfolio Toronto, A6 376,344376.3k $9.4m $9.4m 0.01% Reduced -90.6k -90,616
51 ROYCE & ASSOCIATES LP 0.09% of their portfolio New York, NY 362,873362.9k $9.1m $9.1m 0.09% Added +115.5k +115,486
52 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.03% of their portfolio JUPITER, FL 348,279348.3k $8.7m $8.7m 0.03% New
53 SummitTX Capital, L.P. 0.25% of their portfolio FORT WORTH, TX 332,708332.7k $8.3m $8.3m 0.25% New
54 Rock Springs Capital Management LP 0.42% of their portfolio Baltimore, MD 324,015324.0k $8.1m $8.1m 0.42% Added +254.8k +254,775
55 Saturn V Capital Management LP 1.30% of their portfolio AUSTIN, TX 282,692282.7k $7.1m $7.1m 1.30% Reduced -451.8k -451,847
56 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 280,120280.1k $7.0m $7.0m 0.00% Added +172.1k +172,118
57 RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio NEW YORK, NY 279,300279.3k $7.0m $7.0m 0.01% Added +114.7k +114,700
58 SG Americas Securities, LLC 0.01% of their portfolio NEW YORK, NY 263,625263.6k $6.6m $6.6m 0.01% Added +240.0k +240,039
59 WCM INVESTMENT MANAGEMENT, LLC 0.01% of their portfolio LAGUNA BEACH, CA 257,190257.2k $6.4m $6.4m 0.01% New
60 Nantahala Capital Management, LLC 0.38% of their portfolio NEW CANAAN, CT 254,803254.8k $6.4m $6.4m 0.38% Reduced -150.0k -150,000
61 HighMark Wealth Management LLC 2.41% of their portfolio ST. PAUL, MN 236,785236.8k $5.9m $5.9m 2.41% Reduced -500 -500
62 MARSHALL WACE, LLP 0.01% of their portfolio LONDON, X0 216,130216.1k $5.4m $5.4m 0.01% Added +102.5k +102,540
63 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 211,253211.3k $5.2m $5.2m 0.00% Reduced -50.9k -50,893
64 Logos Global Management LP 0.33% of their portfolio San Francisco, CA 200,000200.0k $5.0m $5.0m 0.33% Reduced -325.0k -325,000
65 FRED ALGER MANAGEMENT, LLC 0.02% of their portfolio NEW YORK, NY 162,147162.1k $4.1m $4.1m 0.02% Reduced -28.2k -28,213
66 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 156,205156.2k $3.9m $3.9m 0.00% New
67 PLATINUM INVESTMENT MANAGEMENT LTD 0.90% of their portfolio SYDNEY AUSTRALIA 2000, C3 155,101155.1k $3.9m $3.9m 0.90% Reduced -31.3k -31,298
68 Burkehill Global Management, LP 0.25% of their portfolio NEW YORK, NY 150,000150.0k $3.8m $3.8m 0.25% New
69 Trexquant Investment LP 0.03% of their portfolio STAMFORD, CT 146,523146.5k $3.7m $3.7m 0.03% Added +84.2k +84,213
70 Blue Owl Capital Holdings LP 1.08% of their portfolio New York, NY 139,450139.4k $3.5m $3.5m 1.08% Reduced -30.0k -30,000
71 TUDOR INVESTMENT CORP ET AL 0.02% of their portfolio STAMFORD, CT 121,810121.8k $3.0m $3.0m 0.02% Added +64.0k +64,000
72 Legal & General Group Plc 0.00% of their portfolio London, X0 105,427105.4k $2.6m $2.6m 0.00% Added +3.7k +3,734
73 Eagle Health Investments LP 0.57% of their portfolio Greenwich, CT 103,100103.1k $2.6m $2.6m 0.57% Unchanged
74 Holocene Advisors, LP 0.01% of their portfolio New York, NY 101,597101.6k $2.5m $2.5m 0.01% New
75 Rhenman & Partners Asset Management AB 0.23% of their portfolio Stockholm, V7 100,000100.0k $2.5m $2.5m 0.23% New
76 Verition Fund Management LLC 0.01% of their portfolio GREENWICH, CT 94,91294.9k $2.4m $2.4m 0.01% Reduced -19.4k -19,394
77 DIADEMA PARTNERS LP 1.34% of their portfolio MORRISTOWN, NJ 90,00090.0k $2.3m $2.3m 1.34% New
78 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 87,61087.6k $2.2m $2.2m 0.00% Reduced -7.4k -7,422
79 Squarepoint Ops LLC 0.00% of their portfolio NEW YORK, NY 81,81281.8k $2.0m $2.0m 0.00% Added +62.4k +62,399
80 DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main 0.00% of their portfolio FRANKFURT AM MAIN, 2M 81,52581.5k $2.0m $2.0m 0.00% Reduced -34.9k -34,872
81 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 81,48681.5k $2.0m $2.0m 0.00% Reduced -402.3k -402,304
82 XTX Topco Ltd 0.05% of their portfolio LONDON, X0 79,07779.1k $2.0m $2.0m 0.05% New
83 Voleon Capital Management LP 0.04% of their portfolio BERKELEY, CA 79,07479.1k $2.0m $2.0m 0.04% New
84 Spruce Street Capital LP 0.64% of their portfolio NEW YORK, NY 77,99778.0k $2.0m $2.0m 0.64% First filing
85 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 74,81974.8k $1.9m $1.9m 0.00% Reduced -107.5k -107,481
86 Cinctive Capital Management LP 0.11% of their portfolio New York, NY 72,83172.8k $1.8m $1.8m 0.11% Reduced -19.8k -19,797
87 Aquatic Capital Management LLC 0.05% of their portfolio CHICAGO, IL 69,75569.8k $1.7m $1.7m 0.05% New
88 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 57,44457.4k $1.4m $1.4m 0.00% Unchanged
89 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 50,18050.2k $1.3m $1.3m 0.00% Reduced -32.5k -32,485
90 SEVEN GRAND MANAGERS, LLC 0.10% of their portfolio BRONXVILLE, NY 50,00050.0k $1.3m $1.3m 0.10% New
91 HighVista Strategies LLC 0.29% of their portfolio BOSTON, MA 44,49044.5k $1.1m $1.1m 0.29% Reduced -18.8k -18,811
92 Persistent Asset Partners Ltd 0.52% of their portfolio HONG KONG, K3 43,26643.3k $1.1m $1.1m 0.52% New
93 ADAR1 Capital Management, LLC 0.07% of their portfolio AUSTIN, TX 38,56638.6k $964.5k $964.5k 0.07% Reduced -15.1k -15,100
94 B. Metzler seel. Sohn & Co. AG 0.01% of their portfolio FRANKFURT, 2M 38,43238.4k $961.2k $961.2k 0.01% New
95 GSA CAPITAL PARTNERS LLP 0.07% of their portfolio LONDON, X0 33,10433.1k $828.0k $828.0k 0.07% Added +14.3k +14,343
96 BOOTHBAY FUND MANAGEMENT, LLC 0.02% of their portfolio NEW YORK, NY 32,50832.5k $813.0k $813.0k 0.02% Added +11.2k +11,189
97 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 29,67029.7k $742.0k $742.0k 0.00% Unchanged
98 PSP Research LLC 0.48% of their portfolio LAS VEGAS, NV 21,87921.9k $547.2k $547.2k 0.48% First filing
99 Atom Investors LP 0.04% of their portfolio AUSTIN, TX 18,34718.3k $458.9k $458.9k 0.04% New
100 Meridian Wealth Partners, LLC 0.06% of their portfolio EXTON, PA 18,10118.1k $452.7k $452.7k 0.06% Unchanged