Vault-13

CENTESSA PHARMACEUTICALS PLC

SPONSORED ADS · ADR · CUSIP 152309100

126 institutional holders +8 vs Q2 2025
128,463,819128.5m shares reported held*
$3.1bnreported value*
27 new 32 added 52 reduced 18 sold out net bought ≈ $121.2m (+5.0m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($2.7m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $24.25. Options: 11 managers hold calls ($33.2m notional), 10 hold puts ($22.6m).

Trends to Q3 2025

Institutional holders

Managers reporting a position, each quarter

050100150Q3 22: 45Q4 22: 45Q1 23: 45Q2 23: 46Q3 23: 50Q4 23: 59Q1 24: 71Q2 24: 81Q3 24: 104Q4 24: 115Q1 25: 131Q2 25: 118Q3 25: 126126Q3 22Q2 23Q1 24Q4 24Q3 25
Numbers
QuarterHolders
Q3 202245
Q4 202245
Q1 202345
Q2 202346
Q3 202350
Q4 202359
Q1 202471
Q2 202481
Q3 2024104
Q4 2024115
Q1 2025131
Q2 2025118
Q3 2025126

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q4 23: 28 bought or addedQ4 23: 12 cut or sold outQ1 24: 45 bought or addedQ1 24: 13 cut or sold outQ1 24Q2 24: 44 bought or addedQ2 24: 26 cut or sold outQ3 24: 74 bought or addedQ3 24: 24 cut or sold outQ3 24Q4 24: 52 bought or addedQ4 24: 52 cut or sold outQ1 25: 74 bought or addedQ1 25: 51 cut or sold outQ1 25Q2 25: 63 bought or addedQ2 25: 67 cut or sold outQ3 25: 59 bought or addedQ3 25: 70 cut or sold outQ3 25
Numbers
QuarterBought or addedCut or sold out
Q4 20232812
Q1 20244513
Q2 20244426
Q3 20247424
Q4 20245252
Q1 20257451
Q2 20256367
Q3 20255970

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$10m$20m$30m$40mQ4 24 calls: $117.2kQ4 24 puts: $3.7mQ4 24P/C 31.44Q1 25 calls: $2.4mQ1 25 puts: $11.7mQ1 25P/C 4.94Q2 25 calls: $8.5mQ2 25 puts: $2.0mQ2 25P/C 0.24Q3 25 calls: $33.2mQ3 25 puts: $22.6mQ3 25P/C 0.68
Numbers
QuarterCallsPutsP/C
Q4 2024$117.2k$3.7m31.44
Q1 2025$2.4m$11.7m4.94
Q2 2025$8.5m$2.0m0.24
Q3 2025$33.2m$22.6m0.68

Biggest buyers

Avoro Capital Advisors LLC Added +5,808,080+5.8m
FMR LLC Added +2,451,049+2.5m
PERCEPTIVE ADVISORS LLC Added +1,953,967+2.0m
FEDERATED HERMES, INC. New +1,749,650+1.7m
ADAGE CAPITAL PARTNERS GP, L.L.C. Added +1,632,000+1.6m
RTW INVESTMENTS, LP Added +761,911+761.9k
EcoR1 Capital, LLC New +550,000+550.0k
Logos Global Management LP New +525,000+525.0k
BANK OF AMERICA CORP /DE/ Added +417,209+417.2k
PFM Health Sciences, LP Added +321,224+321.2k

Biggest sellers

Point72 Asset Management, L.P. Reduced -1,518,931-1.5m
JANUS HENDERSON GROUP PLC Reduced -1,124,569-1.1m
PRICE T ROWE ASSOCIATES INC /MD/ Reduced -1,103,936-1.1m
Polar Capital Holdings Plc Sold out -1,000,000-1.0m
MILLENNIUM MANAGEMENT LLC Reduced -755,619-755.6k
MORGAN STANLEY Reduced -669,026-669.0k
First Light Asset Management, LLC Reduced -657,595-657.6k
STEMPOINT CAPITAL LP Reduced -610,287-610.3k
Deep Track Capital, LP Sold out -500,000-500.0k
Commodore Capital LP Reduced -448,289-448.3k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $10.4m430.3k shares
Caption Management, LLC Added $8.0m330.6k shares
Ikarian Capital, LLC Added $7.5m307.7k shares
BOOTHBAY FUND MANAGEMENT, LLC Added $2.8m114.2k shares
UBS Group AG Unchanged $1.1m45.3k shares
JANE STREET GROUP, LLC New $1.0m42.0k shares
STEMPOINT CAPITAL LP New $905.6k172.5k shares
CITADEL ADVISORS LLC Reduced $766.3k31.6k shares
WOLVERINE TRADING, LLC New $329.4k13.5k shares
SIMPLEX TRADING, LLC Added $237.0k9.8k shares

Biggest puts

Caption Management, LLC New $11.5m473.0k shares
SIMPLEX TRADING, LLC Added $2.5m102.4k shares
CITADEL ADVISORS LLC Added $2.3m95.0k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $1.9m77.7k shares
JANE STREET GROUP, LLC New $1.7m71.6k shares
MILLENNIUM MANAGEMENT LLC New $1.2m50.0k shares
Exome Asset Management LLC New $606.2k25.0k shares
GROUP ONE TRADING LLC Added $441.4k18.2k shares
DLD Asset Management, LP New $242.5k10.0k shares
WOLVERINE TRADING, LLC New $226.9k9.3k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
Avoro Capital Advisors LLC 13G · institution -2.6 pts · filed 2026-05-15 7.4% -2.6 pts 11.4m 2026-05-15
General Atlantic Cooperatief U.A. 13D · may seek influence -1.6 pts · filed 2025-11-28 5.0% -1.6 pts 7.4m 2025-11-28

Fell to 5% or below in the last year: Pentwater Capital Management LP (0.0%, 2026-08-14), INDEX VENTURES LIFE VI (JERSEY) L.P. (0.0%, 2026-08-14), Adage Capital Management, L.P. (0.0%, 2026-08-12), Medicxi Growth I LP (0.0%, 2026-08-04), FMR LLC (0.0%, 2026-07-08), FARALLON CAPITAL MANAGEMENT, L.L.C. (0.0%, 2026-06-26)

Holders, Q3 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Medicxi Ventures Management (Jersey) Ltd 65.03% of their portfolio ST. HELIER, Y9 19,963,15720.0m $484.1m $484.1m 65.03% Unchanged
2 Avoro Capital Advisors LLC 3.39% of their portfolio NEW YORK, NY 10,808,08010.8m $262.1m $262.1m 3.39% Added +5.8m +5,808,080
3 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.39% of their portfolio Boston, MA 10,035,00010.0m $243.3m $243.3m 0.39% Added +1.6m +1,632,000
4 Index Venture Life Associates VI Ltd 100.00% of their portfolio ST. HELIER, Y9 9,961,78910.0m $241.6m $241.6m 100.00% Unchanged
5 GENERAL ATLANTIC, L.P. 7.05% of their portfolio New York, NY 9,681,8189.7m $234.8m $234.8m 7.05% Unchanged
6 FMR LLC 0.01% of their portfolio BOSTON, MA 6,277,2436.3m $152.2m $152.2m 0.01% Added +2.5m +2,451,049
7 JANUS HENDERSON GROUP PLC 0.06% of their portfolio LONDON, X0 5,408,1995.4m $131.1m $131.1m 0.06% Reduced -1.1m -1,124,569
8 PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio BALTIMORE, MD 4,804,0564.8m $116.5m $116.5m 0.01% Reduced -1.1m -1,103,936
9 FARALLON CAPITAL MANAGEMENT, L.L.C. 0.59% of their portfolio SAN FRANCISCO, CA 4,331,3184.3m $105.0m $105.0m 0.59% Reduced -198.0k -198,000
10 First Light Asset Management, LLC 8.31% of their portfolio Edina, MN 3,635,8163.6m $88.2m $88.2m 8.31% Reduced -657.6k -657,595
11 Siren, L.L.C. 3.06% of their portfolio New York, NY 3,227,5173.2m $78.3m $78.3m 3.06% Reduced -232.5k -232,512
12 TCG Crossover Management, LLC 3.74% of their portfolio PALO ALTO, CA 3,136,4803.1m $76.1m $76.1m 3.74% Added +245.7k +245,664
13 PERCEPTIVE ADVISORS LLC 2.17% of their portfolio NEW YORK, NY 3,100,9023.1m $75.2m $75.2m 2.17% Added +2.0m +1,953,967
14 Commodore Capital LP 3.37% of their portfolio NEW YORK, NY 2,850,0002.9m $69.1m $69.1m 3.37% Reduced -448.3k -448,289
15 FRANKLIN RESOURCES INC 0.02% of their portfolio San Mateo, CA 2,558,4142.6m $62.0m $62.0m 0.02% Added +14.9k +14,875
16 RTW INVESTMENTS, LP 0.68% of their portfolio NEW YORK, NY 2,291,7472.3m $55.6m $55.6m 0.68% Added +761.9k +761,911
17 Cormorant Asset Management, LP 3.22% of their portfolio BOSTON, MA 1,925,0001.9m $46.7m $46.7m 3.22% Reduced -161.6k -161,600
18 FEDERATED HERMES, INC. 0.07% of their portfolio PITTSBURGH, PA 1,749,6501.7m $42.4m $42.4m 0.07% New
19 Foresite Capital Management VI LLC 12.31% of their portfolio WEST HOLLYWOOD, CA 1,314,0191.3m $31.9m $31.9m 12.31% Added +60.6k +60,640
20 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 1,124,4451.1m $27.3m $27.3m 0.00% Reduced -669.0k -669,026
21 Affinity Asset Advisors, LLC 2.50% of their portfolio NEW YORK, NY 1,107,1621.1m $26.8m $26.8m 2.50% Added +207.0k +207,000
22 AMERICAN CENTURY COMPANIES INC 0.01% of their portfolio KANSAS CITY, MO 1,096,7041.1m $26.6m $26.6m 0.01% Reduced -34.0k -34,004
23 Point72 Asset Management, L.P. 0.06% of their portfolio STAMFORD, CT 1,072,6651.1m $26.0m $26.0m 0.06% Reduced -1.5m -1,518,931
24 MILLENNIUM MANAGEMENT LLC 0.02% of their portfolio NEW YORK, NY 902,268902.3k $21.9m $21.9m 0.02% Reduced -755.6k -755,619
25 Octagon Capital Advisors LP 3.14% of their portfolio NEW YORK, NY 830,000830.0k $20.1m $20.1m 3.14% Reduced -200.0k -200,000
26 Balyasny Asset Management L.P. 0.04% of their portfolio Chicago, IL 805,611805.6k $19.5m $19.5m 0.04% Reduced -416.0k -415,999
27 Saturn V Capital Management LP 3.91% of their portfolio AUSTIN, TX 734,539734.5k $17.8m $17.8m 3.91% Reduced -58.8k -58,788
28 Capital World Investors 0.00% of their portfolio LOS ANGELES, CA 684,805684.8k $16.6m $16.6m 0.00% Added +268.0k +267,982
29 5AM Venture Management, LLC 6.05% of their portfolio SAN FRANCISCO, CA 680,945680.9k $16.5m $16.5m 6.05% Reduced -150.0k -150,000
30 PFM Health Sciences, LP 1.38% of their portfolio SAN FRANCISCO, CA 666,196666.2k $16.2m $16.2m 1.38% Added +321.2k +321,224
31 STEMPOINT CAPITAL LP 3.20% of their portfolio NEW YORK, NY 655,385655.4k $15.9m $15.9m 3.20% Reduced -610.3k -610,287
32 Tanager Wealth Management LLP 1.52% of their portfolio Goring On Thames, X0 598,044598.0k $14.5m $14.5m 1.52% Unchanged
33 Ensign Peak Advisors, Inc 0.02% of their portfolio SALT LAKE CITY, UT 559,744559.7k $13.6m $13.6m 0.02% Unchanged
34 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 553,007553.0k $13.4m $13.4m 0.00% Added +417.2k +417,209
35 EcoR1 Capital, LLC 0.64% of their portfolio San Francisco, CA 550,000550.0k $13.3m $13.3m 0.64% New
36 Logos Global Management LP 1.26% of their portfolio San Francisco, CA 525,000525.0k $12.7m $12.7m 1.26% New
37 Driehaus Capital Management LLC 0.09% of their portfolio Chicago, IL 515,979516.0k $12.5m $12.5m 0.09% Added +5.2k +5,200
38 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 483,790483.8k $11.7m $11.7m 0.00% Added +55.4k +55,356
39 TD Asset Management Inc 0.01% of their portfolio Toronto, A6 466,960467.0k $11.3m $11.3m 0.01% Reduced -86.3k -86,332
40 BlackRock, Inc. 0.00% of their portfolio New York, NY 408,386408.4k $9.9m $9.9m 0.00% Added +27.3k +27,261
41 Nantahala Capital Management, LLC 0.61% of their portfolio NEW CANAAN, CT 404,803404.8k $9.8m $9.8m 0.61% Reduced -150.0k -150,000
42 ARMISTICE CAPITAL, LLC 0.29% of their portfolio NEW YORK, NY 378,000378.0k $9.2m $9.2m 0.29% Reduced -22.0k -22,000
43 Candriam S.C.A. 0.04% of their portfolio STRASSEN, N4 343,207343.2k $8.3m $8.3m 0.04% Reduced -4.4k -4,392
44 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio Toronto, A6 262,146262.1k $6.4m $6.4m 0.01% Reduced -55.4k -55,428
45 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 247,555247.6k $6.0m $6.0m 0.00% Reduced -311.7k -311,728
46 ROYCE & ASSOCIATES LP 0.06% of their portfolio New York, NY 247,387247.4k $6.0m $6.0m 0.06% New
47 Jain Global LLC 0.08% of their portfolio NEW YORK, NY 241,975242.0k $5.9m $5.9m 0.08% New
48 HighMark Wealth Management LLC 2.53% of their portfolio ST. PAUL, MN 237,285237.3k $5.8m $5.8m 2.53% Unchanged
49 TANG CAPITAL MANAGEMENT LLC 0.19% of their portfolio SAN DIEGO, CA 200,000200.0k $4.8m $4.8m 0.19% Added +150.0k +150,000
50 FRED ALGER MANAGEMENT, LLC 0.02% of their portfolio NEW YORK, NY 190,360190.4k $4.6m $4.6m 0.02% Added +66.6k +66,604
51 PLATINUM INVESTMENT MANAGEMENT LTD 0.29% of their portfolio SYDNEY AUSTRALIA 2000, C3 186,399186.4k $4.5m $4.5m 0.29% Reduced -104.4k -104,437
52 Russell Investments Group, Ltd. 0.01% of their portfolio Seattle, WA 182,300182.3k $4.4m $4.4m 0.01% Added +41.3k +41,335
53 Schonfeld Strategic Advisors LLC 0.03% of their portfolio NEW YORK, NY 172,696172.7k $4.2m $4.2m 0.03% Added +54.5k +54,533
54 Blue Owl Capital Holdings LP 1.28% of their portfolio New York, NY 169,450169.4k $4.1m $4.1m 1.28% Reduced -161.2k -161,150
55 RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio NEW YORK, NY 164,600164.6k $4.0m $4.0m 0.01% Reduced -220.3k -220,300
56 Windmill Hill Asset Management Ltd 1.04% of their portfolio WADDESDON, X0 163,768163.8k $4.0m $4.0m 1.04% Unchanged
57 SILVERARC CAPITAL MANAGEMENT, LLC 0.50% of their portfolio BOSTON, MA 141,238141.2k $3.4m $3.4m 0.50% Added +136.2k +136,238
58 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 137,201137.2k $3.3m $3.3m 0.00% New
59 Artia Global Partners LP 0.57% of their portfolio MIAMI, FL 133,291133.3k $3.2m $3.2m 0.57% New
60 Caption Management, LLC 0.18% of their portfolio OKLAHOMA CITY, OK 125,309125.3k $3.0m $3.0m 0.18% New
61 DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main 0.00% of their portfolio FRANKFURT AM MAIN, 2M 116,397116.4k $2.8m $2.8m 0.00% Reduced -141.0k -141,021
62 Verition Fund Management LLC 0.02% of their portfolio GREENWICH, CT 114,306114.3k $2.8m $2.8m 0.02% New
63 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 113,590113.6k $2.8m $2.8m 0.00% Reduced -229.7k -229,728
64 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 108,002108.0k $2.6m $2.6m 0.00% New
65 Woodline Partners LP 0.01% of their portfolio San Francisco, CA 107,671107.7k $2.6m $2.6m 0.01% Reduced -292.6k -292,607
66 Cubist Systematic Strategies, LLC 0.04% of their portfolio STAMFORD, CT 103,909103.9k $2.5m $2.5m 0.04% Reduced -172.5k -172,543
67 Eagle Health Investments LP 0.66% of their portfolio Greenwich, CT 103,100103.1k $2.5m $2.5m 0.66% New
68 Legal & General Group Plc 0.00% of their portfolio London, X0 101,693101.7k $2.5m $2.5m 0.00% Added +3.4k +3,437
69 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 95,03295.0k $2.3m $2.3m 0.00% Added +7.6k +7,597
70 Cinctive Capital Management LP 0.11% of their portfolio New York, NY 92,62892.6k $2.2m $2.2m 0.11% New
71 Exome Asset Management LLC 1.41% of their portfolio NEW YORK, NY 88,02488.0k $2.1m $2.1m 1.41% Reduced -78.9k -78,920
72 UBS Group AG 0.00% of their portfolio ZURICH, V8 85,17885.2k $2.1m $2.1m 0.00% Reduced -124.6k -124,572
73 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 82,66582.7k $2.0m $2.0m 0.00% Reduced -66.8k -66,786
74 Rock Springs Capital Management LP 0.10% of their portfolio Baltimore, MD 69,24069.2k $1.7m $1.7m 0.10% New
75 D. E. Shaw & Co., Inc. 0.00% of their portfolio New York, NY 64,38964.4k $1.6m $1.6m 0.00% Added +48.6k +48,625
76 HighVista Strategies LLC 0.38% of their portfolio BOSTON, MA 63,30163.3k $1.5m $1.5m 0.38% Added +22.6k +22,617
77 Trexquant Investment LP 0.02% of their portfolio STAMFORD, CT 62,31062.3k $1.5m $1.5m 0.02% Reduced -89.0k -89,042
78 TUDOR INVESTMENT CORP ET AL 0.01% of their portfolio STAMFORD, CT 57,81057.8k $1.4m $1.4m 0.01% Added +7.0k +6,959
79 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 57,44457.4k $1.4m $1.4m 0.00% Reduced -14.7k -14,700
80 ADAR1 Capital Management, LLC 0.13% of their portfolio AUSTIN, TX 53,66653.7k $1.3m $1.3m 0.13% Reduced -243.1k -243,100
81 Aberdeen Group plc 0.00% of their portfolio EDINBURGH, X0 53,57453.6k $1.3m $1.3m 0.00% Reduced -65.8k -65,815
82 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 29,67029.7k $719.5k $719.5k 0.00% Unchanged
83 PRELUDE CAPITAL MANAGEMENT, LLC 0.05% of their portfolio NEW YORK, NY 26,65626.7k $646.4k $646.4k 0.05% Reduced -23.4k -23,444
84 Campbell & CO Investment Adviser LLC 0.05% of their portfolio BALTIMORE, MD 25,84525.8k $626.7k $626.7k 0.05% Added +9.2k +9,226
85 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 24,09124.1k $584.2k $584.2k 0.00% Reduced -70.3k -70,274
86 SG Americas Securities, LLC 0.00% of their portfolio NEW YORK, NY 23,58623.6k $572.0k $572.0k 0.00% New
87 BOOTHBAY FUND MANAGEMENT, LLC 0.01% of their portfolio NEW YORK, NY 21,31921.3k $517.0k $517.0k 0.01% Reduced -20.6k -20,581
88 Squarepoint Ops LLC 0.00% of their portfolio NEW YORK, NY 19,41319.4k $470.8k $470.8k 0.00% Reduced -20.3k -20,347
89 GSA CAPITAL PARTNERS LLP 0.04% of their portfolio LONDON, X0 18,76118.8k $455.0k $455.0k 0.04% New
90 Meridian Wealth Partners, LLC 0.06% of their portfolio EXTON, PA 18,10118.1k $438.9k $438.9k 0.06% Reduced -20.0k -20,000
91 OMERS ADMINISTRATION Corp 0.00% of their portfolio TORONTO, A6 17,50017.5k $424.4k $424.4k 0.00% Reduced -37.7k -37,700
92 China Universal Asset Management Co., Ltd. 0.03% of their portfolio SHANGHAI, F4 16,81616.8k $407.8k $407.8k 0.03% Reduced -2.4k -2,365
93 Pictet Asset Management Holding SA 0.00% of their portfolio CAROUGE, V8 13,86913.9k $336.3k $336.3k 0.00% New
94 Atria Investments, Inc 0.00% of their portfolio Charlotte, NC 13,51813.5k $327.8k $327.8k 0.00% Reduced -411 -411
95 J. Goldman & Co LP 0.01% of their portfolio NEW YORK, NY 13,10513.1k $317.8k $317.8k 0.01% Reduced -20.1k -20,079
96 Coastal Bridge Advisors, LLC 0.02% of their portfolio WESTPORT, CT 13,10213.1k $317.7k $317.7k 0.02% Reduced -6.6k -6,551
97 Virtus Investment Advisers, LLC 0.07% of their portfolio HARTFORD, CT 9,4519.5k $229.2k $229.2k 0.07% Added +1.6k +1,641
98 DNB Asset Management AS 0.00% of their portfolio Oslo, Q8 8,9889.0k $218.0k $218.0k 0.00% New
99 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 8,7278.7k $211.6k $211.6k 0.00% New
100 Point72 Asia (Singapore) Pte. Ltd. 0.03% of their portfolio SINGAPORE, U0 6,6906.7k $162.2k $162.2k 0.03% New