Vault-13

CENTESSA PHARMACEUTICALS PLC

SPONSORED ADS · ADR · CUSIP 152309100

131 institutional holders +16 vs Q4 2024
124,940,136124.9m shares reported held*
$1.8bnreported value*
31 new 43 added 37 reduced 14 sold out net bought ≈ $7.4m (+508.9k shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $14.39. Options: 9 managers hold calls ($2.4m notional), 8 hold puts ($11.7m).

Trends to Q1 2025

Institutional holders

Managers reporting a position, each quarter

050100150Q3 22: 45Q4 22: 45Q1 23: 45Q2 23: 46Q3 23: 50Q4 23: 59Q1 24: 71Q2 24: 81Q3 24: 104Q4 24: 115Q1 25: 131131Q3 22Q1 23Q3 23Q1 24Q3 24Q1 25
Numbers
QuarterHolders
Q3 202245
Q4 202245
Q1 202345
Q2 202346
Q3 202350
Q4 202359
Q1 202471
Q2 202481
Q3 2024104
Q4 2024115
Q1 2025131

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q2 23: 20 bought or addedQ2 23: 11 cut or sold outQ3 23: 21 bought or addedQ3 23: 12 cut or sold outQ3 23Q4 23: 28 bought or addedQ4 23: 12 cut or sold outQ1 24: 45 bought or addedQ1 24: 13 cut or sold outQ1 24Q2 24: 44 bought or addedQ2 24: 26 cut or sold outQ3 24: 74 bought or addedQ3 24: 24 cut or sold outQ3 24Q4 24: 52 bought or addedQ4 24: 52 cut or sold outQ1 25: 74 bought or addedQ1 25: 51 cut or sold outQ1 25
Numbers
QuarterBought or addedCut or sold out
Q2 20232011
Q3 20232112
Q4 20232812
Q1 20244513
Q2 20244426
Q3 20247424
Q4 20245252
Q1 20257451

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$5m$10m$15mQ2 24 calls: $119.3kQ2 24 puts: $27.1kQ2 24P/C 0.23Q3 24 calls: $98.5kQ3 24 puts: $848.5kQ3 24P/C 8.61Q4 24 calls: $117.2kQ4 24 puts: $3.7mQ4 24P/C 31.44Q1 25 calls: $2.4mQ1 25 puts: $11.7mQ1 25P/C 4.94
Numbers
QuarterCallsPutsP/C
Q2 2024$119.3k$27.1k0.23
Q3 2024$98.5k$848.5k8.61
Q4 2024$117.2k$3.7m31.44
Q1 2025$2.4m$11.7m4.94

Biggest buyers

Avoro Capital Advisors LLC New +4,050,000+4.0m
Holocene Advisors, LP New +2,255,679+2.3m
ADAGE CAPITAL PARTNERS GP, L.L.C. Added +1,834,973+1.8m
JANUS HENDERSON GROUP PLC Added +1,012,999+1.0m
MORGAN STANLEY Added +1,012,958+1.0m
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added +883,759+883.8k
FARALLON CAPITAL MANAGEMENT, L.L.C. Added +835,609+835.6k
ARMISTICE CAPITAL, LLC New +468,000+468.0k
Affinity Asset Advisors, LLC Added +450,738+450.7k
Saturn V Capital Management LP New +448,692+448.7k

Biggest sellers

Vida Ventures Advisors, LLC Sold out -3,931,818-3.9m
PERCEPTIVE ADVISORS LLC Reduced -3,308,825-3.3m
T. Rowe Price Investment Management, Inc. Reduced -1,665,352-1.7m
Deep Track Capital, LP Sold out -1,350,000-1.4m
Point72 Asset Management, L.P. Reduced -1,140,166-1.1m
UBS Group AG Reduced -996,726-996.7k
First Light Asset Management, LLC Reduced -931,060-931.1k
Avidity Partners Management LP Reduced -636,800-636.8k
Octagon Capital Advisors LP Reduced -568,052-568.1k
Driehaus Capital Management LLC Reduced -502,650-502.6k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP New $1.1m79.3k shares
Hudson Bay Capital Management LP New $251.7k17.5k shares
CITADEL ADVISORS LLC Added $245.9k17.1k shares
WOLVERINE TRADING, LLC New $245.1k16.8k shares
Squarepoint Ops LLC New $228.6k15.9k shares
Caption Management, LLC New $228.6k15.9k shares
GROUP ONE TRADING LLC New $25.9k1.8k shares
SIMPLEX TRADING, LLC New $7.0k500 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

Octagon Capital Advisors LP Added $8.6m600.0k shares
J. Goldman & Co LP Added $1.4m94.6k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP New $815.3k56.7k shares
GOLDMAN SACHS GROUP INC New $431.4k30.0k shares
Hudson Bay Capital Management LP New $251.7k17.5k shares
CITADEL ADVISORS LLC Added $247.3k17.2k shares
SIMPLEX TRADING, LLC New $1.0k100 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
Avoro Capital Advisors LLC 13G · institution -2.6 pts · filed 2026-05-15 7.4% -2.6 pts 11.4m 2026-05-15
General Atlantic Cooperatief U.A. 13D · may seek influence -1.6 pts · filed 2025-11-28 5.0% -1.6 pts 7.4m 2025-11-28

Fell to 5% or below in the last year: Pentwater Capital Management LP (0.0%, 2026-08-14), INDEX VENTURES LIFE VI (JERSEY) L.P. (0.0%, 2026-08-14), Adage Capital Management, L.P. (0.0%, 2026-08-12), Medicxi Growth I LP (0.0%, 2026-08-04), FMR LLC (0.0%, 2026-07-08), FARALLON CAPITAL MANAGEMENT, L.L.C. (0.0%, 2026-06-26)

Holders, Q1 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Medicxi Ventures Management (Jersey) Ltd 65.59% of their portfolio ST. HELIER, Y9 19,963,15720.0m $287.1m $287.1m 65.59% Unchanged
2 Index Venture Life Associates VI Ltd 100.00% of their portfolio ST. HELIER, Y9 9,961,78910.0m $143.3m $143.3m 100.00% Unchanged
3 GENERAL ATLANTIC, L.P. 4.67% of their portfolio New York, NY 9,681,8189.7m $139.2m $139.2m 4.67% Unchanged
4 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.19% of their portfolio Boston, MA 6,954,0007.0m $100.0m $100.0m 0.19% Added +1.8m +1,834,973
5 JANUS HENDERSON GROUP PLC 0.05% of their portfolio LONDON, X0 5,922,4865.9m $86.4m $86.4m 0.05% Added +1.0m +1,012,999
6 PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio BALTIMORE, MD 5,342,3445.3m $76.8m $76.8m 0.01% Reduced -22.0k -22,048
7 First Light Asset Management, LLC 8.00% of their portfolio Edina, MN 4,874,1244.9m $70.1m $70.1m 8.00% Reduced -931.1k -931,060
8 FARALLON CAPITAL MANAGEMENT, L.L.C. 0.34% of their portfolio SAN FRANCISCO, CA 4,334,3184.3m $62.3m $62.3m 0.34% Added +835.6k +835,609
9 Avoro Capital Advisors LLC 0.91% of their portfolio NEW YORK, NY 4,050,0004.0m $58.2m $58.2m 0.91% New
10 FMR LLC 0.00% of their portfolio BOSTON, MA 3,826,1943.8m $55.0m $55.0m 0.00% Added +174.6k +174,600
11 PERCEPTIVE ADVISORS LLC 1.55% of their portfolio NEW YORK, NY 3,040,3953.0m $43.7m $43.7m 1.55% Reduced -3.3m -3,308,825
12 Siren, L.L.C. 2.40% of their portfolio New York, NY 2,960,0293.0m $42.6m $42.6m 2.40% Reduced -44.6k -44,648
13 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 2,937,4672.9m $42.2m $42.2m 0.00% Added +1.0m +1,012,958
14 TCG Crossover Management, LLC 5.67% of their portfolio PALO ALTO, CA 2,890,8162.9m $41.6m $41.6m 5.67% Unchanged
15 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 2,541,9992.5m $36.6m $36.6m 0.01% Added +233.5k +233,453
16 Commodore Capital LP 2.51% of their portfolio NEW YORK, NY 2,367,5782.4m $34.0m $34.0m 2.51% Added +149.2k +149,153
17 Point72 Asset Management, L.P. 0.09% of their portfolio STAMFORD, CT 2,286,4332.3m $32.9m $32.9m 0.09% Reduced -1.1m -1,140,166
18 Cormorant Asset Management, LP 2.46% of their portfolio BOSTON, MA 2,261,6002.3m $32.5m $32.5m 2.46% Reduced -300.0k -300,000
19 Holocene Advisors, LP 0.10% of their portfolio New York, NY 2,255,6792.3m $32.4m $32.4m 0.10% New
20 T. Rowe Price Investment Management, Inc. 0.02% of their portfolio BALTIMORE, MD 1,753,2481.8m $25.2m $25.2m 0.02% Reduced -1.7m -1,665,352
21 Affinity Asset Advisors, LLC 3.48% of their portfolio NEW YORK, NY 1,546,6621.5m $22.2m $22.2m 3.48% Added +450.7k +450,738
22 Octagon Capital Advisors LP 4.03% of their portfolio NEW YORK, NY 1,425,0001.4m $20.5m $20.5m 4.03% Reduced -568.1k -568,052
23 Foresite Capital Management VI LLC 9.87% of their portfolio WEST HOLLYWOOD, CA 1,253,3791.3m $18.0m $18.0m 9.87% Unchanged
24 BAKER BROS. ADVISORS LP 0.20% of their portfolio NEW YORK, NY 1,227,1781.2m $17.6m $17.6m 0.20% Unchanged
25 Driehaus Capital Management LLC 0.15% of their portfolio Chicago, IL 1,095,5331.1m $15.8m $15.8m 0.15% Reduced -502.6k -502,650
26 AMERICAN CENTURY COMPANIES INC 0.01% of their portfolio KANSAS CITY, MO 1,092,7541.1m $15.7m $15.7m 0.01% Added +13.0k +13,046
27 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.02% of their portfolio BALA CYNWYD, PA 899,505899.5k $12.9m $12.9m 0.02% Added +883.8k +883,759
28 5AM Venture Management, LLC 4.52% of their portfolio SAN FRANCISCO, CA 830,945830.9k $11.9m $11.9m 4.52% Unchanged
29 CITADEL ADVISORS LLC 0.01% of their portfolio MIAMI, FL 706,331706.3k $10.2m $10.2m 0.01% Added +81.0k +81,015
30 Tanager Wealth Management LLP 1.30% of their portfolio Goring On Thames, X0 696,096696.1k $10.0m $10.0m 1.30% Unchanged
31 MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio NEW YORK, NY 609,188609.2k $8.8m $8.8m 0.01% Added +210.7k +210,737
32 STEMPOINT CAPITAL LP 2.73% of their portfolio NEW YORK, NY 593,335593.3k $8.5m $8.5m 2.73% Reduced -48.6k -48,629
33 TD Asset Management Inc 0.01% of their portfolio Toronto, A6 588,122588.1k $8.5m $8.5m 0.01% Reduced -53.6k -53,592
34 PFM Health Sciences, LP 0.63% of their portfolio SAN FRANCISCO, CA 570,546570.5k $8.2m $8.2m 0.63% Added +198.8k +198,780
35 Nantahala Capital Management, LLC 0.66% of their portfolio NEW CANAAN, CT 554,803554.8k $8.0m $8.0m 0.66% Added +42.2k +42,156
36 Avidity Partners Management LP 1.57% of their portfolio DALLAS, TX 529,000529.0k $7.6m $7.6m 1.57% Reduced -636.8k -636,800
37 ARMISTICE CAPITAL, LLC 0.18% of their portfolio NEW YORK, NY 468,000468.0k $6.7m $6.7m 0.18% New
38 Saturn V Capital Management LP 3.26% of their portfolio AUSTIN, TX 448,692448.7k $6.5m $6.5m 3.26% New
39 LORD, ABBETT & CO. LLC 0.02% of their portfolio JERSEY CITY, NJ 446,196446.2k $6.4m $6.4m 0.02% Added +5.7k +5,701
40 Ensign Peak Advisors, Inc 0.01% of their portfolio SALT LAKE CITY, UT 438,133438.1k $6.3m $6.3m 0.01% Added +359.1k +359,133
41 Cutter Capital Management, LP 2.62% of their portfolio NEW YORK, NY 418,127418.1k $6.0m $6.0m 2.62% Added +271.1k +271,051
42 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 401,764401.8k $5.8m $5.8m 0.00% Added +226.2k +226,198
43 Woodline Partners LP 0.04% of their portfolio San Francisco, CA 400,278400.3k $5.8m $5.8m 0.04% Reduced -145.4k -145,367
44 BlackRock, Inc. 0.00% of their portfolio New York, NY 399,966400.0k $5.8m $5.8m 0.00% Reduced -101.0k -100,958
45 Allostery Investments LP 7.93% of their portfolio Stamford, CT 382,524382.5k $5.5m $5.5m 7.93% Added +98.0k +98,007
46 Blue Owl Capital Holdings LP 1.46% of their portfolio New York, NY 315,000315.0k $4.5m $4.5m 1.46% Added +95.0k +95,000
47 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 302,646302.6k $4.4m $4.4m 0.00% Reduced -14.7k -14,683
48 Wildcat Capital Management, LLC 2.16% of their portfolio NEW YORK, NY 281,859281.9k $4.1m $4.1m 2.16% New
49 Schonfeld Strategic Advisors LLC 0.03% of their portfolio NEW YORK, NY 277,570277.6k $4.0m $4.0m 0.03% Reduced -87.6k -87,630
50 PLATINUM INVESTMENT MANAGEMENT LTD 0.22% of their portfolio SYDNEY AUSTRALIA 2000, C3 267,887267.9k $3.9m $3.9m 0.22% Reduced -102.4k -102,391
51 Trexquant Investment LP 0.04% of their portfolio STAMFORD, CT 263,994264.0k $3.8m $3.8m 0.04% Added +2.8k +2,810
52 DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main 0.00% of their portfolio FRANKFURT AM MAIN, 2M 257,418257.4k $3.7m $3.7m 0.00% Reduced -46.1k -46,061
53 Ally Bridge Group (NY) LLC 3.40% of their portfolio NEW YORK, NY 243,086243.1k $3.5m $3.5m 3.40% Reduced -1.5k -1,452
54 HighMark Wealth Management LLC 2.00% of their portfolio ST. PAUL, MN 235,785235.8k $3.4m $3.4m 2.00% Added +69.7k +69,650
55 SILVERARC CAPITAL MANAGEMENT, LLC 0.70% of their portfolio BOSTON, MA 232,758232.8k $3.3m $3.3m 0.70% Reduced -366.2k -366,194
56 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 227,598227.6k $3.3m $3.3m 0.00% New
57 ADAR1 Capital Management, LLC 0.60% of their portfolio AUSTIN, TX 216,166216.2k $3.1m $3.1m 0.60% Added +62.1k +62,139
58 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 207,028207.0k $3.0m $3.0m 0.00% Added +163.3k +163,320
59 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 178,000178.0k $2.6m $2.6m 0.00% Reduced -600 -600
60 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 167,732167.7k $2.4m $2.4m 0.00% Reduced -22.7k -22,653
61 DIADEMA PARTNERS LP 1.88% of their portfolio MORRISTOWN, NJ 164,048164.0k $2.4m $2.4m 1.88% Added +32.2k +32,186
62 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 151,296151.3k $2.2m $2.2m 0.00% New
63 GREAT POINT PARTNERS LLC 1.17% of their portfolio Greenwich, CT 149,702149.7k $2.2m $2.2m 1.17% New
64 FRED ALGER MANAGEMENT, LLC 0.01% of their portfolio NEW YORK, NY 146,398146.4k $2.1m $2.1m 0.01% Reduced -44.1k -44,053
65 Exome Asset Management LLC 1.84% of their portfolio NEW YORK, NY 142,744142.7k $2.1m $2.1m 1.84% Added +5.0k +5,028
66 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 138,767138.8k $2.0m $2.0m 0.00% Added +23.7k +23,660
67 J. Goldman & Co LP 0.07% of their portfolio NEW YORK, NY 136,674136.7k $2.0m $2.0m 0.07% Reduced -28.0k -28,029
68 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 136,027136.0k $2.0m $2.0m 0.00% Reduced -3.7k -3,705
69 Windmill Hill Asset Management Ltd 0.52% of their portfolio WADDESDON, X0 117,913117.9k $1.7m $1.7m 0.52% New
70 TUDOR INVESTMENT CORP ET AL 0.01% of their portfolio STAMFORD, CT 105,925105.9k $1.5m $1.5m 0.01% New
71 OAKMONT Corp 0.26% of their portfolio Los Angeles, CA 92,06492.1k $1.3m $1.3m 0.26% New
72 Aberdeen Group plc 0.00% of their portfolio EDINBURGH, X0 90,88390.9k $1.3m $1.3m 0.00% New
73 Walleye Capital LLC 0.01% of their portfolio NEW YORK, NY 82,19982.2k $1.2m $1.2m 0.01% New
74 REGENTS OF THE UNIVERSITY OF CALIFORNIA 0.25% of their portfolio OAKLAND, CA 81,88481.9k $1.2m $1.2m 0.25% New
75 Legal & General Group Plc 0.00% of their portfolio London, X0 76,05176.1k $1.1m $1.1m 0.00% Added +600 +600
76 LAZARD ASSET MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 73,71873.7k $1.1m $1.1m 0.00% Added +529 +529
77 UBS Group AG 0.00% of their portfolio ZURICH, V8 73,48373.5k $1.1m $1.1m 0.00% Reduced -996.7k -996,726
78 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 60,44160.4k $869.1k $869.1k 0.00% Added +3.2k +3,184
79 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 59,34059.3k $853.3k $853.3k 0.00% Added +29.7k +29,670
80 TANG CAPITAL MANAGEMENT LLC 0.04% of their portfolio SAN DIEGO, CA 50,00050.0k $719.0k $719.0k 0.04% New
81 RTW INVESTMENTS, LP 0.01% of their portfolio NEW YORK, NY 50,00050.0k $719.0k $719.0k 0.01% Unchanged
82 Ellsworth Advisors, LLC 0.18% of their portfolio HUDSON, OH 48,87248.9k $702.8k $702.8k 0.18% New
83 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 46,64446.6k $670.7k $670.7k 0.00% Reduced -1.5k -1,462
84 Squarepoint Ops LLC 0.00% of their portfolio NEW YORK, NY 42,86242.9k $616.4k $616.4k 0.00% Added +16.1k +16,056
85 Verition Fund Management LLC 0.00% of their portfolio GREENWICH, CT 42,43742.4k $610.2k $610.2k 0.00% Added +6.2k +6,242
86 BOOTHBAY FUND MANAGEMENT, LLC 0.02% of their portfolio NEW YORK, NY 41,90041.9k $602.5k $602.5k 0.02% Unchanged
87 XTX Topco Ltd 0.03% of their portfolio LONDON, X0 41,05741.1k $590.4k $590.4k 0.03% Added +18.4k +18,377
88 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 40,86840.9k $587.7k $587.7k 0.00% Added +21.7k +21,746
89 HighVista Strategies LLC 0.22% of their portfolio BOSTON, MA 39,02039.0k $561.1k $561.1k 0.22% Reduced -7.1k -7,096
90 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 38,17438.2k $548.9k $548.9k 0.00% Added +32.9k +32,872
91 Persistent Asset Partners Ltd 0.48% of their portfolio HONG KONG, K3 37,72037.7k $542.4k $542.4k 0.48% Added +19 +19
92 PRELUDE CAPITAL MANAGEMENT, LLC 0.05% of their portfolio NEW YORK, NY 35,80035.8k $514.8k $514.8k 0.05% Unchanged
93 Artia Global Partners LP 0.15% of their portfolio MIAMI, FL 35,22635.2k $506.6k $506.6k 0.15% Reduced -45.2k -45,154
94 Cerity Partners LLC 0.00% of their portfolio NEW YORK, NY 32,75432.8k $471.0k $471.0k 0.00% New
95 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 31,44631.4k $452.2k $452.2k 0.00% New
96 Qube Research & Technologies Ltd 0.00% of their portfolio LONDON, X0 29,43429.4k $423.3k $423.3k 0.00% Reduced -77.6k -77,624
97 SummitTX Capital, L.P. 0.02% of their portfolio FORT WORTH, TX 28,38128.4k $408.1k $408.1k 0.02% First filing
98 Caption Management, LLC 0.01% of their portfolio OKLAHOMA CITY, OK 21,91721.9k $315.2k $315.2k 0.01% New
99 China Universal Asset Management Co., Ltd. 0.02% of their portfolio SHANGHAI, F4 18,31118.3k $263.3k $263.3k 0.02% Reduced -598 -598
100 Rathbones Group PLC 0.00% of their portfolio Liverpool, X0 16,50016.5k $237.3k $237.3k 0.00% Reduced -150 -150