Vault-13

CENTESSA PHARMACEUTICALS PLC

SPONSORED ADS · ADR · CUSIP 152309100

115 institutional holders +11 vs Q3 2024
124,367,251124.4m shares reported held*
$2.1bnreported value*
17 new 35 added 37 reduced 15 sold out net bought ≈ $64.8m (+3.9m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($768.6k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $16.75. Options: 2 managers hold calls ($117.2k notional), 4 hold puts ($3.7m).

Trends to Q4 2024

Institutional holders

Managers reporting a position, each quarter

050100150Q3 22: 45Q4 22: 45Q1 23: 45Q2 23: 46Q3 23: 50Q4 23: 59Q1 24: 71Q2 24: 81Q3 24: 104Q4 24: 115115Q3 22Q1 23Q3 23Q1 24Q3 24Q4 24
Numbers
QuarterHolders
Q3 202245
Q4 202245
Q1 202345
Q2 202346
Q3 202350
Q4 202359
Q1 202471
Q2 202481
Q3 2024104
Q4 2024115

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q1 23: 17 bought or addedQ1 23: 16 cut or sold outQ2 23: 20 bought or addedQ2 23: 11 cut or sold outQ2 23Q3 23: 21 bought or addedQ3 23: 12 cut or sold outQ4 23: 28 bought or addedQ4 23: 12 cut or sold outQ4 23Q1 24: 45 bought or addedQ1 24: 13 cut or sold outQ2 24: 44 bought or addedQ2 24: 26 cut or sold outQ2 24Q3 24: 74 bought or addedQ3 24: 24 cut or sold outQ4 24: 52 bought or addedQ4 24: 52 cut or sold outQ4 24
Numbers
QuarterBought or addedCut or sold out
Q1 20231716
Q2 20232011
Q3 20232112
Q4 20232812
Q1 20244513
Q2 20244426
Q3 20247424
Q4 20245252

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$1m$2m$3m$4mQ1 24 calls: $216.0kQ1 24 puts: $76.5kQ1 24P/C 0.35Q2 24 calls: $119.3kQ2 24 puts: $27.1kQ2 24P/C 0.23Q3 24 calls: $98.5kQ3 24 puts: $848.5kQ3 24P/C 8.61Q4 24 calls: $117.2kQ4 24 puts: $3.7mQ4 24P/C 31.44
Numbers
QuarterCallsPutsP/C
Q1 2024$216.0k$76.5k0.35
Q2 2024$119.3k$27.1k0.23
Q3 2024$98.5k$848.5k8.61
Q4 2024$117.2k$3.7m31.44

Biggest buyers

JANUS HENDERSON GROUP PLC Added +3,614,623+3.6m
UBS Group AG Added +1,065,202+1.1m
ADAGE CAPITAL PARTNERS GP, L.L.C. Added +924,027+924.0k
Commodore Capital LP Added +868,425+868.4k
FMR LLC Added +735,100+735.1k
Point72 Asset Management, L.P. Added +710,936+710.9k
PRICE T ROWE ASSOCIATES INC /MD/ Added +685,371+685.4k
FARALLON CAPITAL MANAGEMENT, L.L.C. Added +684,391+684.4k
STEMPOINT CAPITAL LP Added +558,302+558.3k
MORGAN STANLEY Added +544,858+544.9k

Biggest sellers

EcoR1 Capital, LLC Sold out -3,223,851-3.2m
Avidity Partners Management LP Reduced -966,200-966.2k
Polar Capital Holdings Plc Sold out -640,000-640.0k
Driehaus Capital Management LLC Reduced -563,545-563.5k
Balyasny Asset Management L.P. Reduced -505,993-506.0k
5AM Venture Management, LLC Reduced -454,055-454.1k
TANG CAPITAL MANAGEMENT LLC Sold out -400,000-400.0k
BANK OF AMERICA CORP /DE/ Reduced -269,630-269.6k
Siren, L.L.C. Reduced -254,000-254.0k
JANE STREET GROUP, LLC Sold out -177,260-177.3k

Biggest calls

CITADEL ADVISORS LLC Added $117.2k7.0k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

Octagon Capital Advisors LP New $2.5m152.0k shares
J. Goldman & Co LP New $1.1m67.7k shares
CITADEL ADVISORS LLC Reduced $6.7k400 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
Avoro Capital Advisors LLC 13G · institution -2.6 pts · filed 2026-05-15 7.4% -2.6 pts 11.4m 2026-05-15
General Atlantic Cooperatief U.A. 13D · may seek influence -1.6 pts · filed 2025-11-28 5.0% -1.6 pts 7.4m 2025-11-28

Fell to 5% or below in the last year: Pentwater Capital Management LP (0.0%, 2026-08-14), INDEX VENTURES LIFE VI (JERSEY) L.P. (0.0%, 2026-08-14), Adage Capital Management, L.P. (0.0%, 2026-08-12), Medicxi Growth I LP (0.0%, 2026-08-04), FMR LLC (0.0%, 2026-07-08), FARALLON CAPITAL MANAGEMENT, L.L.C. (0.0%, 2026-06-26)

Holders, Q4 2024

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Medicxi Ventures Management (Jersey) Ltd 63.20% of their portfolio ST. HELIER, Y9 19,963,15720.0m $334.4m $334.4m 63.20% Unchanged
2 Index Venture Life Associates VI Ltd 99.89% of their portfolio ST. HELIER, Y9 9,961,78910.0m $166.9m $166.9m 99.89% First filing
3 GENERAL ATLANTIC, L.P. 5.77% of their portfolio New York, NY 9,681,8189.7m $162.2m $162.2m 5.77% Unchanged
4 PERCEPTIVE ADVISORS LLC 2.96% of their portfolio NEW YORK, NY 6,349,2206.3m $106.3m $106.3m 2.96% Added +66.9k +66,930
5 First Light Asset Management, LLC 9.30% of their portfolio Edina, MN 5,805,1845.8m $97.2m $97.2m 9.30% Reduced -134.9k -134,948
6 PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio BALTIMORE, MD 5,364,3925.4m $89.9m $89.9m 0.01% Added +685.4k +685,371
7 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.15% of their portfolio Boston, MA 5,119,0275.1m $85.7m $85.7m 0.15% Added +924.0k +924,027
8 JANUS HENDERSON GROUP PLC 0.04% of their portfolio LONDON, X0 4,909,4874.9m $82.2m $82.2m 0.04% Added +3.6m +3,614,623
9 Vida Ventures Advisors, LLC 45.01% of their portfolio BOSTON, MA 3,931,8183.9m $65.9m $65.9m 45.01% Unchanged
10 FMR LLC 0.00% of their portfolio BOSTON, MA 3,651,5943.7m $61.2m $61.2m 0.00% Added +735.1k +735,100
11 FARALLON CAPITAL MANAGEMENT, L.L.C. 0.31% of their portfolio SAN FRANCISCO, CA 3,498,7093.5m $58.6m $58.6m 0.31% Added +684.4k +684,391
12 Point72 Asset Management, L.P. 0.16% of their portfolio STAMFORD, CT 3,426,5993.4m $57.4m $57.4m 0.16% Added +710.9k +710,936
13 T. Rowe Price Investment Management, Inc. 0.04% of their portfolio BALTIMORE, MD 3,418,6003.4m $57.3m $57.3m 0.04% Reduced -137.4k -137,423
14 Siren, L.L.C. 2.22% of their portfolio New York, NY 3,004,6773.0m $50.3m $50.3m 2.22% Reduced -254.0k -254,000
15 TCG Crossover Management, LLC 4.73% of their portfolio PALO ALTO, CA 2,890,8162.9m $48.4m $48.4m 4.73% Unchanged
16 Cormorant Asset Management, LP 2.36% of their portfolio BOSTON, MA 2,561,6002.6m $42.9m $42.9m 2.36% Unchanged
17 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 2,308,5462.3m $38.7m $38.7m 0.01% Added +6.0k +6,000
18 Commodore Capital LP 2.72% of their portfolio NEW YORK, NY 2,218,4252.2m $37.2m $37.2m 2.72% Added +868.4k +868,425
19 Octagon Capital Advisors LP 5.68% of their portfolio NEW YORK, NY 1,993,0522.0m $33.4m $33.4m 5.68% Reduced -19.0k -19,000
20 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 1,924,5091.9m $32.2m $32.2m 0.00% Added +544.9k +544,858
21 Driehaus Capital Management LLC 0.22% of their portfolio Chicago, IL 1,598,1831.6m $26.8m $26.8m 0.22% Reduced -563.5k -563,545
22 Deep Track Capital, LP 0.85% of their portfolio GREENWICH, CT 1,350,0001.4m $22.6m $22.6m 0.85% Unchanged
23 Foresite Capital Management VI LLC 9.35% of their portfolio WEST HOLLYWOOD, CA 1,253,3791.3m $21.0m $21.0m 9.35% First filing
24 BAKER BROS. ADVISORS LP 0.22% of their portfolio NEW YORK, NY 1,227,1781.2m $20.6m $20.6m 0.22% Unchanged
25 Avidity Partners Management LP 1.95% of their portfolio DALLAS, TX 1,165,8001.2m $19.5m $19.5m 1.95% Reduced -966.2k -966,200
26 Affinity Asset Advisors, LLC 2.87% of their portfolio NEW YORK, NY 1,095,9241.1m $18.4m $18.4m 2.87% Added +130.3k +130,312
27 AMERICAN CENTURY COMPANIES INC 0.01% of their portfolio KANSAS CITY, MO 1,079,7081.1m $18.1m $18.1m 0.01% Reduced -59.8k -59,838
28 UBS Group AG 0.00% of their portfolio ZURICH, V8 1,070,2091.1m $17.9m $17.9m 0.00% Added +1.1m +1,065,202
29 5AM Venture Management, LLC 3.32% of their portfolio SAN FRANCISCO, CA 830,945830.9k $13.9m $13.9m 3.32% Reduced -454.1k -454,055
30 Tanager Wealth Management LLP 1.51% of their portfolio Goring On Thames, X0 696,096696.1k $11.7m $11.7m 1.51% Unchanged
31 STEMPOINT CAPITAL LP 2.70% of their portfolio NEW YORK, NY 641,964642.0k $10.8m $10.8m 2.70% Added +558.3k +558,302
32 TD Asset Management Inc 0.01% of their portfolio Toronto, A6 641,714641.7k $10.7m $10.7m 0.01% Added +83.0k +83,000
33 CITADEL ADVISORS LLC 0.01% of their portfolio MIAMI, FL 625,316625.3k $10.5m $10.5m 0.01% Added +37.8k +37,798
34 SILVERARC CAPITAL MANAGEMENT, LLC 2.24% of their portfolio BOSTON, MA 598,952599.0k $10.0m $10.0m 2.24% Reduced -145.6k -145,640
35 Woodline Partners LP 0.06% of their portfolio San Francisco, CA 545,645545.6k $9.1m $9.1m 0.06% Added +29.3k +29,266
36 Nantahala Capital Management, LLC 0.60% of their portfolio NEW CANAAN, CT 512,647512.6k $8.6m $8.6m 0.60% Unchanged
37 BlackRock, Inc. 0.00% of their portfolio New York, NY 500,924500.9k $8.4m $8.4m 0.00% Reduced -58.8k -58,796
38 LORD, ABBETT & CO. LLC 0.02% of their portfolio JERSEY CITY, NJ 440,495440.5k $7.4m $7.4m 0.02% Added +171.3k +171,290
39 MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio NEW YORK, NY 398,451398.5k $6.7m $6.7m 0.01% Added +168.1k +168,072
40 PFM Health Sciences, LP 0.47% of their portfolio SAN FRANCISCO, CA 371,766371.8k $6.2m $6.2m 0.47% Added +102.6k +102,608
41 PLATINUM INVESTMENT MANAGEMENT LTD 0.36% of their portfolio SYDNEY AUSTRALIA 2000, C3 370,278370.3k $6.2m $6.2m 0.36% Reduced -59.4k -59,423
42 Schonfeld Strategic Advisors LLC 0.04% of their portfolio NEW YORK, NY 365,200365.2k $6.1m $6.1m 0.04% New
43 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 317,329317.3k $5.3m $5.3m 0.00% Added +52.4k +52,360
44 DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main 0.01% of their portfolio FRANKFURT AM MAIN, 2M 303,479303.5k $5.1m $5.1m 0.01% New
45 Allostery Investments LP 9.36% of their portfolio Stamford, CT 284,517284.5k $4.8m $4.8m 9.36% First filing
46 Trexquant Investment LP 0.05% of their portfolio STAMFORD, CT 261,184261.2k $4.4m $4.4m 0.05% Added +90.2k +90,233
47 Ally Bridge Group (NY) LLC 3.51% of their portfolio NEW YORK, NY 244,538244.5k $4.1m $4.1m 3.51% Reduced -65.1k -65,076
48 Blue Owl Capital Holdings LP 0.85% of their portfolio New York, NY 220,000220.0k $3.7m $3.7m 0.85% Reduced -35.0k -35,000
49 FRED ALGER MANAGEMENT, LLC 0.02% of their portfolio NEW YORK, NY 190,451190.5k $3.2m $3.2m 0.02% Added +12.9k +12,898
50 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 190,385190.4k $3.2m $3.2m 0.00% Reduced -81.4k -81,421
51 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 178,600178.6k $3.0m $3.0m 0.00% Reduced -31.0k -31,000
52 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 175,566175.6k $2.9m $2.9m 0.00% Added +162.5k +162,511
53 Balyasny Asset Management L.P. 0.01% of their portfolio Chicago, IL 175,428175.4k $2.9m $2.9m 0.01% Reduced -506.0k -505,993
54 HighMark Wealth Management LLC 1.60% of their portfolio ST. PAUL, MN 166,135166.1k $2.8m $2.8m 1.60% Reduced -1.0k -1,000
55 J. Goldman & Co LP 0.10% of their portfolio NEW YORK, NY 164,703164.7k $2.8m $2.8m 0.10% New
56 ADAR1 Capital Management, LLC 0.53% of their portfolio AUSTIN, TX 154,027154.0k $2.6m $2.6m 0.53% Added +130.7k +130,725
57 Cutter Capital Management, LP 1.01% of their portfolio NEW YORK, NY 147,076147.1k $2.5m $2.5m 1.01% New
58 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 139,732139.7k $2.3m $2.3m 0.00% Reduced -41.1k -41,121
59 Exome Asset Management LLC 1.74% of their portfolio NEW YORK, NY 137,716137.7k $2.3m $2.3m 1.74% Reduced -138.6k -138,588
60 DIADEMA PARTNERS LP 2.49% of their portfolio MORRISTOWN, NJ 131,862131.9k $2.2m $2.2m 2.49% First filing
61 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 115,107115.1k $1.9m $1.9m 0.00% Added +14.5k +14,494
62 Qube Research & Technologies Ltd 0.00% of their portfolio LONDON, X0 107,058107.1k $1.8m $1.8m 0.00% Added +10.5k +10,543
63 Artia Global Partners LP 0.54% of their portfolio MIAMI, FL 80,38080.4k $1.3m $1.3m 0.54% Unchanged
64 Ensign Peak Advisors, Inc 0.00% of their portfolio SALT LAKE CITY, UT 79,00079.0k $1.3m $1.3m 0.00% Unchanged
65 Legal & General Group Plc 0.00% of their portfolio London, X0 75,45175.5k $1.3m $1.3m 0.00% New
66 LAZARD ASSET MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 73,18973.2k $1.2m $1.2m 0.00% New
67 GSA CAPITAL PARTNERS LLP 0.09% of their portfolio LONDON, X0 71,94771.9k $1.2m $1.2m 0.09% Reduced -21.7k -21,711
68 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 57,25757.3k $959.1k $959.1k 0.00% Added +660 +660
69 RTW INVESTMENTS, LP 0.01% of their portfolio NEW YORK, NY 50,00050.0k $837.5k $837.5k 0.01% Unchanged
70 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 48,10648.1k $805.8k $805.8k 0.00% Reduced -486 -486
71 DAFNA Capital Management LLC 0.20% of their portfolio LOS ANGELES, CA 47,45347.5k $794.8k $794.8k 0.20% Reduced -72.9k -72,898
72 HighVista Strategies LLC 0.29% of their portfolio BOSTON, MA 46,11646.1k $772.4k $772.4k 0.29% Unchanged
73 Cubist Systematic Strategies, LLC 0.01% of their portfolio STAMFORD, CT 45,88545.9k $768.6k $768.6k 0.01% Reduced -88.2k -88,235
74 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 43,70843.7k $732.1k $732.1k 0.00% Reduced -269.6k -269,630
75 BOOTHBAY FUND MANAGEMENT, LLC 0.02% of their portfolio NEW YORK, NY 41,90041.9k $701.8k $701.8k 0.02% New
76 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 37,90037.9k $634.8k $634.8k 0.00% Reduced -66.0k -66,008
77 Persistent Asset Partners Ltd 0.55% of their portfolio HONG KONG, K3 37,70137.7k $637.9k $637.9k 0.55% First filing
78 Verition Fund Management LLC 0.00% of their portfolio GREENWICH, CT 36,19536.2k $606.3k $606.3k 0.00% New
79 PRELUDE CAPITAL MANAGEMENT, LLC 0.05% of their portfolio NEW YORK, NY 35,80035.8k $599.6k $599.6k 0.05% Reduced -1.1k -1,100
80 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 29,67029.7k $497.0k $497.0k 0.00% New
81 Squarepoint Ops LLC 0.00% of their portfolio NEW YORK, NY 26,80626.8k $449.0k $449.0k 0.00% Added +6.7k +6,685
82 Jump Financial, LLC 0.01% of their portfolio Chicago, IL 25,70025.7k $430.5k $430.5k 0.01% Reduced -23.4k -23,411
83 Jain Global LLC 0.01% of their portfolio NEW YORK, NY 23,46623.5k $393.1k $393.1k 0.01% First filing
84 XTX Topco Ltd 0.03% of their portfolio LONDON, X0 22,68022.7k $379.9k $379.9k 0.03% Added +12.5k +12,506
85 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 19,12219.1k $320.3k $320.3k 0.00% New
86 China Universal Asset Management Co., Ltd. 0.03% of their portfolio SHANGHAI, F4 18,90918.9k $316.7k $316.7k 0.03% Added +5.3k +5,316
87 Lynx1 Capital Management LP 0.11% of their portfolio DORADO, PR 17,40017.4k $291.4k $291.4k 0.11% Unchanged
88 Atom Investors LP 0.04% of their portfolio AUSTIN, TX 17,19717.2k $288.1k $288.1k 0.04% New
89 Rathbones Group PLC 0.00% of their portfolio Liverpool, X0 16,65016.6k $278.9k $278.9k 0.00% Reduced -13.8k -13,750
90 Harbour Capital Advisors, LLC 0.06% of their portfolio TYSONS CORNER, VA 16,37516.4k $278.5k $278.5k 0.06% Reduced -300 -300
91 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 15,74615.7k $263.7k $263.7k 0.00% Reduced -12.1k -12,138
92 Shay Capital LLC 0.06% of their portfolio NEW YORK, NY 14,26914.3k $239.0k $239.0k 0.06% New
93 Atria Investments, Inc 0.00% of their portfolio Charlotte, NC 13,77413.8k $230.7k $230.7k 0.00% Reduced -3.4k -3,360
94 OMERS ADMINISTRATION Corp 0.00% of their portfolio TORONTO, A6 10,20010.2k $170.8k $170.8k 0.00% New
95 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 9,6729.7k $162.0k $162.0k 0.00% New
96 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 8,3438.3k $139.0k $139.0k 0.00% Added +2.1k +2,064
97 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 5,3025.3k $88.8k $88.8k 0.00% Added +5.0k +4,952
98 VIRTUS ADVISERS, LLC 0.03% of their portfolio HARTFORD, CT 4,2144.2k $70.6k $70.6k 0.03% Reduced -5.1k -5,071
99 GAMMA Investing LLC 0.01% of their portfolio FOSTER CITY, CA 3,8373.8k $64.3k $64.3k 0.01% Added +865 +865
100 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 2,9723.0k $50.4k $50.4k 0.00% Added +416 +416