Vault-13

CENTESSA PHARMACEUTICALS PLC

SPONSORED ADS · ADR · CUSIP 152309100

104 institutional holders +23 vs Q2 2024
108,713,038108.7m shares reported held*
$1.7bnreported value*
30 new 44 added 16 reduced 8 sold out net bought ≈ $296.1m (+18.5m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($2.1m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $16.00. Options: 4 managers hold calls ($98.5k notional), 4 hold puts ($848.5k).

Trends to Q3 2024

Institutional holders

Managers reporting a position, each quarter

050100150Q3 22: 45Q4 22: 45Q1 23: 45Q2 23: 46Q3 23: 50Q4 23: 59Q1 24: 71Q2 24: 81Q3 24: 104104Q3 22Q1 23Q3 23Q1 24Q3 24
Numbers
QuarterHolders
Q3 202245
Q4 202245
Q1 202345
Q2 202346
Q3 202350
Q4 202359
Q1 202471
Q2 202481
Q3 2024104

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q4 22: 17 bought or addedQ4 22: 12 cut or sold outQ1 23: 17 bought or addedQ1 23: 16 cut or sold outQ1 23Q2 23: 20 bought or addedQ2 23: 11 cut or sold outQ3 23: 21 bought or addedQ3 23: 12 cut or sold outQ3 23Q4 23: 28 bought or addedQ4 23: 12 cut or sold outQ1 24: 45 bought or addedQ1 24: 13 cut or sold outQ1 24Q2 24: 44 bought or addedQ2 24: 26 cut or sold outQ3 24: 74 bought or addedQ3 24: 24 cut or sold outQ3 24
Numbers
QuarterBought or addedCut or sold out
Q4 20221712
Q1 20231716
Q2 20232011
Q3 20232112
Q4 20232812
Q1 20244513
Q2 20244426
Q3 20247424

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$250k$500k$750k$1mQ4 23 calls: $168.6kQ4 23 puts: $31.8kQ4 23P/C 0.19Q1 24 calls: $216.0kQ1 24 puts: $76.5kQ1 24P/C 0.35Q2 24 calls: $119.3kQ2 24 puts: $27.1kQ2 24P/C 0.23Q3 24 calls: $98.5kQ3 24 puts: $848.5kQ3 24P/C 8.61
Numbers
QuarterCallsPutsP/C
Q4 2023$168.6k$31.8k0.19
Q1 2024$216.0k$76.5k0.35
Q2 2024$119.3k$27.1k0.23
Q3 2024$98.5k$848.5k8.61

Biggest buyers

T. Rowe Price Investment Management, Inc. Added +2,722,030+2.7m
PERCEPTIVE ADVISORS LLC Added +2,348,983+2.3m
Avidity Partners Management LP New +2,132,000+2.1m
Deep Track Capital, LP New +1,350,000+1.4m
Commodore Capital LP New +1,350,000+1.4m
JANUS HENDERSON GROUP PLC New +1,294,864+1.3m
First Light Asset Management, LLC Added +1,159,572+1.2m
PRICE T ROWE ASSOCIATES INC /MD/ Added +1,148,648+1.1m
FRANKLIN RESOURCES INC Added +1,145,823+1.1m
ADAGE CAPITAL PARTNERS GP, L.L.C. Added +1,070,000+1.1m

Biggest sellers

EcoR1 Capital, LLC Reduced -2,490,553-2.5m
Artal Group S.A. Sold out -2,112,500-2.1m
MORGAN STANLEY Reduced -670,741-670.7k
Nantahala Capital Management, LLC Reduced -387,353-387.4k
PFM Health Sciences, LP Reduced -366,485-366.5k
Balyasny Asset Management L.P. Reduced -341,701-341.7k
Octagon Capital Advisors LP Reduced -333,023-333.0k
ADAR1 Capital Management, LLC Reduced -229,895-229.9k
Affinity Asset Advisors, LLC Reduced -170,090-170.1k
ExodusPoint Capital Management, LP Sold out -87,210-87.2k

Biggest calls

CITADEL ADVISORS LLC Reduced $94.3k5.9k shares
GROUP ONE TRADING LLC New $3.2k200 shares
SIMPLEX TRADING, LLC Reduced $1.0k100 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

CITADEL ADVISORS LLC Added $471.7k29.5k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP New $375.8k23.5k shares
SIMPLEX TRADING, LLC Unchanged $1.0k100 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
Avoro Capital Advisors LLC 13G · institution -2.6 pts · filed 2026-05-15 7.4% -2.6 pts 11.4m 2026-05-15
General Atlantic Cooperatief U.A. 13D · may seek influence -1.6 pts · filed 2025-11-28 5.0% -1.6 pts 7.4m 2025-11-28

Fell to 5% or below in the last year: Pentwater Capital Management LP (0.0%, 2026-08-14), INDEX VENTURES LIFE VI (JERSEY) L.P. (0.0%, 2026-08-14), Adage Capital Management, L.P. (0.0%, 2026-08-12), Medicxi Growth I LP (0.0%, 2026-08-04), FMR LLC (0.0%, 2026-07-08), FARALLON CAPITAL MANAGEMENT, L.L.C. (0.0%, 2026-06-26)

Holders, Q3 2024

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Medicxi Ventures Management (Jersey) Ltd 60.35% of their portfolio ST. HELIER, Y9 19,963,15720.0m $319.2m $319.2m 60.35% Unchanged
2 GENERAL ATLANTIC, L.P. 4.40% of their portfolio New York, NY 9,681,8189.7m $154.8m $154.8m 4.40% Unchanged
3 PERCEPTIVE ADVISORS LLC 2.16% of their portfolio NEW YORK, NY 6,282,2906.3m $100.5m $100.5m 2.16% Added +2.3m +2,348,983
4 First Light Asset Management, LLC 7.90% of their portfolio Edina, MN 5,940,1325.9m $95.0m $95.0m 7.90% Added +1.2m +1,159,572
5 PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio BALTIMORE, MD 4,679,0214.7m $74.8m $74.8m 0.01% Added +1.1m +1,148,648
6 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.12% of their portfolio Boston, MA 4,195,0004.2m $67.1m $67.1m 0.12% Added +1.1m +1,070,000
7 Vida Ventures Advisors, LLC 45.36% of their portfolio BOSTON, MA 3,931,8183.9m $62.9m $62.9m 45.36% Unchanged
8 T. Rowe Price Investment Management, Inc. 0.03% of their portfolio BALTIMORE, MD 3,556,0233.6m $56.9m $56.9m 0.03% Added +2.7m +2,722,030
9 Siren, L.L.C. 2.61% of their portfolio New York, NY 3,258,6773.3m $52.1m $52.1m 2.61% First filing
10 EcoR1 Capital, LLC 1.77% of their portfolio San Francisco, CA 3,223,8513.2m $51.5m $51.5m 1.77% Reduced -2.5m -2,490,553
11 FMR LLC 0.00% of their portfolio BOSTON, MA 2,916,4942.9m $46.6m $46.6m 0.00% Added +129.3k +129,300
12 TCG Crossover Management, LLC 3.92% of their portfolio PALO ALTO, CA 2,890,8162.9m $46.2m $46.2m 3.92% Unchanged
13 FARALLON CAPITAL MANAGEMENT, L.L.C. 0.25% of their portfolio SAN FRANCISCO, CA 2,814,3182.8m $45.0m $45.0m 0.25% Added +818.3k +818,318
14 Point72 Asset Management, L.P. 0.15% of their portfolio STAMFORD, CT 2,715,6632.7m $43.4m $43.4m 0.15% Added +953.7k +953,659
15 Cormorant Asset Management, LP 2.17% of their portfolio BOSTON, MA 2,561,6002.6m $41.0m $41.0m 2.17% Added +950.0k +950,000
16 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 2,302,5462.3m $38.4m $38.4m 0.01% Added +1.1m +1,145,823
17 Driehaus Capital Management LLC 0.30% of their portfolio Chicago, IL 2,161,7282.2m $34.6m $34.6m 0.30% Added +69.7k +69,717
18 Avidity Partners Management LP 1.74% of their portfolio DALLAS, TX 2,132,0002.1m $34.1m $34.1m 1.74% New
19 Octagon Capital Advisors LP 5.15% of their portfolio NEW YORK, NY 2,012,0522.0m $32.2m $32.2m 5.15% Reduced -333.0k -333,023
20 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 1,379,6511.4m $22.1m $22.1m 0.00% Reduced -670.7k -670,741
21 Commodore Capital LP 1.35% of their portfolio NEW YORK, NY 1,350,0001.4m $21.6m $21.6m 1.35% New
22 Deep Track Capital, LP 0.69% of their portfolio GREENWICH, CT 1,350,0001.4m $21.6m $21.6m 0.69% New
23 JANUS HENDERSON GROUP PLC 0.01% of their portfolio LONDON, X0 1,294,8641.3m $20.7m $20.7m 0.01% New
24 5AM Venture Management, LLC 4.25% of their portfolio SAN FRANCISCO, CA 1,285,0001.3m $20.5m $20.5m 4.25% Added +40.0k +40,000
25 BAKER BROS. ADVISORS LP 0.20% of their portfolio NEW YORK, NY 1,227,1781.2m $19.6m $19.6m 0.20% Added +678.0k +677,966
26 AMERICAN CENTURY COMPANIES INC 0.01% of their portfolio KANSAS CITY, MO 1,139,5461.1m $18.2m $18.2m 0.01% Added +204.4k +204,395
27 Affinity Asset Advisors, LLC 2.40% of their portfolio NEW YORK, NY 965,612965.6k $15.4m $15.4m 2.40% Reduced -170.1k -170,090
28 SILVERARC CAPITAL MANAGEMENT, LLC 2.68% of their portfolio BOSTON, MA 744,592744.6k $11.9m $11.9m 2.68% New
29 Tanager Wealth Management LLP 1.50% of their portfolio Goring On Thames, X0 696,096696.1k $11.1m $11.1m 1.50% Unchanged
30 Balyasny Asset Management L.P. 0.03% of their portfolio Chicago, IL 681,421681.4k $10.9m $10.9m 0.03% Reduced -341.7k -341,701
31 Polar Capital Holdings Plc 0.06% of their portfolio London, X0 640,000640.0k $10.2m $10.2m 0.06% New
32 CITADEL ADVISORS LLC 0.01% of their portfolio MIAMI, FL 587,518587.5k $9.4m $9.4m 0.01% Added +549.2k +549,242
33 BlackRock, Inc. 0.00% of their portfolio New York, NY 559,720559.7k $8.9m $8.9m 0.00% First filing
34 TD Asset Management Inc 0.01% of their portfolio Toronto, A6 558,714558.7k $8.8m $8.8m 0.01% Added +237.5k +237,546
35 Woodline Partners LP 0.07% of their portfolio San Francisco, CA 516,379516.4k $8.3m $8.3m 0.07% Added +392.9k +392,918
36 Nantahala Capital Management, LLC 0.69% of their portfolio NEW CANAAN, CT 512,647512.6k $8.2m $8.2m 0.69% Reduced -387.4k -387,353
37 PLATINUM INVESTMENT MANAGEMENT LTD 0.31% of their portfolio SYDNEY AUSTRALIA 2000, C3 429,701429.7k $6.9m $6.9m 0.31% Reduced -66.2k -66,194
38 TANG CAPITAL MANAGEMENT LLC 0.46% of their portfolio SAN DIEGO, CA 400,000400.0k $6.4m $6.4m 0.46% New
39 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 313,338313.3k $5.0m $5.0m 0.00% Added +240.1k +240,061
40 Ally Bridge Group (NY) LLC 2.65% of their portfolio NEW YORK, NY 309,614309.6k $5.0m $5.0m 2.65% New
41 Exome Asset Management LLC 1.50% of their portfolio NEW YORK, NY 276,304276.3k $4.4m $4.4m 1.50% Added +1.4k +1,404
42 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 271,806271.8k $4.3m $4.3m 0.00% Added +258.7k +258,670
43 LORD, ABBETT & CO. LLC 0.01% of their portfolio JERSEY CITY, NJ 269,205269.2k $4.3m $4.3m 0.01% New
44 PFM Health Sciences, LP 0.25% of their portfolio SAN FRANCISCO, CA 269,158269.2k $4.3m $4.3m 0.25% Reduced -366.5k -366,485
45 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 264,969265.0k $4.2m $4.2m 0.00% Added +124.1k +124,075
46 Blue Owl Capital Holdings LP 0.79% of their portfolio New York, NY 255,000255.0k $4.1m $4.1m 0.79% New
47 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 230,379230.4k $3.7m $3.7m 0.00% Added +180.9k +180,894
48 RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio NEW YORK, NY 209,600209.6k $3.4m $3.4m 0.01% Added +35.9k +35,900
49 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 180,853180.9k $2.9m $2.9m 0.00% Reduced -44.1k -44,095
50 FRED ALGER MANAGEMENT, LLC 0.01% of their portfolio NEW YORK, NY 177,553177.6k $2.8m $2.8m 0.01% Added +166.6k +166,560
51 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 177,260177.3k $2.8m $2.8m 0.00% New
52 Trexquant Investment LP 0.03% of their portfolio STAMFORD, CT 170,951171.0k $2.7m $2.7m 0.03% Added +127.2k +127,203
53 HighMark Wealth Management LLC 1.46% of their portfolio ST. PAUL, MN 167,135167.1k $2.7m $2.7m 1.46% Added +74.1k +74,135
54 Monashee Investment Management LLC 0.28% of their portfolio Boston, MA 161,293161.3k $2.6m $2.6m 0.28% Added +58.1k +58,102
55 Cubist Systematic Strategies, LLC 0.03% of their portfolio STAMFORD, CT 134,120134.1k $2.1m $2.1m 0.03% Added +108.0k +108,047
56 DAFNA Capital Management LLC 0.45% of their portfolio LOS ANGELES, CA 120,351120.4k $1.9m $1.9m 0.45% Reduced -2.5k -2,531
57 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 103,908103.9k $1.7m $1.7m 0.00% Added +52.1k +52,108
58 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 100,613100.6k $1.6m $1.6m 0.00% New
59 Qube Research & Technologies Ltd 0.00% of their portfolio LONDON, X0 96,51596.5k $1.5m $1.5m 0.00% Added +93.0k +92,992
60 GSA CAPITAL PARTNERS LLP 0.11% of their portfolio LONDON, X0 93,65893.7k $1.5m $1.5m 0.11% Added +37.3k +37,275
61 STEMPOINT CAPITAL LP 0.40% of their portfolio NEW YORK, NY 83,66283.7k $1.3m $1.3m 0.40% New
62 Artia Global Partners LP 0.36% of their portfolio MIAMI, FL 80,38080.4k $1.3m $1.3m 0.36% New
63 Ensign Peak Advisors, Inc 0.00% of their portfolio SALT LAKE CITY, UT 79,00079.0k $1.3m $1.3m 0.00% New
64 MONTANOVA CAPITAL, LLC 0.04% of their portfolio New York, NY 70,00070.0k $1.1m $1.1m 0.04% New
65 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 56,59756.6k $905.0k $905.0k 0.00% Added +23.1k +23,058
66 RTW INVESTMENTS, LP 0.01% of their portfolio NEW YORK, NY 50,00050.0k $799.5k $799.5k 0.01% New
67 Jump Financial, LLC 0.02% of their portfolio Chicago, IL 49,11149.1k $785.3k $785.3k 0.02% Added +24.7k +24,735
68 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 48,59248.6k $777.0k $777.0k 0.00% New
69 D. E. Shaw & Co., Inc. 0.00% of their portfolio New York, NY 48,07848.1k $768.8k $768.8k 0.00% New
70 HighVista Strategies LLC 0.25% of their portfolio BOSTON, MA 46,11646.1k $737.4k $737.4k 0.25% New
71 PRELUDE CAPITAL MANAGEMENT, LLC 0.05% of their portfolio NEW YORK, NY 36,90036.9k $590.0k $590.0k 0.05% Reduced -32.0k -32,000
72 TWO SIGMA SECURITIES, LLC 0.04% of their portfolio NEW YORK, NY 32,91732.9k $526.3k $526.3k 0.04% New
73 Rathbones Group PLC 0.00% of their portfolio Liverpool, X0 30,40030.4k $486.1k $486.1k 0.00% Reduced -900 -900
74 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 27,88427.9k $445.9k $445.9k 0.00% New
75 ADAR1 Capital Management, LLC 0.06% of their portfolio AUSTIN, TX 23,30223.3k $372.6k $372.6k 0.06% Reduced -229.9k -229,895
76 Squarepoint Ops LLC 0.00% of their portfolio NEW YORK, NY 20,12120.1k $321.7k $321.7k 0.00% New
77 Lynx1 Capital Management LP 0.10% of their portfolio DORADO, PR 17,40017.4k $278.2k $278.2k 0.10% Unchanged
78 Atria Investments, Inc 0.00% of their portfolio Charlotte, NC 17,13417.1k $274.0k $274.0k 0.00% Added +1.1k +1,116
79 Harbour Capital Advisors, LLC 0.06% of their portfolio TYSONS CORNER, VA 16,67516.7k $259.1k $259.1k 0.06% New
80 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 14,09414.1k $225.4k $225.4k 0.00% Added +12.9k +12,866
81 EntryPoint Capital, LLC 0.12% of their portfolio NEW YORK, NY 13,65113.7k $218.3k $218.3k 0.12% Added +5.5k +5,515
82 China Universal Asset Management Co., Ltd. 0.02% of their portfolio SHANGHAI, F4 13,59313.6k $217.4k $217.4k 0.02% Added +6.8k +6,785
83 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 13,05513.1k $208.7k $208.7k 0.00% New
84 Walleye Capital LLC 0.00% of their portfolio NEW YORK, NY 11,72111.7k $187.4k $187.4k 0.00% New
85 XTX Topco Ltd 0.01% of their portfolio LONDON, X0 10,17410.2k $162.7k $162.7k 0.01% Reduced -6.2k -6,211
86 VIRTUS ADVISERS, LLC 0.07% of their portfolio HARTFORD, CT 9,2859.3k $148.5k $148.5k 0.07% Added +169 +169
87 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 6,2796.3k $101.0k $101.0k 0.00% Added +5.2k +5,162
88 UBS Group AG 0.00% of their portfolio ZURICH, V8 5,0075.0k $80.1k $80.1k 0.00% Added +2.2k +2,198
89 Sandia Investment Management LP 0.13% of their portfolio BOSTON, MA 5,0005.0k $80.0k $80.0k 0.13% Reduced -5.0k -5,000
90 Advisors Preferred, LLC 0.01% of their portfolio ROCKVILLE, MD 4,5554.6k $78.3k $78.3k 0.01% New
91 GAMMA Investing LLC 0.00% of their portfolio FOSTER CITY, CA 2,9723.0k $47.5k $47.5k 0.00% Added +1.5k +1,509
92 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 2,5562.6k $40.4k $40.4k 0.00% Added +826 +826
93 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 2,2892.3k $36.6k $36.6k 0.00% Added +991 +991
94 Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio ZURICH, V8 2,1992.2k $35.2k $35.2k 0.00% Reduced -35 -35
95 Ascentis Independent Advisors 0.00% of their portfolio DALLAS, TX 1,7001.7k $27.2k $27.2k 0.00% New
96 Blue Trust, Inc. 0.00% of their portfolio BRENTWOOD, TN 1,0151.0k $9.2k $9.2k 0.00% Added +306 +306
97 ADIRONDACK TRUST CO 0.01% of their portfolio SARATOGA SPRINGS, NY 925925 $14.8k $14.8k 0.01% Unchanged
98 Global Retirement Partners, LLC 0.00% of their portfolio San Rafael, CA 700700 $11.2k $11.2k 0.00% Unchanged
99 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 350350 $5.6k $5.6k 0.00% New
100 Daiwa Securities Group Inc. 0.00% of their portfolio CHIYODA-KU,TOKYO, M0 211211 $3.0k $3.0k 0.00% Unchanged