Vault-13

CENTESSA PHARMACEUTICALS PLC

SPONSORED ADS · ADR · CUSIP 152309100

81 institutional holders +10 vs Q1 2024
86,947,79986.9m shares reported held*
$785.1mreported value*
17 new 27 added 19 reduced 7 sold out net bought ≈ $74.7m (+8.3m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($235.4k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $9.03. Options: 3 managers hold calls ($119.3k notional), 3 hold puts ($27.1k).

Trends to Q2 2024

Institutional holders

Managers reporting a position, each quarter

050100Q3 22: 45Q4 22: 45Q1 23: 45Q2 23: 46Q3 23: 50Q4 23: 59Q1 24: 71Q2 24: 8181Q3 22Q1 23Q3 23Q1 24Q2 24
Numbers
QuarterHolders
Q3 202245
Q4 202245
Q1 202345
Q2 202346
Q3 202350
Q4 202359
Q1 202471
Q2 202481

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
50050Q4 22: 17 bought or addedQ4 22: 12 cut or sold outQ4 22Q1 23: 17 bought or addedQ1 23: 16 cut or sold outQ2 23: 20 bought or addedQ2 23: 11 cut or sold outQ2 23Q3 23: 21 bought or addedQ3 23: 12 cut or sold outQ4 23: 28 bought or addedQ4 23: 12 cut or sold outQ4 23Q1 24: 45 bought or addedQ1 24: 13 cut or sold outQ2 24: 44 bought or addedQ2 24: 26 cut or sold outQ2 24
Numbers
QuarterBought or addedCut or sold out
Q4 20221712
Q1 20231716
Q2 20232011
Q3 20232112
Q4 20232812
Q1 20244513
Q2 20244426

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$100k$200k$300kQ3 23 calls: $166.0kQ3 23 puts: $13.6kQ3 23P/C 0.08Q4 23 calls: $168.6kQ4 23 puts: $31.8kQ4 23P/C 0.19Q1 24 calls: $216.0kQ1 24 puts: $76.5kQ1 24P/C 0.35Q2 24 calls: $119.3kQ2 24 puts: $27.1kQ2 24P/C 0.23
Numbers
QuarterCallsPutsP/C
Q3 2023$166.0k$13.6k0.08
Q4 2023$168.6k$31.8k0.19
Q1 2024$216.0k$76.5k0.35
Q2 2024$119.3k$27.1k0.23

Biggest buyers

First Light Asset Management, LLC Added +1,778,515+1.8m
FARALLON CAPITAL MANAGEMENT, L.L.C. Added +1,625,000+1.6m
Cormorant Asset Management, LP Added +1,050,000+1.1m
Driehaus Capital Management LLC Added +987,997+988.0k
Nantahala Capital Management, LLC New +900,000+900.0k
ADAGE CAPITAL PARTNERS GP, L.L.C. Added +875,000+875.0k
PERCEPTIVE ADVISORS LLC Added +850,000+850.0k
TCG Crossover Management, LLC Added +850,000+850.0k
T. Rowe Price Investment Management, Inc. New +833,993+834.0k
Balyasny Asset Management L.P. Added +768,676+768.7k

Biggest sellers

MORGAN STANLEY Reduced -4,361,703-4.4m
Point72 Asset Management, L.P. Reduced -495,714-495.7k
ExodusPoint Capital Management, LP Reduced -292,104-292.1k
MILLENNIUM MANAGEMENT LLC Reduced -237,908-237.9k
Ensign Peak Advisors, Inc Sold out -125,157-125.2k
LANDSCAPE CAPITAL MANAGEMENT, L.L.C. Sold out -90,240-90.2k
GOLDMAN SACHS GROUP INC Sold out -55,027-55.0k
Trexquant Investment LP Reduced -52,783-52.8k
Cubist Systematic Strategies, LLC Reduced -46,536-46.5k
RENAISSANCE TECHNOLOGIES LLC Reduced -45,100-45.1k

Biggest calls

CITADEL ADVISORS LLC Reduced $109.3k12.1k shares
SIMPLEX TRADING, LLC Reduced $10.0k1.2k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

CITADEL ADVISORS LLC Reduced $27.1k3.0k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares
SIMPLEX TRADING, LLC Reduced $0100 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
Avoro Capital Advisors LLC 13G · institution -2.6 pts · filed 2026-05-15 7.4% -2.6 pts 11.4m 2026-05-15
General Atlantic Cooperatief U.A. 13D · may seek influence -1.6 pts · filed 2025-11-28 5.0% -1.6 pts 7.4m 2025-11-28

Fell to 5% or below in the last year: Pentwater Capital Management LP (0.0%, 2026-08-14), INDEX VENTURES LIFE VI (JERSEY) L.P. (0.0%, 2026-08-14), Adage Capital Management, L.P. (0.0%, 2026-08-12), Medicxi Growth I LP (0.0%, 2026-08-04), FMR LLC (0.0%, 2026-07-08), FARALLON CAPITAL MANAGEMENT, L.L.C. (0.0%, 2026-06-26)

Holders, Q2 2024

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Medicxi Ventures Management (Jersey) Ltd 53.77% of their portfolio ST. HELIER, Y9 19,963,15720.0m $180.3m $180.3m 53.77% Unchanged
2 GENERAL ATLANTIC, L.P. 2.75% of their portfolio New York, NY 9,681,8189.7m $87.4m $87.4m 2.75% Unchanged
3 EcoR1 Capital, LLC 1.58% of their portfolio San Francisco, CA 5,714,4045.7m $51.6m $51.6m 1.58% Added +95.6k +95,625
4 First Light Asset Management, LLC 3.78% of their portfolio Edina, MN 4,780,5604.8m $43.2m $43.2m 3.78% Added +1.8m +1,778,515
5 PERCEPTIVE ADVISORS LLC 0.86% of their portfolio NEW YORK, NY 3,933,3073.9m $35.5m $35.5m 0.86% Added +850.0k +850,000
6 Vida Ventures Advisors, LLC 38.83% of their portfolio BOSTON, MA 3,931,8183.9m $35.5m $35.5m 38.83% Unchanged
7 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 3,530,3733.5m $31.9m $31.9m 0.00% Added +572.3k +572,294
8 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.05% of their portfolio Boston, MA 3,125,0003.1m $28.2m $28.2m 0.05% Added +875.0k +875,000
9 TCG Crossover Management, LLC 2.72% of their portfolio PALO ALTO, CA 2,890,8162.9m $26.1m $26.1m 2.72% Added +850.0k +850,000
10 FMR LLC 0.00% of their portfolio BOSTON, MA 2,787,1942.8m $25.2m $25.2m 0.00% Unchanged
11 Octagon Capital Advisors LP 3.49% of their portfolio NEW YORK, NY 2,345,0752.3m $21.2m $21.2m 3.49% Added +285.0k +284,975
12 Artal Group S.A. 0.49% of their portfolio LUXEMBOURG, N4 2,112,5002.1m $19.1m $19.1m 0.49% Added +700.0k +700,000
13 Driehaus Capital Management LLC 0.18% of their portfolio Chicago, IL 2,092,0112.1m $18.9m $18.9m 0.18% Added +988.0k +987,997
14 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 2,050,3922.1m $18.5m $18.5m 0.00% Reduced -4.4m -4,361,703
15 FARALLON CAPITAL MANAGEMENT, L.L.C. 0.11% of their portfolio SAN FRANCISCO, CA 1,996,0002.0m $18.0m $18.0m 0.11% Added +1.6m +1,625,000
16 Point72 Asset Management, L.P. 0.05% of their portfolio STAMFORD, CT 1,762,0041.8m $15.9m $15.9m 0.05% Reduced -495.7k -495,714
17 Cormorant Asset Management, LP 0.85% of their portfolio BOSTON, MA 1,611,6001.6m $14.6m $14.6m 0.85% Added +1.1m +1,050,000
18 5AM Venture Management, LLC 2.51% of their portfolio SAN FRANCISCO, CA 1,245,0001.2m $11.2m $11.2m 2.51% Unchanged
19 FRANKLIN RESOURCES INC 0.00% of their portfolio San Mateo, CA 1,156,7231.2m $10.4m $10.4m 0.00% Unchanged
20 Affinity Asset Advisors, LLC 1.62% of their portfolio NEW YORK, NY 1,135,7021.1m $10.3m $10.3m 1.62% Added +305.2k +305,156
21 Balyasny Asset Management L.P. 0.02% of their portfolio Chicago, IL 1,023,1221.0m $9.2m $9.2m 0.02% Added +768.7k +768,676
22 AMERICAN CENTURY COMPANIES INC 0.01% of their portfolio KANSAS CITY, MO 935,151935.2k $8.4m $8.4m 0.01% Added +12.0k +12,031
23 Nantahala Capital Management, LLC 0.41% of their portfolio NEW CANAAN, CT 900,000900.0k $8.1m $8.1m 0.41% New
24 T. Rowe Price Investment Management, Inc. 0.00% of their portfolio BALTIMORE, MD 833,993834.0k $7.5m $7.5m 0.00% New
25 Tanager Wealth Management LLP 0.94% of their portfolio Goring On Thames, X0 696,096696.1k $6.3m $6.3m 0.94% Unchanged
26 PFM Health Sciences, LP 0.31% of their portfolio SAN FRANCISCO, CA 635,643635.6k $5.7m $5.7m 0.31% Added +321.0k +320,969
27 BAKER BROS. ADVISORS LP 0.06% of their portfolio NEW YORK, NY 549,212549.2k $5.0m $5.0m 0.06% New
28 PLATINUM INVESTMENT MANAGEMENT LTD 0.18% of their portfolio SYDNEY AUSTRALIA 2000, C3 495,895495.9k $4.5m $4.5m 0.18% Added +10.7k +10,721
29 BlackRock Inc. 0.00% of their portfolio New York, NY 464,622464.6k $4.2m $4.2m 0.00% Added +82.2k +82,160
30 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 321,168321.2k $2.9m $2.9m 0.00% Added +92.5k +92,524
31 Exome Asset Management LLC 2.21% of their portfolio NEW YORK, NY 274,900274.9k $2.5m $2.5m 2.21% Unchanged
32 ADAR1 Capital Management, LLC 0.46% of their portfolio AUSTIN, TX 253,197253.2k $2.3m $2.3m 0.46% Added +46.3k +46,341
33 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 224,948224.9k $2.0m $2.0m 0.00% Reduced -6.6k -6,617
34 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 173,700173.7k $1.6m $1.6m 0.00% Reduced -45.1k -45,100
35 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 140,894140.9k $1.3m $1.3m 0.00% Added +32.8k +32,846
36 Woodline Partners LP 0.01% of their portfolio San Francisco, CA 123,461123.5k $1.1m $1.1m 0.01% New
37 DAFNA Capital Management LLC 0.27% of their portfolio LOS ANGELES, CA 122,882122.9k $1.1m $1.1m 0.27% New
38 Monashee Investment Management LLC 0.12% of their portfolio Boston, MA 103,191103.2k $931.8k $931.8k 0.12% New
39 HighMark Wealth Management LLC 0.51% of their portfolio ST. PAUL, MN 93,00093.0k $839.8k $839.8k 0.51% New
40 ExodusPoint Capital Management, LP 0.01% of their portfolio NEW YORK, NY 87,21087.2k $788.0k $788.0k 0.01% Reduced -292.1k -292,104
41 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 73,27773.3k $661.7k $661.7k 0.00% Reduced -3.7k -3,707
42 PRELUDE CAPITAL MANAGEMENT, LLC 0.05% of their portfolio NEW YORK, NY 68,90068.9k $622.2k $622.2k 0.05% Reduced -209 -209
43 GSA CAPITAL PARTNERS LLP 0.04% of their portfolio LONDON, X0 56,38356.4k $509.0k $509.0k 0.04% Added +42.8k +42,796
44 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 51,80051.8k $467.8k $467.8k 0.00% Reduced -27.0k -26,981
45 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 49,48549.5k $446.9k $446.9k 0.00% Reduced -237.9k -237,908
46 Trexquant Investment LP 0.01% of their portfolio STAMFORD, CT 43,74843.7k $395.0k $395.0k 0.01% Reduced -52.8k -52,783
47 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 38,27638.3k $345.6k $345.6k 0.00% Reduced -8.7k -8,692
48 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 33,53933.5k $302.9k $302.9k 0.00% Unchanged
49 Rathbones Group PLC 0.00% of their portfolio Liverpool, X0 31,30031.3k $282.6k $282.6k 0.00% Unchanged
50 Cubist Systematic Strategies, LLC 0.00% of their portfolio STAMFORD, CT 26,07326.1k $235.4k $235.4k 0.00% Reduced -46.5k -46,536
51 Jump Financial, LLC 0.00% of their portfolio Chicago, IL 24,37624.4k $220.1k $220.1k 0.00% Reduced -8.5k -8,497
52 Vestcor Inc 0.01% of their portfolio FREDERICTON, A3 20,30020.3k $183.0k $183.0k 0.01% New
53 Quarry LP 0.04% of their portfolio NEW YORK, NY 19,21619.2k $173.5k $173.5k 0.04% Added +12.7k +12,716
54 Lynx1 Capital Management LP 0.06% of their portfolio DORADO, PR 17,40017.4k $157.1k $157.1k 0.06% Unchanged
55 XTX Topco Ltd 0.01% of their portfolio LONDON, X0 16,38516.4k $148.0k $148.0k 0.01% New
56 Atria Investments, Inc 0.00% of their portfolio Charlotte, NC 16,01816.0k $144.6k $144.6k 0.00% New
57 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 13,13613.1k $118.6k $118.6k 0.00% Reduced -41.4k -41,394
58 Schonfeld Strategic Advisors LLC 0.00% of their portfolio NEW YORK, NY 12,30012.3k $111.1k $111.1k 0.00% New
59 FRED ALGER MANAGEMENT, LLC 0.00% of their portfolio NEW YORK, NY 10,99311.0k $99.3k $99.3k 0.00% New
60 Sandia Investment Management LP 0.11% of their portfolio BOSTON, MA 10,00010.0k $90.3k $90.3k 0.11% New
61 VIRTUS ADVISERS, LLC 0.04% of their portfolio HARTFORD, CT 9,1169.1k $82.3k $82.3k 0.04% New
62 EntryPoint Capital, LLC 0.03% of their portfolio NEW YORK, NY 8,1368.1k $73.5k $73.5k 0.03% Reduced -1.5k -1,500
63 China Universal Asset Management Co., Ltd. 0.01% of their portfolio SHANGHAI, F4 6,8086.8k $61.5k $61.5k 0.01% Reduced -4.0k -4,009
64 Qube Research & Technologies Ltd 0.00% of their portfolio LONDON, X0 3,5233.5k $31.8k $31.8k 0.00% Reduced -5.4k -5,421
65 UBS Group AG 0.00% of their portfolio ZURICH, V8 2,8092.8k $25.4k $25.4k 0.00% Added +931 +931
66 Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio ZURICH, V8 2,2342.2k $20.2k $20.2k 0.00% Reduced -33 -33
67 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 1,7301.7k $15.5k $15.5k 0.00% New
68 GAMMA Investing LLC 0.00% of their portfolio FOSTER CITY, CA 1,4631.5k $13.2k $13.2k 0.00% Reduced -35 -35
69 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 1,2981.3k $11.7k $11.7k 0.00% Added +288 +288
70 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 1,2281.2k $11.1k $11.1k 0.00% Added +1.0k +1,024
71 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 1,1171.1k $10.0k $10.0k 0.00% Added +501 +501
72 ADIRONDACK TRUST CO 0.00% of their portfolio SARATOGA SPRINGS, NY 925925 $8.4k $8.4k 0.00% Unchanged
73 Blue Trust, Inc. 0.00% of their portfolio BRENTWOOD, TN 709709 $8.0k $8.0k 0.00% New
74 Global Retirement Partners, LLC 0.00% of their portfolio San Rafael, CA 700700 $6.3k $6.3k 0.00% Unchanged
75 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 520520 $4.7k $4.7k 0.00% New
76 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 407407 $3.7k $3.7k 0.00% Added +107 +107
77 Daiwa Securities Group Inc. 0.00% of their portfolio CHIYODA-KU,TOKYO, M0 211211 $2.0k $2.0k 0.00% Unchanged
78 LANARK FINANCIAL, INC. 0.00% of their portfolio BIRMINGHAM, AL 138138 $1.0k $1.0k 0.00% Unchanged
79 CALDWELL SUTTER CAPITAL, INC. 0.00% of their portfolio SAUSALITO, CA 8686 $777 $777 0.00% Unchanged
80 Spire Wealth Management 0.00% of their portfolio MCLEAN, VA 7070 $632 $632 0.00% Unchanged
81 CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio BIRMINGHAM, AL 00 $0 $0 0.00% Unchanged