Vault-13

CENTESSA PHARMACEUTICALS PLC

SPONSORED ADS · ADR · CUSIP 152309100

50 institutional holders +4 vs Q2 2023
72,578,79472.6m shares reported held*
$469.6mreported value*
4 new 17 added 11 reduced 1 sold out net bought ≈ $14.5m (+2.2m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $6.47. Options: 4 managers hold calls ($166.0k notional), 2 hold puts ($13.6k).

Trends to Q3 2023

Institutional holders

Managers reporting a position, each quarter

0204060Q3 22: 45Q4 22: 45Q1 23: 45Q2 23: 46Q3 23: 5050Q3 22Q4 22Q1 23Q2 23Q3 23
Numbers
QuarterHolders
Q3 202245
Q4 202245
Q1 202345
Q2 202346
Q3 202350

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
40040Q4 22: 17 bought or addedQ4 22: 12 cut or sold outQ4 22Q1 23: 17 bought or addedQ1 23: 16 cut or sold outQ1 23Q2 23: 20 bought or addedQ2 23: 11 cut or sold outQ2 23Q3 23: 21 bought or addedQ3 23: 12 cut or sold outQ3 23
Numbers
QuarterBought or addedCut or sold out
Q4 20221712
Q1 20231716
Q2 20232011
Q3 20232112

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$50k$100k$150k$200kQ4 22 calls: $0Q4 22 puts: $3.1kQ4 22P/C —Q1 23 calls: $0Q1 23 puts: $0Q1 23P/C —Q2 23 calls: $7.4kQ2 23 puts: $32.8kQ2 23P/C 4.42Q3 23 calls: $166.0kQ3 23 puts: $13.6kQ3 23P/C 0.08
Numbers
QuarterCallsPutsP/C
Q4 2022$0$3.1k—
Q1 2023$0$0—
Q2 2023$7.4k$32.8k4.42
Q3 2023$166.0k$13.6k0.08

Biggest buyers

TCG Crossover Management, LLC New +2,040,816+2.0m
ADAGE CAPITAL PARTNERS GP, L.L.C. Added +580,500+580.5k
ACUTA CAPITAL PARTNERS, LLC New +323,349+323.3k
PRICE T ROWE ASSOCIATES INC /MD/ Added +185,923+185.9k
PLATINUM INVESTMENT MANAGEMENT LTD Added +165,919+165.9k
MORGAN STANLEY Added +133,322+133.3k
Affinity Asset Advisors, LLC Added +117,368+117.4k
TD Asset Management Inc Added +104,255+104.3k
Octagon Capital Advisors LP Added +63,672+63.7k
BANK OF AMERICA CORP /DE/ Added +47,732+47.7k

Biggest sellers

Boxer Capital, LLC Reduced -480,429-480.4k
Woodline Partners LP Reduced -477,559-477.6k
BVF INC/IL Reduced -320,161-320.2k
Point72 Asset Management, L.P. Reduced -170,906-170.9k
Sio Capital Management, LLC Reduced -120,302-120.3k
JPMORGAN CHASE & CO Reduced -49,263-49.3k
Tower Research Capital LLC (TRC) Reduced -1,206-1.2k
CITADEL ADVISORS LLC Reduced -1,086-1.1k
OSAIC HOLDINGS, INC. Reduced -363-363
CITIGROUP INC Reduced -239-239

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP New $119.7k18.5k shares
CITADEL ADVISORS LLC Added $45.3k7.0k shares
SIMPLEX TRADING, LLC New $1.0k300 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

CITADEL ADVISORS LLC Reduced $13.6k2.1k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
Avoro Capital Advisors LLC 13G · institution -2.6 pts · filed 2026-05-15 7.4% -2.6 pts 11.4m 2026-05-15
General Atlantic Cooperatief U.A. 13D · may seek influence -1.6 pts · filed 2025-11-28 5.0% -1.6 pts 7.4m 2025-11-28

Fell to 5% or below in the last year: Pentwater Capital Management LP (0.0%, 2026-08-14), INDEX VENTURES LIFE VI (JERSEY) L.P. (0.0%, 2026-08-14), Adage Capital Management, L.P. (0.0%, 2026-08-12), Medicxi Growth I LP (0.0%, 2026-08-04), FMR LLC (0.0%, 2026-07-08), FARALLON CAPITAL MANAGEMENT, L.L.C. (0.0%, 2026-06-26)

Holders, Q3 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Medicxi Ventures Management (Jersey) Ltd 41.24% of their portfolio ST. HELIER, Y9 19,963,15720.0m $129.2m $129.2m 41.24% Unchanged
2 GENERAL ATLANTIC, L.P. 0.97% of their portfolio New York, NY 9,681,8189.7m $62.6m $62.6m 0.97% Unchanged
3 BVF INC/IL 1.59% of their portfolio San Francisco, CA 9,103,0549.1m $58.9m $58.9m 1.59% Reduced -320.2k -320,161
4 EcoR1 Capital, LLC 1.24% of their portfolio San Francisco, CA 5,618,7795.6m $36.4m $36.4m 1.24% Unchanged
5 Vida Ventures Advisors, LLC 39.38% of their portfolio BOSTON, MA 3,931,8183.9m $25.4m $25.4m 39.38% Unchanged
6 OUP Management Co., LLC 42.74% of their portfolio Bala Cynwyd, PA 2,937,6152.9m $19.0m $19.0m 42.74% Unchanged
7 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.04% of their portfolio Boston, MA 2,830,5002.8m $18.3m $18.3m 0.04% Added +580.5k +580,500
8 FMR LLC 0.00% of their portfolio BOSTON, MA 2,787,1942.8m $18.0m $18.0m 0.00% Unchanged
9 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 2,549,1342.5m $16.5m $16.5m 0.00% Added +185.9k +185,923
10 TCG Crossover Management, LLC 1.94% of their portfolio PALO ALTO, CA 2,040,8162.0m $13.2m $13.2m 1.94% New
11 Point72 Asset Management, L.P. 0.04% of their portfolio STAMFORD, CT 1,840,4821.8m $11.9m $11.9m 0.04% Reduced -170.9k -170,906
12 Affinity Asset Advisors, LLC 2.15% of their portfolio NEW YORK, NY 1,018,0911.0m $6.6m $6.6m 2.15% Added +117.4k +117,368
13 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 957,951958.0k $6.2m $6.2m 0.00% Added +133.3k +133,322
14 FRANKLIN RESOURCES INC 0.00% of their portfolio San Mateo, CA 832,348832.3k $5.4m $5.4m 0.00% Unchanged
15 Boxer Capital, LLC 0.27% of their portfolio San Diego, CA 770,708770.7k $5.0m $5.0m 0.27% Reduced -480.4k -480,429
16 Sio Capital Management, LLC 1.52% of their portfolio NEW YORK, NY 756,891756.9k $4.9m $4.9m 1.52% Reduced -120.3k -120,302
17 Kynam Capital Management, LP 0.79% of their portfolio PRINCETON, NJ 730,472730.5k $4.7m $4.7m 0.79% Added +1.4k +1,395
18 Tanager Wealth Management LLP 0.93% of their portfolio Goring On Thames, X0 696,096696.1k $4.5m $4.5m 0.93% Unchanged
19 AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio KANSAS CITY, MO 694,885694.9k $4.5m $4.5m 0.00% Added +23 +23
20 Cormorant Asset Management, LP 0.21% of their portfolio BOSTON, MA 561,600561.6k $3.6m $3.6m 0.21% Unchanged
21 Octagon Capital Advisors LP 0.54% of their portfolio NEW YORK, NY 475,600475.6k $3.1m $3.1m 0.54% Added +63.7k +63,672
22 PLATINUM INVESTMENT MANAGEMENT LTD 0.09% of their portfolio SYDNEY AUSTRALIA 2000, C3 337,544337.5k $2.2m $2.2m 0.09% Added +165.9k +165,919
23 BlackRock Inc. 0.00% of their portfolio New York, NY 325,843325.8k $2.1m $2.1m 0.00% Added +31.3k +31,343
24 ACUTA CAPITAL PARTNERS, LLC 1.52% of their portfolio REDWOOD CITY, CA 323,349323.3k $2.1m $2.1m 1.52% New
25 Woodline Partners LP 0.02% of their portfolio San Francisco, CA 210,204210.2k $1.4m $1.4m 0.02% Reduced -477.6k -477,559
26 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 186,310186.3k $1.2m $1.2m 0.00% Added +104.3k +104,255
27 Ensign Peak Advisors, Inc 0.00% of their portfolio SALT LAKE CITY, UT 125,157125.2k $809.8k $809.8k 0.00% Unchanged
28 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 63,02163.0k $407.7k $407.7k 0.00% Added +5.6k +5,600
29 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 53,10053.1k $344.0k $344.0k 0.00% Added +18.8k +18,800
30 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 51,94351.9k $336.1k $336.1k 0.00% Added +47.7k +47,732
31 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 31,83331.8k $206.0k $206.0k 0.00% Added +6.7k +6,713
32 Rathbones Group PLC 0.00% of their portfolio Liverpool, X0 31,30031.3k $202.5k $202.5k 0.00% New
33 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 11,60011.6k $75.1k $75.1k 0.00% Added +500 +500
34 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 10,65010.7k $68.9k $68.9k 0.00% Unchanged
35 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 10,10110.1k $65.4k $65.4k 0.00% Reduced -49.3k -49,263
36 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 6,4006.4k $41.4k $41.4k 0.00% Unchanged
37 Compagnie Lombard Odier SCmA 0.00% of their portfolio 1204 GENEVA, V8 5,8205.8k $37.7k $37.7k 0.00% Unchanged
38 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 3,0663.1k $19.8k $19.8k 0.00% Reduced -1.2k -1,206
39 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 3,0193.0k $19.5k $19.5k 0.00% Reduced -1.1k -1,086
40 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 2,8132.8k $18.2k $18.2k 0.00% Reduced -363 -363
41 UBS Group AG 0.00% of their portfolio ZURICH, V8 2,6362.6k $17.1k $17.1k 0.00% Added +518 +518
42 China Universal Asset Management Co., Ltd. 0.00% of their portfolio SHANGHAI, F4 1,3571.4k $8.8k $8.8k 0.00% Added +666 +666
43 ADIRONDACK TRUST CO 0.00% of their portfolio SARATOGA SPRINGS, NY 925925 $6.0k $6.0k 0.00% Unchanged
44 Global Retirement Partners, LLC 0.00% of their portfolio San Rafael, CA 700700 $4.1k $4.1k 0.00% Unchanged
45 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 656656 $4.2k $4.2k 0.00% Reduced -239 -239
46 Daiwa Securities Group Inc. 0.00% of their portfolio CHIYODA-KU,TOKYO, M0 211211 $1.0k $1.0k 0.00% Unchanged
47 LANARK FINANCIAL, INC. 0.00% of their portfolio BIRMINGHAM, AL 138138 $0 $0 0.00% First filing
48 Qube Research & Technologies Ltd 0.00% of their portfolio LONDON, X0 6969 $446 $446 0.00% New
49 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 2020 $0 $0 0.00% Reduced -165 -165
50 CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio BIRMINGHAM, AL 00 $0 $0 0.00% Unchanged