CASSAVA SCIENCES INC FLNA
COM · Common Stock · CUSIP 14817C107 · ISIN US14817C1071
American pharmaceutical company
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersAustin, TX
- Founded1998
- Websitecassavasciences.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 48.3m as of 2026-07-27, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $1.19. Options: 8 managers hold calls ($635.3k notional), 8 hold puts ($407.2k).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 174 |
| Q4 2022 | 152 |
| Q1 2023 | 145 |
| Q2 2023 | 152 |
| Q3 2023 | 141 |
| Q4 2023 | 153 |
| Q1 2024 | 142 |
| Q2 2024 | 146 |
| Q3 2024 | 161 |
| Q4 2024 | 138 |
| Q1 2025 | 118 |
| Q2 2025 | 98 |
| Q3 2025 | 103 |
| Q4 2025 | 107 |
| Q1 2026 | 101 |
| Q2 2026 | 85 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 81 | 54 |
| Q4 2024 | 68 | 89 |
| Q1 2025 | 45 | 76 |
| Q2 2025 | 38 | 71 |
| Q3 2025 | 41 | 45 |
| Q4 2025 | 43 | 44 |
| Q1 2026 | 28 | 58 |
| Q2 2026 | 29 | 55 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $4.7m | $1.7m | 0.35 |
| Q4 2025 | $2.6m | $2.0m | 0.78 |
| Q1 2026 | $1.2m | $849.2k | 0.73 |
| Q2 2026 | $635.3k | $407.2k | 0.64 |
Biggest buyers
| GOLDMAN SACHS GROUP INC | Added | +627.5k |
| Squarepoint Ops LLC | New | +318.4k |
| STIFEL FINANCIAL CORP | New | +75.0k |
| RENAISSANCE TECHNOLOGIES LLC | Added | +62.8k |
| GSA CAPITAL PARTNERS LLP | Added | +51.6k |
| VANGUARD CAPITAL MANAGEMENT LLC | Added | +44.0k |
| VANGUARD FIDUCIARY TRUST CO | Added | +42.0k |
| BlackRock, Inc. | Added | +39.0k |
| XTX Topco Ltd | Added | +31.3k |
| UBS Group AG | Added | +27.5k |
Biggest sellers
| MARSHALL WACE, LLP | Reduced | -415.0k |
| TWO SIGMA INVESTMENTS, LP | Reduced | -277.5k |
| DIMENSIONAL FUND ADVISORS LP | Reduced | -214.0k |
| JACOBS LEVY EQUITY MANAGEMENT, INC | Sold out | -209.1k |
| CANADA PENSION PLAN INVESTMENT BOARD | Sold out | -189.1k |
| JANE STREET GROUP, LLC | Reduced | -166.2k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -155.3k |
| Susquehanna Portfolio Strategies, LLC | Sold out | -100.8k |
| D. E. Shaw & Co., Inc. | Reduced | -74.2k |
| MILLENNIUM MANAGEMENT LLC | Sold out | -72.6k |
Biggest calls
| CITADEL ADVISORS LLC | Reduced | $187.3k157.4k shares |
| GROUP ONE TRADING LLC | Reduced | $102.7k86.3k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $99.8k83.9k shares |
| JANE STREET GROUP, LLC | Reduced | $73.5k61.8k shares |
| Walleye Trading LLC | Reduced | $56.2k47.2k shares |
| SIMPLEX TRADING, LLC | Reduced | $51.1k42.9k shares |
| IMC-Chicago, LLC | Reduced | $40.7k34.2k shares |
| Walleye Capital LLC | New | $24.0k20.2k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $121.5k102.1k shares |
| CITADEL ADVISORS LLC | Reduced | $72.2k60.7k shares |
| Verition Fund Management LLC | Unchanged | $65.7k55.2k shares |
| GROUP ONE TRADING LLC | Added | $53.2k44.7k shares |
| SIMPLEX TRADING, LLC | Reduced | $37.8k31.8k shares |
| JANE STREET GROUP, LLC | Added | $30.8k25.9k shares |
| IMC-Chicago, LLC | Reduced | $20.7k17.4k shares |
| Walleye Trading LLC | Reduced | $5.2k4.4k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 2 | $253.9k | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 2 | $591.0k | 0 | — | — |
| Q4 2025 | 2 | $640.7k | 0 | — | — |
| Q1 2026 | 0 | — | 0 | — | — |
| Q2 2026 | 0 | — | 0 | — | — |
| Q3 2026 | 1 | $78.2k | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-09-28 | Barry Richard President & CEO, director · By Trust | Bought | $78.2k93.1k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 2.0m $2.4m | Added +44.0k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 1.7m $2.0m | Reduced -277.5k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 1.6m $1.9m | Reduced -415.0k |
| BlackRock, Inc. 0.00% of their portfolio | 1.5m $1.7m | Added +39.0k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 668.8k $795.9k | Added +627.5k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 615.5k $732.7k | Added +19.3k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 485.0k $577.2k | Reduced -74.2k |
| GMT Capital Corp 0.03% of their portfolio | 450.1k $535.6k | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 389.6k $463.6k | Added +62.8k |
| Squarepoint Ops LLC 0.00% of their portfolio | 318.4k $378.9k | New |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 315.9k $375.9k | Added +42.0k |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 295.1k $350.0k | Added +10.8k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 292.0k $347.5k | Reduced -155.3k |
| GSA CAPITAL PARTNERS LLP 0.02% of their portfolio | 269.4k $321.0k | Added +51.6k |
| GROUP ONE TRADING LLC 0.01% of their portfolio | 244.0k $290.4k | Reduced -58.6k |
| STATE STREET CORP 0.00% of their portfolio | 209.1k $248.8k | Reduced -30.9k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 132.6k $157.8k | Reduced -96 |
| Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio | 132.3k $157.4k | Reduced -4.6k |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 120.0k $142.7k | Added +4.9k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 114.3k $136.0k | Reduced -34.9k |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 99.9k $118.9k | Reduced -40.1k |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 75.0k $89.2k | New |
| XTX Topco Ltd 0.00% of their portfolio | 64.6k $76.9k | Added +31.3k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 59.0k $70.2k | Reduced -166.2k |
| Verition Fund Management LLC 0.00% of their portfolio | 46.9k $55.8k | Added +8.7k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 40.9k $49.0k | Added +9.5k |
| LPL Financial LLC 0.00% of their portfolio | 40.2k $47.8k | Reduced -821 |
| UBS Group AG 0.00% of their portfolio | 39.1k $46.5k | Added +27.5k |
| MGO ONE SEVEN LLC 0.00% of their portfolio | 33.3k $39.7k | Added +13.5k |
| Engineers Gate Manager LP 0.00% of their portfolio | 31.7k $37.7k | Reduced -7.8k |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 29.0k $34.5k | Reduced -2.2k |
| NewEdge Advisors, LLC 0.00% of their portfolio | 28.3k $33.7k | Added +25.0k |
| Virtu Financial LLC 0.00% of their portfolio | 27.2k $32.0k | New |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 25.9k $31.0k | Reduced -214.0k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 20.3k $24.1k | Reduced -197 |
| Apollon Wealth Management, LLC 0.00% of their portfolio | 18.9k $22.5k | Reduced -16.2k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 17.0k $20.8k | Added +17.0k |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 15.9k $18.9k | Unchanged |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 15.6k $18.5k | Reduced -1.5k |
| Marex Group Ltd 0.00% of their portfolio | 15.5k $18.4k | Added +5.0k |
| Cetera Investment Advisers 0.00% of their portfolio | 15.2k $18.1k | Added +776 |
| MORGAN STANLEY 0.00% of their portfolio | 13.6k $16.1k | Reduced -4.4k |
| MAYPORT, LLC 0.00% of their portfolio | 13.4k $15.9k | Unchanged |
| Vanguard Personalized Indexing Management, LLC 0.00% of their portfolio | 12.1k $14.3k | Reduced -1.8k |
| JOHNSON INVESTMENT COUNSEL INC 0.00% of their portfolio | 12.0k $14.3k | Unchanged |
| Point72 Asset Management, L.P. 0.00% of their portfolio | 11.6k $13.8k | Reduced -27.5k |
| Quadrature Capital Ltd 0.00% of their portfolio | 11.2k $13.4k | New |
| Catalyst Funds Management Pty Ltd 0.00% of their portfolio | 10.8k $12.9k | Reduced -7.3k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 10.5k $12.5k | Added +2.0k |
| JONES FINANCIAL COMPANIES LLLP 0.00% of their portfolio | 8.4k $10.1k | Added +8.0k |
| Federation des caisses Desjardins du Quebec 0.00% of their portfolio | 4.7k $5.6k | Unchanged |
| Activest Wealth Management 0.00% of their portfolio | 4.0k $4.8k | Unchanged |
| FMR LLC 0.00% of their portfolio | 2.9k $3.5k | Reduced -3.2k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 2.4k $2.9k | Reduced -4.9k |
| Signature Equity Partners, LLC 0.00% of their portfolio | 2.0k $2.4k | Unchanged |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 1.9k $2.2k | Added +655 |
| NATIONAL BANK OF CANADA /FI/ 0.00% of their portfolio | 1.5k $1.8k | Reduced -200 |
| Smartleaf Asset Management LLC 0.00% of their portfolio | 1.4k $1.7k | Unchanged |
| MidFirst Bank 0.00% of their portfolio | 1.0k $1.2k | Unchanged |
| Walleye Trading LLC 0.00% of their portfolio | 947 $1.1k | Reduced -20.0k |
| EverSource Wealth Advisors, LLC 0.00% of their portfolio | 425 $506 | Reduced -2.1k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 422 $502 | Reduced -3 |
| TD Waterhouse Canada Inc. 0.00% of their portfolio | 400 $496 | Unchanged |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 314 $0 | Reduced -1.2k |
| BARCLAYS PLC 0.00% of their portfolio | 292 $347 | Reduced -42.1k |
| SALEM INVESTMENT COUNSELORS INC 0.00% of their portfolio | 275 $328 | Unchanged |
| HARBOUR INVESTMENTS, INC. 0.00% of their portfolio | 250 $298 | Unchanged |
| MATHER GROUP, LLC. 0.00% of their portfolio | 250 $298 | Unchanged |
| Parallel Advisors, LLC 0.00% of their portfolio | 244 $290 | Unchanged |
| US BANCORP \DE\ 0.00% of their portfolio | 88 $105 | New |
| SOA Wealth Advisors, LLC. 0.00% of their portfolio | 78 $93 | Unchanged |
| Steward Partners Investment Advisory, LLC 0.00% of their portfolio | 75 $89 | Reduced -237 |
| Caitong International Asset Management Co., Ltd 0.00% of their portfolio | 51 $61 | Reduced -56 |
| HM PAYSON & CO 0.00% of their portfolio | 50 $60 | Unchanged |
| HANTZ FINANCIAL SERVICES, INC. 0.00% of their portfolio | 50 $0 | Unchanged |
| CREATIVE FINANCIAL DESIGNS INC /ADV 0.00% of their portfolio | 40 $48 | Unchanged |
| Redwood Park Advisors LLC 0.00% of their portfolio | 40 $48 | New |
| Golden State Wealth Management, LLC 0.00% of their portfolio | 36 $43 | Unchanged |
| CITIGROUP INC 0.00% of their portfolio | 19 $23 | Reduced -1 |
| Farther Finance Advisors, LLC 0.00% of their portfolio | 16 $19 | Unchanged |
| IFP Advisors, Inc 0.00% of their portfolio | 10 $12 | Unchanged |
| Larson Financial Group LLC 0.00% of their portfolio | 10 $12 | Unchanged |
| LRI Investments, LLC 0.00% of their portfolio | 10 $12 | Unchanged |
| Capital Advisors, Ltd. LLC 0.00% of their portfolio | 4 $0 | New |
| Integrated Wealth Concepts LLC 0.00% of their portfolio | 2 $2 | New |