CARIS LIFE SCIENCES INC CAI
COM · Common Stock · CUSIP 142152107 · ISIN US1421521071
Company in Irving, United States
- SectorHealth care
- IndustryServices-Medical Laboratories
- HeadquartersIrving, TX
- Founded2008
- Websitecarislifesciences.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($5.5m this quarter). Holder counts are more reliable. Shares outstanding: 282.6m as of 2026-08-03, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $17.83. Options: 8 managers hold calls ($10.5m notional), 7 hold puts ($6.3m).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q2 2025 | 117 |
| Q3 2025 | 138 |
| Q4 2025 | 186 |
| Q1 2026 | 202 |
| Q2 2026 | 246 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2025 | 98 | 44 |
| Q4 2025 | 134 | 57 |
| Q1 2026 | 138 | 74 |
| Q2 2026 | 172 | 70 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $13.0m | $1.6m | 0.13 |
| Q4 2025 | $14.4m | $5.1m | 0.35 |
| Q1 2026 | $4.6m | $5.7m | 1.25 |
| Q2 2026 | $10.5m | $6.3m | 0.59 |
Biggest buyers
| JPMORGAN CHASE & CO | Added | +3.1m |
| MAK CAPITAL ONE LLC | New | +1.9m |
| LOS ANGELES CAPITAL MANAGEMENT LLC | Added | +1.7m |
| HRT FINANCIAL LP | New | +1.4m |
| Amundi | Added | +1.2m |
| VANGUARD PORTFOLIO MANAGEMENT LLC | Added | +1.1m |
| VANGUARD CAPITAL MANAGEMENT LLC | Added | +951.2k |
| MORGAN STANLEY | Added | +856.1k |
| BNP PARIBAS FINANCIAL MARKETS | Added | +756.0k |
| BlackRock, Inc. | Added | +679.7k |
Biggest sellers
| Sixth Street Partners Management Company, L.P. | Reduced | -7.1m |
| J. H. Whitney Equity Partners VI, LLC | Reduced | -7.0m |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -3.2m |
| UBS Group AG | Reduced | -1.3m |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | Reduced | -1.1m |
| Invesco Ltd. | Reduced | -1.1m |
| Point72 Asset Management, L.P. | Sold out | -918.3k |
| Gotham Asset Management, LLC | Reduced | -654.9k |
| PointState Capital LP | Reduced | -531.6k |
| T. Rowe Price Investment Management, Inc. | Reduced | -509.1k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $3.7m208.7k shares |
| JANE STREET GROUP, LLC | Added | $3.6m199.9k shares |
| Caption Management, LLC | New | $1.1m60.0k shares |
| CITADEL ADVISORS LLC | Added | $760.9k42.7k shares |
| IMC-Chicago, LLC | Added | $636.2k35.7k shares |
| Tidal Investments LLC | New | $327.9k18.4k shares |
| GROUP ONE TRADING LLC | Added | $294.0k16.5k shares |
| SIMPLEX TRADING, LLC | Added | $156.8k8.8k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $2.8m157.8k shares |
| CITADEL ADVISORS LLC | Added | $964.1k54.1k shares |
| Caption Management, LLC | Reduced | $891.0k50.0k shares |
| IMC-Chicago, LLC | Added | $800.1k44.9k shares |
| GROUP ONE TRADING LLC | Reduced | $368.9k20.7k shares |
| JANE STREET GROUP, LLC | Added | $368.9k20.7k shares |
| SIMPLEX TRADING, LLC | Reduced | $46.3k2.6k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| HALBERT DAVID D 13G · exempt (held before listing) new · filed 2025-08-13 | 44.1% |
| FMR LLC 13G · institution +5.8 pts · filed 2026-04-07 | 10.8% |
Fell to 5% or below in the last year: J H Whitney VI L P (4.0%, 2026-08-12), TSSP Sub-Fund HoldCo LLC (2.6%, 2026-08-07)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 2 | $787.5k | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 2 | $110.3k | 1 | $1.7m | $1.7m |
| Q1 2026 | 0 | — | 0 | — | — |
| Q2 2026 | 2 | $1.5m | 0 | — | — |
| Q3 2026 | 0 | — | 3 | $27.2m | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-09-22 | Denton John Russel Officer | Sold | $238.7k7.5k shares |
| 2026-09-17 | Brille Brian J Officer, director | Sold | $12.1m400.0k shares |
| 2026-09-04 | Spetzler David Baxley President | Sold | $3.0m119.2k shares |
| 2026-09-03 | Spetzler David Baxley President | Sold | $11.9m478.0k shares |
| 2026-05-15 | HALBERT JON Director · By LAH Investments, Ltd. | Bought | $990.1k68.0k shares |
| 2026-05-11 | Vacirca Jeff L Director | Bought | $501.5k31.1k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.02% of their portfolio | 30.9m $551.1m | Added +138.3k |
| J. H. Whitney Equity Partners VI, LLC 100.00% of their portfolio | 11.3m $200.6m | Reduced -7.0m |
| COATUE MANAGEMENT LLC 0.36% of their portfolio | 9.8m $175.0m | Unchanged |
| BRAIDWELL LP 5.44% of their portfolio | 8.3m $147.1m | Added +246.6k |
| Sixth Street Partners Management Company, L.P. 22.54% of their portfolio | 7.3m $130.6m | Reduced -7.1m |
| PointState Capital LP 2.14% of their portfolio | 6.8m $121.7m | Reduced -531.6k |
| JPMORGAN CHASE & CO 0.01% of their portfolio | 6.6m $120.2m | Added +3.1m |
| BlackRock, Inc. 0.00% of their portfolio | 5.5m $98.7m | Added +679.7k |
| T. Rowe Price Investment Management, Inc. 0.06% of their portfolio | 5.1m $90.5m | Reduced -509.1k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 4.8m $86.3m | Added +1.1m |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 4.3m $76.3m | Added +951.2k |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.26% of their portfolio | 4.0m $70.5m | Added +1.7m |
| NEUBERGER BERMAN GROUP LLC 0.04% of their portfolio | 3.6m $64.0m | Added +377 |
| ORBIMED ADVISORS LLC 0.95% of their portfolio | 2.8m $50.0m | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS 0.02% of their portfolio | 2.4m $42.2m | Added +756.0k |
| MILLENNIUM MANAGEMENT LLC 0.03% of their portfolio | 2.2m $39.3m | Added +674.9k |
| MAK CAPITAL ONE LLC 4.84% of their portfolio | 1.9m $34.5m | New |
| MORGAN STANLEY 0.00% of their portfolio | 1.9m $34.5m | Added +856.1k |
| Duquesne Family Office LLC 0.78% of their portfolio | 1.9m $33.8m | Unchanged |
| Clearbridge Investments, LLC 0.02% of their portfolio | 1.6m $28.4m | Added +44.1k |
| FIL Ltd 0.02% of their portfolio | 1.5m $27.6m | Added +2.8k |
| UBS Group AG 0.00% of their portfolio | 1.4m $25.4m | Reduced -1.3m |
| HRT FINANCIAL LP 0.06% of their portfolio | 1.4m $25.3m | New |
| CANADA PENSION PLAN INVESTMENT BOARD 0.01% of their portfolio | 1.4m $24.5m | Added +52.2k |
| Amundi 0.01% of their portfolio | 1.2m $21.7m | Added +1.2m |
| STATE STREET CORP 0.00% of their portfolio | 1.2m $21.7m | Added +232.6k |
| Capital World Investors 0.00% of their portfolio | 1.2m $21.6m | Added +33.1k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 1.2m $21.5m | Reduced -3.2m |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 1.2m $21.4m | Added +677.3k |
| Champlain Investment Partners, LLC 0.48% of their portfolio | 1.0m $18.7m | Reduced -159.1k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.0m $18.6m | Added +266.1k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 951.9k $17.0m | Added +541.6k |
| ZEVENBERGEN CAPITAL INVESTMENTS LLC 0.33% of their portfolio | 802.1k $14.3m | Added +191.8k |
| SEI INVESTMENTS CO 0.01% of their portfolio | 762.7k $13.6m | Added +163.9k |
| Trexquant Investment LP 0.08% of their portfolio | 727.9k $13.0m | Added +237.4k |
| Woodline Partners LP 0.04% of their portfolio | 723.2k $12.9m | Unchanged |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.01% of their portfolio | 655.6k $11.7m | Added +445.1k |
| Nuveen, LLC 0.00% of their portfolio | 604.4k $10.8m | Reduced -59.2k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 572.8k $10.2m | Added +164.7k |
| RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio | 568.0k $10.1m | Added +118.1k |
| Rock Springs Capital Management LP 0.42% of their portfolio | 487.5k $8.7m | Reduced -75.5k |
| Quantinno Capital Management LP 0.01% of their portfolio | 441.7k $7.9m | Added +300.8k |
| Walleye Capital LLC 0.04% of their portfolio | 424.4k $7.6m | New |
| Squarepoint Ops LLC 0.01% of their portfolio | 380.9k $6.8m | New |
| TD Asset Management Inc 0.01% of their portfolio | 379.4k $6.8m | Reduced -291.0k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 308.4k $5.5m | Added +76.7k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 297.9k $5.3m | Added +220.0k |
| FEDERATED HERMES, INC. 0.01% of their portfolio | 285.6k $5.1m | Added +46.4k |
| PICTON MAHONEY ASSET MANAGEMENT 0.04% of their portfolio | 264.1k $4.7m | Reduced -14.9k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 258.8k $4.6m | Added +84.7k |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 0.01% of their portfolio | 247.6k $4.4m | New |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 226.9k $4.0m | Added +39.4k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 222.7k $4.0m | New |
| Maxi Investments CY Ltd 0.77% of their portfolio | 210.7k $3.8m | New |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 204.8k $3.6m | Added +75.2k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 204.4k $3.6m | Added +151.4k |
| WORLDQUANT MILLENNIUM ADVISORS LLC 0.01% of their portfolio | 204.2k $3.6m | Added +9.4k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 182.3k $3.2m | Added +177.3k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 173.0k $3.1m | Added +142.7k |
| Militia Capital Management LLC 0.54% of their portfolio | 166.6k $3.0m | New |
| SG Americas Securities, LLC 0.00% of their portfolio | 152.2k $2.7m | New |
| DekaBank Deutsche Girozentrale 0.00% of their portfolio | 146.1k $0 | Unchanged |
| XTX Topco Ltd 0.03% of their portfolio | 136.5k $2.4m | Added +58.0k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 132.5k $2.4m | Added +35.9k |
| CastleKnight Management LP 0.09% of their portfolio | 132.2k $2.4m | Added +91.2k |
| Invesco Ltd. 0.00% of their portfolio | 132.1k $2.4m | Reduced -1.1m |
| NATIXIS 0.01% of their portfolio | 124.7k $2.2m | Added +71.9k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 123.1k $2.2m | Reduced -13.2k |
| Cambridge Investment Research Advisors, Inc. 0.00% of their portfolio | 119.7k $2.1m | New |
| CITIGROUP INC 0.00% of their portfolio | 111.2k $2.0m | Added +34.1k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 102.0k $1.8m | Added +83.4k |
| TUDOR INVESTMENT CORP ET AL 0.01% of their portfolio | 100.3k $1.8m | Unchanged |
| SALEM INVESTMENT COUNSELORS INC 0.04% of their portfolio | 100.0k $1.8m | New |
| Ghisallo Capital Management LLC 0.03% of their portfolio | 100.0k $1.8m | Reduced -150.0k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 98.8k $1.8m | Added +24.2k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 98.6k $1.8m | Added +8.4k |
| Smartleaf Asset Management LLC 0.06% of their portfolio | 94.1k $1.7m | Unchanged |
| Gotham Asset Management, LLC 0.00% of their portfolio | 89.5k $1.6m | Reduced -654.9k |
| Mitsubishi UFJ Asset Management Co., Ltd. 0.00% of their portfolio | 85.6k $1.5m | New |
| Pathstone Holdings, LLC 0.00% of their portfolio | 82.8k $1.5m | New |
| LAZARD ASSET MANAGEMENT LLC 0.00% of their portfolio | 81.7k $1.5m | Reduced -224.2k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 81.0k $1.4m | Added +23.9k |
| Exome Asset Management LLC 0.86% of their portfolio | 78.2k $1.4m | New |
| Creative Planning 0.00% of their portfolio | 77.5k $1.4m | Reduced -542 |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 71.7k $1.3m | Added +18.1k |
| Jain Global LLC 0.01% of their portfolio | 68.2k $1.2m | New |
| MOORE CAPITAL MANAGEMENT, LP 0.03% of their portfolio | 63.9k $1.1m | New |
| Renaissance Capital LLC 0.62% of their portfolio | 62.9k $1.1m | Added +19.4k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 61.3k $1.1m | Added +15.6k |
| JONES FINANCIAL COMPANIES LLLP 0.00% of their portfolio | 61.2k $1.1m | Added +48.9k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 59.1k $1.1m | Added +30.1k |
| Sumitomo Mitsui Trust Group, Inc. 0.00% of their portfolio | 54.9k $978.1k | Reduced -1.9k |
| Police & Firemen's Retirement System of New Jersey 0.01% of their portfolio | 54.1k $963.3k | Added +14.6k |
| Treasurer of the State of North Carolina 0.00% of their portfolio | 52.5k $936.0k | Added +13.5k |
| LPL Financial LLC 0.00% of their portfolio | 51.5k $917.8k | Added +9.5k |
| NATIXIS ADVISORS, LLC 0.00% of their portfolio | 49.6k $883.0k | Added +35.8k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 47.6k $848.1k | Reduced -105.9k |
| Y-Intercept (Hong Kong) Ltd 0.02% of their portfolio | 46.1k $820.9k | New |
| China Universal Asset Management Co., Ltd. 0.05% of their portfolio | 45.0k $801.7k | Reduced -5.1k |
| Virtu Financial LLC 0.02% of their portfolio | 44.0k $784.0k | New |