Vault-13

BLUEPRINT MEDICINES CORP BPMC

COM · Common Stock · CUSIP 09627Y109 · ISIN US09627Y1091

306 institutional holders +23 vs Q1 2024
68,702,65768.7m shares reported held*
$7.4bnreported value*
45 new 115 added 100 reduced 24 sold out net sold ≈ $211.6m (-2.0m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($5.3m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $107.79. Options: 20 managers hold calls ($295.4m notional), 19 hold puts ($140.5m).

Trends to Q2 2024

Institutional holders

Managers reporting a position, each quarter

0200400Q3 22: 240Q4 22: 223Q1 23: 215Q2 23: 222Q3 23: 220Q4 23: 260Q1 24: 283Q2 24: 306306Q3 22Q1 23Q3 23Q1 24Q2 24
Numbers
QuarterHolders
Q3 2022240
Q4 2022223
Q1 2023215
Q2 2023222
Q3 2023220
Q4 2023260
Q1 2024283
Q2 2024306

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q4 22: 117 bought or addedQ4 22: 112 cut or sold outQ4 22Q1 23: 120 bought or addedQ1 23: 93 cut or sold outQ2 23: 103 bought or addedQ2 23: 103 cut or sold outQ2 23Q3 23: 123 bought or addedQ3 23: 81 cut or sold outQ4 23: 120 bought or addedQ4 23: 114 cut or sold outQ4 23Q1 24: 152 bought or addedQ1 24: 116 cut or sold outQ2 24: 160 bought or addedQ2 24: 124 cut or sold outQ2 24
Numbers
QuarterBought or addedCut or sold out
Q4 2022117112
Q1 202312093
Q2 2023103103
Q3 202312381
Q4 2023120114
Q1 2024152116
Q2 2024160124

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$100m$200m$300mQ3 23 calls: $13.3mQ3 23 puts: $40.4mQ3 23P/C 3.04Q4 23 calls: $131.3mQ4 23 puts: $102.3mQ4 23P/C 0.78Q1 24 calls: $134.1mQ1 24 puts: $100.0mQ1 24P/C 0.75Q2 24 calls: $295.4mQ2 24 puts: $140.5mQ2 24P/C 0.48
Numbers
QuarterCallsPutsP/C
Q3 2023$13.3m$40.4m3.04
Q4 2023$131.3m$102.3m0.78
Q1 2024$134.1m$100.0m0.75
Q2 2024$295.4m$140.5m0.48

Biggest buyers

MILLENNIUM MANAGEMENT LLC Added +539,966+540.0k
1832 Asset Management L.P. Added +502,400+502.4k
VANGUARD GROUP INC Added +228,489+228.5k
Holocene Advisors, LP Added +228,161+228.2k
Point72 Asset Management, L.P. Added +221,813+221.8k
Clearbridge Investments, LLC New +220,980+221.0k
BlackRock Inc. Added +199,836+199.8k
STATE STREET CORP Added +187,182+187.2k
First Turn Management, LLC New +184,901+184.9k
Driehaus Capital Management LLC Added +180,043+180.0k

Biggest sellers

MORGAN STANLEY Reduced -2,754,808-2.8m
WELLINGTON MANAGEMENT GROUP LLP Reduced -939,597-939.6k
Pictet Asset Management Holding SA Reduced -737,236-737.2k
PRICE T ROWE ASSOCIATES INC /MD/ Reduced -377,431-377.4k
FMR LLC Reduced -335,833-335.8k
LORD, ABBETT & CO. LLC Reduced -256,508-256.5k
T. Rowe Price Investment Management, Inc. Reduced -211,478-211.5k
NOVO HOLDINGS A/S Reduced -183,626-183.6k
JPMORGAN CHASE & CO Reduced -173,436-173.4k
PANAGORA ASSET MANAGEMENT INC Reduced -115,910-115.9k

Biggest calls

JANE STREET GROUP, LLC Added $157.4m1.5m shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $22.8m212.0k shares
GROUP ONE TRADING LLC Added $20.1m186.2k shares
BARCLAYS PLC Added $19.9m184.4k shares
Twin Tree Management, LP Added $18.3m169.6k shares
CITADEL ADVISORS LLC Added $17.5m162.4k shares
BANK OF AMERICA CORP /DE/ Unchanged $8.5m79.2k shares
BIT Capital GmbH Unchanged $8.1m75.0k shares
Rock Springs Capital Management LP New $6.1m57.0k shares
SIMPLEX TRADING, LLC Added $3.5m32.9k shares

Biggest puts

JANE STREET GROUP, LLC Added $65.6m608.5k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $38.2m354.4k shares
GROUP ONE TRADING LLC Added $10.3m95.2k shares
CITADEL ADVISORS LLC Added $9.2m85.1k shares
Walleye Capital LLC Added $3.6m33.4k shares
SIMPLEX TRADING, LLC Reduced $3.5m32.2k shares
Twin Tree Management, LP Reduced $2.7m24.9k shares
CAPITAL FUND MANAGEMENT S.A. Added $2.0m18.5k shares
D. E. Shaw & Co., Inc. Added $1.1m10.6k shares
PEAK6 Investments LLC Reduced $926.9k8.6k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
BlackRock, Inc. 13G · institution filed 2025-04-23 8.0% 5.1m 2025-04-23
Pentwater Capital Management LP 13G · institution new · filed 2025-08-14 6.0% new 3.9m 2025-08-14

Holders, Q2 2024

#ManagerLocationShares Value% of their portfolioChangeShares change
1 BlackRock Inc. 0.02% of their portfolio New York, NY 6,647,2976.6m $716.4m $716.4m 0.02% Added +199.8k +199,836
2 VANGUARD GROUP INC 0.01% of their portfolio Valley Forge, PA 6,538,4666.5m $704.7m $704.7m 0.01% Added +228.5k +228,489
3 PRICE T ROWE ASSOCIATES INC /MD/ 0.08% of their portfolio BALTIMORE, MD 5,873,3925.9m $633.0m $633.0m 0.08% Reduced -377.4k -377,431
4 FMR LLC 0.03% of their portfolio BOSTON, MA 4,833,6844.8m $521.0m $521.0m 0.03% Reduced -335.8k -335,833
5 WELLINGTON MANAGEMENT GROUP LLP 0.06% of their portfolio Boston, MA 3,235,5553.2m $348.7m $348.7m 0.06% Reduced -939.6k -939,597
6 Rock Springs Capital Management LP 8.00% of their portfolio Baltimore, MD 2,460,4172.5m $265.2m $265.2m 8.00% Reduced -38.0k -38,031
7 JPMORGAN CHASE & CO 0.01% of their portfolio NEW YORK, NY 2,449,3082.4m $264.0m $264.0m 0.01% Reduced -173.4k -173,436
8 LORD, ABBETT & CO. LLC 0.42% of their portfolio JERSEY CITY, NJ 2,380,3002.4m $256.5m $256.5m 0.42% Reduced -256.5k -256,508
9 STATE STREET CORP 0.01% of their portfolio BOSTON, MA 2,379,8842.4m $256.5m $256.5m 0.01% Added +187.2k +187,182
10 WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC 0.45% of their portfolio CHICAGO, IL 1,593,9161.6m $171.8m $171.8m 0.45% Reduced -114.1k -114,132
11 GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio BOSTON, MA 1,459,4841.5m $157.3m $157.3m 0.01% Added +88.4k +88,357
12 MACQUARIE GROUP LTD 0.16% of their portfolio Sydney, NSW 2000, C3 1,312,0671.3m $141.4m $141.4m 0.16% Added +829 +829
13 ALLIANCEBERNSTEIN L.P. 0.04% of their portfolio NASHVILLE, TN 1,139,0021.1m $122.8m $122.8m 0.04% Reduced -64.6k -64,590
14 Pictet Asset Management Holding SA 0.14% of their portfolio CAROUGE, V8 1,127,3021.1m $121.5m $121.5m 0.14% Reduced -737.2k -737,236
15 Holocene Advisors, LP 0.42% of their portfolio New York, NY 943,464943.5k $101.7m $101.7m 0.42% Added +228.2k +228,161
16 Invesco Ltd. 0.02% of their portfolio ATLANTA, GA 932,429932.4k $100.5m $100.5m 0.02% Added +122.8k +122,829
17 ALKEON CAPITAL MANAGEMENT LLC 0.49% of their portfolio New York, NY 893,928893.9k $96.3m $96.3m 0.49% Added +100.0k +100,000
18 Woodline Partners LP 0.91% of their portfolio San Francisco, CA 880,147880.1k $94.9m $94.9m 0.91% Added +53.0k +52,974
19 Polar Capital Holdings Plc 0.56% of their portfolio London, X0 875,000875.0k $94.3m $94.3m 0.56% Added +10.0k +10,000
20 AMERICAN CENTURY COMPANIES INC 0.05% of their portfolio KANSAS CITY, MO 802,733802.7k $86.5m $86.5m 0.05% Added +32.6k +32,600
21 T. Rowe Price Investment Management, Inc. 0.05% of their portfolio BALTIMORE, MD 791,718791.7k $85.3m $85.3m 0.05% Reduced -211.5k -211,478
22 GOLDMAN SACHS GROUP INC 0.02% of their portfolio NEW YORK, NY 739,238739.2k $79.7m $79.7m 0.02% Added +172.6k +172,584
23 MILLENNIUM MANAGEMENT LLC 0.06% of their portfolio NEW YORK, NY 627,626627.6k $67.6m $67.6m 0.06% Added +540.0k +539,966
24 BROWN ADVISORY INC 0.09% of their portfolio BALTIMORE, MD 617,992618.0k $66.6m $66.6m 0.09% Reduced -56.4k -56,370
25 NORGES BANK 0.01% of their portfolio OSLO, Q8 592,126592.1k $63.8m $63.8m 0.01% Added +24.0k +23,961
26 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio SAN FRANCISCO, CA 546,496546.5k $58.9m $58.9m 0.01% Added +45.4k +45,361
27 NORTHERN TRUST CORP 0.01% of their portfolio CHICAGO, IL 543,877543.9k $58.6m $58.6m 0.01% Reduced -15.0k -15,013
28 Hood River Capital Management LLC 1.12% of their portfolio PALM BEACH GARDENS, FL 502,820502.8k $54.2m $54.2m 1.12% Added +32.7k +32,694
29 1832 Asset Management L.P. 0.10% of their portfolio TORONTO, A6 502,651502.7k $54.2m $54.2m 0.10% Added +502.4k +502,400
30 Point72 Asset Management, L.P. 0.17% of their portfolio STAMFORD, CT 501,581501.6k $54.1m $54.1m 0.17% Added +221.8k +221,813
31 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 421,259421.3k $45.4m $45.4m 0.00% Reduced -2.8m -2,754,808
32 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 403,696403.7k $43.5m $43.5m 0.00% Added +67.9k +67,921
33 Man Group plc 0.11% of their portfolio LONDON, X0 392,898392.9k $42.3m $42.3m 0.11% Reduced -16.0k -15,982
34 Avidity Partners Management LP 1.75% of their portfolio DALLAS, TX 383,000383.0k $41.3m $41.3m 1.75% Reduced -43.0k -43,000
35 Driehaus Capital Management LLC 0.37% of their portfolio Chicago, IL 358,255358.3k $38.6m $38.6m 0.37% Added +180.0k +180,043
36 MARSHALL WACE, LLP 0.05% of their portfolio LONDON, X0 351,756351.8k $37.9m $37.9m 0.05% Added +121.5k +121,464
37 EMERALD ADVISERS, LLC 1.54% of their portfolio LEOLA, PA 341,200341.2k $36.8m $36.8m 1.54% Reduced -61.7k -61,710
38 Integral Health Asset Management, LLC 3.65% of their portfolio New York, NY 340,000340.0k $36.6m $36.6m 3.65% Added +130.0k +130,000
39 Nuveen Asset Management, LLC 0.01% of their portfolio CHICAGO, IL 339,493339.5k $36.6m $36.6m 0.01% Added +73.1k +73,146
40 Fisher Asset Management, LLC 0.02% of their portfolio PLANO, TX 336,165336.2k $36.2m $36.2m 0.02% Added +1.0k +1,037
41 Casdin Capital, LLC 2.69% of their portfolio New York, NY 326,378326.4k $35.2m $35.2m 2.69% Unchanged
42 TD Asset Management Inc 0.03% of their portfolio Toronto, A6 323,500323.5k $34.9m $34.9m 0.03% Reduced -60.0k -59,970
43 Ensign Peak Advisors, Inc 0.06% of their portfolio SALT LAKE CITY, UT 306,316306.3k $33.0m $33.0m 0.06% Reduced -13.2k -13,212
44 D. E. Shaw & Co., Inc. 0.05% of their portfolio New York, NY 302,635302.6k $32.6m $32.6m 0.05% Reduced -73.5k -73,542
45 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio NEW YORK, NY 301,873301.9k $32.5m $32.5m 0.01% Added +67.3k +67,258
46 EMERALD MUTUAL FUND ADVISERS TRUST 1.57% of their portfolio LEOLA, PA 278,333278.3k $30.0m $30.0m 1.57% Reduced -37.5k -37,486
47 Bank of New York Mellon Corp 0.01% of their portfolio NEW YORK, NY 273,930273.9k $29.5m $29.5m 0.01% Added +32.7k +32,740
48 VICTORY CAPITAL MANAGEMENT INC 0.03% of their portfolio San Antonio, TX 264,995265.0k $28.6m $28.6m 0.03% Added +58.8k +58,796
49 EVENTIDE ASSET MANAGEMENT, LLC 0.43% of their portfolio Boston, MA 231,685231.7k $25.0m $25.0m 0.43% Unchanged
50 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.09% of their portfolio JUPITER, FL 226,580226.6k $24.4m $24.4m 0.09% Added +8.1k +8,144
51 Clearbridge Investments, LLC 0.02% of their portfolio NEW YORK, NY 220,980221.0k $23.8m $23.8m 0.02% New
52 DEUTSCHE BANK AG\ 0.01% of their portfolio FRANKFURT AM MAIN, 2M 220,031220.0k $23.7m $23.7m 0.01% Added +93.6k +93,564
53 JACOBS LEVY EQUITY MANAGEMENT, INC 0.08% of their portfolio FLORHAM PARK, NJ 190,008190.0k $20.5m $20.5m 0.08% Added +118.6k +118,567
54 EAGLE ASSET MANAGEMENT INC 0.11% of their portfolio ST PETERSBURG, FL 188,867188.9k $20.6m $20.6m 0.11% Reduced -32.4k -32,384
55 FRONTIER CAPITAL MANAGEMENT CO LLC 0.20% of their portfolio Boston, MA 185,528185.5k $20.0m $20.0m 0.20% Added +64.0k +64,029
56 First Turn Management, LLC 3.24% of their portfolio DEL MAR, CA 184,901184.9k $19.9m $19.9m 3.24% New
57 VOYA INVESTMENT MANAGEMENT LLC 0.02% of their portfolio ATLANTA, GA 177,633177.6k $19.1m $19.1m 0.02% Added +70.5k +70,454
58 NOVO HOLDINGS A/S 1.02% of their portfolio HELLERUP, G7 175,000175.0k $18.9m $18.9m 1.02% Reduced -183.6k -183,626
59 MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.01% of their portfolio Boston, MA 169,543169.5k $18.3m $18.3m 0.01% New
60 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.02% of their portfolio Toronto, A6 168,759168.8k $18.2m $18.2m 0.02% Reduced -15.5k -15,461
61 Assenagon Asset Management S.A. 0.04% of their portfolio SENNINGERBERG, N4 165,245165.2k $17.8m $17.8m 0.04% Reduced -9.9k -9,864
62 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 159,812159.8k $17.2m $17.2m 0.00% Added +91.3k +91,306
63 BIT Capital GmbH 1.51% of their portfolio BERLIN, 2M 154,132154.1k $16.6m $16.6m 1.51% Reduced -15.5k -15,513
64 PANAGORA ASSET MANAGEMENT INC 0.08% of their portfolio BOSTON, MA 147,564147.6k $15.9m $15.9m 0.08% Reduced -115.9k -115,910
65 JANE STREET GROUP, LLC 0.02% of their portfolio NEW YORK, NY 142,357142.4k $15.3m $15.3m 0.02% Reduced -25.3k -25,349
66 Granahan Investment Management, LLC 0.60% of their portfolio WALTHAM, MA 139,732139.7k $15.1m $15.1m 0.60% Reduced -39.6k -39,585
67 Trexquant Investment LP 0.22% of their portfolio STAMFORD, CT 133,243133.2k $14.4m $14.4m 0.22% Added +130.9k +130,946
68 Qube Research & Technologies Ltd 0.03% of their portfolio LONDON, X0 132,048132.0k $14.2m $14.2m 0.03% Added +120.2k +120,176
69 SEGALL BRYANT & HAMILL, LLC 0.24% of their portfolio CHICAGO, IL 126,954127.0k $13.7m $13.7m 0.24% Added +3.5k +3,457
70 CITIGROUP INC 0.01% of their portfolio NEW YORK, NY 120,252120.3k $13.0m $13.0m 0.01% Added +16.4k +16,389
71 Aquilo Capital Management, LLC 11.91% of their portfolio SAN FRANCISCO, CA 114,600114.6k $12.4m $12.4m 11.91% Reduced -67.6k -67,551
72 Swiss National Bank 0.01% of their portfolio ZURICH, V8 114,400114.4k $12.3m $12.3m 0.01% Added +400 +400
73 RENAISSANCE TECHNOLOGIES LLC 0.02% of their portfolio NEW YORK, NY 110,400110.4k $11.9m $11.9m 0.02% Added +62.9k +62,900
74 Orion Investment Co 4.67% of their portfolio ST. LOUIS, MO 108,790108.8k $11.7m $11.7m 4.67% First filing
75 DAFNA Capital Management LLC 2.70% of their portfolio LOS ANGELES, CA 104,763104.8k $11.3m $11.3m 2.70% Reduced -2.0k -2,000
76 Rafferty Asset Management, LLC 0.04% of their portfolio New York, NY 94,96395.0k $10.2m $10.2m 0.04% Reduced -4.4k -4,388
77 Redmile Group, LLC 0.62% of their portfolio LARKSPUR, CA 94,40594.4k $10.2m $10.2m 0.62% Reduced -18.7k -18,655
78 ExodusPoint Capital Management, LP 0.11% of their portfolio NEW YORK, NY 91,63691.6k $9.9m $9.9m 0.11% Added +70.6k +70,595
79 RHUMBLINE ADVISERS 0.01% of their portfolio BOSTON, MA 91,54391.5k $9.9m $9.9m 0.01% Added +5.2k +5,160
80 Legal & General Group Plc 0.00% of their portfolio London, X0 87,21587.2k $9.4m $9.4m 0.00% Added +27.7k +27,716
81 UBS Group AG 0.00% of their portfolio ZURICH, V8 84,62384.6k $9.1m $9.1m 0.00% Reduced -40.8k -40,812
82 California Public Employees Retirement System 0.01% of their portfolio Sacramento, CA 83,90483.9k $9.0m $9.0m 0.01% Reduced -4.8k -4,821
83 PEREGRINE CAPITAL MANAGEMENT LLC 0.25% of their portfolio MINNEAPOLIS, MN 79,56079.6k $8.6m $8.6m 0.25% Reduced -14.0k -14,023
84 AQR CAPITAL MANAGEMENT LLC 0.01% of their portfolio Greenwich, CT 78,10378.1k $8.4m $8.4m 0.01% Added +18.1k +18,099
85 Ally Bridge Group (NY) LLC 4.86% of their portfolio NEW YORK, NY 75,63875.6k $8.2m $8.2m 4.86% Reduced -85.3k -85,312
86 PRUDENTIAL FINANCIAL INC 0.01% of their portfolio NEWARK, NJ 74,55074.5k $8.0m $8.0m 0.01% Reduced -29.6k -29,614
87 BANK OF MONTREAL /CAN/ 0.00% of their portfolio TORONTO, A6 69,04069.0k $7.5m $7.5m 0.00% New
88 Cinctive Capital Management LP 0.39% of their portfolio New York, NY 67,50267.5k $7.3m $7.3m 0.39% Added +9.2k +9,157
89 ALGERT GLOBAL LLC 0.23% of their portfolio SAN FRANCISCO, CA 65,54065.5k $7.1m $7.1m 0.23% Added +29.3k +29,330
90 FEDERATED HERMES, INC. 0.02% of their portfolio PITTSBURGH, PA 62,35462.4k $6.7m $6.7m 0.02% Added +13.6k +13,579
91 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio BALA CYNWYD, PA 61,58161.6k $6.6m $6.6m 0.01% Reduced -67.9k -67,916
92 FIRST TRUST ADVISORS LP 0.01% of their portfolio Wheaton, IL 60,13860.1k $6.5m $6.5m 0.01% Added +12.9k +12,867
93 PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio DES MOINES, IA 58,19158.2k $6.3m $6.3m 0.00% Reduced -4.5k -4,479
94 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio WEST SACRAMENTO, CA 57,15257.2k $6.2m $6.2m 0.01% Reduced -919 -919
95 Russell Investments Group, Ltd. 0.01% of their portfolio Seattle, WA 56,49356.5k $6.1m $6.1m 0.01% Reduced -1.2k -1,221
96 NEUBERGER BERMAN GROUP LLC 0.00% of their portfolio NEW YORK, NY 53,76953.8k $5.8m $5.8m 0.00% Added +2.5k +2,461
97 CAPITAL FUND MANAGEMENT S.A. 0.07% of their portfolio PARIS, I0 53,23653.2k $5.7m $5.7m 0.07% New
98 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 53,20353.2k $5.7m $5.7m 0.00% Reduced -12.2k -12,192
99 SEI INVESTMENTS CO 0.01% of their portfolio OAKS, PA 52,98653.0k $5.7m $5.7m 0.01% Added +7.1k +7,073
100 Candriam S.C.A. 0.03% of their portfolio STRASSEN, N4 52,06652.1k $5.6m $5.6m 0.03% Added +12.0k +12,001