Vault-13

BLUEPRINT MEDICINES CORP BPMC

COM · Common Stock · CUSIP 09627Y109 · ISIN US09627Y1091

215 institutional holders -8 vs Q4 2022
72,267,74972.3m shares reported held*
$3.3bnreported value*
27 new 93 added 60 reduced 33 sold out net bought ≈ $446.8m (+9.8m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.1m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $45.04. Options: 9 managers hold calls ($15.8m notional), 14 hold puts ($21.8m).

Trends to Q1 2023

Institutional holders

Managers reporting a position, each quarter

0100200300Q3 22: 240Q4 22: 223Q1 23: 215215Q3 22Q4 22Q1 23
Numbers
QuarterHolders
Q3 2022240
Q4 2022223
Q1 2023215

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q4 22: 117 bought or addedQ4 22: 112 cut or sold outQ4 22Q1 23: 120 bought or addedQ1 23: 93 cut or sold outQ1 23
Numbers
QuarterBought or addedCut or sold out
Q4 2022117112
Q1 202312093

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$10m$20m$30mQ3 22 calls: $24.4mQ3 22 puts: $14.2mQ3 22P/C 0.58Q4 22 calls: $10.8mQ4 22 puts: $15.9mQ4 22P/C 1.47Q1 23 calls: $15.8mQ1 23 puts: $21.8mQ1 23P/C 1.38
Numbers
QuarterCallsPutsP/C
Q3 2022$24.4m$14.2m0.58
Q4 2022$10.8m$15.9m1.47
Q1 2023$15.8m$21.8m1.38

Biggest buyers

FMR LLC Added +8,669,699+8.7m
PRICE T ROWE ASSOCIATES INC /MD/ Added +649,144+649.1k
Hudson Bay Capital Management LP Added +412,850+412.9k
PICTET ASSET MANAGEMENT SA Added +411,615+411.6k
BlackRock Inc. Added +347,618+347.6k
BAKER BROS. ADVISORS LP New +333,665+333.7k
ALLIANCEBERNSTEIN L.P. Added +205,649+205.6k
Candriam S.C.A. Added +195,701+195.7k
MACQUARIE GROUP LTD Added +186,636+186.6k
ExodusPoint Capital Management, LP Added +170,492+170.5k

Biggest sellers

Casdin Capital, LLC Reduced -807,800-807.8k
MARSHALL WACE, LLP Sold out -529,456-529.5k
WESTFIELD CAPITAL MANAGEMENT CO LP Sold out -479,467-479.5k
MILLENNIUM MANAGEMENT LLC Reduced -270,321-270.3k
Nextech Invest Ltd. Sold out -188,228-188.2k
Woodline Partners LP Reduced -135,317-135.3k
PFM Health Sciences, LP Sold out -130,366-130.4k
SEGALL BRYANT & HAMILL, LLC Reduced -87,480-87.5k
RENAISSANCE TECHNOLOGIES LLC Sold out -85,400-85.4k
STATE STREET CORP Reduced -79,642-79.6k

Biggest calls

JANE STREET GROUP, LLC Added $6.6m146.9k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $4.1m91.8k shares
SIMPLEX TRADING, LLC Added $1.5m32.5k shares
GROUP ONE TRADING LLC New $1.3m27.8k shares
CITIGROUP INC Unchanged $1.1m25.0k shares
CITADEL ADVISORS LLC Reduced $463.4k10.3k shares
Walleye Capital LLC Added $391.4k8.7k shares
Walleye Trading LLC Added $382.4k8.5k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $9.9m220.8k shares
JANE STREET GROUP, LLC Reduced $4.0m88.0k shares
GROUP ONE TRADING LLC Added $2.1m47.7k shares
CITADEL ADVISORS LLC Reduced $1.3m28.1k shares
CITIGROUP INC Unchanged $1.1m25.0k shares
UBS Group AG New $674.9k15.0k shares
SIMPLEX TRADING, LLC Added $593.0k13.2k shares
Jefferies Financial Group Inc. Unchanged $499.4k11.1k shares
GOLDMAN SACHS GROUP INC New $463.4k10.3k shares
Walleye Capital LLC Added $386.9k8.6k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
BlackRock, Inc. 13G · institution filed 2025-04-23 8.0% 5.1m 2025-04-23
Pentwater Capital Management LP 13G · institution new · filed 2025-08-14 6.0% new 3.9m 2025-08-14

Holders, Q1 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 FMR LLC 0.04% of their portfolio BOSTON, MA 17,644,24417.6m $793.8m $793.8m 0.04% Added +8.7m +8,669,699
2 BlackRock Inc. 0.01% of their portfolio New York, NY 6,622,3036.6m $297.9m $297.9m 0.01% Added +347.6k +347,618
3 VANGUARD GROUP INC 0.01% of their portfolio Valley Forge, PA 5,878,9445.9m $264.5m $264.5m 0.01% Added +104.5k +104,488
4 WELLINGTON MANAGEMENT GROUP LLP 0.05% of their portfolio Boston, MA 5,137,7035.1m $231.1m $231.1m 0.05% Added +134.3k +134,275
5 PRICE T ROWE ASSOCIATES INC /MD/ 0.03% of their portfolio BALTIMORE, MD 4,948,4344.9m $222.6m $222.6m 0.03% Added +649.1k +649,144
6 STATE STREET CORP 0.01% of their portfolio BOSTON, MA 2,755,2792.8m $124.0m $124.0m 0.01% Reduced -79.6k -79,642
7 T. Rowe Price Investment Management, Inc. 0.08% of their portfolio BALTIMORE, MD 2,486,9502.5m $111.9m $111.9m 0.08% Reduced -5.4k -5,431
8 Rock Springs Capital Management LP 2.18% of their portfolio Baltimore, MD 2,033,0482.0m $91.5m $91.5m 2.18% Added +141.5k +141,538
9 ALLIANCEBERNSTEIN L.P. 0.03% of their portfolio NASHVILLE, TN 1,741,8041.7m $78.4m $78.4m 0.03% Added +205.6k +205,649
10 JPMORGAN CHASE & CO 0.01% of their portfolio NEW YORK, NY 1,551,7561.6m $69.8m $69.8m 0.01% Added +103.5k +103,541
11 MACQUARIE GROUP LTD 0.08% of their portfolio Sydney, NSW 2000, C3 1,497,3861.5m $67.4m $67.4m 0.08% Added +186.6k +186,636
12 GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio BOSTON, MA 1,162,6401.2m $52.3m $52.3m 0.01% Added +48.3k +48,303
13 WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC 0.17% of their portfolio CHICAGO, IL 1,082,4491.1m $48.7m $48.7m 0.17% Added +57.8k +57,835
14 Fisher Asset Management, LLC 0.02% of their portfolio PLANO, TX 794,071794.1k $35.7m $35.7m 0.02% Reduced -49.0k -49,019
15 Casdin Capital, LLC 2.49% of their portfolio New York, NY 670,000670.0k $30.1m $30.1m 2.49% Reduced -807.8k -807,800
16 BROWN ADVISORY INC 0.05% of their portfolio BALTIMORE, MD 633,408633.4k $28.5m $28.5m 0.05% Added +32.1k +32,126
17 Hudson Bay Capital Management LP 0.17% of their portfolio STAMFORD, CT 626,018626.0k $28.2m $28.2m 0.17% Added +412.9k +412,850
18 Aquilo Capital Management, LLC 16.42% of their portfolio SAN FRANCISCO, CA 622,829622.8k $28.0m $28.0m 16.42% Added +41.1k +41,061
19 AMERICAN CENTURY COMPANIES INC 0.02% of their portfolio KANSAS CITY, MO 614,721614.7k $26.6m $26.6m 0.02% Reduced -1.6k -1,571
20 NORTHERN TRUST CORP 0.01% of their portfolio CHICAGO, IL 577,626577.6k $26.0m $26.0m 0.01% Added +19.7k +19,738
21 PICTET ASSET MANAGEMENT SA 0.03% of their portfolio GENEVA 73, V8 573,644573.6k $25.8m $25.8m 0.03% Added +411.6k +411,615
22 NORGES BANK 0.01% of their portfolio OSLO, Q8 560,792560.8k $25.2m $25.2m 0.01% Reduced -73.3k -73,253
23 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 532,327532.3k $23.9m $23.9m 0.00% Added +66.8k +66,798
24 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio SAN FRANCISCO, CA 472,890472.9k $21.3m $21.3m 0.01% Added +4.4k +4,431
25 Candriam S.C.A. 0.13% of their portfolio STRASSEN, N4 454,012454.0k $18.8m $18.8m 0.13% Added +195.7k +195,701
26 NOVO HOLDINGS A/S 1.33% of their portfolio HELLERUP, G7 448,804448.8k $20.2m $20.2m 1.33% Added +78.8k +78,804
27 EVENTIDE ASSET MANAGEMENT, LLC 0.36% of their portfolio Boston, MA 438,500438.5k $19.7m $19.7m 0.36% Unchanged
28 EMERALD ADVISERS, LLC 0.95% of their portfolio LEOLA, PA 438,249438.2k $19.7m $19.7m 0.95% Added +47.1k +47,093
29 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 413,023413.0k $18.6m $18.6m 0.00% Added +76.9k +76,942
30 EMERALD MUTUAL FUND ADVISERS TRUST 0.95% of their portfolio LEOLA, PA 358,820358.8k $16.1m $16.1m 0.95% Added +53.1k +53,111
31 ALKEON CAPITAL MANAGEMENT LLC 0.10% of their portfolio New York, NY 352,183352.2k $15.8m $15.8m 0.10% Reduced -74.1k -74,085
32 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 334,591334.6k $15.1m $15.1m 0.00% Added +17.3k +17,329
33 BAKER BROS. ADVISORS LP 0.08% of their portfolio NEW YORK, NY 333,665333.7k $15.0m $15.0m 0.08% New
34 ExodusPoint Capital Management, LP 0.17% of their portfolio NEW YORK, NY 327,859327.9k $14.8m $14.8m 0.17% Added +170.5k +170,492
35 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 308,101308.1k $13.9m $13.9m 0.00% Reduced -49.6k -49,630
36 CITADEL ADVISORS LLC 0.01% of their portfolio MIAMI, FL 289,055289.1k $13.0m $13.0m 0.01% Added +65.6k +65,633
37 PANAGORA ASSET MANAGEMENT INC 0.08% of their portfolio BOSTON, MA 274,341274.3k $12.3m $12.3m 0.08% Added +38.7k +38,747
38 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 263,557263.6k $11.9m $11.9m 0.00% Added +1.0k +1,021
39 DAFNA Capital Management LLC 3.52% of their portfolio LOS ANGELES, CA 261,235261.2k $11.8m $11.8m 3.52% Unchanged
40 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio NEW YORK, NY 252,349252.3k $11.4m $11.4m 0.01% Reduced -9.3k -9,336
41 Granahan Investment Management, LLC 0.32% of their portfolio WALTHAM, MA 232,219232.2k $10.4m $10.4m 0.32% Added +7.4k +7,405
42 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 179,950179.9k $8.1m $8.1m 0.00% Reduced -14.6k -14,647
43 TD Asset Management Inc 0.01% of their portfolio Toronto, A6 167,352167.4k $7.5m $7.5m 0.01% Added +24.2k +24,228
44 EAGLE ASSET MANAGEMENT INC 0.04% of their portfolio ST PETERSBURG, FL 164,636164.6k $7.4m $7.4m 0.04% Reduced -14.8k -14,800
45 Rafferty Asset Management, LLC 0.05% of their portfolio New York, NY 161,890161.9k $7.3m $7.3m 0.05% Reduced -8.8k -8,792
46 PEREGRINE CAPITAL MANAGEMENT LLC 0.21% of their portfolio MINNEAPOLIS, MN 159,604159.6k $7.2m $7.2m 0.21% Added +31.4k +31,362
47 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio BALA CYNWYD, PA 159,432159.4k $7.2m $7.2m 0.01% Added +98.1k +98,055
48 CITIGROUP INC 0.01% of their portfolio NEW YORK, NY 148,307148.3k $6.7m $6.7m 0.01% Added +61.0k +60,988
49 Man Group plc 0.02% of their portfolio LONDON, X0 132,493132.5k $6.0m $6.0m 0.02% New
50 Swiss National Bank 0.00% of their portfolio ZURICH, V8 129,100129.1k $5.8m $5.8m 0.00% Reduced -15.1k -15,100
51 JACOBS LEVY EQUITY MANAGEMENT, INC 0.03% of their portfolio FLORHAM PARK, NJ 126,852126.9k $5.7m $5.7m 0.03% New
52 CAPITAL FUND MANAGEMENT S.A. 0.11% of their portfolio PARIS, I0 125,635125.6k $5.7m $5.7m 0.11% Reduced -52.7k -52,659
53 SECTORAL ASSET MANAGEMENT INC 1.05% of their portfolio MONTREAL, A8 121,900121.9k $5.5m $5.5m 1.05% Added +6.0k +6,000
54 VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio ATLANTA, GA 112,139112.1k $5.0m $5.0m 0.01% Reduced -135 -135
55 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 111,223111.2k $5.0m $5.0m 0.00% Added +17.7k +17,725
56 EFG Asset Management (North America) Corp. 1.09% of their portfolio Portland, OR 110,141110.1k $5.0m $5.0m 1.09% Reduced -712 -712
57 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 107,008107.0k $4.8m $4.8m 0.00% Added +21.8k +21,791
58 NOMURA HOLDINGS INC 0.05% of their portfolio TOKYO, M0 106,693106.7k $4.8m $4.8m 0.05% Reduced -22.8k -22,758
59 Woodline Partners LP 0.07% of their portfolio San Francisco, CA 105,377105.4k $4.7m $4.7m 0.07% Reduced -135.3k -135,317
60 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 101,400101.4k $4.6m $4.6m 0.00% Reduced -22.8k -22,786
61 California Public Employees Retirement System 0.00% of their portfolio Sacramento, CA 95,83595.8k $4.3m $4.3m 0.00% Reduced -10.8k -10,846
62 SEGALL BRYANT & HAMILL, LLC 0.05% of their portfolio CHICAGO, IL 95,18095.2k $4.3m $4.3m 0.05% Reduced -87.5k -87,480
63 Russell Investments Group, Ltd. 0.01% of their portfolio Seattle, WA 90,52690.5k $4.1m $4.1m 0.01% Added +28.3k +28,340
64 UBS Group AG 0.00% of their portfolio ZURICH, V8 84,67384.7k $3.8m $3.8m 0.00% Reduced -50.2k -50,185
65 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 81,23381.2k $3.7m $3.7m 0.00% Added +226 +226
66 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio WEST SACRAMENTO, CA 74,79374.8k $3.4m $3.4m 0.01% Reduced -1.0k -1,025
67 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 72,75672.8k $3.3m $3.3m 0.00% Added +3.3k +3,291
68 Schonfeld Strategic Advisors LLC 0.03% of their portfolio NEW YORK, NY 69,62969.6k $3.1m $3.1m 0.03% New
69 BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio PARIS, I0 68,26868.3k $3.1m $3.1m 0.01% Added +1.4k +1,373
70 STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio MADISON, WI 67,79267.8k $3.0m $3.0m 0.01% Added +7.9k +7,946
71 Tekla Capital Management LLC 0.12% of their portfolio Boston, MA 67,71067.7k $3.0m $3.0m 0.12% Unchanged
72 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 64,64064.6k $2.9m $2.9m 0.00% Reduced -8.2k -8,213
73 Squarepoint Ops LLC 0.02% of their portfolio NEW YORK, NY 63,98964.0k $2.9m $2.9m 0.02% Added +48.5k +48,526
74 CREDIT SUISSE AG/ 0.00% of their portfolio ZURICH, V8 63,27663.3k $2.8m $2.8m 0.00% Added +3.7k +3,726
75 Legal & General Group Plc 0.00% of their portfolio London, X0 58,26358.3k $2.6m $2.6m 0.00% Added +4.8k +4,824
76 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 57,97258.0k $2.6m $2.6m 0.00% Reduced -270.3k -270,321
77 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 56,99157.0k $2.6m $2.6m 0.00% Reduced -6.6k -6,598
78 PLATINUM INVESTMENT MANAGEMENT LTD 0.09% of their portfolio SYDNEY AUSTRALIA 2000, C3 56,17156.2k $2.5m $2.5m 0.09% Added +16.3k +16,329
79 NBW CAPITAL LLC 0.59% of their portfolio BOSTON, MA 53,59753.6k $2.4m $2.4m 0.59% Added +33.0k +33,009
80 State of New Jersey Common Pension Fund D 0.01% of their portfolio TRENTON, NJ 51,95952.0k $2.3m $2.3m 0.01% Unchanged
81 Assenagon Asset Management S.A. 0.01% of their portfolio SENNINGERBERG, N4 49,84749.8k $2.2m $2.2m 0.01% Added +13.6k +13,636
82 OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.05% of their portfolio CHICAGO, IL 49,23349.2k $2.2m $2.2m 0.05% New
83 TWO SIGMA ADVISERS, LP 0.01% of their portfolio NEW YORK, NY 47,20047.2k $2.1m $2.1m 0.01% Reduced -28.7k -28,700
84 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 45,15845.2k $2.0m $2.0m 0.00% Added +36.1k +36,089
85 NEUBERGER BERMAN GROUP LLC 0.00% of their portfolio NEW YORK, NY 43,17643.2k $1.9m $1.9m 0.00% Added +3.7k +3,736
86 SYNOVUS FINANCIAL CORP 0.02% of their portfolio Columbus, GA 43,11343.1k $1.9m $1.9m 0.02% Reduced -4.7k -4,710
87 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 41,92541.9k $1.9m $1.9m 0.00% Reduced -10.7k -10,650
88 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.01% of their portfolio JUPITER, FL 41,35241.4k $1.9m $1.9m 0.01% New
89 ALPS ADVISORS INC 0.02% of their portfolio Denver, CO 39,52339.5k $1.8m $1.8m 0.02% Reduced -1.0k -1,034
90 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 37,32837.3k $1.7m $1.7m 0.00% Added +7.1k +7,090
91 MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC 0.02% of their portfolio New York, NY 35,81135.8k $1.6m $1.6m 0.02% Reduced -1.7k -1,651
92 Raymond James Financial Services Advisors, Inc. 0.00% of their portfolio ST. PETERSBURG, FL 35,35535.4k $1.6m $1.6m 0.00% Reduced -298 -298
93 MetLife Investment Management, LLC 0.01% of their portfolio Whippany, NJ 31,78231.8k $1.4m $1.4m 0.01% Unchanged
94 PROFUND ADVISORS LLC 0.09% of their portfolio BETHESDA, MD 30,60030.6k $1.4m $1.4m 0.09% Added +22.5k +22,502
95 AMERICAN INTERNATIONAL GROUP, INC. 0.01% of their portfolio New York, NY 28,84028.8k $1.3m $1.3m 0.01% Added +574 +574
96 Ensign Peak Advisors, Inc 0.00% of their portfolio SALT LAKE CITY, UT 28,14028.1k $1.3m $1.3m 0.00% Added +1.6k +1,600
97 CAPTRUST FINANCIAL ADVISORS 0.01% of their portfolio RALEIGH, NC 27,57827.6k $1.2m $1.2m 0.01% Added +8.3k +8,316
98 GUGGENHEIM CAPITAL LLC 0.01% of their portfolio CHICAGO, IL 25,87725.9k $1.2m $1.2m 0.01% Reduced -13.0k -12,968
99 DekaBank Deutsche Girozentrale 0.00% of their portfolio FRANKFURT, 2M 25,15025.1k $1.1m $1.1m 0.00% Unchanged
100 Erste Asset Management GmbH 0.02% of their portfolio VIENNA, C4 25,10025.1k $1.1m $1.1m 0.02% Unchanged