BICYCLE THERAPEUTICS PLC BCYC
SPONSORED ADS · ADR · CUSIP 088786108 · ISIN US0887861088
Company in Cambridge, United Kingdom
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersCambridge, United Kingdom
- Founded2009
- Websitebicycletherapeutics.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.8m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $20.09. Options: 6 managers hold calls ($2.0m notional), 6 hold puts ($3.8m).
Trends to Q3 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 80 |
| Q4 2022 | 87 |
| Q1 2023 | 90 |
| Q2 2023 | 86 |
| Q3 2023 | 102 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 32 | 43 |
| Q1 2023 | 53 | 29 |
| Q2 2023 | 39 | 41 |
| Q3 2023 | 58 | 31 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q4 2022 | $538.2k | $3.3m | 6.12 |
| Q1 2023 | $9.7m | $2.5m | 0.26 |
| Q2 2023 | $170.8k | $5.3m | 30.96 |
| Q3 2023 | $2.0m | $3.8m | 1.89 |
Biggest buyers
| Paradigm Biocapital Advisors LP | Added | +1.7m |
| BRAIDWELL LP | New | +1.3m |
| MONTANOVA CAPITAL, LLC | New | +1.0m |
| Point72 Asset Management, L.P. | Added | +821.5k |
| RA CAPITAL MANAGEMENT, L.P. | New | +800.0k |
| Deep Track Capital, LP | Added | +671.5k |
| DEERFIELD MANAGEMENT COMPANY, L.P. | New | +448.8k |
| Camber Capital Management LP | New | +400.0k |
| First Light Asset Management, LLC | Added | +331.4k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +295.8k |
Biggest sellers
| Logos Global Management LP | Sold out | -520.0k |
| JANUS HENDERSON GROUP PLC | Reduced | -370.4k |
| Ikarian Capital, LLC | Sold out | -203.0k |
| Sio Capital Management, LLC | Reduced | -171.7k |
| ExodusPoint Capital Management, LP | Sold out | -112.0k |
| TWO SIGMA ADVISERS, LP | Reduced | -68.7k |
| Parkman Healthcare Partners LLC | Reduced | -49.6k |
| BOOTHBAY FUND MANAGEMENT, LLC | Sold out | -42.1k |
| SIMPLEX TRADING, LLC | Reduced | -34.9k |
| TWO SIGMA INVESTMENTS, LP | Reduced | -29.7k |
Biggest calls
| JANE STREET GROUP, LLC | New | $1.8m89.1k shares |
| SIMPLEX TRADING, LLC | Added | $90.0k4.5k shares |
| CITADEL ADVISORS LLC | Added | $84.4k4.2k shares |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | Not comparable | $52.3k23.5k shares |
| GROUP ONE TRADING LLC | Reduced | $18.1k900 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| SIMPLEX TRADING, LLC | Added | $1.4m67.4k shares |
| GROUP ONE TRADING LLC | Reduced | $1.0m50.2k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $863.9k43.0k shares |
| CITADEL ADVISORS LLC | Added | $602.7k30.0k shares |
| Cutler Group LLC / CA | Reduced | $8.0k800 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Forbion Growth Opportunities Fund II Cooperatief U.A. 13G · passive investor new · filed 2024-12-19 | 7.3% |
| ARMISTICE CAPITAL, LLC 13G · institution no change · filed 2026-08-14 | 6.7% |
| Long Focus Capital Management, LLC 13G · institution new · filed 2026-05-15 | 6.6% |
Fell to 5% or below in the last year: Invus Global Management, LLC (3.1%, 2026-05-04), WESTFIELD CAPITAL MANAGEMENT CO LP (0.0%, 2026-03-04)
Insider purchases and sales in Q3 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2021 | 0 | — | 3 | $9.4m | — |
| Q1 2022 | 0 | — | 0 | — | — |
| Q2 2022 | 0 | — | 0 | — | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 0 | — | — |
| Q1 2023 | 0 | — | 7 | $332.2k | — |
| Q2 2023 | 0 | — | 6 | $55.5k | — |
| Q3 2023 | 0 | — | 6 | $58.9k | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2023-07-03 | Lee Kevin Chief Executive Officer, director | Sold | $37.6k1.5k shares |
| 2023-07-03 | Crockett Nigel Chief Business Officer | Sold | $11.3k451 shares |
| 2023-07-03 | Milnes Alistair Chief Operating Officer | Sold | $11.3k451 shares |
| 2023-07-03 | Skynner Michael Chief Technology Officer | Sold | $11.3k451 shares |
| 2023-07-03 | Keen Nicholas Chief Scientific Officer | Sold | $8.4k336 shares |
| 2023-07-03 | Thompson Travis Alvin Chief Accounting Officer | Sold | $1.5k61 shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q3 2023
| Manager | Shares | Change |
|---|---|---|
| Paradigm Biocapital Advisors LP 4.99% of their portfolio | 3.6m $73.2m | Added +1.7m |
| Deep Track Capital, LP 2.72% of their portfolio | 3.5m $70.1m | Added +671.5k |
| First Light Asset Management, LLC 3.95% of their portfolio | 2.1m $41.6m | Added +331.4k |
| Jefferies Financial Group Inc. 0.98% of their portfolio | 1.9m $39.1m | Unchanged |
| MORGAN STANLEY 0.00% of their portfolio | 1.6m $32.6m | Added +182.2k |
| Point72 Asset Management, L.P. 0.09% of their portfolio | 1.3m $26.1m | Added +821.5k |
| BRAIDWELL LP 0.82% of their portfolio | 1.3m $25.9m | New |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD 3.60% of their portfolio | 1.3m $25.8m | Unchanged |
| Candriam S.C.A. 0.18% of their portfolio | 1.3m $25.2m | Reduced -20.0k |
| Polar Capital Holdings Plc 0.15% of their portfolio | 1.0m $20.3m | Added +252.0k |
| MONTANOVA CAPITAL, LLC 1.10% of their portfolio | 1.0m $20.3m | New |
| ARMISTICE CAPITAL, LLC 0.60% of their portfolio | 1.0m $20.1m | Added +124.0k |
| Verition Fund Management LLC 0.25% of their portfolio | 916.4k $18.4m | Added +237.4k |
| JANUS HENDERSON GROUP PLC 0.01% of their portfolio | 910.9k $18.3m | Reduced -370.4k |
| BAKER BROS. ADVISORS LP 0.10% of their portfolio | 843.8k $17.0m | Unchanged |
| RA CAPITAL MANAGEMENT, L.P. 0.32% of their portfolio | 800.0k $16.1m | New |
| Sio Capital Management, LLC 4.96% of their portfolio | 796.9k $16.0m | Reduced -171.7k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.04% of their portfolio | 640.9k $12.9m | Added +131.6k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 593.1k $11.9m | Added +295.8k |
| AXA S.A. 0.04% of their portfolio | 575.1k $11.6m | Added +21.4k |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.20% of their portfolio | 448.8k $9.0m | New |
| NOMURA HOLDINGS INC 0.09% of their portfolio | 400.0k $8.0m | Unchanged |
| Camber Capital Management LP 0.29% of their portfolio | 400.0k $8.0m | New |
| Soleus Capital Management, L.P. 0.79% of their portfolio | 391.8k $7.9m | Reduced -20.0k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 315.1k $6.3m | Added +236.3k |
| PLATINUM INVESTMENT MANAGEMENT LTD 0.22% of their portfolio | 285.5k $5.7m | New |
| FMR LLC 0.00% of their portfolio | 266.3k $5.4m | Reduced -20.8k |
| Rubric Capital Management LP 0.17% of their portfolio | 205.4k $4.1m | Unchanged |
| BlackRock Inc. 0.00% of their portfolio | 194.1k $3.9m | Added +13.0k |
| KENNEDY CAPITAL MANAGEMENT LLC 0.08% of their portfolio | 156.7k $3.1m | Added +33.5k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 135.7k $2.7m | Added +24.5k |
| Handelsbanken Fonder AB 0.02% of their portfolio | 134.5k $2.7m | Unchanged |
| Parkman Healthcare Partners LLC 0.45% of their portfolio | 122.7k $2.5m | Reduced -49.6k |
| DAFNA Capital Management LLC 0.76% of their portfolio | 122.2k $2.5m | Unchanged |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 113.4k $2.3m | Added +25.0k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 96.4k $1.9m | Added +88.0k |
| Legal & General Group Plc 0.00% of their portfolio | 92.5k $1.9m | Added +12.2k |
| HighVista Strategies LLC 0.86% of their portfolio | 92.4k $1.9m | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 82.0k $1.6m | Added +11.1k |
| TD Asset Management Inc 0.00% of their portfolio | 81.8k $1.6m | Added +58.2k |
| GROUP ONE TRADING LLC 0.06% of their portfolio | 81.2k $1.6m | Reduced -2.7k |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.03% of their portfolio | 77.9k $1.6m | Unchanged |
| Trexquant Investment LP 0.04% of their portfolio | 70.7k $1.4m | New |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 70.7k $1.4m | Reduced -68.7k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 68.5k $1.4m | Reduced -27.7k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 65.7k $1.3m | Added +3.0k |
| Cubist Systematic Strategies, LLC 0.02% of their portfolio | 65.5k $1.3m | Added +40.8k |
| AlphaCentric Advisors LLC 0.67% of their portfolio | 58.5k $1.2m | New |
| Schonfeld Strategic Advisors LLC 0.01% of their portfolio | 52.1k $1.0m | Reduced -14.0k |
| Ghisallo Capital Management LLC 0.10% of their portfolio | 50.0k $1.0m | New |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 49.4k $991.9k | New |
| Bellevue Group AG 0.01% of their portfolio | 39.2k $787.5k | Added +14.2k |
| FISHMAN JAY A LTD/MI 0.10% of their portfolio | 37.5k $753.4k | Reduced -3.5k |
| Jump Financial, LLC 0.03% of their portfolio | 37.1k $744.7k | Added +18.9k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 36.1k $725.1k | Added +11.0k |
| STATE STREET CORP 0.00% of their portfolio | 35.9k $720.5k | Added +27.2k |
| SIMPLEX TRADING, LLC 0.02% of their portfolio | 31.5k $633.0k | Reduced -34.9k |
| DekaBank Deutsche Girozentrale 0.00% of their portfolio | 30.0k $584.0k | Unchanged |
| Alpha DNA Investment Management LLC 0.36% of their portfolio | 28.0k $561.7k | New |
| AE Wealth Management LLC 0.00% of their portfolio | 24.8k $497.7k | New |
| Mach-1 Financial Group, LLC 0.21% of their portfolio | 24.7k $496.2k | New |
| HARBOR CAPITAL ADVISORS, INC. 0.10% of their portfolio | 24.2k $486.4k | Added +3.2k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 22.9k $460.7k | Reduced -29.7k |
| Maven Securities LTD 0.05% of their portfolio | 22.5k $452.0k | New |
| WOODSTOCK CORP 0.05% of their portfolio | 20.6k $412.9k | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 17.1k $344.4k | Unchanged |
| Allianz Asset Management GmbH 0.00% of their portfolio | 17.0k $341.5k | Reduced -3.4k |
| Engineers Gate Manager LP 0.01% of their portfolio | 16.1k $323.0k | New |
| HORIZON KINETICS ASSET MANAGEMENT LLC 0.01% of their portfolio | 15.0k $301.4k | Unchanged |
| Erste Asset Management GmbH 0.00% of their portfolio | 14.0k $283.2k | Unchanged |
| AtonRa Partners 0.49% of their portfolio | 11.6k $232.8k | Reduced -2.6k |
| UBS Group AG 0.00% of their portfolio | 11.3k $227.1k | Reduced -1.3k |
| Tower Research Capital LLC (TRC) 0.01% of their portfolio | 9.9k $198.2k | Added +7.4k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 6.3k $126.5k | Reduced -236 |
| EXCHANGE TRADED CONCEPTS, LLC 0.00% of their portfolio | 5.0k $100.9k | Reduced -255 |
| Sandia Investment Management LP 0.03% of their portfolio | 5.0k $100.5k | New |
| BIT Capital GmbH 0.01% of their portfolio | 4.8k $97.4k | Unchanged |
| HighMark Wealth Management LLC 0.07% of their portfolio | 4.4k $89.1k | Added +200 |
| VIRTUS ADVISERS, LLC 0.05% of their portfolio | 3.7k $74.4k | Reduced -369 |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 3.3k $67.3k | Added +1.0k |
| NATIXIS 0.00% of their portfolio | 2.8k $55.1k | Reduced -7 |
| Cutler Group LLC / CA 0.01% of their portfolio | 2.4k $48.0k | Reduced -3.7k |
| FIRST MANHATTAN CO. LLC. 0.00% of their portfolio | 2.2k $44.2k | New |
| Nicholas Wealth, LLC. 0.03% of their portfolio | 1.5k $30.8k | First filing |
| Aquatic Capital Management LLC 0.00% of their portfolio | 900 $18.0k | New |
| China Universal Asset Management Co., Ltd. 0.00% of their portfolio | 679 $13.6k | Added +340 |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 535 $11.0k | Added +153 |
| CITIGROUP INC 0.00% of their portfolio | 532 $10.7k | Reduced -71 |
| Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio | 514 $10.3k | Reduced -170 |
| COMERICA BANK 0.00% of their portfolio | 450 $9.0k | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 410 $8.2k | Added +30 |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 348 $7.0k | Added +159 |
| MACROVIEW INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 335 $6.7k | New |
| Quantbot Technologies LP 0.00% of their portfolio | 300 $6.0k | New |
| Raleigh Capital Management Inc. 0.00% of their portfolio | 185 $3.7k | Unchanged |
| BARCLAYS PLC 0.00% of their portfolio | 168 $3.4k | Added +84 |
| HIGHLINE WEALTH PARTNERS LLC 0.00% of their portfolio | 110 $2.2k | New |
| Daiwa Securities Group Inc. 0.00% of their portfolio | 103 $2.0k | Unchanged |
| NFSG Corp 0.00% of their portfolio | 40 $804 | Unchanged |
| Bell Investment Advisors, Inc 0.00% of their portfolio | 24 $483 | Reduced -13 |