AXSOME THERAPEUTICS INC AXSM
COM · Common Stock · CUSIP 05464T104 · ISIN US05464T1043
American biopharmaceutical company
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersNew York, NY
- Founded2012
- Websiteaxsome.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($2.6m this quarter). Holder counts are more reliable. Shares outstanding: 48.0m as of 2024-07-29, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $80.45. Options: 16 managers hold calls ($50.0m notional), 13 hold puts ($45.3m).
Trends to Q2 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 189 |
| Q4 2022 | 219 |
| Q1 2023 | 198 |
| Q2 2023 | 233 |
| Q3 2023 | 229 |
| Q4 2023 | 247 |
| Q1 2024 | 261 |
| Q2 2024 | 258 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 110 | 101 |
| Q1 2023 | 90 | 106 |
| Q2 2023 | 135 | 72 |
| Q3 2023 | 111 | 98 |
| Q4 2023 | 106 | 112 |
| Q1 2024 | 140 | 100 |
| Q2 2024 | 109 | 130 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2023 | $56.4m | $36.8m | 0.65 |
| Q4 2023 | $79.2m | $41.4m | 0.52 |
| Q1 2024 | $49.5m | $66.4m | 1.34 |
| Q2 2024 | $50.0m | $45.3m | 0.91 |
Biggest buyers
| BVF INC/IL | New | +955.0k |
| BANK OF AMERICA CORP /DE/ | Added | +705.3k |
| EVENTIDE ASSET MANAGEMENT, LLC | Added | +592.0k |
| Deep Track Capital, LP | Added | +548.1k |
| Cormorant Asset Management, LP | New | +400.0k |
| MACQUARIE GROUP LTD | Added | +372.8k |
| Invesco Ltd. | Added | +312.2k |
| Sofinnova Investments, Inc. | New | +310.2k |
| Vestal Point Capital, LP | New | +300.0k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Added | +215.0k |
Biggest sellers
| MORGAN STANLEY | Reduced | -2.5m |
| PERCEPTIVE ADVISORS LLC | Reduced | -646.2k |
| CITADEL ADVISORS LLC | Reduced | -390.4k |
| Pictet Asset Management Holding SA | Reduced | -348.1k |
| Jefferies Financial Group Inc. | Reduced | -316.9k |
| Driehaus Capital Management LLC | Sold out | -204.7k |
| BARCLAYS PLC | Reduced | -203.8k |
| Bellevue Group AG | Reduced | -168.9k |
| Nuveen Asset Management, LLC | Reduced | -142.9k |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | Sold out | -138.3k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $15.0m186.8k shares |
| GROUP ONE TRADING LLC | Added | $12.4m154.2k shares |
| CITADEL ADVISORS LLC | Added | $6.6m81.5k shares |
| JANE STREET GROUP, LLC | Reduced | $5.8m72.0k shares |
| SIMPLEX TRADING, LLC | Reduced | $3.7m46.3k shares |
| GTS SECURITIES LLC | Reduced | $1.9m23.2k shares |
| WOLVERINE TRADING, LLC | Added | $1.6m20.3k shares |
| Point72 Asset Management, L.P. | Added | $1.0m12.9k shares |
| D. E. Shaw & Co., Inc. | Unchanged | $821.1k10.2k shares |
| PEAK6 Investments LLC | Reduced | $603.8k7.5k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $19.6m243.0k shares |
| GROUP ONE TRADING LLC | Reduced | $6.3m77.7k shares |
| CITADEL ADVISORS LLC | Reduced | $6.0m74.6k shares |
| D. E. Shaw & Co., Inc. | Unchanged | $2.5m31.5k shares |
| JANE STREET GROUP, LLC | Reduced | $2.5m31.3k shares |
| SpiderRock Advisors, LLC | Unchanged | $2.4m30.0k shares |
| SIMPLEX TRADING, LLC | Reduced | $2.1m26.4k shares |
| WOLVERINE TRADING, LLC | Reduced | $1.4m16.9k shares |
| GTS SECURITIES LLC | Reduced | $1.2m14.7k shares |
| Point72 Asset Management, L.P. | Added | $877.5k10.9k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution filed 2026-07-27 | 5.3% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-26)
Insider purchases and sales in Q2 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 0 | — | — |
| Q1 2023 | 0 | — | 0 | — | — |
| Q2 2023 | 0 | — | 0 | — | — |
| Q3 2023 | 0 | — | 1 | $2.2m | $2.2m |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 0 | — | 1 | $2.3m | $2.3m |
| Q2 2024 | 0 | — | 2 | $3.3m | $2.7m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-05-29 | Jacobson Mark L. Chief Operating Officer | Sold | $587.8k7.9k shares |
| 2024-05-29 | Coleman Mark Director | Sold plan | $394.3k5.2k shares |
| 2024-05-28 | Coleman Mark Director | Sold plan | $394.8k5.2k shares |
| 2024-04-01 | Jacobson Mark L. Chief Operating Officer | Sold plan | $1.9m24.7k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2024
| Manager | Shares | Change |
|---|---|---|
| RTW INVESTMENTS, LP 5.78% of their portfolio | 4.6m $373.1m | Added +141.7k |
| VANGUARD GROUP INC 0.01% of their portfolio | 3.7m $301.2m | Added +1.7k |
| BlackRock Inc. 0.01% of their portfolio | 3.3m $265.6m | Added +104.5k |
| Fairmount Funds Management LLC 21.46% of their portfolio | 2.4m $190.0m | Unchanged |
| Deep Track Capital, LP 4.45% of their portfolio | 1.9m $149.1m | Added +548.1k |
| MACQUARIE GROUP LTD 0.10% of their portfolio | 1.1m $86.4m | Added +372.8k |
| RA CAPITAL MANAGEMENT, L.P. 1.06% of their portfolio | 1.0m $80.5m | Unchanged |
| BVF INC/IL 2.15% of their portfolio | 955.0k $76.9m | New |
| EVENTIDE ASSET MANAGEMENT, LLC 1.29% of their portfolio | 938.7k $75.6m | Added +592.0k |
| STATE STREET CORP 0.00% of their portfolio | 938.5k $75.5m | Reduced -213 |
| FMR LLC 0.00% of their portfolio | 902.1k $72.6m | Added +73.6k |
| BANK OF AMERICA CORP /DE/ 0.01% of their portfolio | 891.0k $71.7m | Added +705.3k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 884.9k $71.2m | Added +39.5k |
| CITADEL ADVISORS LLC 0.06% of their portfolio | 753.2k $60.6m | Reduced -390.4k |
| ALETHEA CAPITAL MANAGEMENT, LLC 45.25% of their portfolio | 740.9k $59.6m | Added +97 |
| MILLENNIUM MANAGEMENT LLC 0.05% of their portfolio | 739.8k $59.6m | Reduced -1.7k |
| WELLINGTON MANAGEMENT GROUP LLP 0.01% of their portfolio | 734.6k $59.1m | Added +58.0k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.11% of their portfolio | 730.0k $58.8m | Added +215.0k |
| Invesco Ltd. 0.01% of their portfolio | 557.9k $44.9m | Added +312.2k |
| Hood River Capital Management LLC 0.92% of their portfolio | 549.1k $44.2m | Added +28.3k |
| Bellevue Group AG 0.68% of their portfolio | 516.5k $41.6m | Reduced -168.9k |
| Point72 Asset Management, L.P. 0.12% of their portfolio | 479.0k $38.6m | Added +100.2k |
| PFM Health Sciences, LP 2.05% of their portfolio | 467.4k $37.6m | Unchanged |
| PERCEPTIVE ADVISORS LLC 0.89% of their portfolio | 459.1k $37.0m | Reduced -646.2k |
| NORGES BANK 0.00% of their portfolio | 404.2k $32.5m | Added +18.7k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 401.3k $32.3m | Added +109.7k |
| Boxer Capital, LLC 1.70% of their portfolio | 400.0k $32.2m | Unchanged |
| Cormorant Asset Management, LP 1.87% of their portfolio | 400.0k $32.2m | New |
| Avidity Partners Management LP 1.29% of their portfolio | 376.0k $30.3m | Reduced -55.0k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 369.2k $29.7m | Reduced -21.4k |
| First Turn Management, LLC 4.42% of their portfolio | 337.2k $27.1m | Reduced -4.9k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 324.5k $26.1m | Reduced -11.6k |
| MORGAN STANLEY 0.00% of their portfolio | 322.0k $25.9m | Reduced -2.5m |
| Woodline Partners LP 0.25% of their portfolio | 318.0k $25.6m | Reduced -42.1k |
| Sofinnova Investments, Inc. 1.57% of their portfolio | 310.2k $25.0m | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 309.8k $24.9m | Added +8.7k |
| Tri Locum Partners LP 6.24% of their portfolio | 306.5k $24.7m | Added +203.8k |
| Vestal Point Capital, LP 1.80% of their portfolio | 300.0k $24.1m | New |
| Checkpoint Capital L.P. 14.11% of their portfolio | 290.8k $23.4m | Added +158.3k |
| LOOMIS SAYLES & CO L P 0.03% of their portfolio | 269.1k $21.7m | Reduced -10.7k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 168.8k $13.6m | Added +88.6k |
| JANE STREET GROUP, LLC 0.01% of their portfolio | 168.4k $13.6m | Reduced -30.6k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 165.6k $13.3m | Added +11.8k |
| Ghost Tree Capital, LLC 4.20% of their portfolio | 150.0k $12.1m | Reduced -60.0k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 135.9k $10.9m | Added +108.8k |
| US BANCORP \DE\ 0.01% of their portfolio | 132.7k $10.7m | Reduced -800 |
| MPM BIOIMPACT LLC 1.66% of their portfolio | 132.3k $10.7m | Added +18.2k |
| Rhenman & Partners Asset Management AB 0.99% of their portfolio | 127.6k $10.3m | Reduced -16.0k |
| IRIDIAN ASSET MANAGEMENT LLC/CT 2.31% of their portfolio | 126.9k $10.2m | Reduced -1.9k |
| WCM INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio | 113.3k $9.1m | Added +1.8k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 108.8k $8.8m | Added +967 |
| Clearbridge Investments, LLC 0.01% of their portfolio | 106.8k $8.6m | Added +17.4k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 102.6k $8.3m | Reduced -142.9k |
| EAGLE ASSET MANAGEMENT INC 0.04% of their portfolio | 98.6k $8.0m | Reduced -127.9k |
| FRONTIER CAPITAL MANAGEMENT CO LLC 0.08% of their portfolio | 96.0k $7.7m | Reduced -9.3k |
| VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 91.8k $7.4m | Added +72.5k |
| Artia Global Partners LP 1.81% of their portfolio | 87.8k $7.1m | Unchanged |
| PEREGRINE CAPITAL MANAGEMENT LLC 0.21% of their portfolio | 87.4k $7.0m | Added +1.2k |
| Cannell & Spears LLC 0.14% of their portfolio | 82.1k $6.6m | Reduced -638 |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 80.2k $6.5m | Reduced -2.9k |
| Affinity Asset Advisors, LLC 1.01% of their portfolio | 80.0k $6.4m | Reduced -59.8k |
| Walleye Capital LLC 0.06% of their portfolio | 76.0k $6.1m | Reduced -21.1k |
| NEUBERGER BERMAN GROUP LLC 0.00% of their portfolio | 74.8k $6.0m | Reduced -16.9k |
| Privium Fund Management B.V. 1.50% of their portfolio | 74.3k $5.9m | Reduced -7.7k |
| Lindbrook Capital, LLC 0.53% of their portfolio | 70.3k $5.7m | Reduced -13.4k |
| SpiderRock Advisors, LLC 0.15% of their portfolio | 70.0k $5.6m | Reduced -11 |
| SCOUT INVESTMENTS, INC. 0.15% of their portfolio | 69.6k $5.6m | New |
| Hennion & Walsh Asset Management, Inc. 0.27% of their portfolio | 64.7k $5.2m | Reduced -4.8k |
| HighVista Strategies LLC 1.83% of their portfolio | 62.2k $5.0m | Added +13.7k |
| Moody Aldrich Partners LLC 0.97% of their portfolio | 61.8k $5.0m | Reduced -3.9k |
| Swiss National Bank 0.00% of their portfolio | 60.5k $4.9m | Unchanged |
| BLAIR WILLIAM & CO/IL 0.01% of their portfolio | 59.2k $4.8m | Reduced -4.4k |
| Schonfeld Strategic Advisors LLC 0.04% of their portfolio | 58.9k $4.7m | Reduced -1.3k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio | 58.3k $4.7m | Unchanged |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 56.2k $4.5m | Added +27.4k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 54.9k $4.4m | Added +2.7k |
| Altium Capital Management LLC 1.66% of their portfolio | 50.0k $4.0m | Reduced -88.0k |
| BALDWIN WEALTH PARTNERS LLC/MA 0.31% of their portfolio | 49.7k $4.0m | Unchanged |
| Atika Capital Management LLC 0.46% of their portfolio | 49.0k $3.9m | Reduced -19.0k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 45.3k $3.6m | Added +32.7k |
| WMS Partners, LLC 0.21% of their portfolio | 40.7k $3.3m | Unchanged |
| SEI INVESTMENTS CO 0.00% of their portfolio | 40.6k $3.3m | Added +5.0k |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC 0.04% of their portfolio | 39.9k $3.2m | Reduced -1.7k |
| UBS Group AG 0.00% of their portfolio | 39.7k $3.2m | Reduced -21.6k |
| Aberdeen Group plc 0.01% of their portfolio | 39.7k $3.2m | New |
| Assenagon Asset Management S.A. 0.01% of their portfolio | 34.0k $2.7m | New |
| SVB FINANCIAL GROUP 1.91% of their portfolio | 33.8k $2.7m | Unchanged |
| NATIXIS 0.02% of their portfolio | 33.7k $2.7m | Added +32.4k |
| Legal & General Group Plc 0.00% of their portfolio | 33.6k $2.7m | Added +782 |
| Knights of Columbus Asset Advisors LLC 0.17% of their portfolio | 32.5k $2.6m | Added +10.0k |
| Point72 Europe (London) LLP 0.21% of their portfolio | 30.7k $2.5m | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 30.6k $2.5m | Reduced -700 |
| DekaBank Deutsche Girozentrale 0.00% of their portfolio | 30.0k $2.4m | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 27.2k $2.2m | Added +1.9k |
| Jump Financial, LLC 0.04% of their portfolio | 27.1k $2.2m | New |
| FIRST TRUST ADVISORS LP 0.00% of their portfolio | 26.6k $2.1m | Reduced -38.9k |
| Strategic Financial Concepts, LLC 0.00% of their portfolio | 26.0k $306 | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 25.6k $2.1m | Reduced -13.7k |
| State of New Jersey Common Pension Fund D 0.01% of their portfolio | 24.7k $2.0m | Reduced -9.1k |
| CWM, LLC 0.01% of their portfolio | 23.9k $1.9m | Reduced -5.7k |