AXSOME THERAPEUTICS INC AXSM
COM · Common Stock · CUSIP 05464T104 · ISIN US05464T1043
American biopharmaceutical company
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersNew York, NY
- Founded2012
- Websiteaxsome.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($353.4k this quarter). Holder counts are more reliable. Shares outstanding: 43.6m as of 2023-05-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $61.66. Options: 15 managers hold calls ($79.2m notional), 13 hold puts ($56.9m).
Trends to Q1 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 189 |
| Q4 2022 | 219 |
| Q1 2023 | 198 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 110 | 101 |
| Q1 2023 | 90 | 106 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $113.6m | $113.3m | 1.00 |
| Q4 2022 | $179.1m | $132.8m | 0.74 |
| Q1 2023 | $79.2m | $56.9m | 0.72 |
Biggest buyers
| FMR LLC | Added | +2.0m |
| MILLENNIUM MANAGEMENT LLC | New | +1.0m |
| RTW INVESTMENTS, LP | Added | +800.4k |
| Holocene Advisors, LP | New | +529.1k |
| Point72 Asset Management, L.P. | Added | +519.8k |
| BVF INC/IL | Added | +376.1k |
| Woodline Partners LP | Added | +347.2k |
| Privium Fund Management B.V. | New | +159.5k |
| Nicholas Investment Partners, LP | Added | +140.2k |
| Sofinnova Investments, Inc. | New | +120.9k |
Biggest sellers
| Venrock Adviser, LLC | Sold out | -670.7k |
| PFM Health Sciences, LP | Reduced | -486.8k |
| Cannell & Co. | Reduced | -250.8k |
| CITADEL ADVISORS LLC | Reduced | -164.7k |
| JANE STREET GROUP, LLC | Reduced | -154.2k |
| Balyasny Asset Management L.P. | Sold out | -120.9k |
| GROUP ONE TRADING LLC | Reduced | -119.9k |
| 1832 Asset Management L.P. | Sold out | -118.2k |
| Man Group plc | Sold out | -116.5k |
| Hood River Capital Management LLC | Reduced | -79.5k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $23.2m376.0k shares |
| JANE STREET GROUP, LLC | Added | $18.1m292.7k shares |
| CITADEL ADVISORS LLC | Reduced | $9.5m154.8k shares |
| Ikarian Capital, LLC | New | $9.3m150.0k shares |
| SIMPLEX TRADING, LLC | Reduced | $5.9m96.4k shares |
| GROUP ONE TRADING LLC | Reduced | $4.8m78.3k shares |
| BOOTHBAY FUND MANAGEMENT, LLC | Reduced | $1.9m31.3k shares |
| D. E. Shaw & Co., Inc. | Added | $1.9m30.6k shares |
| Caption Management, LLC | Reduced | $1.9m30.0k shares |
| WOLVERINE TRADING, LLC | Reduced | $1.8m30.2k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $14.7m239.0k shares |
| CITADEL ADVISORS LLC | Reduced | $13.1m211.7k shares |
| Ikarian Capital, LLC | New | $9.3m150.0k shares |
| JANE STREET GROUP, LLC | Reduced | $6.4m103.5k shares |
| SIMPLEX TRADING, LLC | Reduced | $4.5m73.1k shares |
| GROUP ONE TRADING LLC | Reduced | $3.1m49.9k shares |
| BOOTHBAY FUND MANAGEMENT, LLC | Reduced | $1.9m31.3k shares |
| Caption Management, LLC | Reduced | $1.9m30.0k shares |
| WOLVERINE TRADING, LLC | Reduced | $1.3m21.1k shares |
| PEAK6 Investments LLC | New | $623.0k10.1k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution filed 2026-07-27 | 5.3% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-26)
Insider purchases and sales in Q1 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2021 | 0 | — | 0 | — | — |
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 4 | $345.1k | 0 | — | — |
| Q1 2022 | 0 | — | 0 | — | — |
| Q2 2022 | 0 | — | 0 | — | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 0 | — | — |
| Q1 2023 | 0 | — | 0 | — | — |
None reported in Q1 2023.
Holders, Q1 2023
| Manager | Shares | Change |
|---|---|---|
| RTW INVESTMENTS, LP 4.86% of their portfolio | 3.8m $233.2m | Added +800.4k |
| VANGUARD GROUP INC 0.01% of their portfolio | 3.5m $215.0m | Added +68.1k |
| FMR LLC 0.01% of their portfolio | 2.7m $168.4m | Added +2.0m |
| BlackRock Inc. 0.00% of their portfolio | 2.5m $152.2m | Reduced -34.8k |
| BVF INC/IL 4.81% of their portfolio | 2.1m $131.4m | Added +376.1k |
| Fairmount Funds Management LLC 21.34% of their portfolio | 2.0m $124.1m | Unchanged |
| Point72 Asset Management, L.P. 0.26% of their portfolio | 1.2m $72.2m | Added +519.8k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.15% of their portfolio | 1.1m $64.8m | Reduced -15.0k |
| MILLENNIUM MANAGEMENT LLC 0.07% of their portfolio | 1.0m $64.1m | New |
| STATE STREET CORP 0.00% of their portfolio | 796.0k $49.1m | Added +39.2k |
| ALETHEA CAPITAL MANAGEMENT, LLC 51.17% of their portfolio | 785.7k $48.5m | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 652.4k $40.2m | Added +27.8k |
| Avidity Partners Management LP 1.27% of their portfolio | 619.2k $38.2m | Reduced -50.8k |
| PFM Health Sciences, LP 1.72% of their portfolio | 606.1k $37.4m | Reduced -486.8k |
| Woodline Partners LP 0.50% of their portfolio | 570.8k $35.2m | Added +347.2k |
| Holocene Advisors, LP 0.16% of their portfolio | 529.1k $32.6m | New |
| MORGAN STANLEY 0.00% of their portfolio | 447.8k $27.6m | Reduced -29.5k |
| Bellevue Group AG 0.40% of their portfolio | 441.4k $27.2m | Added +4.7k |
| Boxer Capital, LLC 1.21% of their portfolio | 400.0k $24.7m | Unchanged |
| Hood River Capital Management LLC 0.76% of their portfolio | 380.8k $23.5m | Reduced -79.5k |
| Nicholas Investment Partners, LP 1.60% of their portfolio | 340.4k $21.0m | Added +140.2k |
| TANG CAPITAL MANAGEMENT LLC 2.94% of their portfolio | 320.0k $19.7m | Unchanged |
| NORTHERN TRUST CORP 0.00% of their portfolio | 318.1k $19.6m | Added +6.1k |
| Cormorant Asset Management, LP 1.22% of their portfolio | 300.0k $18.5m | Reduced -25.0k |
| IRIDIAN ASSET MANAGEMENT LLC/CT 1.47% of their portfolio | 290.8k $17.9m | Reduced -27.8k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 269.3k $16.6m | Added +3.5k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 249.1k $15.4m | Reduced -652 |
| Ghost Tree Capital, LLC 5.25% of their portfolio | 225.0k $13.9m | Reduced -10.0k |
| NORGES BANK 0.00% of their portfolio | 210.2k $13.0m | Reduced -46.2k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 199.0k $12.3m | Reduced -164.7k |
| WMS Partners, LLC 1.04% of their portfolio | 193.3k $11.9m | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 174.2k $10.7m | Added +6.6k |
| Driehaus Capital Management LLC 0.14% of their portfolio | 166.5k $10.3m | Reduced -66.6k |
| Privium Fund Management B.V. 3.30% of their portfolio | 159.5k $9.8m | New |
| Atika Capital Management LLC 1.49% of their portfolio | 155.0k $9.6m | Reduced -71.5k |
| Tri Locum Partners LP 2.80% of their portfolio | 149.2k $9.2m | Reduced -50.8k |
| US BANCORP \DE\ 0.01% of their portfolio | 135.5k $8.4m | Reduced -3.3k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 125.1k $7.7m | Reduced -3.4k |
| SEI INVESTMENTS CO 0.01% of their portfolio | 124.1k $7.7m | Reduced -13.4k |
| Sofinnova Investments, Inc. 0.51% of their portfolio | 120.9k $7.5m | New |
| Cannell & Co. 0.26% of their portfolio | 119.2k $7.4m | Reduced -250.8k |
| PUTNAM INVESTMENTS LLC 0.01% of their portfolio | 114.8k $7.1m | Added +581 |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 114.5k $7.1m | Reduced -7.4k |
| PEREGRINE CAPITAL MANAGEMENT LLC 0.19% of their portfolio | 108.3k $6.7m | Added +11.9k |
| ExodusPoint Capital Management, LP 0.07% of their portfolio | 96.7k $6.0m | New |
| Candriam S.C.A. 0.04% of their portfolio | 95.1k $5.4m | Reduced -76.4k |
| Hennion & Walsh Asset Management, Inc. 0.36% of their portfolio | 94.3k $5.8m | Added +1.1k |
| WCM INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio | 88.5k $5.5m | Reduced -194 |
| Lindbrook Capital, LLC 0.61% of their portfolio | 84.2k $5.2m | Reduced -329 |
| MPM BIOIMPACT LLC 1.13% of their portfolio | 70.4k $4.3m | Added +18.4k |
| Swiss National Bank 0.00% of their portfolio | 70.3k $4.3m | Reduced -2.7k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 66.3k $4.1m | Reduced -10.7k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 64.9k $4.0m | Added +16.8k |
| J. Goldman & Co LP 0.22% of their portfolio | 62.4k $3.8m | Added +59.7k |
| HighVista Strategies LLC 3.05% of their portfolio | 60.8k $3.7m | Added +5.7k |
| Invesco Ltd. 0.00% of their portfolio | 60.5k $3.7m | Reduced -78.9k |
| Jump Financial, LLC 0.15% of their portfolio | 60.0k $3.7m | Added +27.2k |
| CITIGROUP INC 0.00% of their portfolio | 48.3k $3.0m | Added +7.7k |
| BALDWIN WEALTH PARTNERS LLC/MA 0.26% of their portfolio | 47.5k $2.9m | Unchanged |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 44.1k $2.7m | Added +1.1k |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC 0.03% of their portfolio | 41.2k $2.5m | Added +2.0k |
| FRONTIER CAPITAL MANAGEMENT CO LLC 0.03% of their portfolio | 40.7k $2.5m | Reduced -48.7k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 40.7k $2.5m | Unchanged |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 40.5k $2.5m | Added +1.4k |
| CREDIT SUISSE AG/ 0.00% of their portfolio | 40.2k $2.5m | Reduced -4.9k |
| State of New Jersey Common Pension Fund D 0.01% of their portfolio | 37.1k $2.3m | New |
| SVB FINANCIAL GROUP 3.99% of their portfolio | 33.8k $2.1m | Unchanged |
| CIBC Private Wealth Group LLC 0.00% of their portfolio | 33.2k $2.0m | Added +15.8k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 33.2k $2.0m | Added +30.5k |
| Moody Aldrich Partners LLC 0.41% of their portfolio | 32.6k $2.0m | Reduced -19.6k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 32.5k $2.0m | Added +1.3k |
| Brookfield Corp /ON/ 0.01% of their portfolio | 31.6k $1.9m | Added +20.8k |
| Legal & General Group Plc 0.00% of their portfolio | 30.6k $1.9m | Added +3.6k |
| DekaBank Deutsche Girozentrale 0.00% of their portfolio | 30.0k $1.8m | Unchanged |
| STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio | 29.6k $1.8m | Reduced -672 |
| ALPS ADVISORS INC 0.02% of their portfolio | 28.7k $1.8m | Reduced -748 |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 25.4k $1.6m | Reduced -5.1k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 24.8k $1.5m | Reduced -2.1k |
| TUDOR INVESTMENT CORP ET AL 0.03% of their portfolio | 23.9k $1.5m | New |
| Trexquant Investment LP 0.04% of their portfolio | 22.7k $1.4m | Reduced -1.2k |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.03% of their portfolio | 22.6k $1.4m | New |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 21.7k $1.3m | Reduced -154.2k |
| Soleus Capital Management, L.P. 0.16% of their portfolio | 20.7k $1.3m | Reduced -29.3k |
| STRS OHIO 0.00% of their portfolio | 20.1k $1.2m | Added +16.3k |
| MACQUARIE GROUP LTD 0.00% of their portfolio | 19.9k $1.2m | Added +1.5k |
| Dana Investment Advisors, Inc. 0.06% of their portfolio | 18.8k $1.2m | Reduced -80 |
| MetLife Investment Management, LLC 0.01% of their portfolio | 16.9k $1.0m | Unchanged |
| Raymond James Financial Services Advisors, Inc. 0.00% of their portfolio | 16.8k $1.0m | Added +361 |
| Meridian Wealth Management, LLC 0.09% of their portfolio | 16.5k $1.0m | Added +1.5k |
| UBS Group AG 0.00% of their portfolio | 16.3k $1.0m | Added +3.2k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 16.2k $1.0m | Added +1.8k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 15.7k $966.0k | Added +6.1k |
| AMERICAN INTERNATIONAL GROUP, INC. 0.01% of their portfolio | 15.5k $954.0k | Added +307 |
| Lion Street Advisors, LLC 0.29% of their portfolio | 15.1k $933.3k | Added +2.0k |
| Rhenman & Partners Asset Management AB 0.10% of their portfolio | 15.0k $908.2k | New |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 14.9k $920.0k | Reduced -26 |
| JANUS HENDERSON GROUP PLC 0.00% of their portfolio | 14.2k $876.9k | Added +9.3k |
| BLAIR WILLIAM & CO/IL 0.00% of their portfolio | 13.5k $834.2k | Added +4.2k |
| SG Americas Securities, LLC 0.01% of their portfolio | 13.3k $818.0k | Added +11.6k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 13.0k $803.3k | Added +35 |