Vault-13

AXSOME THERAPEUTICS INC AXSM

COM · Common Stock · CUSIP 05464T104 · ISIN US05464T1043

American biopharmaceutical company

198 institutional holders -21 vs Q4 2022
33,292,05533.3m shares reported held*
76.4% of all shares outstanding*
$2.1bnreported value*
21 new 69 added 65 reduced 41 sold out net bought ≈ $200.0m (+3.2m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($353.4k this quarter). Holder counts are more reliable. Shares outstanding: 43.6m as of 2023-05-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $61.66. Options: 15 managers hold calls ($79.2m notional), 13 hold puts ($56.9m).

Trends to Q1 2023

Institutional holders

Managers reporting a position, each quarter

0100200300Q3 22: 189Q4 22: 219Q1 23: 198198Q3 22Q4 22Q1 23
Numbers
QuarterHolders
Q3 2022189
Q4 2022219
Q1 2023198

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q4 22: 110 bought or addedQ4 22: 101 cut or sold outQ4 22Q1 23: 90 bought or addedQ1 23: 106 cut or sold outQ1 23
Numbers
QuarterBought or addedCut or sold out
Q4 2022110101
Q1 202390106

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$50m$100m$150m$200mQ3 22 calls: $113.6mQ3 22 puts: $113.3mQ3 22P/C 1.00Q4 22 calls: $179.1mQ4 22 puts: $132.8mQ4 22P/C 0.74Q1 23 calls: $79.2mQ1 23 puts: $56.9mQ1 23P/C 0.72
Numbers
QuarterCallsPutsP/C
Q3 2022$113.6m$113.3m1.00
Q4 2022$179.1m$132.8m0.74
Q1 2023$79.2m$56.9m0.72

Biggest buyers

FMR LLC Added +1,995,471+2.0m
MILLENNIUM MANAGEMENT LLC New +1,039,367+1.0m
RTW INVESTMENTS, LP Added +800,373+800.4k
Holocene Advisors, LP New +529,144+529.1k
Point72 Asset Management, L.P. Added +519,762+519.8k
BVF INC/IL Added +376,100+376.1k
Woodline Partners LP Added +347,173+347.2k
Privium Fund Management B.V. New +159,474+159.5k
Nicholas Investment Partners, LP Added +140,176+140.2k
Sofinnova Investments, Inc. New +120,896+120.9k

Biggest sellers

Venrock Adviser, LLC Sold out -670,718-670.7k
PFM Health Sciences, LP Reduced -486,750-486.8k
Cannell & Co. Reduced -250,810-250.8k
CITADEL ADVISORS LLC Reduced -164,720-164.7k
JANE STREET GROUP, LLC Reduced -154,155-154.2k
Balyasny Asset Management L.P. Sold out -120,874-120.9k
GROUP ONE TRADING LLC Reduced -119,859-119.9k
1832 Asset Management L.P. Sold out -118,200-118.2k
Man Group plc Sold out -116,492-116.5k
Hood River Capital Management LLC Reduced -79,473-79.5k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $23.2m376.0k shares
JANE STREET GROUP, LLC Added $18.1m292.7k shares
CITADEL ADVISORS LLC Reduced $9.5m154.8k shares
Ikarian Capital, LLC New $9.3m150.0k shares
SIMPLEX TRADING, LLC Reduced $5.9m96.4k shares
GROUP ONE TRADING LLC Reduced $4.8m78.3k shares
BOOTHBAY FUND MANAGEMENT, LLC Reduced $1.9m31.3k shares
D. E. Shaw & Co., Inc. Added $1.9m30.6k shares
Caption Management, LLC Reduced $1.9m30.0k shares
WOLVERINE TRADING, LLC Reduced $1.8m30.2k shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $14.7m239.0k shares
CITADEL ADVISORS LLC Reduced $13.1m211.7k shares
Ikarian Capital, LLC New $9.3m150.0k shares
JANE STREET GROUP, LLC Reduced $6.4m103.5k shares
SIMPLEX TRADING, LLC Reduced $4.5m73.1k shares
GROUP ONE TRADING LLC Reduced $3.1m49.9k shares
BOOTHBAY FUND MANAGEMENT, LLC Reduced $1.9m31.3k shares
Caption Management, LLC Reduced $1.9m30.0k shares
WOLVERINE TRADING, LLC Reduced $1.3m21.1k shares
PEAK6 Investments LLC New $623.0k10.1k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
BlackRock, Inc. 13G · institution filed 2026-07-27 5.3% 2.7m≈ $669.8m 2026-07-27

Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-26)

Insider purchases and sales in Q1 2023

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
404Q2 21: 0 buyingQ2 21: 0 sellingQ3 21: 0 buyingQ3 21: 0 sellingQ3 21Q4 21: 4 buyingQ4 21: 0 sellingQ1 22: 0 buyingQ1 22: 0 sellingQ1 22Q2 22: 0 buyingQ2 22: 0 sellingQ3 22: 0 buyingQ3 22: 0 sellingQ3 22Q4 22: 0 buyingQ4 22: 0 sellingQ1 23: 0 buyingQ1 23: 0 sellingQ1 23
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q2 20210—0——
Q3 20210—0——
Q4 20214$345.1k0——
Q1 20220—0——
Q2 20220—0——
Q3 20220—0——
Q4 20220—0——
Q1 20230—0——

None reported in Q1 2023.

Holders, Q1 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 RTW INVESTMENTS, LP 4.86% of their portfolio NEW YORK, NY 3,780,8553.8m $233.2m $233.2m 4.86% Added +800.4k +800,373
2 VANGUARD GROUP INC 0.01% of their portfolio Valley Forge, PA 3,485,7503.5m $215.0m $215.0m 0.01% Added +68.1k +68,122
3 FMR LLC 0.01% of their portfolio BOSTON, MA 2,729,9082.7m $168.4m $168.4m 0.01% Added +2.0m +1,995,471
4 BlackRock Inc. 0.00% of their portfolio New York, NY 2,468,2242.5m $152.2m $152.2m 0.00% Reduced -34.8k -34,753
5 BVF INC/IL 4.81% of their portfolio San Francisco, CA 2,131,1002.1m $131.4m $131.4m 4.81% Added +376.1k +376,100
6 Fairmount Funds Management LLC 21.34% of their portfolio WEST CONSHOHOCKEN, PA 2,011,6472.0m $124.1m $124.1m 21.34% Unchanged
7 Point72 Asset Management, L.P. 0.26% of their portfolio STAMFORD, CT 1,169,8271.2m $72.2m $72.2m 0.26% Added +519.8k +519,762
8 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.15% of their portfolio Boston, MA 1,050,0001.1m $64.8m $64.8m 0.15% Reduced -15.0k -15,000
9 MILLENNIUM MANAGEMENT LLC 0.07% of their portfolio NEW YORK, NY 1,039,3671.0m $64.1m $64.1m 0.07% New
10 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 796,045796.0k $49.1m $49.1m 0.00% Added +39.2k +39,175
11 ALETHEA CAPITAL MANAGEMENT, LLC 51.17% of their portfolio MERCER ISLAND, WA 785,683785.7k $48.5m $48.5m 51.17% Unchanged
12 GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio BOSTON, MA 652,436652.4k $40.2m $40.2m 0.01% Added +27.8k +27,847
13 Avidity Partners Management LP 1.27% of their portfolio DALLAS, TX 619,200619.2k $38.2m $38.2m 1.27% Reduced -50.8k -50,800
14 PFM Health Sciences, LP 1.72% of their portfolio SAN FRANCISCO, CA 606,081606.1k $37.4m $37.4m 1.72% Reduced -486.8k -486,750
15 Woodline Partners LP 0.50% of their portfolio San Francisco, CA 570,825570.8k $35.2m $35.2m 0.50% Added +347.2k +347,173
16 Holocene Advisors, LP 0.16% of their portfolio New York, NY 529,144529.1k $32.6m $32.6m 0.16% New
17 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 447,772447.8k $27.6m $27.6m 0.00% Reduced -29.5k -29,484
18 Bellevue Group AG 0.40% of their portfolio ZURICH, V8 441,350441.4k $27.2m $27.2m 0.40% Added +4.7k +4,692
19 Boxer Capital, LLC 1.21% of their portfolio San Diego, CA 400,000400.0k $24.7m $24.7m 1.21% Unchanged
20 Hood River Capital Management LLC 0.76% of their portfolio PALM BEACH GARDENS, FL 380,822380.8k $23.5m $23.5m 0.76% Reduced -79.5k -79,473
21 Nicholas Investment Partners, LP 1.60% of their portfolio RANCHO SANTA FE, CA 340,430340.4k $21.0m $21.0m 1.60% Added +140.2k +140,176
22 TANG CAPITAL MANAGEMENT LLC 2.94% of their portfolio SAN DIEGO, CA 320,000320.0k $19.7m $19.7m 2.94% Unchanged
23 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 318,052318.1k $19.6m $19.6m 0.00% Added +6.1k +6,107
24 Cormorant Asset Management, LP 1.22% of their portfolio BOSTON, MA 300,000300.0k $18.5m $18.5m 1.22% Reduced -25.0k -25,000
25 IRIDIAN ASSET MANAGEMENT LLC/CT 1.47% of their portfolio WESTPORT, CT 290,772290.8k $17.9m $17.9m 1.47% Reduced -27.8k -27,839
26 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 269,320269.3k $16.6m $16.6m 0.00% Added +3.5k +3,481
27 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 249,118249.1k $15.4m $15.4m 0.00% Reduced -652 -652
28 Ghost Tree Capital, LLC 5.25% of their portfolio NEW YORK, NY 225,000225.0k $13.9m $13.9m 5.25% Reduced -10.0k -10,000
29 NORGES BANK 0.00% of their portfolio OSLO, Q8 210,222210.2k $13.0m $13.0m 0.00% Reduced -46.2k -46,175
30 CITADEL ADVISORS LLC 0.01% of their portfolio MIAMI, FL 199,021199.0k $12.3m $12.3m 0.01% Reduced -164.7k -164,720
31 WMS Partners, LLC 1.04% of their portfolio TOWSON, MD 193,289193.3k $11.9m $11.9m 1.04% Unchanged
32 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 174,156174.2k $10.7m $10.7m 0.00% Added +6.6k +6,579
33 Driehaus Capital Management LLC 0.14% of their portfolio Chicago, IL 166,505166.5k $10.3m $10.3m 0.14% Reduced -66.6k -66,590
34 Privium Fund Management B.V. 3.30% of their portfolio AMSTERDAM, P7 159,474159.5k $9.8m $9.8m 3.30% New
35 Atika Capital Management LLC 1.49% of their portfolio NEW YORK, NY 155,000155.0k $9.6m $9.6m 1.49% Reduced -71.5k -71,535
36 Tri Locum Partners LP 2.80% of their portfolio NEW YORK, NY 149,205149.2k $9.2m $9.2m 2.80% Reduced -50.8k -50,849
37 US BANCORP \DE\ 0.01% of their portfolio MINNEAPOLIS, MN 135,491135.5k $8.4m $8.4m 0.01% Reduced -3.3k -3,301
38 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 125,116125.1k $7.7m $7.7m 0.00% Reduced -3.4k -3,382
39 SEI INVESTMENTS CO 0.01% of their portfolio OAKS, PA 124,109124.1k $7.7m $7.7m 0.01% Reduced -13.4k -13,358
40 Sofinnova Investments, Inc. 0.51% of their portfolio Menlo Park, CA 120,896120.9k $7.5m $7.5m 0.51% New
41 Cannell & Co. 0.26% of their portfolio New York, NY 119,210119.2k $7.4m $7.4m 0.26% Reduced -250.8k -250,810
42 PUTNAM INVESTMENTS LLC 0.01% of their portfolio BOSTON, MA 114,820114.8k $7.1m $7.1m 0.01% Added +581 +581
43 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 114,522114.5k $7.1m $7.1m 0.00% Reduced -7.4k -7,423
44 PEREGRINE CAPITAL MANAGEMENT LLC 0.19% of their portfolio MINNEAPOLIS, MN 108,281108.3k $6.7m $6.7m 0.19% Added +11.9k +11,895
45 ExodusPoint Capital Management, LP 0.07% of their portfolio NEW YORK, NY 96,68496.7k $6.0m $6.0m 0.07% New
46 Candriam S.C.A. 0.04% of their portfolio STRASSEN, N4 95,08495.1k $5.4m $5.4m 0.04% Reduced -76.4k -76,390
47 Hennion & Walsh Asset Management, Inc. 0.36% of their portfolio Parsippany, NJ 94,26494.3k $5.8m $5.8m 0.36% Added +1.1k +1,074
48 WCM INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio LAGUNA BEACH, CA 88,54588.5k $5.5m $5.5m 0.02% Reduced -194 -194
49 Lindbrook Capital, LLC 0.61% of their portfolio CALABASAS, CA 84,22184.2k $5.2m $5.2m 0.61% Reduced -329 -329
50 MPM BIOIMPACT LLC 1.13% of their portfolio BOSTON, MA 70,40270.4k $4.3m $4.3m 1.13% Added +18.4k +18,427
51 Swiss National Bank 0.00% of their portfolio ZURICH, V8 70,30070.3k $4.3m $4.3m 0.00% Reduced -2.7k -2,700
52 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 66,26866.3k $4.1m $4.1m 0.00% Reduced -10.7k -10,698
53 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 64,85964.9k $4.0m $4.0m 0.00% Added +16.8k +16,815
54 J. Goldman & Co LP 0.22% of their portfolio NEW YORK, NY 62,35162.4k $3.8m $3.8m 0.22% Added +59.7k +59,652
55 HighVista Strategies LLC 3.05% of their portfolio BOSTON, MA 60,77460.8k $3.7m $3.7m 3.05% Added +5.7k +5,650
56 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 60,52760.5k $3.7m $3.7m 0.00% Reduced -78.9k -78,932
57 Jump Financial, LLC 0.15% of their portfolio Chicago, IL 59,99160.0k $3.7m $3.7m 0.15% Added +27.2k +27,241
58 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 48,32248.3k $3.0m $3.0m 0.00% Added +7.7k +7,724
59 BALDWIN WEALTH PARTNERS LLC/MA 0.26% of their portfolio Marion, MA 47,49547.5k $2.9m $2.9m 0.26% Unchanged
60 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 44,07744.1k $2.7m $2.7m 0.00% Added +1.1k +1,138
61 MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC 0.03% of their portfolio New York, NY 41,24541.2k $2.5m $2.5m 0.03% Added +2.0k +1,993
62 FRONTIER CAPITAL MANAGEMENT CO LLC 0.03% of their portfolio Boston, MA 40,70540.7k $2.5m $2.5m 0.03% Reduced -48.7k -48,706
63 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 40,70040.7k $2.5m $2.5m 0.00% Unchanged
64 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 40,53540.5k $2.5m $2.5m 0.00% Added +1.4k +1,439
65 CREDIT SUISSE AG/ 0.00% of their portfolio ZURICH, V8 40,22340.2k $2.5m $2.5m 0.00% Reduced -4.9k -4,919
66 State of New Jersey Common Pension Fund D 0.01% of their portfolio TRENTON, NJ 37,07937.1k $2.3m $2.3m 0.01% New
67 SVB FINANCIAL GROUP 3.99% of their portfolio Dallas, TX 33,84933.8k $2.1m $2.1m 3.99% Unchanged
68 CIBC Private Wealth Group LLC 0.00% of their portfolio ATLANTA, GA 33,19033.2k $2.0m $2.0m 0.00% Added +15.8k +15,768
69 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 33,17833.2k $2.0m $2.0m 0.00% Added +30.5k +30,532
70 Moody Aldrich Partners LLC 0.41% of their portfolio MARBLEHEAD, MA 32,57932.6k $2.0m $2.0m 0.41% Reduced -19.6k -19,567
71 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 32,53732.5k $2.0m $2.0m 0.00% Added +1.3k +1,311
72 Brookfield Corp /ON/ 0.01% of their portfolio TORONTO, A6 31,60031.6k $1.9m $1.9m 0.01% Added +20.8k +20,822
73 Legal & General Group Plc 0.00% of their portfolio London, X0 30,64830.6k $1.9m $1.9m 0.00% Added +3.6k +3,637
74 DekaBank Deutsche Girozentrale 0.00% of their portfolio FRANKFURT, 2M 30,00030.0k $1.8m $1.8m 0.00% Unchanged
75 STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio MADISON, WI 29,59629.6k $1.8m $1.8m 0.01% Reduced -672 -672
76 ALPS ADVISORS INC 0.02% of their portfolio Denver, CO 28,67528.7k $1.8m $1.8m 0.02% Reduced -748 -748
77 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 25,36625.4k $1.6m $1.6m 0.00% Reduced -5.1k -5,073
78 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 24,83524.8k $1.5m $1.5m 0.00% Reduced -2.1k -2,119
79 TUDOR INVESTMENT CORP ET AL 0.03% of their portfolio STAMFORD, CT 23,86823.9k $1.5m $1.5m 0.03% New
80 Trexquant Investment LP 0.04% of their portfolio STAMFORD, CT 22,73222.7k $1.4m $1.4m 0.04% Reduced -1.2k -1,223
81 OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.03% of their portfolio CHICAGO, IL 22,56622.6k $1.4m $1.4m 0.03% New
82 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 21,74421.7k $1.3m $1.3m 0.00% Reduced -154.2k -154,155
83 Soleus Capital Management, L.P. 0.16% of their portfolio GREENWICH, CT 20,70020.7k $1.3m $1.3m 0.16% Reduced -29.3k -29,300
84 STRS OHIO 0.00% of their portfolio COLUMBUS, OH 20,10020.1k $1.2m $1.2m 0.00% Added +16.3k +16,300
85 MACQUARIE GROUP LTD 0.00% of their portfolio Sydney, NSW 2000, C3 19,90419.9k $1.2m $1.2m 0.00% Added +1.5k +1,498
86 Dana Investment Advisors, Inc. 0.06% of their portfolio BROOKFIELD, WI 18,84618.8k $1.2m $1.2m 0.06% Reduced -80 -80
87 MetLife Investment Management, LLC 0.01% of their portfolio Whippany, NJ 16,90016.9k $1.0m $1.0m 0.01% Unchanged
88 Raymond James Financial Services Advisors, Inc. 0.00% of their portfolio ST. PETERSBURG, FL 16,79316.8k $1.0m $1.0m 0.00% Added +361 +361
89 Meridian Wealth Management, LLC 0.09% of their portfolio LEXINGTON, KY 16,47316.5k $1.0m $1.0m 0.09% Added +1.5k +1,525
90 UBS Group AG 0.00% of their portfolio ZURICH, V8 16,27116.3k $1.0m $1.0m 0.00% Added +3.2k +3,214
91 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 16,24916.2k $1.0m $1.0m 0.00% Added +1.8k +1,770
92 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 15,66215.7k $966.0k $966.0k 0.00% Added +6.1k +6,119
93 AMERICAN INTERNATIONAL GROUP, INC. 0.01% of their portfolio New York, NY 15,46715.5k $954.0k $954.0k 0.01% Added +307 +307
94 Lion Street Advisors, LLC 0.29% of their portfolio Austin, TX 15,13215.1k $933.3k $933.3k 0.29% Added +2.0k +1,955
95 Rhenman & Partners Asset Management AB 0.10% of their portfolio Stockholm, V7 15,00015.0k $908.2k $908.2k 0.10% New
96 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 14,91614.9k $920.0k $920.0k 0.00% Reduced -26 -26
97 JANUS HENDERSON GROUP PLC 0.00% of their portfolio LONDON, X0 14,22414.2k $876.9k $876.9k 0.00% Added +9.3k +9,256
98 BLAIR WILLIAM & CO/IL 0.00% of their portfolio CHICAGO, IL 13,52513.5k $834.2k $834.2k 0.00% Added +4.2k +4,175
99 SG Americas Securities, LLC 0.01% of their portfolio NEW YORK, NY 13,26913.3k $818.0k $818.0k 0.01% Added +11.6k +11,561
100 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 13,02313.0k $803.3k $803.3k 0.00% Added +35 +35