AVALO THERAPEUTICS INC AVTX
COM NEW · Common Stock · CUSIP 05338F306
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersWayne, PA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 53.6m as of 2026-08-03, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $18.48. Options: 6 managers hold calls ($9.7m notional), 7 hold puts ($8.0m).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q4 2023 | 13 |
| Q1 2024 | 19 |
| Q2 2024 | 22 |
| Q3 2024 | 30 |
| Q4 2024 | 34 |
| Q1 2025 | 35 |
| Q2 2025 | 37 |
| Q3 2025 | 66 |
| Q4 2025 | 84 |
| Q1 2026 | 97 |
| Q2 2026 | 126 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 13 | 3 |
| Q4 2024 | 15 | 9 |
| Q1 2025 | 16 | 8 |
| Q2 2025 | 13 | 14 |
| Q3 2025 | 47 | 10 |
| Q4 2025 | 58 | 28 |
| Q1 2026 | 60 | 38 |
| Q2 2026 | 102 | 42 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $1.4m | $658.8k | 0.48 |
| Q4 2025 | $6.0m | $3.3m | 0.55 |
| Q1 2026 | $43.0m | $5.7m | 0.13 |
| Q2 2026 | $9.7m | $8.0m | 0.82 |
Biggest buyers
| BlackRock, Inc. | Added | +4.0m |
| Deep Track Capital, LP | New | +3.6m |
| STATE STREET CORP | Added | +2.8m |
| Nantahala Capital Management, LLC | Added | +2.5m |
| TCG Crossover Management, LLC | Added | +2.3m |
| FMR LLC | Added | +2.2m |
| BRAIDWELL LP | New | +1.6m |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | Added | +1.6m |
| Affinity Asset Advisors, LLC | Added | +1.6m |
| VANGUARD CAPITAL MANAGEMENT LLC | Added | +1.5m |
Biggest sellers
| T. Rowe Price Investment Management, Inc. | Sold out | -2.2m |
| MILLENNIUM MANAGEMENT LLC | Sold out | -835.5k |
| RTW INVESTMENTS, LP | Reduced | -682.0k |
| ORBIMED ADVISORS LLC | Sold out | -475.2k |
| JENNISON ASSOCIATES LLC | Sold out | -470.8k |
| KENNEDY CAPITAL MANAGEMENT LLC | Sold out | -388.0k |
| DV Trading LLC | Sold out | -360.1k |
| BNP PARIBAS FINANCIAL MARKETS | Reduced | -288.7k |
| STEMPOINT CAPITAL LP | Sold out | -269.5k |
| Caption Management, LLC | Reduced | -245.0k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $4.5m241.9k shares |
| CITADEL ADVISORS LLC | Added | $2.1m112.6k shares |
| LMR Partners LLP | New | $1.7m94.1k shares |
| JANE STREET GROUP, LLC | Added | $1.1m57.8k shares |
| SIMPLEX TRADING, LLC | Reduced | $341.9k18.5k shares |
| GROUP ONE TRADING LLC | Reduced | $11.1k600 shares |
Biggest puts
| Caption Management, LLC | New | $6.4m344.8k shares |
| LMR Partners LLP | New | $554.4k30.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $304.9k16.5k shares |
| CITADEL ADVISORS LLC | New | $255.0k13.8k shares |
| SIMPLEX TRADING, LLC | Added | $232.8k12.6k shares |
| GROUP ONE TRADING LLC | Added | $194.0k10.5k shares |
| JPMORGAN CHASE & CO | New | $54.0k2.8k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution +1.1 pts · filed 2026-08-07 | 10.8% |
| Commodore Capital LP 13G · passive investor new · filed 2026-06-18 | 9.9% |
| TCG Crossover GP II, LLC 13G · passive investor new · filed 2026-05-12 | 7.9% |
| Deep Track Capital, LP 13G · passive investor +1.1 pts · filed 2026-08-14 | 6.9% |
| BlackRock, Inc. 13G · institution new · filed 2026-07-27 | 6.5% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor -3.6 pts · filed 2026-08-14 | 6.3% |
| Caligan Partners LP 13G · institution -1.3 pts · filed 2026-08-14 | 5.9% |
| Affinity Asset Advisors, LLC 13G · institution no change · filed 2026-08-13 | 5.5% |
| STATE STREET CORP 13G · institution new · filed 2026-08-07 | 5.5% |
| BIOTECHNOLOGY VALUE FUND L P 13G · passive investor -4.7 pts · filed 2026-08-14 | 5.3% |
| Point72 Asset Management, L.P. 13G · passive investor +1.7 pts · filed 2026-05-26 | 5.2% |
Fell to 5% or below in the last year: T. Rowe Price Investment Management, Inc. (0.0%, 2026-08-14), Nantahala Capital Management, LLC (3.5%, 2026-08-14), Avoro Capital Advisors LLC (4.4%, 2026-08-14), MILLENNIUM MANAGEMENT LLC (0.0%, 2026-07-06), Logos Global Management LP (3.2%, 2026-05-15), ORBIMED ADVISORS LLC (2.1%, 2026-05-15), BALYASNY ASSET MANAGEMENT L.P. (2.4%, 2026-02-17), SILVERARC CAPITAL MANAGEMENT, LLC (2.8%, 2026-02-10), VANGUARD GROUP INC (4.4%, 2026-01-30), Ikarian Capital, LLC (3.8%, 2025-11-14)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 1 | $12.8k | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 0 | — | 1 | $163.0k | — |
| Q1 2026 | 0 | — | 1 | $411.7k | $411.7k |
| Q2 2026 | 0 | — | 4 | $6.0m | $6.0m |
| Q3 2026 | 0 | — | 3 | $2.0m | $1.9m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-09-16 | Sullivan Christopher Ryan Chief Financial Officer | Sold plan | $202.4k12.4k shares |
| 2026-09-10 | Sullivan Christopher Ryan Chief Financial Officer | Sold plan | $179.5k10.2k shares |
| 2026-08-28 | Doyle Mittie Chief Medical Officer | Sold plan | $13.6k679 shares |
| 2026-08-18 | Sullivan Christopher Ryan Chief Financial Officer | Sold plan | $622.2k31.0k shares |
| 2026-08-17 | Sullivan Christopher Ryan Chief Financial Officer | Sold plan | $828.0k41.7k shares |
| 2026-08-17 | Doyle Mittie Chief Medical Officer | Sold plan | $20.0k1.0k shares |
| 2026-08-11 | Riley Jennifer Chief Strategy Officer | Sold | $52.0k2.7k shares |
| 2026-08-10 | Doyle Mittie Chief Medical Officer | Sold plan | $13.6k679 shares |
| 2026-07-27 | Doyle Mittie Chief Medical Officer | Sold plan | $20.0k1.0k shares |
| 2026-06-30 | Doyle Mittie Chief Medical Officer | Sold plan | $93.1k4.7k shares |
| 2026-06-23 | Doyle Mittie Chief Medical Officer | Sold plan | $26.1k1.4k shares |
| 2026-05-28 | Doyle Mittie Chief Medical Officer | Sold plan | $10.9k679 shares |
| 2026-05-15 | Doyle Mittie Chief Medical Officer | Sold plan | $56.3k3.0k shares |
| 2026-05-07 | Sullivan Christopher Ryan Chief Financial Officer | Sold plan | $448.8k18.6k shares |
| 2026-05-06 | Doyle Mittie Chief Medical Officer | Sold plan | $2.2m106.6k shares |
| 2026-05-06 | VARKI PAUL Chief Legal Officer | Sold plan | $1.5m75.1k shares |
| 2026-05-06 | Sullivan Christopher Ryan Chief Financial Officer | Sold plan | $948.6k47.0k shares |
| 2026-05-06 | Chan Mitchell Director | Sold plan | $72.5k3.2k shares |
| 2026-05-05 | Doyle Mittie Chief Medical Officer | Sold plan | $26.9k1.7k shares |
| 2026-04-30 | Sullivan Christopher Ryan Chief Financial Officer | Sold plan | $111.9k8.5k shares |
| 2026-04-29 | Sullivan Christopher Ryan Chief Financial Officer | Sold plan | $110.7k8.5k shares |
| 2026-04-06 | Doyle Mittie Chief Medical Officer | Sold plan | $71.5k4.0k shares |
| 2026-04-02 | Sullivan Christopher Ryan Chief Financial Officer | Sold plan | $136.8k8.0k shares |
| 2026-04-01 | Sullivan Christopher Ryan Chief Financial Officer | Sold plan | $133.8k8.0k shares |
| 2026-04-01 | Doyle Mittie Chief Medical Officer | Sold plan | $10.9k679 shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.00% of their portfolio | 5.1m $94.3m | Added +2.2m |
| BlackRock, Inc. 0.00% of their portfolio | 4.4m $80.7m | Added +4.0m |
| Nantahala Capital Management, LLC 2.09% of their portfolio | 3.7m $68.8m | Added +2.5m |
| Deep Track Capital, LP 0.98% of their portfolio | 3.6m $66.7m | New |
| Caligan Partners LP 2.82% of their portfolio | 3.2m $58.5m | Added +1.5m |
| TCG Crossover Management, LLC 1.34% of their portfolio | 3.0m $55.8m | Added +2.3m |
| Affinity Asset Advisors, LLC 2.62% of their portfolio | 2.9m $53.6m | Added +1.6m |
| STATE STREET CORP 0.00% of their portfolio | 2.9m $53.4m | Added +2.8m |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 0.27% of their portfolio | 2.5m $46.2m | Added +1.6m |
| Point72 Asset Management, L.P. 0.07% of their portfolio | 2.4m $44.1m | Added +1.5m |
| Avoro Capital Advisors LLC 0.39% of their portfolio | 2.3m $43.1m | Added +923.3k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 2.3m $41.8m | Added +1.5m |
| BVF INC/IL 0.98% of their portfolio | 2.1m $38.4m | Added +442.7k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 1.9m $35.4m | Added +1.3m |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.04% of their portfolio | 1.7m $32.0m | Added +875.0k |
| Soleus Capital Management, L.P. 1.05% of their portfolio | 1.7m $30.6m | Added +1.2m |
| BRAIDWELL LP 1.11% of their portfolio | 1.6m $30.1m | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 1.3m $24.2m | New |
| ALLIANCEBERNSTEIN L.P. 0.01% of their portfolio | 1.3m $23.3m | New |
| UBS Group AG 0.00% of their portfolio | 1.2m $22.3m | Added +67.1k |
| Logos Global Management LP 0.91% of their portfolio | 1.1m $21.3m | Added +850.0k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.1m $20.4m | Added +935.2k |
| Commodore Capital LP 1.12% of their portfolio | 1.0m $18.8m | Added +535.3k |
| RA CAPITAL MANAGEMENT, L.P. 0.16% of their portfolio | 1.0m $18.5m | Added +337.0k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 946.3k $17.5m | Added +886.2k |
| Trails Edge Capital Partners, LP 2.62% of their portfolio | 891.9k $16.5m | New |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 891.4k $16.5m | Added +719.3k |
| Balyasny Asset Management L.P. 0.03% of their portfolio | 861.7k $15.9m | Added +130.1k |
| Vestal Point Capital, LP 0.33% of their portfolio | 775.0k $14.3m | New |
| Seven Fleet Capital Management LP 2.35% of their portfolio | 770.8k $14.2m | Added +196.9k |
| Parkman Healthcare Partners LLC 1.45% of their portfolio | 766.3k $14.2m | New |
| BOOTHBAY FUND MANAGEMENT, LLC 0.24% of their portfolio | 702.1k $13.0m | Added +377.8k |
| Squarepoint Ops LLC 0.02% of their portfolio | 589.2k $10.9m | Added +508.0k |
| BAKER BROS. ADVISORS LP 0.05% of their portfolio | 550.0k $10.2m | New |
| SILVERARC CAPITAL MANAGEMENT, LLC 1.03% of their portfolio | 500.4k $9.2m | New |
| Davern Capital Partners, LP 1.48% of their portfolio | 468.7k $8.7m | New |
| Pivotal bioVenture Partners Investment Advisor LLC 2.61% of their portfolio | 434.0k $8.0m | Added +138.1k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 404.2k $7.5m | New |
| Boxer Capital Management, LLC 0.52% of their portfolio | 375.0k $6.9m | Added +75.0k |
| RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio | 357.2k $6.6m | Added +237.1k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 344.5k $6.4m | Added +314.0k |
| DV EQUITIES, LLC 0.89% of their portfolio | 332.2k $6.1m | First filing |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 324.8k $6.0m | Added +238.4k |
| Velan Capital Investment Management LP 3.67% of their portfolio | 324.5k $6.0m | Added +139.3k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 323.8k $6.0m | Added +130.1k |
| Schonfeld Strategic Advisors LLC 0.03% of their portfolio | 310.0k $5.7m | New |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 284.7k $5.3m | New |
| Vivo Capital, LLC 0.46% of their portfolio | 275.0k $5.1m | New |
| Eagle Health Investments LP 0.72% of their portfolio | 235.1k $4.3m | New |
| SPHERA FUNDS MANAGEMENT LTD. 0.61% of their portfolio | 232.3k $4.3m | New |
| PERCEPTIVE ADVISORS LLC 0.06% of their portfolio | 219.8k $4.1m | Added +80.1k |
| Caption Management, LLC 0.14% of their portfolio | 210.0k $3.9m | Reduced -245.0k |
| Jump Financial, LLC 0.03% of their portfolio | 201.9k $3.7m | Added +189.1k |
| NAN FUNG TRINITY (HK) LTD 0.34% of their portfolio | 189.0k $3.5m | Unchanged |
| ACUTA CAPITAL PARTNERS, LLC 2.40% of their portfolio | 186.3k $3.4m | Added +125.5k |
| Walleye Capital LLC 0.02% of their portfolio | 185.6k $3.4m | New |
| RTW INVESTMENTS, LP 0.03% of their portfolio | 175.0k $3.2m | Reduced -682.0k |
| Ally Bridge Group (NY) LLC 3.57% of their portfolio | 150.0k $2.8m | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 137.5k $2.5m | Added +127.5k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 134.1k $2.5m | Reduced -288.7k |
| CenterBook Partners LP 0.12% of their portfolio | 132.9k $2.5m | New |
| MORGAN STANLEY 0.00% of their portfolio | 128.1k $2.4m | Reduced -33.3k |
| Moody Aldrich Partners LLC 0.42% of their portfolio | 125.6k $2.3m | Reduced -33.7k |
| HighVista Strategies LLC 0.52% of their portfolio | 122.6k $2.3m | Added +64.0k |
| Aberdeen Group plc 0.00% of their portfolio | 122.2k $2.3m | Reduced -49.5k |
| SECTORAL ASSET MANAGEMENT INC 1.55% of their portfolio | 119.9k $2.2m | New |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 105.3k $1.9m | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 102.7k $1.9m | New |
| Nuveen, LLC 0.00% of their portfolio | 100.6k $1.9m | New |
| Ikarian Capital, LLC 0.27% of their portfolio | 90.2k $1.7m | New |
| TD Asset Management Inc 0.00% of their portfolio | 77.5k $1.4m | Added +26.1k |
| CITIGROUP INC 0.00% of their portfolio | 69.0k $1.3m | New |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 67.1k $1.2m | Added +2.7k |
| Rafferty Asset Management, LLC 0.00% of their portfolio | 56.4k $1.0m | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 53.8k $994.2k | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 53.3k $984.8k | New |
| XTX Topco Ltd 0.01% of their portfolio | 52.6k $971.7k | Reduced -74.1k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 41.2k $760.7k | Reduced -108.8k |
| Verition Fund Management LLC 0.00% of their portfolio | 38.2k $706.7k | New |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 38.2k $706.9k | Reduced -2.7k |
| Man Group plc 0.00% of their portfolio | 36.9k $681.5k | Reduced -9.7k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 36.6k $675.9k | New |
| Verdad Advisers, LP 0.58% of their portfolio | 32.8k $606.6k | New |
| PROFUND ADVISORS LLC 0.01% of their portfolio | 28.3k $523.1k | New |
| GLENMEDE TRUST CO NA 0.00% of their portfolio | 28.3k $522.6k | Added +2.5k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 27.2k $503.2k | New |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 25.7k $480.5k | New |
| Persistent Asset Partners Ltd 0.14% of their portfolio | 24.5k $453.6k | Added +16.6k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 24.5k $452.7k | New |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 22.5k $416.5k | Added +2.5k |
| Invesco Ltd. 0.00% of their portfolio | 22.2k $410.7k | New |
| Virtus Investment Advisers, LLC 0.10% of their portfolio | 22.2k $409.7k | New |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 20.0k $369.8k | Added +14.4k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 18.1k $350.0k | Reduced -176.2k |
| SEI INVESTMENTS CO 0.00% of their portfolio | 17.9k $331.4k | Reduced -38.9k |
| BARCLAYS PLC 0.00% of their portfolio | 17.8k $329.1k | Added +3.2k |
| ExodusPoint Capital Management, LP 0.00% of their portfolio | 16.5k $304.8k | Reduced -1.3k |
| Quadrature Capital Ltd 0.00% of their portfolio | 15.4k $284.7k | Reduced -109.8k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 14.7k $271.7k | New |
| Jain Global LLC 0.00% of their portfolio | 12.7k $234.4k | New |