Vault-13

ARROWHEAD PHARMACEUTICALS IN ARWR

COM · Common Stock · CUSIP 04280A100 · ISIN US04280A1007

Biopharmaceutical company

438 institutional holders +36 vs Q4 2025
120,795,085120.8m shares reported held*
85.8% of all shares outstanding*
$7.6bnreported value*
93 new 171 added 112 reduced 59 sold out net bought ≈ $469.7m (+7.5m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($2.2m this quarter). Holder counts are more reliable. Shares outstanding: 140.9m as of 2026-05-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $62.70. Options: 16 managers hold calls ($106.3m notional), 14 hold puts ($55.8m).

Trends to Q1 2026

Institutional holders

Managers reporting a position, each quarter

0200400600Q3 22: 278Q4 22: 283Q1 23: 257Q2 23: 274Q3 23: 258Q4 23: 267Q1 24: 276Q2 24: 274Q3 24: 273Q4 24: 271Q1 25: 266Q2 25: 282Q3 25: 303Q4 25: 402Q1 26: 438438Q3 22Q3 23Q3 24Q3 25Q1 26
Numbers
QuarterHolders
Q3 2022278
Q4 2022283
Q1 2023257
Q2 2023274
Q3 2023258
Q4 2023267
Q1 2024276
Q2 2024274
Q3 2024273
Q4 2024271
Q1 2025266
Q2 2025282
Q3 2025303
Q4 2025402
Q1 2026438

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
4000400Q2 24: 129 bought or addedQ2 24: 121 cut or sold outQ3 24: 121 bought or addedQ3 24: 123 cut or sold outQ3 24Q4 24: 122 bought or addedQ4 24: 127 cut or sold outQ1 25: 130 bought or addedQ1 25: 126 cut or sold outQ1 25Q2 25: 151 bought or addedQ2 25: 120 cut or sold outQ3 25: 165 bought or addedQ3 25: 121 cut or sold outQ3 25Q4 25: 234 bought or addedQ4 25: 137 cut or sold outQ1 26: 264 bought or addedQ1 26: 171 cut or sold outQ1 26
Numbers
QuarterBought or addedCut or sold out
Q2 2024129121
Q3 2024121123
Q4 2024122127
Q1 2025130126
Q2 2025151120
Q3 2025165121
Q4 2025234137
Q1 2026264171

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$50m$100m$150m$200mQ2 25 calls: $8.2mQ2 25 puts: $10.6mQ2 25P/C 1.28Q3 25 calls: $39.1mQ3 25 puts: $9.8mQ3 25P/C 0.25Q4 25 calls: $156.8mQ4 25 puts: $38.8mQ4 25P/C 0.25Q1 26 calls: $106.3mQ1 26 puts: $55.8mQ1 26P/C 0.53
Numbers
QuarterCallsPutsP/C
Q2 2025$8.2m$10.6m1.28
Q3 2025$39.1m$9.8m0.25
Q4 2025$156.8m$38.8m0.25
Q1 2026$106.3m$55.8m0.53

Biggest buyers

Invesco Ltd. Added +2,732,889+2.7m
FRED ALGER MANAGEMENT, LLC Added +1,509,496+1.5m
Vestal Point Capital, LP Added +1,375,000+1.4m
Hood River Capital Management LLC New +1,056,534+1.1m
D. E. Shaw & Co., Inc. Added +1,037,774+1.0m
RENAISSANCE TECHNOLOGIES LLC New +1,036,495+1.0m
GEODE CAPITAL MANAGEMENT, LLC Added +1,013,865+1.0m
FMR LLC Added +746,244+746.2k
AMERICAN CENTURY COMPANIES INC Added +643,802+643.8k
BNP PARIBAS FINANCIAL MARKETS Added +610,201+610.2k

Biggest sellers

BlackRock, Inc. Reduced -3,157,063-3.2m
Slate Path Capital LP Sold out -2,523,500-2.5m
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP Reduced -1,500,828-1.5m
Assenagon Asset Management S.A. Reduced -626,154-626.2k
Driehaus Capital Management LLC Reduced -579,005-579.0k
ADAGE CAPITAL PARTNERS GP, L.L.C. Sold out -550,000-550.0k
MORGAN STANLEY Reduced -515,498-515.5k
Public Sector Pension Investment Board Sold out -478,514-478.5k
CITADEL ADVISORS LLC Reduced -376,065-376.1k
VOLORIDGE INVESTMENT MANAGEMENT, LLC Sold out -288,511-288.5k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $58.6m934.9k shares
CITADEL ADVISORS LLC Reduced $11.7m187.0k shares
JANE STREET GROUP, LLC Reduced $9.7m155.2k shares
SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC Reduced $9.4m150.0k shares
Caption Management, LLC Reduced $4.3m68.6k shares
GROUP ONE TRADING LLC Reduced $4.1m65.1k shares
Point72 Asset Management, L.P. Added $2.2m34.9k shares
CITIGROUP INC New $1.3m20.5k shares
SIMPLEX TRADING, LLC New $1.2m19.4k shares
PEAK6 LLC Reduced $1.0m16.1k shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $32.8m522.7k shares
JANE STREET GROUP, LLC Reduced $7.2m114.1k shares
CITADEL ADVISORS LLC Reduced $4.1m65.3k shares
Ikarian Capital, LLC New $3.6m57.5k shares
Caption Management, LLC New $1.9m30.0k shares
CITIGROUP INC New $1.3m20.5k shares
HRT FINANCIAL LP New $1.1m17.6k shares
BOOTHBAY FUND MANAGEMENT, LLC New $1.1m16.8k shares
SIMPLEX TRADING, LLC New $1.0m16.7k shares
Point72 Asset Management, L.P. Added $721.0k11.5k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
BlackRock, Inc. 13G · institution -2.1 pts · filed 2026-07-27 10.1% -2.1 pts 14.2m≈ $1.2bn 2026-07-27
Avoro Capital Advisors LLC 13G · institution +1.3 pts · filed 2026-08-14 9.6% +1.3 pts 13.8m≈ $1.1bn 2026-08-14
FMR LLC 13G · institution new · filed 2026-05-06 5.2% new 7.3m≈ $599.0m 2026-05-06
VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-29 5.0% new 7.1m≈ $577.2m 2026-04-29

Fell to 5% or below in the last year: VANGUARD PORTFOLIO MANAGEMENT LLC (4.5%, 2026-07-31; now reported by VANGUARD CAPITAL MANAGEMENT LLC), VANGUARD GROUP INC (0.0%, 2026-03-26; now reported by VANGUARD CAPITAL MANAGEMENT LLC)

Insider purchases and sales in Q1 2026

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
10010Q2 24: 1 buyingQ2 24: 2 sellingQ3 24: 0 buyingQ3 24: 1 sellingQ3 24Q4 24: 0 buyingQ4 24: 5 sellingQ1 25: 0 buyingQ1 25: 5 sellingQ1 25Q2 25: 0 buyingQ2 25: 1 sellingQ3 25: 0 buyingQ3 25: 1 sellingQ3 25Q4 25: 0 buyingQ4 25: 7 sellingQ1 26: 0 buyingQ1 26: 3 sellingQ1 26
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q2 20241$27.6k2$210.1k$41.9k
Q3 20240—1$237.5k$237.5k
Q4 20240—5$1.4m$1.4m
Q1 20250—5$8.6m$7.8m
Q2 20250—1$1.5m—
Q3 20250—1$1.0m$1.0m
Q4 20250—7$27.8m$8.5m
Q1 20260—3$7.2m$7.2m
DateInsiderTradeSharesPrice ValueTheir holding
2026-03-05 Hamilton James C Chief Medical Officer Sold plan 10,000 $64.19 $641.9k10.0k shares -4%
2026-01-05 O'Brien Patrick COO Sold plan 49,493 $63.11 $3.1m49.5k shares -9%
2026-01-05 Hamilton James C Chief Medical Officer Sold plan 40,164 $63.11 $2.5m40.2k shares -19%
2026-01-02 Anzalone Christopher Richard Chief Executive Officer, director Sold plan 13,187 $66.10 $871.7k13.2k shares -<1%

Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).

Holders, Q1 2026

#ManagerLocationShares Value% of their portfolioChangeShares change
1 BlackRock, Inc. 0.02% of their portfolio New York, NY 18,161,51918.2m $1.1bn $1.1bn 0.02% Reduced -3.2m -3,157,063
2 Avoro Capital Advisors LLC 6.61% of their portfolio NEW YORK, NY 10,699,99910.7m $670.9m $670.9m 6.61% Added +75.0k +74,999
3 FMR LLC 0.02% of their portfolio BOSTON, MA 7,266,6527.3m $455.6m $455.6m 0.02% Added +746.2k +746,244
4 VANGUARD PORTFOLIO MANAGEMENT LLC 0.02% of their portfolio MALVERN, PA 7,146,1367.1m $448.1m $448.1m 0.02% First filing
5 STATE STREET CORP 0.01% of their portfolio BOSTON, MA 6,496,1306.5m $407.3m $407.3m 0.01% Added +92.3k +92,300
6 VANGUARD CAPITAL MANAGEMENT LLC 0.01% of their portfolio MALVERN, PA 6,032,4166.0m $378.2m $378.2m 0.01% First filing
7 GEODE CAPITAL MANAGEMENT, LLC 0.02% of their portfolio BOSTON, MA 4,278,8284.3m $274.5m $274.5m 0.02% Added +1.0m +1,013,865
8 FRED ALGER MANAGEMENT, LLC 0.92% of their portfolio NEW YORK, NY 3,342,4933.3m $209.6m $209.6m 0.92% Added +1.5m +1,509,496
9 Invesco Ltd. 0.02% of their portfolio ATLANTA, GA 3,280,6473.3m $205.7m $205.7m 0.02% Added +2.7m +2,732,889
10 Vestal Point Capital, LP 3.99% of their portfolio NEW YORK, NY 2,275,0002.3m $142.6m $142.6m 3.99% Added +1.4m +1,375,000
11 BAKER BROS. ADVISORS LP 0.72% of their portfolio NEW YORK, NY 1,992,7832.0m $124.9m $124.9m 0.72% Reduced -182.9k -182,862
12 GOLDMAN SACHS GROUP INC 0.01% of their portfolio NEW YORK, NY 1,739,9231.7m $109.1m $109.1m 0.01% Added +62.4k +62,401
13 NORTHERN TRUST CORP 0.01% of their portfolio CHICAGO, IL 1,655,8371.7m $103.8m $103.8m 0.01% Added +309.6k +309,580
14 Siren, L.L.C. 2.81% of their portfolio New York, NY 1,615,4761.6m $101.3m $101.3m 2.81% Added +115.0k +115,000
15 DEERFIELD MANAGEMENT COMPANY, L.P. 1.16% of their portfolio New York, NY 1,573,2971.6m $98.6m $98.6m 1.16% Reduced -259.6k -259,649
16 JANUS HENDERSON GROUP PLC 0.04% of their portfolio LONDON, X0 1,436,9901.4m $90.1m $90.1m 0.04% Added +156.5k +156,544
17 UBS Group AG 0.01% of their portfolio ZURICH, V8 1,336,2711.3m $83.8m $83.8m 0.01% Added +349.0k +348,984
18 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.02% of their portfolio NEW YORK, NY 1,330,9961.3m $83.5m $83.5m 0.02% Added +70.6k +70,616
19 Pictet Asset Management Holding SA 0.08% of their portfolio CAROUGE, V8 1,273,2661.3m $79.6m $79.6m 0.08% Added +244.5k +244,530
20 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio SAN FRANCISCO, CA 1,192,0851.2m $74.7m $74.7m 0.01% Reduced -161.6k -161,634
21 Driehaus Capital Management LLC 0.55% of their portfolio Chicago, IL 1,190,3351.2m $74.6m $74.6m 0.55% Reduced -579.0k -579,005
22 D. E. Shaw & Co., Inc. 0.06% of their portfolio New York, NY 1,183,8381.2m $74.2m $74.2m 0.06% Added +1.0m +1,037,774
23 Fisher Asset Management, LLC 0.02% of their portfolio PLANO, TX 1,113,5681.1m $69.8m $69.8m 0.02% Reduced -198.2k -198,159
24 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 1,064,4551.1m $66.7m $66.7m 0.00% Added +442.4k +442,426
25 Hood River Capital Management LLC 0.66% of their portfolio PALM BEACH GARDENS, FL 1,056,5341.1m $66.2m $66.2m 0.66% New
26 PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio BALTIMORE, MD 1,043,7321.0m $65.4m $65.4m 0.01% Added +204.9k +204,914
27 RENAISSANCE TECHNOLOGIES LLC 0.10% of their portfolio NEW YORK, NY 1,036,4951.0m $65.0m $65.0m 0.10% New
28 VANGUARD FIDUCIARY TRUST CO 0.02% of their portfolio MALVERN, PA 965,775965.8k $60.6m $60.6m 0.02% First filing
29 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 960,507960.5k $60.2m $60.2m 0.00% Reduced -515.5k -515,498
30 Bank of New York Mellon Corp 0.01% of their portfolio NEW YORK, NY 960,144960.1k $60.2m $60.2m 0.01% Added +72.3k +72,296
31 Connor, Clark & Lunn Investment Management Ltd. 0.12% of their portfolio VANCOUVER, A1 836,981837.0k $52.5m $52.5m 0.12% Added +173.7k +173,719
32 Western Financial Corp/CA 20.13% of their portfolio SAN DIEGO, CA 820,239820.2k $51.4m $51.4m 20.13% Unchanged
33 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 683,068683.1k $39.4m $39.4m 0.00% Added +71.2k +71,158
34 VOYA INVESTMENT MANAGEMENT LLC 0.04% of their portfolio ATLANTA, GA 656,129656.1k $41.1m $41.1m 0.04% Added +233.4k +233,398
35 AMERICAN CENTURY COMPANIES INC 0.02% of their portfolio KANSAS CITY, MO 651,544651.5k $40.9m $40.9m 0.02% Added +643.8k +643,802
36 BNP PARIBAS FINANCIAL MARKETS 0.03% of their portfolio PARIS, I0 650,599650.6k $40.8m $40.8m 0.03% Added +610.2k +610,201
37 DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio AUSTIN, TX 608,531608.5k $38.1m $38.1m 0.01% Added +461.1k +461,119
38 ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.02% of their portfolio BOSTON, MA 587,125587.1k $36.8m $36.8m 0.02% Reduced -1.5m -1,500,828
39 RTW INVESTMENTS, LP 0.37% of their portfolio NEW YORK, NY 585,682585.7k $36.7m $36.7m 0.37% Added +966 +966
40 SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC 1.57% of their portfolio Boston, MA 540,144540.1k $33.9m $33.9m 1.57% Added +70.1k +70,144
41 Nuveen, LLC 0.01% of their portfolio CHARLOTTE, NC 499,837499.8k $31.3m $31.3m 0.01% Added +211.3k +211,259
42 PRINCIPAL FINANCIAL GROUP INC 0.02% of their portfolio DES MOINES, IA 490,122490.1k $30.7m $30.7m 0.02% Reduced -225.4k -225,417
43 Alyeska Investment Group, L.P. 0.08% of their portfolio CHICAGO, IL 472,870472.9k $29.6m $29.6m 0.08% Added +97.5k +97,499
44 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 462,707462.7k $29.0m $29.0m 0.01% Added +355.3k +355,341
45 PANAGORA ASSET MANAGEMENT INC 0.11% of their portfolio BOSTON, MA 461,193461.2k $28.9m $28.9m 0.11% Added +425.2k +425,238
46 RHUMBLINE ADVISERS 0.02% of their portfolio BOSTON, MA 404,436404.4k $25.4m $25.4m 0.02% Added +52.0k +52,041
47 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.03% of their portfolio BALA CYNWYD, PA 378,833378.8k $23.8m $23.8m 0.03% Added +349.9k +349,922
48 EVENTIDE ASSET MANAGEMENT, LLC 0.38% of their portfolio Boston, MA 370,000370.0k $23.2m $23.2m 0.38% Unchanged
49 Privium Fund Management B.V. 4.79% of their portfolio AMSTERDAM, P7 366,936366.9k $23.0m $23.0m 4.79% Reduced -31.3k -31,268
50 Aberdeen Group plc 0.04% of their portfolio EDINBURGH, X0 363,972364.0k $22.8m $22.8m 0.04% Added +77.8k +77,826
51 CANADA PENSION PLAN INVESTMENT BOARD 0.01% of their portfolio TORONTO ONTARIO, A6 325,700325.7k $20.4m $20.4m 0.01% Added +297.1k +297,100
52 LORD, ABBETT & CO. LLC 0.06% of their portfolio JERSEY CITY, NJ 312,824312.8k $19.6m $19.6m 0.06% New
53 NORDEA INVESTMENT MANAGEMENT AB 0.02% of their portfolio STOCKHOLM, V7 306,439306.4k $18.6m $18.6m 0.02% Reduced -17.8k -17,812
54 Integral Health Asset Management, LLC 1.00% of their portfolio New York, NY 300,000300.0k $18.8m $18.8m 1.00% Added +200.0k +200,000
55 ALLIANCEBERNSTEIN L.P. 0.01% of their portfolio NASHVILLE, TN 280,394280.4k $18.6m $18.6m 0.01% Added +107.7k +107,728
56 Trexquant Investment LP 0.13% of their portfolio STAMFORD, CT 277,114277.1k $17.4m $17.4m 0.13% Added +26.2k +26,170
57 DEUTSCHE BANK AG\ 0.01% of their portfolio FRANKFURT AM MAIN, 2M 259,963260.0k $16.3m $16.3m 0.01% Added +17.9k +17,889
58 California Public Employees Retirement System 0.01% of their portfolio Sacramento, CA 257,133257.1k $16.1m $16.1m 0.01% New
59 CITIGROUP INC 0.01% of their portfolio NEW YORK, NY 251,568251.6k $15.8m $15.8m 0.01% Added +208.8k +208,825
60 Swiss National Bank 0.01% of their portfolio ZURICH, V8 242,000242.0k $15.2m $15.2m 0.01% Reduced -3.4k -3,400
61 Legal & General Group Plc 0.00% of their portfolio London, X0 229,097229.1k $14.4m $14.4m 0.00% Reduced -166.2k -166,214
62 Balyasny Asset Management L.P. 0.03% of their portfolio Chicago, IL 206,412206.4k $12.9m $12.9m 0.03% Reduced -169.8k -169,804
63 NEUBERGER BERMAN GROUP LLC 0.01% of their portfolio NEW YORK, NY 203,914203.9k $12.8m $12.8m 0.01% Added +103.5k +103,529
64 SEI INVESTMENTS CO 0.01% of their portfolio OAKS, PA 203,220203.2k $12.7m $12.7m 0.01% Added +90.9k +90,941
65 Clearbridge Investments, LLC 0.01% of their portfolio NEW YORK, NY 202,347202.3k $12.7m $12.7m 0.01% Reduced -5.7k -5,715
66 Woodline Partners LP 0.05% of their portfolio San Francisco, CA 200,184200.2k $12.6m $12.6m 0.05% Reduced -200.0k -200,000
67 Affinity Asset Advisors, LLC 0.74% of their portfolio NEW YORK, NY 200,000200.0k $12.5m $12.5m 0.74% Added +130.0k +130,000
68 Longaeva Partners L.P. 0.59% of their portfolio Chicago, IL 194,589194.6k $12.2m $12.2m 0.59% New
69 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 191,054191.1k $12.0m $12.0m 0.00% Reduced -66.4k -66,423
70 MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC 0.13% of their portfolio New York, NY 184,304184.3k $11.6m $11.6m 0.13% Added +168.5k +168,502
71 RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio ST. PETERSBURG, FL 182,555182.6k $11.4m $11.4m 0.00% Reduced -15.8k -15,832
72 MARSHALL WACE, LLP 0.01% of their portfolio LONDON, X0 179,573179.6k $11.3m $11.3m 0.01% Added +55.7k +55,718
73 PINNACLE ASSOCIATES LTD 0.14% of their portfolio NEW YORK, NY 175,456175.5k $11.0m $11.0m 0.14% Reduced -16.2k -16,213
74 Russell Investments Group, Ltd. 0.01% of their portfolio Seattle, WA 173,995174.0k $10.9m $10.9m 0.01% Added +51.9k +51,880
75 Retirement Systems of Alabama 0.04% of their portfolio MONTGOMERY, AL 171,672171.7k $10.8m $10.8m 0.04% New
76 WCM INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio LAGUNA BEACH, CA 171,575171.6k $9.9m $9.9m 0.02% Added +32.7k +32,670
77 AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio Greenwich, CT 167,210167.2k $10.3m $10.3m 0.00% Added +19.9k +19,857
78 SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio London, X0 162,005162.0k $9.3m $9.3m 0.01% New
79 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio Toronto, A6 160,422160.4k $10.1m $10.1m 0.01% Added +62.3k +62,271
80 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 158,398158.4k $9.9m $9.9m 0.00% Added +5.9k +5,891
81 SEB Asset Management AB 0.04% of their portfolio STOCKHOLM, V7 158,205158.2k $9.9m $9.9m 0.04% First filing
82 HSBC HOLDINGS PLC 0.01% of their portfolio LONDON, X0 151,046151.0k $9.5m $9.5m 0.01% New
83 TORONTO DOMINION BANK 0.02% of their portfolio TORONTO, ONTARIO, A6 150,278150.3k $9.4m $9.4m 0.02% New
84 FIRST TRUST ADVISORS LP 0.01% of their portfolio Wheaton, IL 149,148149.1k $9.4m $9.4m 0.01% Reduced -88.6k -88,582
85 HighTower Advisors, LLC 0.01% of their portfolio CHICAGO, IL 146,462146.5k $9.2m $9.2m 0.01% Added +13.2k +13,233
86 Rhenman & Partners Asset Management AB 1.12% of their portfolio Stockholm, V7 144,500144.5k $9.1m $9.1m 1.12% Unchanged
87 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio WEST SACRAMENTO, CA 144,313144.3k $9.0m $9.0m 0.01% Added +25.9k +25,941
88 WEALTH EFFECTS LLC 3.18% of their portfolio BOSTON, MA 143,300143.3k $9.0m $9.0m 3.18% Unchanged
89 MetLife Investment Management, LLC 0.04% of their portfolio Whippany, NJ 140,404140.4k $8.8m $8.8m 0.04% Added +67.4k +67,364
90 MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.01% of their portfolio CAUSEWAY BAY, K3 139,598139.6k $8.7m $8.7m 0.01% Added +5.7k +5,723
91 Empowered Funds, LLC 0.05% of their portfolio NEWTOWN SQUARE, PA 137,220137.2k $8.6m $8.6m 0.05% Added +119.2k +119,202
92 BANK OF NOVA SCOTIA 0.01% of their portfolio TORONTO, A6 135,960136.0k $8.5m $8.5m 0.01% New
93 LPL Financial LLC 0.00% of their portfolio FORT MILL, SC 129,499129.5k $8.1m $8.1m 0.00% Added +29.2k +29,222
94 Tetragon Partners GP Ltd 1.57% of their portfolio GRAND CAYMAN, E9 127,198127.2k $8.0m $8.0m 1.57% Added +30.3k +30,263
95 NEW YORK STATE TEACHERS RETIREMENT SYSTEM 0.02% of their portfolio ALBANY, NY 124,853124.9k $7.8m $7.8m 0.02% Reduced -24.9k -24,923
96 Universal- Beteiligungs- und Servicegesellschaft mbH 0.01% of their portfolio FRANKFURT AM MAIN, 2M 120,238120.2k $7.5m $7.5m 0.01% Reduced -39.3k -39,300
97 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 115,343115.3k $7.2m $7.2m 0.00% Reduced -206.5k -206,490
98 VANGUARD ASSET MANAGEMENT, Ltd 0.01% of their portfolio London, EC4N 8AF, X0 112,971113.0k $7.1m $7.1m 0.01% First filing
99 SILVERCREST ASSET MANAGEMENT GROUP LLC 0.05% of their portfolio NEW YORK, NY 108,413108.4k $6.8m $6.8m 0.05% Reduced -50.2k -50,209
100 Cormorant Asset Management, LP 0.32% of their portfolio BOSTON, MA 100,000100.0k $6.3m $6.3m 0.32% New