ARROWHEAD PHARMACEUTICALS IN ARWR
COM · Common Stock · CUSIP 04280A100 · ISIN US04280A1007
Biopharmaceutical company
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersPasadena, CA
- Founded1989
- Websitearrowheadpharma.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($876.7k this quarter). Holder counts are more reliable. Shares outstanding: 140.0m as of 2026-01-30, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $66.38. Options: 15 managers hold calls ($156.8m notional), 9 hold puts ($38.8m).
Trends to Q4 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 278 |
| Q4 2022 | 283 |
| Q1 2023 | 257 |
| Q2 2023 | 274 |
| Q3 2023 | 258 |
| Q4 2023 | 267 |
| Q1 2024 | 276 |
| Q2 2024 | 274 |
| Q3 2024 | 273 |
| Q4 2024 | 271 |
| Q1 2025 | 266 |
| Q2 2025 | 282 |
| Q3 2025 | 303 |
| Q4 2025 | 402 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2024 | 144 | 105 |
| Q2 2024 | 129 | 121 |
| Q3 2024 | 121 | 123 |
| Q4 2024 | 122 | 127 |
| Q1 2025 | 130 | 126 |
| Q2 2025 | 151 | 120 |
| Q3 2025 | 165 | 121 |
| Q4 2025 | 234 | 137 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2025 | $4.7m | $6.2m | 1.34 |
| Q2 2025 | $8.2m | $10.6m | 1.28 |
| Q3 2025 | $39.1m | $9.8m | 0.25 |
| Q4 2025 | $156.8m | $38.8m | 0.25 |
Biggest buyers
| FRED ALGER MANAGEMENT, LLC | Added | +1.5m |
| BlackRock, Inc. | Added | +1.1m |
| Vestal Point Capital, LP | New | +900.0k |
| DEERFIELD MANAGEMENT COMPANY, L.P. | Added | +839.9k |
| FMR LLC | Added | +760.6k |
| Pictet Asset Management Holding SA | Added | +737.7k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +728.6k |
| RTW INVESTMENTS, LP | New | +584.7k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | New | +550.0k |
| Connor, Clark & Lunn Investment Management Ltd. | Added | +538.7k |
Biggest sellers
| Slate Path Capital LP | Reduced | -2.5m |
| MARSHALL WACE, LLP | Reduced | -1.3m |
| Siren, L.L.C. | Reduced | -1.2m |
| JPMORGAN CHASE & CO | Reduced | -939.5k |
| VANGUARD GROUP INC | Reduced | -742.7k |
| Woodline Partners LP | Reduced | -600.0k |
| Schonfeld Strategic Advisors LLC | Reduced | -523.8k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | Reduced | -499.1k |
| Balyasny Asset Management L.P. | Reduced | -416.8k |
| Driehaus Capital Management LLC | Reduced | -330.1k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $57.1m859.9k shares |
| PEAK6 LLC | Added | $22.7m342.4k shares |
| JANE STREET GROUP, LLC | Added | $16.2m244.0k shares |
| Caption Management, LLC | New | $15.9m239.9k shares |
| CITADEL ADVISORS LLC | Added | $15.5m234.1k shares |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | New | $13.3m200.0k shares |
| GROUP ONE TRADING LLC | Added | $4.7m71.4k shares |
| Walleye Capital LLC | Added | $4.0m59.7k shares |
| Point72 Asset Management, L.P. | New | $1.8m27.1k shares |
| Centiva Capital, LP | New | $1.7m25.0k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $22.0m331.5k shares |
| JANE STREET GROUP, LLC | Added | $8.8m132.4k shares |
| CITADEL ADVISORS LLC | Added | $4.4m66.7k shares |
| Walleye Capital LLC | Added | $1.0m15.7k shares |
| TUDOR INVESTMENT CORP ET AL | New | $796.7k12.0k shares |
| GOLDMAN SACHS GROUP INC | New | $663.9k10.0k shares |
| Walleye Trading LLC | New | $663.9k10.0k shares |
| Point72 Asset Management, L.P. | New | $318.7k4.8k shares |
| GROUP ONE TRADING LLC | Reduced | $132.8k2.0k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution -2.1 pts · filed 2026-07-27 | 10.1% |
| Avoro Capital Advisors LLC 13G · institution +1.3 pts · filed 2026-08-14 | 9.6% |
| FMR LLC 13G · institution new · filed 2026-05-06 | 5.2% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-29 | 5.0% |
Fell to 5% or below in the last year: VANGUARD PORTFOLIO MANAGEMENT LLC (4.5%, 2026-07-31; now reported by VANGUARD CAPITAL MANAGEMENT LLC), VANGUARD GROUP INC (0.0%, 2026-03-26; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q4 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2024 | 1 | $117.6k | 10 | $6.4m | $5.0m |
| Q2 2024 | 1 | $27.6k | 2 | $210.1k | $41.9k |
| Q3 2024 | 0 | — | 1 | $237.5k | $237.5k |
| Q4 2024 | 0 | — | 5 | $1.4m | $1.4m |
| Q1 2025 | 0 | — | 5 | $8.6m | $7.8m |
| Q2 2025 | 0 | — | 1 | $1.5m | — |
| Q3 2025 | 0 | — | 1 | $1.0m | $1.0m |
| Q4 2025 | 0 | — | 7 | $27.8m | $8.5m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-12-29 | Anzalone Christopher Richard Chief Executive Officer, director | Sold plan | $3.6m51.7k shares |
| 2025-12-26 | Ferrari Mauro Director | Sold plan | $527.1k7.5k shares |
| 2025-12-22 | Anzalone Christopher Richard Chief Executive Officer, director | Sold plan | $861.3k12.6k shares |
| 2025-12-19 | Anzalone Christopher Richard Chief Executive Officer, director | Sold plan | $909.7k13.4k shares |
| 2025-12-19 | Vakiener Victoria Director | Sold plan | $679.5k10.0k shares |
| 2025-12-19 | OLUKOTUN ADEOYE Y Director | Sold plan | $676.6k10.0k shares |
| 2025-12-19 | Waddill William D. Director | Sold plan | $566.0k8.4k shares |
| 2025-12-17 | Anzalone Christopher Richard Chief Executive Officer, director | Sold | $5.4m85.0k shares |
| 2025-12-16 | Anzalone Christopher Richard Chief Executive Officer, director | Sold | $3.4m54.3k shares |
| 2025-12-15 | Anzalone Christopher Richard Chief Executive Officer, director | Sold | $9.0m130.0k shares |
| 2025-12-05 | PERRY MICHAEL S Director | Sold | $991.7k16.2k shares |
| 2025-11-28 | Ferrari Mauro Director | Sold | $493.4k8.8k shares |
| 2025-10-01 | Hamilton James C Chief Medical Officer | Sold plan | $700.0k20.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2025
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.02% of their portfolio | 21.3m $1.4bn | Added +1.1m |
| VANGUARD GROUP INC 0.01% of their portfolio | 15.3m $1.0bn | Reduced -742.7k |
| Avoro Capital Advisors LLC 6.93% of their portfolio | 10.6m $705.4m | Reduced -275.0k |
| FMR LLC 0.02% of their portfolio | 6.5m $432.9m | Added +760.6k |
| STATE STREET CORP 0.01% of their portfolio | 6.4m $425.2m | Added +6.5k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 3.3m $216.8m | Added +133.9k |
| Slate Path Capital LP 2.26% of their portfolio | 2.5m $167.5m | Reduced -2.5m |
| BAKER BROS. ADVISORS LP 0.85% of their portfolio | 2.2m $144.4m | Added +504.9k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.08% of their portfolio | 2.1m $138.6m | Added +6.3k |
| FRED ALGER MANAGEMENT, LLC 0.48% of their portfolio | 1.8m $121.7m | Added +1.5m |
| DEERFIELD MANAGEMENT COMPANY, L.P. 1.56% of their portfolio | 1.8m $121.7m | Added +839.9k |
| Driehaus Capital Management LLC 0.80% of their portfolio | 1.8m $117.5m | Reduced -330.1k |
| NORGES BANK 0.01% of their portfolio | 1.7m $113.2m | Not comparable |
| GOLDMAN SACHS GROUP INC 0.02% of their portfolio | 1.7m $111.4m | Reduced -96.4k |
| Siren, L.L.C. 2.97% of their portfolio | 1.5m $99.6m | Reduced -1.2m |
| MORGAN STANLEY 0.01% of their portfolio | 1.5m $98.0m | Reduced -226.7k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 1.4m $89.9m | Added +7.9k |
| NORTHERN TRUST CORP 0.01% of their portfolio | 1.3m $89.4m | Added +34.7k |
| Fisher Asset Management, LLC 0.03% of their portfolio | 1.3m $87.1m | Added +257.9k |
| JANUS HENDERSON GROUP PLC 0.04% of their portfolio | 1.3m $85.0m | Added +306.9k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.02% of their portfolio | 1.3m $83.7m | Reduced -499.1k |
| Pictet Asset Management Holding SA 0.07% of their portfolio | 1.0m $68.6m | Added +737.7k |
| UBS Group AG 0.01% of their portfolio | 987.3k $65.5m | Added +69.1k |
| Vestal Point Capital, LP 2.19% of their portfolio | 900.0k $59.8m | New |
| Bank of New York Mellon Corp 0.01% of their portfolio | 887.8k $58.9m | Added +73.3k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio | 838.8k $55.7m | Added +728.6k |
| Western Financial Corp/CA 21.60% of their portfolio | 820.2k $54.5m | Unchanged |
| PRINCIPAL FINANCIAL GROUP INC 0.02% of their portfolio | 715.5k $47.5m | Reduced -64.6k |
| Assenagon Asset Management S.A. 0.07% of their portfolio | 684.9k $45.5m | Added +304.3k |
| Connor, Clark & Lunn Investment Management Ltd. 0.12% of their portfolio | 663.3k $44.0m | Added +538.7k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 622.0k $41.3m | Reduced -138.7k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 611.9k $40.6m | Reduced -939.5k |
| RTW INVESTMENTS, LP 0.39% of their portfolio | 584.7k $38.8m | New |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.06% of their portfolio | 550.0k $36.5m | New |
| Invesco Ltd. 0.00% of their portfolio | 547.8k $36.4m | Added +44.9k |
| Public Sector Pension Investment Board 0.11% of their portfolio | 478.5k $31.8m | Reduced -60.8k |
| CITADEL ADVISORS LLC 0.02% of their portfolio | 474.3k $31.5m | Added +156.6k |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC 0.88% of their portfolio | 470.0k $31.2m | New |
| VOYA INVESTMENT MANAGEMENT LLC 0.03% of their portfolio | 422.7k $28.1m | Added +285.2k |
| Woodline Partners LP 0.10% of their portfolio | 400.2k $26.6m | Reduced -600.0k |
| Privium Fund Management B.V. 4.87% of their portfolio | 398.2k $26.4m | Reduced -75.7k |
| Legal & General Group Plc 0.01% of their portfolio | 395.3k $26.2m | Added +8.9k |
| Balyasny Asset Management L.P. 0.05% of their portfolio | 376.2k $25.0m | Reduced -416.8k |
| Alyeska Investment Group, L.P. 0.07% of their portfolio | 375.4k $24.9m | New |
| EVENTIDE ASSET MANAGEMENT, LLC 0.38% of their portfolio | 370.0k $24.6m | New |
| RHUMBLINE ADVISERS 0.02% of their portfolio | 352.4k $23.4m | Reduced -18.7k |
| NORDEA INVESTMENT MANAGEMENT AB 0.02% of their portfolio | 324.3k $21.6m | Reduced -48.0k |
| BARCLAYS PLC 0.01% of their portfolio | 321.8k $21.4m | Reduced -28.4k |
| Nuveen, LLC 0.01% of their portfolio | 288.6k $19.2m | Added +10.2k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.07% of their portfolio | 288.5k $19.2m | Reduced -114.1k |
| Aberdeen Group plc 0.03% of their portfolio | 286.1k $19.0m | Reduced -234.5k |
| FengHe Fund Management Pte. Ltd. 1.00% of their portfolio | 266.7k $17.7m | New |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 257.5k $17.1m | Reduced -16.7k |
| Trexquant Investment LP 0.15% of their portfolio | 250.9k $16.7m | New |
| Swiss National Bank 0.01% of their portfolio | 245.4k $16.3m | Added +31.3k |
| DEUTSCHE BANK AG\ 0.01% of their portfolio | 242.1k $16.1m | Reduced -4.0k |
| FIRST TRUST ADVISORS LP 0.01% of their portfolio | 237.7k $15.8m | Added +29.8k |
| Clearbridge Investments, LLC 0.01% of their portfolio | 208.1k $13.8m | Reduced -183.1k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 198.4k $13.2m | Reduced -28.9k |
| Hillsdale Investment Management Inc. 0.36% of their portfolio | 193.8k $12.9m | New |
| PINNACLE ASSOCIATES LTD 0.16% of their portfolio | 191.7k $12.7m | Reduced -11.6k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 172.7k $11.5m | Added +16.8k |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.02% of their portfolio | 159.5k $10.6m | Reduced -1.4k |
| Skandinaviska Enskilda Banken AB (publ) 0.04% of their portfolio | 159.5k $10.6m | New |
| SILVERCREST ASSET MANAGEMENT GROUP LLC 0.07% of their portfolio | 158.6k $10.5m | Reduced -114.4k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 152.5k $10.1m | Added +72.3k |
| PRUDENTIAL FINANCIAL INC 0.01% of their portfolio | 152.2k $10.1m | Added +15.6k |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM 0.02% of their portfolio | 149.8k $9.9m | Added +1.3k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 147.4k $9.8m | Reduced -327.1k |
| AQR CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 147.4k $9.8m | Added +4.5k |
| D. E. Shaw & Co., Inc. 0.01% of their portfolio | 146.1k $9.7m | Added +125.8k |
| Rhenman & Partners Asset Management AB 0.90% of their portfolio | 144.5k $9.6m | New |
| WEALTH EFFECTS LLC 2.98% of their portfolio | 143.3k $9.5m | Reduced -25.1k |
| WCM INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio | 138.9k $9.3m | New |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.01% of their portfolio | 133.9k $8.9m | Reduced -4.1k |
| HighTower Advisors, LLC 0.01% of their portfolio | 133.2k $8.8m | Added +340 |
| MARSHALL WACE, LLP 0.01% of their portfolio | 123.9k $8.2m | Reduced -1.3m |
| Russell Investments Group, Ltd. 0.01% of their portfolio | 122.1k $8.1m | Added +109.2k |
| CANADA LIFE ASSURANCE Co 0.01% of their portfolio | 118.8k $7.9m | Reduced -11.2k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio | 118.4k $7.9m | Added +14.4k |
| SEI INVESTMENTS CO 0.01% of their portfolio | 112.3k $7.5m | Added +98.7k |
| Weiss Asset Management LP 0.10% of their portfolio | 111.4k $7.4m | Not comparable |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 107.4k $7.1m | Reduced -9.1k |
| NEUBERGER BERMAN GROUP LLC 0.00% of their portfolio | 100.4k $6.7m | Added +87.0k |
| LPL Financial LLC 0.00% of their portfolio | 100.3k $6.7m | Added +50.1k |
| Integral Health Asset Management, LLC 0.34% of their portfolio | 100.0k $6.6m | Reduced -125.0k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio | 98.2k $6.5m | Added +35.2k |
| Tetragon Partners GP Ltd 1.36% of their portfolio | 96.9k $6.4m | Added +15.1k |
| Thrivent Financial for Lutherans 0.01% of their portfolio | 95.0k $6.3m | Reduced -4.7k |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 92.6k $6.1m | Added +47.5k |
| PLATINUM INVESTMENT MANAGEMENT LTD 1.37% of their portfolio | 89.5k $5.9m | Reduced -21.5k |
| Rafferty Asset Management, LLC 0.02% of their portfolio | 84.5k $5.6m | Reduced -29.9k |
| Aquatic Capital Management LLC 0.15% of their portfolio | 81.0k $5.4m | Added +55.3k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio | 79.2k $5.3m | Added +14.3k |
| ACT CAPITAL MANAGEMENT, LLC 4.03% of their portfolio | 75.0k $5.0m | First filing |
| Pinion Investment Advisors, LLC 1.21% of their portfolio | 75.0k $5.0m | Unchanged |
| Creative Planning 0.00% of their portfolio | 74.4k $4.9m | Added +22.4k |
| MetLife Investment Management, LLC 0.02% of their portfolio | 73.0k $4.8m | Added +1.1k |
| Erste Asset Management GmbH 0.04% of their portfolio | 73.0k $5.1m | Unchanged |
| State of Alaska, Department of Revenue 0.05% of their portfolio | 70.4k $4.7m | Added +831 |