ARROWHEAD PHARMACEUTICALS IN ARWR
COM · Common Stock · CUSIP 04280A100 · ISIN US04280A1007
Biopharmaceutical company
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersPasadena, CA
- Founded1989
- Websitearrowheadpharma.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($516.2k this quarter). Holder counts are more reliable. Shares outstanding: 138.3m as of 2025-08-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $15.81. Options: 13 managers hold calls ($8.2m notional), 13 hold puts ($10.6m).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 278 |
| Q4 2022 | 283 |
| Q1 2023 | 257 |
| Q2 2023 | 274 |
| Q3 2023 | 258 |
| Q4 2023 | 267 |
| Q1 2024 | 276 |
| Q2 2024 | 274 |
| Q3 2024 | 273 |
| Q4 2024 | 271 |
| Q1 2025 | 266 |
| Q2 2025 | 282 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 110 | 131 |
| Q4 2023 | 110 | 131 |
| Q1 2024 | 144 | 105 |
| Q2 2024 | 129 | 121 |
| Q3 2024 | 121 | 123 |
| Q4 2024 | 122 | 127 |
| Q1 2025 | 130 | 126 |
| Q2 2025 | 151 | 120 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $3.3m | $8.5m | 2.58 |
| Q4 2024 | $11.8m | $10.1m | 0.86 |
| Q1 2025 | $4.7m | $6.2m | 1.34 |
| Q2 2025 | $8.2m | $10.6m | 1.28 |
Biggest buyers
| VANGUARD GROUP INC | Added | +2.3m |
| MARSHALL WACE, LLP | Added | +2.1m |
| FMR LLC | Added | +1.9m |
| BAKER BROS. ADVISORS LP | New | +939.2k |
| ROYAL BANK OF CANADA | Added | +755.2k |
| Trexquant Investment LP | New | +503.7k |
| Invesco Ltd. | Added | +448.6k |
| Schonfeld Strategic Advisors LLC | Added | +429.4k |
| GOLDMAN SACHS GROUP INC | Added | +373.6k |
| DIMENSIONAL FUND ADVISORS LP | New | +366.7k |
Biggest sellers
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | Reduced | -2.1m |
| T. Rowe Price Investment Management, Inc. | Reduced | -1.7m |
| CITADEL ADVISORS LLC | Reduced | -924.7k |
| TWO SIGMA INVESTMENTS, LP | Reduced | -701.8k |
| STATE STREET CORP | Reduced | -628.2k |
| Aquilo Capital Management, LLC | Sold out | -550.1k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -521.8k |
| Avoro Capital Advisors LLC | Reduced | -511.1k |
| BlackRock, Inc. | Reduced | -501.3k |
| TWO SIGMA ADVISERS, LP | Reduced | -332.0k |
Biggest calls
| GOLDMAN SACHS GROUP INC | New | $1.3m81.3k shares |
| CAPITAL FUND MANAGEMENT S.A. | New | $1.2m76.5k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $1.2m74.1k shares |
| CITADEL ADVISORS LLC | Added | $1.1m72.3k shares |
| JANE STREET GROUP, LLC | Added | $764.7k48.4k shares |
| D. E. Shaw & Co., Inc. | New | $747.3k47.3k shares |
| GROUP ONE TRADING LLC | Added | $662.0k41.9k shares |
| SIMPLEX TRADING, LLC | Added | $603.0k38.2k shares |
| Walleye Capital LLC | Reduced | $325.5k20.6k shares |
| WOLVERINE TRADING, LLC | Reduced | $168.8k10.5k shares |
Biggest puts
| CITADEL ADVISORS LLC | Added | $3.0m187.2k shares |
| WOLVERINE TRADING, LLC | Added | $1.1m67.6k shares |
| SIMPLEX TRADING, LLC | Added | $1.0m65.5k shares |
| D. E. Shaw & Co., Inc. | Added | $924.3k58.5k shares |
| CAPITAL FUND MANAGEMENT S.A. | New | $766.3k48.5k shares |
| JANE STREET GROUP, LLC | Added | $761.6k48.2k shares |
| Caption Management, LLC | Added | $632.0k40.0k shares |
| GROUP ONE TRADING LLC | Added | $583.0k36.9k shares |
| Walleye Capital LLC | Added | $557.7k35.3k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $526.1k33.3k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution -2.1 pts · filed 2026-07-27 | 10.1% |
| Avoro Capital Advisors LLC 13G · institution +1.3 pts · filed 2026-08-14 | 9.6% |
| FMR LLC 13G · institution new · filed 2026-05-06 | 5.2% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-29 | 5.0% |
Fell to 5% or below in the last year: VANGUARD PORTFOLIO MANAGEMENT LLC (4.5%, 2026-07-31; now reported by VANGUARD CAPITAL MANAGEMENT LLC), VANGUARD GROUP INC (0.0%, 2026-03-26; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 0 | — | 3 | $2.0m | — |
| Q4 2023 | 0 | — | 2 | $1.5m | $1.5m |
| Q1 2024 | 1 | $117.6k | 10 | $6.4m | $5.0m |
| Q2 2024 | 1 | $27.6k | 2 | $210.1k | $41.9k |
| Q3 2024 | 0 | — | 1 | $237.5k | $237.5k |
| Q4 2024 | 0 | — | 5 | $1.4m | $1.4m |
| Q1 2025 | 0 | — | 5 | $8.6m | $7.8m |
| Q2 2025 | 0 | — | 1 | $1.5m | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-04-11 | Anzalone Christopher Richard Chief Executive Officer, director | Sold | $583.7k50.8k shares |
| 2025-04-10 | Anzalone Christopher Richard Chief Executive Officer, director | Sold | $543.5k50.0k shares |
| 2025-04-09 | Anzalone Christopher Richard Chief Executive Officer, director | Sold | $406.1k40.3k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.01% of their portfolio | 19.4m $306.9m | Reduced -501.3k |
| VANGUARD GROUP INC 0.00% of their portfolio | 15.5m $245.3m | Added +2.3m |
| Avoro Capital Advisors LLC 2.93% of their portfolio | 10.6m $167.5m | Reduced -511.1k |
| STATE STREET CORP 0.00% of their portfolio | 6.4m $100.7m | Reduced -628.2k |
| Slate Path Capital LP 1.43% of their portfolio | 5.2m $82.7m | Unchanged |
| FMR LLC 0.00% of their portfolio | 5.2m $81.7m | Added +1.9m |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 3.0m $47.1m | Added +28.2k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio | 2.7m $42.4m | Reduced -2.1m |
| Siren, L.L.C. 2.18% of their portfolio | 2.7m $42.2m | Unchanged |
| MARSHALL WACE, LLP 0.04% of their portfolio | 2.2m $34.1m | Added +2.1m |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 2.1m $33.4m | Added +373.6k |
| NORGES BANK 0.00% of their portfolio | 1.9m $30.4m | Added +122.4k |
| MORGAN STANLEY 0.00% of their portfolio | 1.7m $26.9m | Reduced -143.3k |
| UBS Group AG 0.01% of their portfolio | 1.6m $25.3m | Reduced -26.0k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 1.3m $20.1m | Added +61.3k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 1.2m $18.5m | Added +135.5k |
| Aberdeen Group plc 0.03% of their portfolio | 960.2k $15.2m | Reduced -112.6k |
| BAKER BROS. ADVISORS LP 0.14% of their portfolio | 939.2k $14.8m | New |
| T. Rowe Price Investment Management, Inc. 0.01% of their portfolio | 822.3k $13.0m | Reduced -1.7m |
| Western Financial Corp/CA 6.95% of their portfolio | 820.2k $13.0m | Unchanged |
| Bank of New York Mellon Corp 0.00% of their portfolio | 818.1k $12.9m | Added +42.0k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 800.4k $12.6m | Added +755.2k |
| Invesco Ltd. 0.00% of their portfolio | 762.7k $12.1m | Added +448.6k |
| Woodline Partners LP 0.06% of their portfolio | 746.2k $11.8m | Added +184.0k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 624.5k $9.9m | Reduced -173.7k |
| PRINCIPAL FINANCIAL GROUP INC 0.01% of their portfolio | 623.1k $9.8m | Reduced -6.0k |
| Privium Fund Management B.V. 2.13% of their portfolio | 612.2k $9.9m | Reduced -17.0k |
| Trexquant Investment LP 0.09% of their portfolio | 503.7k $8.0m | New |
| Schonfeld Strategic Advisors LLC 0.06% of their portfolio | 482.1k $7.6m | Added +429.4k |
| Fisher Asset Management, LLC 0.00% of their portfolio | 451.7k $7.1m | Reduced -31.6k |
| Public Sector Pension Investment Board 0.03% of their portfolio | 428.4k $6.8m | Added +28.5k |
| BARCLAYS PLC 0.00% of their portfolio | 409.6k $6.5m | Added +179.5k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 407.6k $6.4m | Reduced -80.0k |
| Legal & General Group Plc 0.00% of their portfolio | 407.3k $6.4m | Added +12.2k |
| TWO SIGMA ADVISERS, LP 0.01% of their portfolio | 391.8k $6.2m | Reduced -332.0k |
| Clearbridge Investments, LLC 0.00% of their portfolio | 380.9k $6.0m | Reduced -79.0k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 366.7k $5.8m | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 360.0k $5.7m | Added +14.0k |
| Nuveen, LLC 0.00% of their portfolio | 310.4k $4.9m | Reduced -27.5k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio | 307.7k $4.9m | Added +18.4k |
| SILVERCREST ASSET MANAGEMENT GROUP LLC 0.03% of their portfolio | 280.2k $4.4m | Added +428 |
| Pictet Asset Management Holding SA 0.00% of their portfolio | 277.3k $4.5m | Reduced -10.7k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 267.0k $4.2m | Reduced -19.2k |
| Hudson Bay Capital Management LP 0.03% of their portfolio | 260.0k $4.1m | Added +46.9k |
| JOHNSON & JOHNSON 1.19% of their portfolio | 247.6k $4.0m | Unchanged |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 235.4k $3.7m | Reduced -14.5k |
| CAPITAL FUND MANAGEMENT S.A. 0.04% of their portfolio | 226.4k $3.6m | Added +63.2k |
| NORDEA INVESTMENT MANAGEMENT AB 0.00% of their portfolio | 213.3k $3.5m | Added +82.5k |
| PINNACLE ASSOCIATES LTD 0.05% of their portfolio | 211.6k $3.3m | Added +70.4k |
| Swiss National Bank 0.00% of their portfolio | 209.8k $3.3m | Reduced -7.1k |
| SPHERA FUNDS MANAGEMENT LTD. 0.84% of their portfolio | 203.0k $3.2m | Reduced -74.6k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 169.7k $2.7m | Added +132.0k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 169.0k $2.7m | Reduced -521.8k |
| WEALTH EFFECTS LLC 0.98% of their portfolio | 165.7k $2.6m | Reduced -4.9k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 159.1k $2.5m | Added +4.3k |
| PDT Partners, LLC 0.14% of their portfolio | 153.0k $2.4m | New |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 152.4k $2.4m | Added +111.8k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 151.3k $2.4m | Reduced -87.1k |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 148.5k $2.3m | Added +100 |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 141.9k $2.2m | Reduced -50.9k |
| CITIGROUP INC 0.00% of their portfolio | 140.8k $2.2m | Reduced -186.5k |
| Neo Ivy Capital Management 0.70% of their portfolio | 138.1k $2.2m | New |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 133.4k $2.1m | Reduced -701.8k |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 130.3k $2.4m | Added +6.3k |
| KORNITZER CAPITAL MANAGEMENT INC /KS 0.04% of their portfolio | 126.5k $2.0m | Unchanged |
| HighTower Advisors, LLC 0.00% of their portfolio | 123.9k $2.0m | Added +11.5k |
| Man Group plc 0.00% of their portfolio | 118.8k $1.9m | Added +79.7k |
| CANADA LIFE ASSURANCE Co 0.00% of their portfolio | 116.3k $1.8m | Reduced -1.9k |
| PLATINUM INVESTMENT MANAGEMENT LTD 0.12% of their portfolio | 111.0k $1.8m | Added +12.6k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 104.0k $1.6m | Added +1.3k |
| ALGERT GLOBAL LLC 0.03% of their portfolio | 102.5k $1.6m | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 100.6k $1.6m | Added +7.4k |
| ONTARIO TEACHERS PENSION PLAN BOARD 0.03% of their portfolio | 97.3k $1.5m | Added +51.6k |
| Aquatic Capital Management LLC 0.03% of their portfolio | 93.9k $1.5m | Reduced -7.5k |
| Thrivent Financial for Lutherans 0.00% of their portfolio | 92.4k $1.5m | Reduced -213 |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 81.2k $1.3m | New |
| Pinion Investment Advisors, LLC 0.41% of their portfolio | 75.0k $1.2m | Reduced -75.0k |
| State of Alaska, Department of Revenue 0.01% of their portfolio | 74.8k $1.2m | Added +4.9k |
| ALPS ADVISORS INC 0.01% of their portfolio | 74.5k $1.2m | New |
| Engineers Gate Manager LP 0.01% of their portfolio | 74.4k $1.2m | Added +33.8k |
| MetLife Investment Management, LLC 0.01% of their portfolio | 72.0k $1.1m | Unchanged |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 68.4k $1.1m | Added +1.0k |
| M28 Capital Management LP 1.82% of their portfolio | 67.4k $1.1m | Unchanged |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 64.8k $1.0m | Reduced -1.6k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.00% of their portfolio | 64.2k $1.0m | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 64.0k $1.0m | Reduced -1.7k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 62.2k $983.5k | Reduced -924.7k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.03% of their portfolio | 61.9k $978.8k | New |
| INTECH INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 60.5k $956.4k | Reduced -21.6k |
| Bayforest Capital Ltd 0.41% of their portfolio | 59.4k $938.6k | New |
| Louisiana State Employees Retirement System 0.02% of their portfolio | 58.7k $927.5k | Reduced -700 |
| COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio | 58.3k $921.0k | Added +24.9k |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 57.9k $915.6k | New |
| SIMPLEX TRADING, LLC 0.02% of their portfolio | 57.3k $905.0k | Added +215 |
| ADAR1 Capital Management, LLC 0.14% of their portfolio | 55.2k $872.2k | Reduced -1.1k |
| State of Tennessee, Department of Treasury 0.00% of their portfolio | 54.5k $861.9k | Reduced -686 |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 53.3k $841.6k | Reduced -11.1k |
| KING LUTHER CAPITAL MANAGEMENT CORP 0.00% of their portfolio | 52.1k $823.8k | Reduced -31.4k |
| GUGGENHEIM CAPITAL LLC 0.01% of their portfolio | 50.8k $802.9k | Reduced -2.4k |
| JANUS HENDERSON GROUP PLC 0.00% of their portfolio | 49.8k $787.8k | Unchanged |