ARROWHEAD PHARMACEUTICALS IN ARWR
COM · Common Stock · CUSIP 04280A100 · ISIN US04280A1007
Biopharmaceutical company
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersPasadena, CA
- Founded1989
- Websitearrowheadpharma.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($4.2m this quarter). Holder counts are more reliable. Shares outstanding: 124.3m as of 2024-08-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $25.99. Options: 11 managers hold calls ($35.5m notional), 10 hold puts ($19.0m).
Trends to Q2 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 278 |
| Q4 2022 | 283 |
| Q1 2023 | 257 |
| Q2 2023 | 274 |
| Q3 2023 | 258 |
| Q4 2023 | 267 |
| Q1 2024 | 276 |
| Q2 2024 | 274 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 128 | 130 |
| Q1 2023 | 117 | 143 |
| Q2 2023 | 117 | 137 |
| Q3 2023 | 110 | 131 |
| Q4 2023 | 110 | 131 |
| Q1 2024 | 144 | 105 |
| Q2 2024 | 129 | 121 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2023 | $8.9m | $5.8m | 0.65 |
| Q4 2023 | $21.4m | $13.5m | 0.63 |
| Q1 2024 | $28.4m | $12.8m | 0.45 |
| Q2 2024 | $35.5m | $19.0m | 0.53 |
Biggest buyers
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | Added | +1.4m |
| T. Rowe Price Investment Management, Inc. | Added | +802.0k |
| JANE STREET GROUP, LLC | Added | +568.6k |
| FMR LLC | Added | +417.6k |
| Squarepoint Ops LLC | New | +383.8k |
| BlackRock Inc. | Added | +336.6k |
| Avoro Capital Advisors LLC | Added | +333.3k |
| Hound Partners, LLC | New | +269.9k |
| Woodline Partners LP | Added | +265.9k |
| Aberdeen Group plc | New | +248.7k |
Biggest sellers
| MORGAN STANLEY | Reduced | -1.6m |
| ORBIMED ADVISORS LLC | Sold out | -739.7k |
| STATE STREET CORP | Reduced | -722.9k |
| JPMORGAN CHASE & CO | Reduced | -644.7k |
| Pictet Asset Management Holding SA | Reduced | -482.3k |
| Mirae Asset Global Investments Co., Ltd. | Reduced | -324.1k |
| Rokos Capital Management LLP | Reduced | -289.2k |
| AMERIPRISE FINANCIAL INC | Reduced | -259.1k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -256.6k |
| Assenagon Asset Management S.A. | Reduced | -256.3k |
Biggest calls
| Artal Group S.A. | Added | $26.0m1.0m shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $5.2m198.8k shares |
| CITADEL ADVISORS LLC | Added | $1.2m46.3k shares |
| CITIGROUP INC | Added | $1.2m46.1k shares |
| SIMPLEX TRADING, LLC | Reduced | $600.0k23.1k shares |
| JANE STREET GROUP, LLC | Reduced | $392.4k15.1k shares |
| Walleye Capital LLC | New | $379.5k14.6k shares |
| Caption Management, LLC | New | $293.7k11.3k shares |
| WOLVERINE TRADING, LLC | Reduced | $200.1k7.7k shares |
| GROUP ONE TRADING LLC | Reduced | $88.4k3.4k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $6.8m261.4k shares |
| JANE STREET GROUP, LLC | Added | $3.8m145.8k shares |
| Caption Management, LLC | New | $3.7m141.4k shares |
| CITADEL ADVISORS LLC | Added | $1.9m71.4k shares |
| CITIGROUP INC | Added | $1.2m46.1k shares |
| SIMPLEX TRADING, LLC | Added | $917.0k35.3k shares |
| WOLVERINE TRADING, LLC | Added | $444.4k17.1k shares |
| Walleye Capital LLC | New | $241.7k9.3k shares |
| GROUP ONE TRADING LLC | Reduced | $41.6k1.6k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution -2.1 pts · filed 2026-07-27 | 10.1% |
| Avoro Capital Advisors LLC 13G · institution +1.3 pts · filed 2026-08-14 | 9.6% |
| FMR LLC 13G · institution new · filed 2026-05-06 | 5.2% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-29 | 5.0% |
Fell to 5% or below in the last year: VANGUARD PORTFOLIO MANAGEMENT LLC (4.5%, 2026-07-31; now reported by VANGUARD CAPITAL MANAGEMENT LLC), VANGUARD GROUP INC (0.0%, 2026-03-26; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q2 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 2 | $1.8m | — |
| Q1 2023 | 0 | — | 4 | $1.7m | — |
| Q2 2023 | 0 | — | 3 | $4.9m | — |
| Q3 2023 | 0 | — | 3 | $2.0m | — |
| Q4 2023 | 0 | — | 2 | $1.5m | $1.5m |
| Q1 2024 | 1 | $117.6k | 10 | $6.4m | $5.0m |
| Q2 2024 | 1 | $27.6k | 2 | $210.1k | $41.9k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-05-02 | Vakiener Victoria Director | Sold plan | $41.9k1.8k shares |
| 2024-04-18 | Lu Hongbo Director | Bought | $11.0k500 shares |
| 2024-04-10 | Lu Hongbo Director | Bought | $12.5k500 shares |
| 2024-04-02 | Lu Hongbo Director | Bought | $4.1k150 shares |
| 2024-04-01 | Hamilton James C Chief Discovery/Trans Medicine | Sold | $168.2k6.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2024
| Manager | Shares | Change |
|---|---|---|
| BlackRock Inc. 0.01% of their portfolio | 15.7m $407.6m | Added +336.6k |
| VANGUARD GROUP INC 0.01% of their portfolio | 12.2m $317.4m | Reduced -189.9k |
| Avoro Capital Advisors LLC 3.08% of their portfolio | 8.9m $231.0m | Added +333.3k |
| FMR LLC 0.01% of their portfolio | 6.8m $177.0m | Added +417.6k |
| STATE STREET CORP 0.01% of their portfolio | 5.8m $151.7m | Reduced -722.9k |
| JPMORGAN CHASE & CO 0.01% of their portfolio | 4.6m $120.4m | Reduced -644.7k |
| Slate Path Capital LP 2.18% of their portfolio | 4.1m $107.6m | Unchanged |
| Artal Group S.A. 2.13% of their portfolio | 3.2m $82.9m | Added +152.7k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 2.9m $76.4m | Added +183.3k |
| T. Rowe Price Investment Management, Inc. 0.04% of their portfolio | 2.6m $66.6m | Added +802.0k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.02% of their portfolio | 2.3m $59.5m | Added +1.4m |
| MORGAN STANLEY 0.00% of their portfolio | 1.8m $47.2m | Reduced -1.6m |
| NORGES BANK 0.01% of their portfolio | 1.6m $41.2m | Reduced -87.5k |
| NORTHERN TRUST CORP 0.01% of their portfolio | 1.3m $34.4m | Added +22.1k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 1.3m $32.8m | Added +213.9k |
| Bank of New York Mellon Corp 0.01% of their portfolio | 1.1m $28.2m | Added +30.1k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 994.4k $25.8m | Added +10.6k |
| CITADEL ADVISORS LLC 0.02% of their portfolio | 948.4k $24.7m | Added +206.5k |
| Rokos Capital Management LLP 0.56% of their portfolio | 940.0k $24.4m | Reduced -289.2k |
| Aquilo Capital Management, LLC 22.76% of their portfolio | 908.5k $23.6m | Unchanged |
| Woodline Partners LP 0.20% of their portfolio | 821.5k $21.4m | Added +265.9k |
| Western Financial Corp/CA 12.88% of their portfolio | 820.2k $21.3m | Unchanged |
| Pictet Asset Management Holding SA 0.02% of their portfolio | 743.7k $19.3m | Reduced -482.3k |
| AMERIPRISE FINANCIAL INC 0.01% of their portfolio | 738.2k $19.2m | Reduced -259.1k |
| E. Ohman J:or Asset Management AB 0.46% of their portfolio | 714.2k $18.6m | Added +74.0k |
| JANE STREET GROUP, LLC 0.02% of their portfolio | 696.7k $18.1m | Added +568.6k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 529.3k $13.8m | Added +202.3k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 524.0k $13.6m | Added +63.2k |
| EVENTIDE ASSET MANAGEMENT, LLC 0.21% of their portfolio | 463.9k $12.1m | Added +150.6k |
| PRINCIPAL FINANCIAL GROUP INC 0.01% of their portfolio | 424.8k $11.0m | Reduced -59.4k |
| Schonfeld Strategic Advisors LLC 0.08% of their portfolio | 410.4k $10.7m | Reduced -5.4k |
| Squarepoint Ops LLC 0.04% of their portfolio | 383.8k $10.0m | New |
| RHUMBLINE ADVISERS 0.01% of their portfolio | 383.0k $10.0m | Added +10.9k |
| UBS Group AG 0.00% of their portfolio | 348.3k $9.1m | Reduced -102.6k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 338.0k $8.8m | Added +10.0k |
| Privium Fund Management B.V. 1.85% of their portfolio | 286.9k $7.2m | Added +13.0k |
| VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 275.4k $7.2m | Added +85.9k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 275.1k $7.1m | Added +31.2k |
| Hound Partners, LLC 1.41% of their portfolio | 269.9k $7.0m | New |
| Russell Investments Group, Ltd. 0.01% of their portfolio | 264.8k $6.9m | Added +22.1k |
| Invesco Ltd. 0.00% of their portfolio | 259.6k $6.7m | Added +5.3k |
| Capital International Investors 0.00% of their portfolio | 255.9k $6.7m | Reduced -223.2k |
| Aberdeen Group plc 0.01% of their portfolio | 248.7k $6.5m | New |
| JOHNSON & JOHNSON 1.61% of their portfolio | 247.6k $6.4m | Unchanged |
| Swiss National Bank 0.00% of their portfolio | 243.3k $6.3m | Unchanged |
| Legal & General Group Plc 0.00% of their portfolio | 240.9k $6.3m | Reduced -33.1k |
| CITIGROUP INC 0.01% of their portfolio | 238.0k $6.2m | Reduced -43.0k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.01% of their portfolio | 231.5k $6.0m | First filing |
| WCM INVESTMENT MANAGEMENT, LLC 0.01% of their portfolio | 229.3k $5.9m | Added +3.7k |
| Candriam S.C.A. 0.04% of their portfolio | 228.1k $5.9m | Unchanged |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 225.4k $5.9m | Reduced -7.0k |
| Corebridge Financial, Inc. 0.03% of their portfolio | 220.4k $5.7m | First filing |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 188.3k $4.9m | Added +155.0k |
| Hudson Bay Capital Management LP 0.04% of their portfolio | 180.0k $4.7m | Added +45.0k |
| California Public Employees Retirement System 0.00% of their portfolio | 164.3k $4.3m | Added +1.2k |
| WEALTH EFFECTS LLC 1.50% of their portfolio | 159.6k $4.1m | Reduced -4.9k |
| Retirement Systems of Alabama 0.02% of their portfolio | 153.3k $4.0m | Reduced -195.5k |
| SILVERCREST ASSET MANAGEMENT GROUP LLC 0.03% of their portfolio | 152.3k $4.0m | Added +2.1k |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 149.6k $3.9m | Reduced -124.6k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 149.2k $3.9m | Added +1.7k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 145.9k $3.8m | Added +84.9k |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio | 138.7k $3.6m | Unchanged |
| MetLife Investment Management, LLC 0.02% of their portfolio | 132.1k $3.4m | Added +6.2k |
| NORDEA INVESTMENT MANAGEMENT AB 0.00% of their portfolio | 129.7k $3.2m | Reduced -23.7k |
| KORNITZER CAPITAL MANAGEMENT INC /KS 0.06% of their portfolio | 126.5k $3.3m | Unchanged |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 120.7k $3.1m | Reduced -1.8k |
| SUPERSTRING CAPITAL MANAGEMENT LP 3.64% of their portfolio | 111.1k $2.9m | New |
| HighTower Advisors, LLC 0.00% of their portfolio | 110.8k $2.9m | Added +9.8k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.01% of their portfolio | 109.5k $2.8m | New |
| BARCLAYS PLC 0.00% of their portfolio | 109.1k $2.8m | Reduced -114.1k |
| BANQUE PICTET & CIE SA 0.03% of their portfolio | 104.8k $2.7m | Reduced -3.3k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 102.9k $2.7m | Reduced -256.6k |
| ESSEX INVESTMENT MANAGEMENT CO LLC 0.50% of their portfolio | 102.3k $2.7m | Added +30.0k |
| TWO SIGMA ADVISERS, LP 0.01% of their portfolio | 102.1k $2.7m | Added +63.3k |
| CANADA LIFE ASSURANCE Co 0.00% of their portfolio | 102.1k $2.7m | Added +11.5k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.00% of their portfolio | 100.0k $2.6m | New |
| Trexquant Investment LP 0.04% of their portfolio | 97.5k $2.5m | New |
| Jump Financial, LLC 0.05% of their portfolio | 92.9k $2.4m | Added +61.2k |
| PLATINUM INVESTMENT MANAGEMENT LTD 0.09% of their portfolio | 88.4k $2.3m | Reduced -8.7k |
| Assenagon Asset Management S.A. 0.01% of their portfolio | 88.2k $2.3m | Reduced -256.3k |
| State of New Jersey Common Pension Fund D 0.01% of their portfolio | 81.3k $2.1m | Reduced -10.1k |
| CWM, LLC 0.01% of their portfolio | 80.2k $2.1m | Reduced -19.2k |
| State of Tennessee, Department of Treasury 0.01% of their portfolio | 75.2k $2.0m | Added +12.7k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 73.9k $1.9m | Added +2.8k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 71.6k $1.9m | Reduced -4.0k |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC 0.02% of their portfolio | 71.1k $1.8m | Reduced -2.7k |
| ExodusPoint Capital Management, LP 0.02% of their portfolio | 71.0k $1.8m | Added +2.4k |
| Caption Management, LLC 0.20% of their portfolio | 71.0k $1.8m | Added +22.0k |
| M28 Capital Management LP 2.27% of their portfolio | 67.4k $1.8m | Unchanged |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 61.0k $1.6m | Added +10.1k |
| GUGGENHEIM CAPITAL LLC 0.01% of their portfolio | 60.6k $1.6m | Reduced -54.9k |
| NEOS Investment Management LLC 0.06% of their portfolio | 60.4k $1.6m | Added +25.9k |
| AMALGAMATED BANK 0.01% of their portfolio | 60.1k $1.6m | Reduced -4.6k |
| JANUS HENDERSON GROUP PLC 0.00% of their portfolio | 56.8k $1.5m | Reduced -604 |
| READYSTATE ASSET MANAGEMENT LP 0.07% of their portfolio | 56.5k $1.5m | New |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio | 55.3k $1.4m | Reduced -543 |
| TD Asset Management Inc 0.00% of their portfolio | 54.2k $1.4m | Added +25.8k |
| Edgestream Partners, L.P. 0.07% of their portfolio | 53.9k $1.4m | New |
| YOUSIF CAPITAL MANAGEMENT, LLC 0.02% of their portfolio | 53.4k $1.4m | Reduced -4.0k |
| EFG Asset Management (North America) Corp. 0.23% of their portfolio | 51.8k $1.3m | Added +24.1k |