Vault-13

APPLIED THERAPEUTICS INC APLT

COM · Common Stock · CUSIP 03828A101

37 institutional holders -2 vs Q4 2022
22,249,87122.2m shares reported held*
$18.0mreported value*
7 new 12 added 9 reduced 9 sold out net bought ≈ $2.1m (+2.6m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $0.81. Options: 3 managers hold calls ($3.5m notional), 1 hold puts ($0).

Trends to Q1 2023

Institutional holders

Managers reporting a position, each quarter

0204060Q3 22: 45Q4 22: 39Q1 23: 3737Q3 22Q4 22Q1 23
Numbers
QuarterHolders
Q3 202245
Q4 202239
Q1 202337

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
40040Q4 22: 11 bought or addedQ4 22: 29 cut or sold outQ4 22Q1 23: 19 bought or addedQ1 23: 18 cut or sold outQ1 23
Numbers
QuarterBought or addedCut or sold out
Q4 20221129
Q1 20231918

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$2m$4m$6mQ3 22 calls: $4.1mQ3 22 puts: $2.0kQ3 22P/C 0.00Q4 22 calls: $84.6kQ4 22 puts: $76Q4 22P/C 0.00Q1 23 calls: $3.5mQ1 23 puts: $0Q1 23P/C 0.00
Numbers
QuarterCallsPutsP/C
Q3 2022$4.1m$2.0k0.00
Q4 2022$84.6k$760.00
Q1 2023$3.5m$00.00

Biggest buyers

FMR LLC Added +2,972,371+3.0m
Simplify Asset Management Inc. New +2,382,621+2.4m
Knoll Capital Management, LLC Added +1,000,000+1.0m
CITIGROUP INC Added +352,845+352.8k
Rock Springs Capital Management LP Added +184,111+184.1k
MILLENNIUM MANAGEMENT LLC Added +119,883+119.9k
JPMORGAN CHASE & CO Added +75,358+75.4k
UBS Group AG Added +62,333+62.3k
BRIDGEWAY CAPITAL MANAGEMENT, LLC Added +60,000+60.0k
VANGUARD GROUP INC Added +58,593+58.6k

Biggest sellers

ORBIMED ADVISORS LLC Sold out -3,050,921-3.1m
Alyeska Investment Group, L.P. Reduced -468,950-468.9k
Artal Group S.A. Sold out -400,000-400.0k
BANK OF MONTREAL /CAN/ Sold out -323,100-323.1k
PURA VIDA INVESTMENTS, LLC Sold out -101,654-101.7k
TWO SIGMA ADVISERS, LP Reduced -100,113-100.1k
RENAISSANCE TECHNOLOGIES LLC Reduced -98,178-98.2k
TWO SIGMA INVESTMENTS, LP Reduced -88,624-88.6k
ACADIAN ASSET MANAGEMENT LLC Reduced -39,900-39.9k
Ergoteles LLC Sold out -36,524-36.5k

Biggest calls

Alyeska Investment Group, L.P. New $3.4m4.2m shares
SIMPLEX TRADING, LLC Reduced $17.0k21.5k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
T. Rowe Price Investment Management, Inc. 13G · institution +1.7 pts · filed 2025-11-14 14.9% +1.7 pts 21.4m 2025-11-14
Alyeska Investment Group, L.P. 13G · institution new · filed 2025-02-14 5.8% new 6.7m 2025-02-14

Fell to 5% or below in the last year: Venrock Healthcare Capital Partners III, L.P. (0.0%, 2026-08-14), Vestal Point Capital, LP (0.0%, 2026-02-17), Propel Bio Management, LLC (4.2%, 2025-12-31), ALEXANDRIA REAL ESTATE EQUITIES, INC. (4.3%, 2025-12-15)

Holders, Q1 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 FMR LLC 0.00% of their portfolio BOSTON, MA 5,944,7425.9m $4.8m $4.8m 0.00% Added +3.0m +2,972,371
2 FRANKLIN RESOURCES INC 0.00% of their portfolio San Mateo, CA 4,775,4844.8m $3.9m $3.9m 0.00% Unchanged
3 Knoll Capital Management, LLC 4.68% of their portfolio MIAMI, FL 3,450,0003.5m $2.8m $2.8m 4.68% Added +1.0m +1,000,000
4 Simplify Asset Management Inc. 0.35% of their portfolio Las Vegas, NV 2,382,6212.4m $1.9m $1.9m 0.35% New
5 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 855,155855.2k $693.6k $693.6k 0.00% Added +58.6k +58,593
6 Alyeska Investment Group, L.P. 0.01% of their portfolio CHICAGO, IL 799,102799.1k $648.2k $648.2k 0.01% Reduced -468.9k -468,950
7 Rock Springs Capital Management LP 0.02% of their portfolio Baltimore, MD 780,791780.8k $633.3k $633.3k 0.02% Added +184.1k +184,111
8 Point72 Asset Management, L.P. 0.00% of their portfolio STAMFORD, CT 719,938719.9k $583.9k $583.9k 0.00% Unchanged
9 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 361,078361.1k $292.9k $292.9k 0.00% Unchanged
10 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 353,138353.1k $286.4k $286.4k 0.00% Added +352.8k +352,845
11 Laurion Capital Management LP 0.01% of their portfolio NEW YORK, NY 345,900345.9k $280.6k $280.6k 0.01% Unchanged
12 BlackRock Inc. 0.00% of their portfolio New York, NY 273,011273.0k $221.4k $221.4k 0.00% Reduced -20.8k -20,770
13 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 219,800219.8k $178.0k $178.0k 0.00% Reduced -98.2k -98,178
14 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 181,826181.8k $147.0k $147.0k 0.00% Added +119.9k +119,883
15 TWO SIGMA ADVISERS, LP 0.00% of their portfolio NEW YORK, NY 149,787149.8k $121.5k $121.5k 0.00% Reduced -100.1k -100,113
16 BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.00% of their portfolio HOUSTON, TX 118,800118.8k $96.4k $96.4k 0.00% Added +60.0k +60,000
17 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 94,41594.4k $76.6k $76.6k 0.00% Unchanged
18 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 89,14989.1k $72.3k $72.3k 0.00% Reduced -88.6k -88,624
19 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 75,74675.7k $61.0k $61.0k 0.00% Added +75.4k +75,358
20 UBS Group AG 0.00% of their portfolio ZURICH, V8 73,70173.7k $59.8k $59.8k 0.00% Added +62.3k +62,333
21 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 50,96051.0k $41.3k $41.3k 0.00% Unchanged
22 ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio Boston, MA 47,49547.5k $38.0k $38.0k 0.00% Reduced -39.9k -39,900
23 WealthTrust Axiom LLC 0.01% of their portfolio WAYNE, PA 43,00043.0k $34.9k $34.9k 0.01% New
24 US BANCORP \DE\ 0.00% of their portfolio MINNEAPOLIS, MN 18,09118.1k $14.7k $14.7k 0.00% New
25 Virtu Financial LLC 0.00% of their portfolio New York, NY 14,49714.5k $12.0k $12.0k 0.00% New
26 Perennial Investment Advisors, LLC 0.00% of their portfolio Los Angeles, CA 11,60011.6k $9.4k $9.4k 0.00% Unchanged
27 Essex Financial Services, Inc. 0.00% of their portfolio ESSEX, CT 10,00010.0k $8.1k $8.1k 0.00% New
28 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 6,8086.8k $6.0k $6.0k 0.00% Added +1.7k +1,730
29 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 1,6701.7k $1.4k $1.4k 0.00% Reduced -1.5k -1,451
30 GROUP ONE TRADING LLC 0.00% of their portfolio CHICAGO, IL 501501 $406 $406 0.00% Reduced -585 -585
31 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 365365 $296 $296 0.00% Added +236 +236
32 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 273273 $221 $221 0.00% Added +5 +5
33 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 196196 $159 $159 0.00% Reduced -4.3k -4,284
34 SIMPLEX TRADING, LLC 0.00% of their portfolio CHICAGO, IL 136136 $0 $0 0.00% New
35 Federation des caisses Desjardins du Quebec 0.00% of their portfolio LEVIS, A8 8484 $68 $68 0.00% Unchanged
36 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 1111 $9 $9 0.00% New
37 CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio BIRMINGHAM, AL 00 $0 $0 0.00% Unchanged