Vault-13

APOGEE THERAPEUTICS INC

COM · CUSIP 03770N101 · ISIN US03770N1019

184 institutional holders +14 vs Q1 2025
57,753,43457.8m shares reported held*
$2.5bnreported value*
36 new 55 added 65 reduced 22 sold out net sold ≈ $163.2m (-3.8m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($3.7m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $43.43. Options: 10 managers hold calls ($18.5m notional), 12 hold puts ($34.4m).

Trends to Q2 2025

Institutional holders

Managers reporting a position, each quarter

0100200Q3 23: 74Q4 23: 86Q1 24: 140Q2 24: 140Q3 24: 140Q4 24: 159Q1 25: 170Q2 25: 184184Q3 23Q1 24Q3 24Q1 25Q2 25
Numbers
QuarterHolders
Q3 202374
Q4 202386
Q1 2024140
Q2 2024140
Q3 2024140
Q4 2024159
Q1 2025170
Q2 2025184

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q4 23: 52 bought or addedQ4 23: 17 cut or sold outQ4 23Q1 24: 112 bought or addedQ1 24: 26 cut or sold outQ2 24: 79 bought or addedQ2 24: 73 cut or sold outQ2 24Q3 24: 71 bought or addedQ3 24: 70 cut or sold outQ4 24: 84 bought or addedQ4 24: 62 cut or sold outQ4 24Q1 25: 83 bought or addedQ1 25: 78 cut or sold outQ2 25: 91 bought or addedQ2 25: 87 cut or sold outQ2 25
Numbers
QuarterBought or addedCut or sold out
Q4 20235217
Q1 202411226
Q2 20247973
Q3 20247170
Q4 20248462
Q1 20258378
Q2 20259187

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$10m$20m$30m$40mQ3 24 calls: $2.6mQ3 24 puts: $15.2mQ3 24P/C 5.76Q4 24 calls: $1.7mQ4 24 puts: $3.3mQ4 24P/C 1.97Q1 25 calls: $14.3mQ1 25 puts: $9.5mQ1 25P/C 0.67Q2 25 calls: $18.5mQ2 25 puts: $34.4mQ2 25P/C 1.86
Numbers
QuarterCallsPutsP/C
Q3 2024$2.6m$15.2m5.76
Q4 2024$1.7m$3.3m1.97
Q1 2025$14.3m$9.5m0.67
Q2 2025$18.5m$34.4m1.86

Biggest buyers

Point72 Asset Management, L.P. Added +837,889+837.9k
ADAGE CAPITAL PARTNERS GP, L.L.C. Added +563,464+563.5k
NOVO HOLDINGS A/S New +449,392+449.4k
CITADEL ADVISORS LLC Added +429,477+429.5k
GOLDMAN SACHS GROUP INC Added +368,487+368.5k
Ikarian Capital, LLC New +232,047+232.0k
Jefferies Financial Group Inc. Added +220,561+220.6k
FRONTIER CAPITAL MANAGEMENT CO LLC Added +200,249+200.2k
D. E. Shaw & Co., Inc. Added +185,752+185.8k
JPMORGAN CHASE & CO Added +162,939+162.9k

Biggest sellers

WELLINGTON MANAGEMENT GROUP LLP Reduced -1,680,044-1.7m
RA CAPITAL MANAGEMENT, L.P. Sold out -1,569,491-1.6m
JANUS HENDERSON GROUP PLC Reduced -1,284,512-1.3m
MERCER GLOBAL ADVISORS INC /ADV Reduced -819,804-819.8k
UBS Group AG Reduced -594,752-594.8k
FMR LLC Reduced -586,526-586.5k
Affinity Asset Advisors, LLC Reduced -459,300-459.3k
BlackRock, Inc. Reduced -348,290-348.3k
Woodline Partners LP Reduced -190,845-190.8k
VOLORIDGE INVESTMENT MANAGEMENT, LLC Sold out -167,991-168.0k

Biggest calls

DIADEMA PARTNERS LP Added $6.8m156.3k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $5.2m118.9k shares
Caption Management, LLC Reduced $4.1m95.0k shares
SIMPLEX TRADING, LLC Added $812.0k18.7k shares
CITADEL ADVISORS LLC Added $503.8k11.6k shares
Persistent Asset Partners Ltd Added $378.3k362 shares
Ikarian Capital, LLC New $364.8k8.4k shares
JANE STREET GROUP, LLC New $321.4k7.4k shares
GROUP ONE TRADING LLC Unchanged $43.4k1.0k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

JPMORGAN CHASE & CO New $17.6m405.0k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $6.6m152.7k shares
Ikarian Capital, LLC Added $3.4m79.1k shares
Caption Management, LLC Added $2.5m57.6k shares
JANE STREET GROUP, LLC Added $1.6m35.8k shares
BOOTHBAY FUND MANAGEMENT, LLC Added $1.1m25.6k shares
J. Goldman & Co LP New $868.6k20.0k shares
MILLENNIUM MANAGEMENT LLC New $434.3k10.0k shares
Affinity Asset Advisors, LLC New $108.6k2.5k shares
BANK OF AMERICA CORP /DE/ Unchanged $73.8k1.7k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
BlackRock, Inc. 13G · institution filed 2025-07-16 5.5% 2.5m≈ $334.3m 2025-07-16

Fell to 5% or below in the last year: Venrock Healthcare Capital Partners III, L.P. (0.0%, 2026-09-08), Fairmount Funds Management LLC (0.0%, 2026-09-03), FMR LLC (4.0%, 2026-07-08), WELLINGTON MANAGEMENT GROUP LLP (0.9%, 2026-07-08), T. Rowe Price Investment Management, Inc. (1.3%, 2026-07-08), VANGUARD GROUP INC (0.0%, 2026-03-26), RTW INVESTMENTS, LP (4.9%, 2026-02-17), DRIEHAUS CAPITAL MANAGEMENT LLC (4.7%, 2025-11-14)

Holders, Q2 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Venrock Adviser, LLC 27.64% of their portfolio NEW YORK, NY 8,493,3218.5m $368.9m $368.9m 27.64% Unchanged
2 FMR LLC 0.02% of their portfolio BOSTON, MA 6,907,1006.9m $300.0m $300.0m 0.02% Reduced -586.5k -586,526
3 WELLINGTON MANAGEMENT GROUP LLP 0.03% of their portfolio Boston, MA 3,805,7103.8m $165.3m $165.3m 0.03% Reduced -1.7m -1,680,044
4 RTW INVESTMENTS, LP 1.68% of their portfolio NEW YORK, NY 2,712,0972.7m $117.8m $117.8m 1.68% Unchanged
5 BlackRock, Inc. 0.00% of their portfolio New York, NY 2,562,5392.6m $111.3m $111.3m 0.00% Reduced -348.3k -348,290
6 Driehaus Capital Management LLC 0.80% of their portfolio Chicago, IL 2,310,7552.3m $100.4m $100.4m 0.80% Reduced -28.8k -28,808
7 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 2,108,9382.1m $91.6m $91.6m 0.00% Added +26.3k +26,332
8 Fairmount Funds Management LLC 11.53% of their portfolio WEST CONSHOHOCKEN, PA 2,048,6472.0m $89.0m $89.0m 11.53% Unchanged
9 BRAIDWELL LP 2.20% of their portfolio STAMFORD, CT 1,478,5121.5m $64.2m $64.2m 2.20% Reduced -61.9k -61,850
10 ALLIANCEBERNSTEIN L.P. 0.02% of their portfolio NASHVILLE, TN 1,388,1491.4m $60.3m $60.3m 0.02% Added +107.2k +107,199
11 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.09% of their portfolio Boston, MA 1,290,4641.3m $56.0m $56.0m 0.09% Added +563.5k +563,464
12 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 1,259,2581.3m $54.7m $54.7m 0.00% Reduced -54.5k -54,492
13 Point72 Asset Management, L.P. 0.13% of their portfolio STAMFORD, CT 1,230,3771.2m $53.4m $53.4m 0.13% Added +837.9k +837,889
14 PERCEPTIVE ADVISORS LLC 1.93% of their portfolio NEW YORK, NY 1,182,1481.2m $51.3m $51.3m 1.93% Added +59.4k +59,381
15 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 1,125,5701.1m $48.9m $48.9m 0.00% Added +162.9k +162,939
16 Paradigm Biocapital Advisors LP 1.78% of their portfolio NEW YORK, NY 958,630958.6k $41.6m $41.6m 1.78% Reduced -3.1k -3,077
17 Woodline Partners LP 0.20% of their portfolio San Francisco, CA 870,208870.2k $37.8m $37.8m 0.20% Reduced -190.8k -190,845
18 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 852,531852.5k $37.0m $37.0m 0.01% Reduced -23.5k -23,545
19 MERCER GLOBAL ADVISORS INC /ADV 0.08% of their portfolio DENVER, CO 820,376820.4k $35.6m $35.6m 0.08% Reduced -819.8k -819,804
20 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 782,641782.6k $34.0m $34.0m 0.00% Reduced -53.1k -53,054
21 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 760,844760.8k $33.0m $33.0m 0.00% Reduced -61.0k -61,006
22 Affinity Asset Advisors, LLC 4.44% of their portfolio NEW YORK, NY 691,899691.9k $30.0m $30.0m 4.44% Reduced -459.3k -459,300
23 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 659,186659.2k $28.6m $28.6m 0.00% Added +368.5k +368,487
24 Jefferies Financial Group Inc. 0.46% of their portfolio NEW YORK, NY 642,357642.4k $27.9m $27.9m 0.46% Added +220.6k +220,561
25 BARCLAYS PLC 0.01% of their portfolio LONDON, X0 608,822608.8k $26.4m $26.4m 0.01% Added +110.2k +110,197
26 Siren, L.L.C. 1.34% of their portfolio New York, NY 594,994595.0k $25.8m $25.8m 1.34% Unchanged
27 JANUS HENDERSON GROUP PLC 0.01% of their portfolio LONDON, X0 509,321509.3k $22.1m $22.1m 0.01% Reduced -1.3m -1,284,512
28 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 508,987509.0k $22.1m $22.1m 0.00% Added +83.1k +83,107
29 CITADEL ADVISORS LLC 0.02% of their portfolio MIAMI, FL 495,659495.7k $21.5m $21.5m 0.02% Added +429.5k +429,477
30 Polar Capital Holdings Plc 0.11% of their portfolio London, X0 495,000495.0k $21.5m $21.5m 0.11% Reduced -55.0k -55,000
31 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 474,702474.7k $20.6m $20.6m 0.00% Reduced -45.2k -45,237
32 NOVO HOLDINGS A/S 1.38% of their portfolio HELLERUP, G7 449,392449.4k $19.5m $19.5m 1.38% New
33 First Turn Management, LLC 2.52% of their portfolio DEL MAR, CA 311,490311.5k $13.5m $13.5m 2.52% Added +81.8k +81,815
34 FRONTIER CAPITAL MANAGEMENT CO LLC 0.12% of their portfolio Boston, MA 309,066309.1k $13.4m $13.4m 0.12% Added +200.2k +200,249
35 Commodore Capital LP 0.89% of their portfolio NEW YORK, NY 290,000290.0k $12.6m $12.6m 0.89% Unchanged
36 JENNISON ASSOCIATES LLC 0.01% of their portfolio NEW YORK, NY 270,366270.4k $11.7m $11.7m 0.01% Reduced -23.4k -23,391
37 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 266,384266.4k $11.6m $11.6m 0.00% Reduced -5.5k -5,495
38 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 264,188264.2k $11.5m $11.5m 0.00% Reduced -50.3k -50,290
39 VICTORY CAPITAL MANAGEMENT INC 0.01% of their portfolio San Antonio, TX 254,770254.8k $11.1m $11.1m 0.01% Added +21.8k +21,787
40 MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio NEW YORK, NY 245,133245.1k $10.6m $10.6m 0.01% Reduced -15.2k -15,202
41 Ikarian Capital, LLC 3.33% of their portfolio DALLAS, TX 232,047232.0k $10.1m $10.1m 3.33% New
42 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 201,151201.2k $8.7m $8.7m 0.00% Reduced -13.1k -13,080
43 TANG CAPITAL MANAGEMENT LLC 0.44% of their portfolio SAN DIEGO, CA 200,000200.0k $8.7m $8.7m 0.44% Unchanged
44 D. E. Shaw & Co., Inc. 0.01% of their portfolio New York, NY 194,528194.5k $8.4m $8.4m 0.01% Added +185.8k +185,752
45 Capital World Investors 0.00% of their portfolio LOS ANGELES, CA 193,895193.9k $8.4m $8.4m 0.00% Unchanged
46 Blackstone Inc. 0.03% of their portfolio NEW YORK, NY 178,546178.5k $7.8m $7.8m 0.03% Reduced -5.2k -5,201
47 Balyasny Asset Management L.P. 0.02% of their portfolio Chicago, IL 158,635158.6k $6.9m $6.9m 0.02% Added +45.9k +45,905
48 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 156,108156.1k $6.8m $6.8m 0.00% Added +59.8k +59,782
49 Granahan Investment Management, LLC 0.23% of their portfolio WALTHAM, MA 131,138131.1k $5.7m $5.7m 0.23% Added +22.8k +22,798
50 Universal- Beteiligungs- und Servicegesellschaft mbH 0.01% of their portfolio FRANKFURT AM MAIN, 2M 125,829125.8k $5.5m $5.5m 0.01% Reduced -1.4k -1,379
51 SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio London, X0 119,246119.2k $5.2m $5.2m 0.00% Added +22.3k +22,254
52 TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio NEW YORK, NY 115,694115.7k $5.0m $5.0m 0.01% Reduced -136.4k -136,441
53 ArrowMark Colorado Holdings LLC 0.09% of their portfolio Denver, CO 109,410109.4k $4.8m $4.8m 0.09% Unchanged
54 UBS Group AG 0.00% of their portfolio ZURICH, V8 107,157107.2k $4.7m $4.7m 0.00% Reduced -594.8k -594,752
55 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 94,58894.6k $4.1m $4.1m 0.00% Reduced -6.8k -6,800
56 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 90,56890.6k $3.9m $3.9m 0.00% Added +79.0k +78,969
57 PLATINUM INVESTMENT MANAGEMENT LTD 0.25% of their portfolio SYDNEY AUSTRALIA 2000, C3 86,51286.5k $3.8m $3.8m 0.25% Reduced -9.1k -9,134
58 BOOTHBAY FUND MANAGEMENT, LLC 0.11% of their portfolio NEW YORK, NY 85,18385.2k $3.7m $3.7m 0.11% New
59 STEMPOINT CAPITAL LP 1.18% of their portfolio NEW YORK, NY 84,46684.5k $3.7m $3.7m 1.18% New
60 Nuveen, LLC 0.00% of their portfolio CHARLOTTE, NC 83,29183.3k $3.6m $3.6m 0.00% Reduced -27.6k -27,564
61 Weiss Asset Management LP 0.06% of their portfolio BOSTON, MA 82,30282.3k $3.6m $3.6m 0.06% Not comparable
62 Sofinnova Investments, Inc. 0.23% of their portfolio Menlo Park, CA 76,18076.2k $3.3m $3.3m 0.23% New
63 KENNEDY CAPITAL MANAGEMENT LLC 0.08% of their portfolio ST LOUIS, MO 75,89775.9k $3.3m $3.3m 0.08% Reduced -2.5k -2,500
64 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 72,93972.9k $3.2m $3.2m 0.00% Reduced -14.4k -14,408
65 PRUDENTIAL FINANCIAL INC 0.00% of their portfolio NEWARK, NJ 68,84568.8k $3.0m $3.0m 0.00% Added +43.9k +43,940
66 Avidity Partners Management LP 0.57% of their portfolio DALLAS, TX 65,00065.0k $2.8m $2.8m 0.57% New
67 Capitolis Liquid Global Markets LLC 0.02% of their portfolio NEW YORK, NY 62,80062.8k $2.7m $2.7m 0.02% New
68 Parkman Healthcare Partners LLC 0.28% of their portfolio STAMFORD, CT 55,40455.4k $2.4m $2.4m 0.28% Added +8.7k +8,741
69 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 55,06255.1k $2.4m $2.4m 0.00% Added +19.3k +19,336
70 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 49,21649.2k $2.1m $2.1m 0.00% Reduced -5.2k -5,169
71 HighVista Strategies LLC 0.72% of their portfolio BOSTON, MA 45,05245.1k $2.0m $2.0m 0.72% Added +1.9k +1,862
72 Swiss National Bank 0.00% of their portfolio ZURICH, V8 42,60042.6k $1.9m $1.9m 0.00% Reduced -1.0k -1,000
73 Rafferty Asset Management, LLC 0.01% of their portfolio New York, NY 42,21142.2k $1.8m $1.8m 0.01% Reduced -790 -790
74 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 41,10041.1k $1.8m $1.8m 0.00% New
75 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 38,69738.7k $1.7m $1.7m 0.00% Reduced -31.6k -31,641
76 FIRST TRUST ADVISORS LP 0.00% of their portfolio Wheaton, IL 37,62237.6k $1.6m $1.6m 0.00% New
77 Blue Owl Capital Holdings LP 0.49% of their portfolio New York, NY 35,00035.0k $1.5m $1.5m 0.49% New
78 B Group, Inc. 1.31% of their portfolio DALLAS, TX 35,00035.0k $1.5m $1.5m 1.31% Added +5.0k +5,000
79 J. Goldman & Co LP 0.05% of their portfolio NEW YORK, NY 34,60534.6k $1.5m $1.5m 0.05% New
80 Brevan Howard Capital Management LP 0.02% of their portfolio ST. HELIER, Y9 33,08533.1k $1.4m $1.4m 0.02% New
81 COMERICA BANK 0.00% of their portfolio DALLAS, TX 29,46929.5k $1.3m $1.3m 0.00% Added +14.1k +14,109
82 Polymer Capital Management (HK) LTD 0.20% of their portfolio HONG KONG, K3 29,26829.3k $1.3m $1.3m 0.20% Unchanged
83 Legal & General Group Plc 0.00% of their portfolio London, X0 27,68927.7k $1.2m $1.2m 0.00% Added +1.9k +1,907
84 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 26,86626.9k $1.2m $1.2m 0.00% Added +2.6k +2,556
85 ALPS ADVISORS INC 0.01% of their portfolio Denver, CO 24,85024.9k $1.1m $1.1m 0.01% Reduced -8.2k -8,246
86 Erste Asset Management GmbH 0.01% of their portfolio VIENNA, C4 24,00024.0k $1.0m $1.0m 0.01% Unchanged
87 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 23,70923.7k $1.0m $1.0m 0.00% Reduced -5.2k -5,160
88 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 22,92822.9k $995.8k $995.8k 0.00% Reduced -38.4k -38,434
89 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 21,76821.8k $945.4k $945.4k 0.00% Added +21.6k +21,564
90 Moody Aldrich Partners LLC 0.18% of their portfolio MARBLEHEAD, MA 21,63221.6k $939.5k $939.5k 0.18% New
91 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 21,38621.4k $928.8k $928.8k 0.00% Reduced -792 -792
92 MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio CAUSEWAY BAY, K3 19,55519.6k $849.2k $849.2k 0.00% Reduced -5.0k -4,974
93 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 19,23819.2k $835.5k $835.5k 0.00% Reduced -3.4k -3,367
94 Lisanti Capital Growth, LLC 0.22% of their portfolio NEW YORK, NY 18,41018.4k $799.5k $799.5k 0.22% New
95 ADAR1 Capital Management, LLC 0.13% of their portfolio AUSTIN, TX 18,07018.1k $784.8k $784.8k 0.13% Reduced -86.8k -86,783
96 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 16,85316.9k $731.9k $731.9k 0.00% Reduced -1.3k -1,251
97 INTECH INVESTMENT MANAGEMENT LLC 0.01% of their portfolio WEST PALM BEACH, FL 16,07016.1k $697.9k $697.9k 0.01% Reduced -2.3k -2,347
98 Birchview Capital, LP 0.69% of their portfolio BURLINGTON, VT 16,00016.0k $694.9k $694.9k 0.69% Added +8.0k +8,000
99 NATIXIS ADVISORS, LLC 0.00% of their portfolio Boston, MA 15,03115.0k $653.0k $653.0k 0.00% Added +15 +15
100 WINTON GROUP Ltd 0.03% of their portfolio LONDON, X0 14,61714.6k $634.8k $634.8k 0.03% New