ANNEXON INC ANNX
COM · Common Stock · CUSIP 03589W102
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersBrisbane, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($90.3k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $5.71. Options: 9 managers hold calls ($8.2m notional), 5 hold puts ($2.5m).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 73 |
| Q4 2022 | 86 |
| Q1 2023 | 102 |
| Q2 2023 | 97 |
| Q3 2023 | 95 |
| Q4 2023 | 101 |
| Q1 2024 | 129 |
| Q2 2024 | 141 |
| Q3 2024 | 143 |
| Q4 2024 | 154 |
| Q1 2025 | 149 |
| Q2 2025 | 130 |
| Q3 2025 | 144 |
| Q4 2025 | 168 |
| Q1 2026 | 217 |
| Q2 2026 | 216 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 77 | 56 |
| Q4 2024 | 84 | 56 |
| Q1 2025 | 79 | 66 |
| Q2 2025 | 68 | 72 |
| Q3 2025 | 83 | 52 |
| Q4 2025 | 111 | 44 |
| Q1 2026 | 144 | 65 |
| Q2 2026 | 109 | 106 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $377.2k | $405.4k | 1.07 |
| Q4 2025 | $4.3m | $2.7m | 0.63 |
| Q1 2026 | $6.7m | $875.3k | 0.13 |
| Q2 2026 | $8.2m | $2.5m | 0.30 |
Biggest buyers
| FMR LLC | Added | +8.9m |
| Woodline Partners LP | Added | +4.6m |
| GOLDMAN SACHS GROUP INC | Added | +3.7m |
| MPM BIOIMPACT LLC | New | +3.5m |
| STATE STREET CORP | Added | +2.9m |
| BlackRock, Inc. | Added | +2.6m |
| Logos Global Management LP | New | +1.5m |
| Candriam S.C.A. | New | +1.2m |
| MAK CAPITAL ONE LLC | Added | +1.1m |
| GREAT POINT PARTNERS LLC | Added | +1.0m |
Biggest sellers
| BANK OF AMERICA CORP /DE/ | Reduced | -3.6m |
| Redmile Group, LLC | Reduced | -2.7m |
| Nuveen, LLC | Reduced | -1.5m |
| Bellevue Group AG | Reduced | -1.1m |
| Balyasny Asset Management L.P. | Reduced | -1.1m |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Reduced | -800.0k |
| Bain Capital Life Sciences Investors, LLC | Reduced | -774.9k |
| MARSHALL WACE, LLP | Reduced | -650.9k |
| UBS Group AG | Reduced | -622.8k |
| Longaeva Partners L.P. | Sold out | -620.4k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $2.4m412.0k shares |
| DIADEMA PARTNERS LP | Unchanged | $2.0m353.2k shares |
| CITADEL ADVISORS LLC | Reduced | $1.3m234.7k shares |
| SIMPLEX TRADING, LLC | Added | $1.2m206.6k shares |
| JANE STREET GROUP, LLC | Added | $516.8k90.5k shares |
| DLD Asset Management, LP | New | $343.2k60.0k shares |
| GROUP ONE TRADING LLC | Reduced | $263.8k46.2k shares |
| Persistent Asset Partners Ltd | Unchanged | $206.6k897 shares |
| BARCLAYS PLC | New | $11.4k2.0k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $1.1m190.2k shares |
| SIMPLEX TRADING, LLC | Added | $650.4k113.9k shares |
| CITADEL ADVISORS LLC | Added | $507.6k88.9k shares |
| GROUP ONE TRADING LLC | Added | $205.6k36.0k shares |
| JANE STREET GROUP, LLC | New | $57.1k10.0k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution +4.8 pts · filed 2026-07-08 | 11.9% |
| Redmile Group, LLC 13G · passive investor no change · filed 2026-07-08 | 9.9% |
| BlackRock, Inc. 13G · institution +1.9 pts · filed 2026-07-27 | 8.0% |
| Satter Muneer A 13D · may seek influence filed 2025-11-21 | 7.2% |
| STATE STREET CORP 13G · institution new · filed 2026-08-07 | 6.0% |
| BIOTECHNOLOGY VALUE FUND L P 13G · passive investor filed 2026-05-15 | 5.4% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-26)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 1 | $36.2k | 1 | $40.1k | $40.1k |
| Q1 2025 | 0 | — | 6 | $126.4k | — |
| Q2 2025 | 1 | $10.1k | 0 | — | — |
| Q3 2025 | 1 | $31.2k | 3 | $8.0k | — |
| Q4 2025 | 3 | $8.8m | 0 | — | — |
| Q1 2026 | 1 | $45.4k | 5 | $286.4k | — |
| Q2 2026 | 2 | $3.4m | 0 | — | — |
| Q3 2026 | 1 | $99.8k | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-09-24 | Love Douglas PRESIDENT AND CEO, director | Bought | $99.8k26.1k shares |
| 2026-05-28 | Satter Muneer A Director · See footnote | Bought | $3.3m613.5k shares |
| 2026-05-11 | Carson William H. Director | Bought plan | $46.2k8.0k shares |
| 2026-04-10 | Carson William H. Director | Bought plan | $49.6k8.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.00% of their portfolio | 19.5m $111.5m | Added +8.9m |
| BlackRock, Inc. 0.00% of their portfolio | 13.5m $77.3m | Added +2.6m |
| Redmile Group, LLC 4.55% of their portfolio | 11.9m $67.8m | Reduced -2.7m |
| STATE STREET CORP 0.00% of their portfolio | 9.8m $56.1m | Added +2.9m |
| BVF INC/IL 1.27% of their portfolio | 8.7m $49.7m | Unchanged |
| Woodline Partners LP 0.12% of their portfolio | 6.9m $39.5m | Added +4.6m |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 6.9m $39.2m | Added +914.4k |
| MAK CAPITAL ONE LLC 4.69% of their portfolio | 5.9m $33.5m | Added +1.1m |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 5.8m $33.3m | Added +3.7m |
| Siren, L.L.C. 0.52% of their portfolio | 4.5m $25.5m | Added +500.0k |
| Bain Capital Life Sciences Investors, LLC 1.51% of their portfolio | 4.4m $25.3m | Reduced -774.9k |
| Bellevue Group AG 0.49% of their portfolio | 4.1m $23.4m | Reduced -1.1m |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 4.0m $23.1m | Added +659.4k |
| MPM BIOIMPACT LLC 1.23% of their portfolio | 3.5m $20.2m | New |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 3.5m $20.0m | Added +60.5k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.03% of their portfolio | 3.5m $20.0m | Reduced -800.0k |
| GREAT POINT PARTNERS LLC 4.71% of their portfolio | 3.5m $20.0m | Added +1.0m |
| MORGAN STANLEY 0.00% of their portfolio | 3.1m $18.0m | Added +408.5k |
| Palo Alto Investors LP 2.33% of their portfolio | 2.9m $16.8m | Unchanged |
| Balyasny Asset Management L.P. 0.03% of their portfolio | 2.8m $16.2m | Reduced -1.1m |
| Nuveen, LLC 0.00% of their portfolio | 2.8m $15.8m | Reduced -1.5m |
| Qube Research & Technologies Ltd 0.02% of their portfolio | 2.7m $15.7m | Reduced -364.4k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 2.2m $12.8m | Added +763.7k |
| Opaleye Management Inc. 0.89% of their portfolio | 1.7m $9.8m | Reduced -617.3k |
| Logos Global Management LP 0.37% of their portfolio | 1.5m $8.6m | New |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 1.5m $8.6m | Added +573.7k |
| Point72 Asset Management, L.P. 0.01% of their portfolio | 1.4m $7.9m | Reduced -489.1k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 1.4m $7.7m | Added +265.1k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 1.3m $7.2m | Added +155.4k |
| Tetragon Partners GP Ltd 1.15% of their portfolio | 1.2m $7.1m | Reduced -50.0k |
| Candriam S.C.A. 0.03% of their portfolio | 1.2m $6.8m | New |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 1.2m $6.8m | Reduced -53.7k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 1.1m $6.3m | Added +216.9k |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.00% of their portfolio | 1.0m $5.9m | Added +134.0k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 1.0m $5.6m | Added +680.4k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 978.1k $5.6m | Added +279.3k |
| PANAGORA ASSET MANAGEMENT INC 0.02% of their portfolio | 967.9k $5.5m | New |
| KENNEDY CAPITAL MANAGEMENT LLC 0.09% of their portfolio | 898.4k $5.1m | Reduced -13.9k |
| Ishara Investments LP 3.44% of their portfolio | 820.0k $4.7m | Added +645.8k |
| Ensign Peak Advisors, Inc 0.01% of their portfolio | 800.5k $4.6m | Added +175.4k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.00% of their portfolio | 737.9k $4.2m | New |
| Y-Intercept (Hong Kong) Ltd 0.08% of their portfolio | 734.6k $4.2m | Reduced -585.3k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 705.3k $4.0m | Reduced -6.1k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 691.8k $4.0m | Reduced -85.4k |
| Parkman Healthcare Partners LLC 0.38% of their portfolio | 641.0k $3.7m | Reduced -33.0k |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 629.1k $3.6m | Reduced -129.1k |
| UBS Group AG 0.00% of their portfolio | 623.1k $3.6m | Reduced -622.8k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 616.5k $3.5m | Added +54.3k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 614.2k $3.5m | Reduced -3.6m |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 596.6k $3.4m | Reduced -3.6k |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.03% of their portfolio | 583.9k $3.3m | Unchanged |
| SIRIOS CAPITAL MANAGEMENT L P 0.40% of their portfolio | 569.3k $3.3m | Reduced -5.8k |
| Schonfeld Strategic Advisors LLC 0.02% of their portfolio | 533.6k $3.0m | Added +410.3k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 512.8k $2.9m | Added +41.4k |
| Hennion & Walsh Asset Management, Inc. 0.08% of their portfolio | 507.1k $2.9m | Reduced -2.6k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 501.4k $2.9m | Added +106.4k |
| Board of Trustees of The Leland Stanford Junior University 0.52% of their portfolio | 482.6k $2.8m | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 459.0k $2.6m | Reduced -85.3k |
| Ikarian Capital, LLC 0.40% of their portfolio | 430.2k $2.5m | Reduced -150.0k |
| MOORE CAPITAL MANAGEMENT, LP 0.06% of their portfolio | 425.3k $2.4m | New |
| Trexquant Investment LP 0.01% of their portfolio | 409.7k $2.3m | Added +6.0k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 406.8k $2.3m | Reduced -114.6k |
| Susquehanna Portfolio Strategies, LLC 0.04% of their portfolio | 395.2k $2.3m | Added +34.9k |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC 0.02% of their portfolio | 394.6k $2.3m | Reduced -22.1k |
| Invesco Ltd. 0.00% of their portfolio | 330.7k $1.9m | Reduced -432.3k |
| Engineers Gate Manager LP 0.02% of their portfolio | 319.1k $1.8m | Added +144.9k |
| DAFNA Capital Management LLC 0.32% of their portfolio | 297.8k $1.7m | Added +180.0k |
| Jump Financial, LLC 0.02% of their portfolio | 297.8k $1.7m | New |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 286.4k $1.6m | Added +236.6k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 265.3k $1.5m | Reduced -437.5k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.01% of their portfolio | 250.0k $1.4m | Reduced -212.0k |
| Swiss National Bank 0.00% of their portfolio | 244.6k $1.4m | Added +8.6k |
| CITIGROUP INC 0.00% of their portfolio | 236.0k $1.3m | Added +205.2k |
| Cinctive Capital Management LP 0.05% of their portfolio | 215.7k $1.2m | Reduced -52.9k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 210.6k $1.2m | Reduced -650.9k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 189.6k $1.1m | Added +29.9k |
| SEI INVESTMENTS CO 0.00% of their portfolio | 183.8k $1.0m | Reduced -19.4k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 180.6k $1.0m | Added +50.0k |
| Squarepoint Ops LLC 0.00% of their portfolio | 173.3k $989.5k | Added +105.3k |
| Rafferty Asset Management, LLC 0.00% of their portfolio | 173.3k $989.4k | Reduced -30.0k |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 147.6k $842.9k | Added +146.4k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 147.2k $815.7k | Added +28.2k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 134.3k $766.6k | Added +127.1k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 129.2k $738.0k | Reduced -299.5k |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 127.3k $727.1k | Added +11.8k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.01% of their portfolio | 120.1k $685.9k | Reduced -46.0k |
| IEQ CAPITAL, LLC 0.00% of their portfolio | 120.0k $685.3k | Reduced -75.8k |
| J. Goldman & Co LP 0.02% of their portfolio | 116.0k $662.6k | Reduced -54.8k |
| XTX Topco Ltd 0.01% of their portfolio | 112.1k $640.4k | Added +31.7k |
| GSA CAPITAL PARTNERS LLP 0.04% of their portfolio | 104.4k $596.0k | Added +72.7k |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 102.1k $582.8k | Added +48.0k |
| Quarry LP 0.09% of their portfolio | 100.0k $571.0k | Added +78.8k |
| SCS Capital Management LLC 0.01% of their portfolio | 99.0k $565.3k | Unchanged |
| Legal & General Group Plc 0.00% of their portfolio | 98.1k $560.3k | Added +18.1k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 91.7k $520.6k | Added +15.4k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 91.0k $519.6k | Added +18.6k |
| J. Safra Sarasin Holding AG 0.01% of their portfolio | 90.5k $516.7k | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio | 88.5k $505.4k | Added +34.7k |
| CAPTRUST FINANCIAL ADVISORS 0.00% of their portfolio | 87.9k $502.0k | Added +8.7k |
| PROFUND ADVISORS LLC 0.01% of their portfolio | 87.5k $499.7k | Reduced -3.5k |