Vault-13

AMICUS THERAPEUTICS INC FOLD

COM · Common Stock · CUSIP 03152W109 · ISIN US03152W1099

228 institutional holders -3 vs Q4 2022
299,960,467300.0m shares reported held*
$3.3bnreported value*
30 new 97 added 57 reduced 28 sold out net bought ≈ $96.3m (+8.6m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($3.4m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $11.09. Options: 9 managers hold calls ($4.4m notional), 8 hold puts ($6.4m).

Trends to Q1 2023

Institutional holders

Managers reporting a position, each quarter

0100200300Q3 22: 223Q4 22: 231Q1 23: 228228Q3 22Q4 22Q1 23
Numbers
QuarterHolders
Q3 2022223
Q4 2022231
Q1 2023228

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q4 22: 123 bought or addedQ4 22: 96 cut or sold outQ4 22Q1 23: 127 bought or addedQ1 23: 85 cut or sold outQ1 23
Numbers
QuarterBought or addedCut or sold out
Q4 202212396
Q1 202312785

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$2.5m$5m$7.5m$10mQ3 22 calls: $8.1mQ3 22 puts: $5.0mQ3 22P/C 0.62Q4 22 calls: $8.9mQ4 22 puts: $7.2mQ4 22P/C 0.82Q1 23 calls: $4.4mQ1 23 puts: $6.4mQ1 23P/C 1.44
Numbers
QuarterCallsPutsP/C
Q3 2022$8.1m$5.0m0.62
Q4 2022$8.9m$7.2m0.82
Q1 2023$4.4m$6.4m1.44

Biggest buyers

Point72 Asset Management, L.P. New +2,249,128+2.2m
FMR LLC Added +1,922,828+1.9m
VICTORY CAPITAL MANAGEMENT INC Added +1,728,159+1.7m
PICTET ASSET MANAGEMENT SA Added +1,553,949+1.6m
MILLENNIUM MANAGEMENT LLC Added +1,467,981+1.5m
ORBIMED ADVISORS LLC Added +655,000+655.0k
GREAT LAKES ADVISORS, LLC New +573,806+573.8k
Avoro Capital Advisors LLC Added +500,000+500.0k
Ghost Tree Capital, LLC New +475,000+475.0k
PRUDENTIAL FINANCIAL INC Added +408,025+408.0k

Biggest sellers

Redmile Group, LLC Reduced -1,902,928-1.9m
MORGAN STANLEY Reduced -1,338,445-1.3m
STATE STREET CORP Reduced -954,954-955.0k
NORDEA INVESTMENT MANAGEMENT AB Sold out -648,280-648.3k
WELLINGTON MANAGEMENT GROUP LLP Reduced -592,306-592.3k
D. E. Shaw & Co., Inc. Reduced -581,728-581.7k
Artal Group S.A. Reduced -473,593-473.6k
BlackRock Inc. Reduced -400,053-400.1k
Saturn V Capital Management LP Reduced -307,891-307.9k
UBS Group AG Reduced -306,104-306.1k

Biggest calls

Caption Management, LLC Added $1.6m140.0k shares
CITIGROUP INC Added $806.2k72.7k shares
J. Goldman & Co LP Reduced $665.4k60.0k shares
CITADEL ADVISORS LLC Reduced $395.9k35.7k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $374.8k33.8k shares
SIMPLEX TRADING, LLC Added $336.0k30.3k shares
GROUP ONE TRADING LLC Reduced $168.6k15.2k shares
Walleye Trading LLC Added $112.0k10.1k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

J. Goldman & Co LP Added $2.6m236.3k shares
Caption Management, LLC Added $1.6m140.0k shares
CITIGROUP INC Added $1.5m132.7k shares
CITADEL ADVISORS LLC Reduced $459.1k41.4k shares
JANE STREET GROUP, LLC Reduced $137.5k12.4k shares
SIMPLEX TRADING, LLC Added $112.0k10.1k shares
GROUP ONE TRADING LLC Reduced $3.3k300 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
BlackRock, Inc. 13G · institution -1.9 pts · filed 2025-04-23 7.4% -1.9 pts 22.8m 2025-04-23
BARCLAYS PLC 13G · institution new · filed 2026-05-14 5.7% new 17.8m 2026-05-14
UBS Group AG 13G · institution new · filed 2026-05-07 5.5% new 17.1m 2026-05-07
VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-29 5.2% new 16.4m 2026-04-29

Fell to 5% or below in the last year: GOLDMAN SACHS GROUP INC (0.0%, 2026-08-12), GLAZER CAPITAL, LLC (0.0%, 2026-05-01), VANGUARD GROUP INC (0.0%, 2026-03-26; now reported by VANGUARD CAPITAL MANAGEMENT LLC), WELLINGTON MANAGEMENT GROUP LLP (0.4%, 2026-02-10), WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC (3.4%, 2026-02-09)

Holders, Q1 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 PERCEPTIVE ADVISORS LLC 9.08% of their portfolio NEW YORK, NY 27,662,91727.7m $306.8m $306.8m 9.08% Added +20.0k +20,000
2 Avoro Capital Advisors LLC 4.49% of their portfolio NEW YORK, NY 27,300,00027.3m $302.8m $302.8m 4.49% Added +500.0k +500,000
3 VANGUARD GROUP INC 0.01% of their portfolio Valley Forge, PA 26,861,94526.9m $297.9m $297.9m 0.01% Added +323.6k +323,574
4 BlackRock Inc. 0.01% of their portfolio New York, NY 19,738,02519.7m $218.9m $218.9m 0.01% Reduced -400.1k -400,053
5 Redmile Group, LLC 8.83% of their portfolio LARKSPUR, CA 18,346,86118.3m $203.5m $203.5m 8.83% Reduced -1.9m -1,902,928
6 MORGAN STANLEY 0.02% of their portfolio NEW YORK, NY 16,500,90916.5m $183.0m $183.0m 0.02% Reduced -1.3m -1,338,445
7 JPMORGAN CHASE & CO 0.02% of their portfolio NEW YORK, NY 13,733,48513.7m $152.3m $152.3m 0.02% Added +186.1k +186,117
8 JANUS HENDERSON GROUP PLC 0.10% of their portfolio LONDON, X0 13,610,43513.6m $150.9m $150.9m 0.10% Reduced -84.1k -84,114
9 STATE STREET CORP 0.01% of their portfolio BOSTON, MA 11,130,88511.1m $123.4m $123.4m 0.01% Reduced -955.0k -954,954
10 Palo Alto Investors LP 9.67% of their portfolio PALO ALTO, CA 10,524,02210.5m $116.7m $116.7m 9.67% Added +30.3k +30,300
11 PICTET ASSET MANAGEMENT SA 0.14% of their portfolio GENEVA 73, V8 9,984,90110.0m $110.7m $110.7m 0.14% Added +1.6m +1,553,949
12 WELLINGTON MANAGEMENT GROUP LLP 0.02% of their portfolio Boston, MA 7,515,0417.5m $83.3m $83.3m 0.02% Reduced -592.3k -592,306
13 MACQUARIE GROUP LTD 0.09% of their portfolio Sydney, NSW 2000, C3 7,171,0357.2m $79.5m $79.5m 0.09% Added +213.0k +212,988
14 NORGES BANK 0.01% of their portfolio OSLO, Q8 5,169,4195.2m $57.3m $57.3m 0.01% Reduced -230.7k -230,667
15 GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio BOSTON, MA 5,142,4075.1m $57.0m $57.0m 0.01% Added +252.0k +251,979
16 Fiera Capital Corp 0.17% of their portfolio MONTREAL, A8 5,101,3645.1m $56.6m $56.6m 0.17% Reduced -87.8k -87,793
17 FMR LLC 0.00% of their portfolio BOSTON, MA 4,414,4764.4m $49.0m $49.0m 0.00% Added +1.9m +1,922,828
18 Artal Group S.A. 2.32% of their portfolio LUXEMBOURG, N4 3,526,4073.5m $39.1m $39.1m 2.32% Reduced -473.6k -473,593
19 NORTHERN TRUST CORP 0.01% of their portfolio CHICAGO, IL 2,716,8342.7m $30.1m $30.1m 0.01% Added +19.3k +19,261
20 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 2,500,0662.5m $27.7m $27.7m 0.00% Added +147.8k +147,769
21 Boxer Capital, LLC 1.27% of their portfolio San Diego, CA 2,325,0002.3m $25.8m $25.8m 1.27% Unchanged
22 WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC 0.09% of their portfolio CHICAGO, IL 2,281,0922.3m $25.3m $25.3m 0.09% Added +179.9k +179,906
23 Point72 Asset Management, L.P. 0.09% of their portfolio STAMFORD, CT 2,249,1282.2m $24.9m $24.9m 0.09% New
24 Balyasny Asset Management L.P. 0.08% of their portfolio Chicago, IL 2,118,6082.1m $23.5m $23.5m 0.08% Added +118.8k +118,752
25 NOVO HOLDINGS A/S 1.53% of their portfolio HELLERUP, G7 2,095,9002.1m $23.2m $23.2m 1.53% Unchanged
26 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio SAN FRANCISCO, CA 2,066,1582.1m $22.9m $22.9m 0.01% Added +975 +975
27 MILLENNIUM MANAGEMENT LLC 0.02% of their portfolio NEW YORK, NY 1,938,5831.9m $21.5m $21.5m 0.02% Added +1.5m +1,467,981
28 VICTORY CAPITAL MANAGEMENT INC 0.02% of their portfolio San Antonio, TX 1,910,7681.9m $21.2m $21.2m 0.02% Added +1.7m +1,728,159
29 GOLDMAN SACHS GROUP INC 0.01% of their portfolio NEW YORK, NY 1,910,7311.9m $21.2m $21.2m 0.01% Added +28.1k +28,103
30 HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.11% of their portfolio TORONTO, A6 1,819,5001.8m $20.2m $20.2m 0.11% Reduced -119.3k -119,300
31 D. E. Shaw & Co., Inc. 0.03% of their portfolio New York, NY 1,651,5971.7m $18.3m $18.3m 0.03% Reduced -581.7k -581,728
32 NEW YORK STATE COMMON RETIREMENT FUND 0.02% of their portfolio ALBANY, NY 1,504,7181.5m $16.7m $16.7m 0.02% Reduced -54.9k -54,883
33 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 1,469,0021.5m $16.3m $16.3m 0.00% Reduced -21.2k -21,193
34 Finepoint Capital LP 6.19% of their portfolio BOSTON, MA 1,460,1751.5m $16.2m $16.2m 6.19% Added +31.7k +31,700
35 PANAGORA ASSET MANAGEMENT INC 0.10% of their portfolio BOSTON, MA 1,366,9651.4m $15.2m $15.2m 0.10% Added +123.6k +123,604
36 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 1,171,3551.2m $13.0m $13.0m 0.00% Reduced -20.5k -20,518
37 ORBIMED ADVISORS LLC 0.26% of their portfolio New York, NY 1,171,0001.2m $13.0m $13.0m 0.26% Added +655.0k +655,000
38 PRIMECAP MANAGEMENT CO/CA/ 0.01% of their portfolio PASADENA, CA 1,153,4001.2m $12.8m $12.8m 0.01% Unchanged
39 DEUTSCHE BANK AG\ 0.01% of their portfolio FRANKFURT AM MAIN, 2M 1,107,2731.1m $12.3m $12.3m 0.01% Added +71.0k +70,969
40 Rock Springs Capital Management LP 0.28% of their portfolio Baltimore, MD 1,063,8061.1m $11.8m $11.8m 0.28% Unchanged
41 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 932,729932.7k $10.3m $10.3m 0.00% Added +111.6k +111,630
42 RICE HALL JAMES & ASSOCIATES, LLC 0.53% of their portfolio San Diego, CA 846,859846.9k $9.4m $9.4m 0.53% Added +139.0k +138,971
43 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 810,206810.2k $9.0m $9.0m 0.00% Reduced -165.1k -165,086
44 PEREGRINE CAPITAL MANAGEMENT LLC 0.25% of their portfolio MINNEAPOLIS, MN 796,564796.6k $8.8m $8.8m 0.25% Added +92.7k +92,697
45 PRUDENTIAL FINANCIAL INC 0.01% of their portfolio NEWARK, NJ 733,784733.8k $8.1m $8.1m 0.01% Added +408.0k +408,025
46 VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio ATLANTA, GA 732,393732.4k $8.1m $8.1m 0.01% Reduced -8.9k -8,919
47 Candriam S.C.A. 0.05% of their portfolio STRASSEN, N4 693,879693.9k $7.1m $7.1m 0.05% Unchanged
48 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 691,813691.8k $7.7m $7.7m 0.00% Added +147.4k +147,422
49 CITIGROUP INC 0.01% of their portfolio NEW YORK, NY 595,643595.6k $6.6m $6.6m 0.01% Added +219.2k +219,224
50 Rafferty Asset Management, LLC 0.04% of their portfolio New York, NY 594,701594.7k $6.6m $6.6m 0.04% Reduced -95.1k -95,068
51 GREAT LAKES ADVISORS, LLC 0.06% of their portfolio CHICAGO, IL 573,806573.8k $6.4m $6.4m 0.06% New
52 SECTORAL ASSET MANAGEMENT INC 1.11% of their portfolio MONTREAL, A8 519,982520.0k $5.8m $5.8m 1.11% Added +12.3k +12,300
53 CITADEL ADVISORS LLC 0.01% of their portfolio MIAMI, FL 503,976504.0k $5.6m $5.6m 0.01% Added +376.9k +376,877
54 Ghost Tree Capital, LLC 1.99% of their portfolio NEW YORK, NY 475,000475.0k $5.3m $5.3m 1.99% New
55 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 458,368458.4k $5.1m $5.1m 0.00% Added +122.9k +122,904
56 BARCLAYS PLC 0.01% of their portfolio LONDON, X0 457,150457.1k $5.1m $5.1m 0.01% Added +35.3k +35,330
57 Swiss National Bank 0.00% of their portfolio ZURICH, V8 454,800454.8k $5.0m $5.0m 0.00% Reduced -53.2k -53,200
58 CM Management, LLC 5.93% of their portfolio GULF BREEZE, FL 450,000450.0k $5.0m $5.0m 5.93% Unchanged
59 TWO SIGMA ADVISERS, LP 0.01% of their portfolio NEW YORK, NY 436,676436.7k $4.8m $4.8m 0.01% Reduced -82.2k -82,200
60 RHUMBLINE ADVISERS 0.01% of their portfolio BOSTON, MA 427,336427.3k $4.7m $4.7m 0.01% Added +33.9k +33,941
61 Hillsdale Investment Management Inc. 0.38% of their portfolio Toronto, A6 400,800400.8k $4.4m $4.4m 0.38% Added +700 +700
62 RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio NEW YORK, NY 389,000389.0k $4.3m $4.3m 0.01% New
63 MPM BIOIMPACT LLC 1.12% of their portfolio BOSTON, MA 388,292388.3k $4.3m $4.3m 1.12% Reduced -12.1k -12,118
64 J. Goldman & Co LP 0.25% of their portfolio NEW YORK, NY 387,654387.7k $4.3m $4.3m 0.25% Added +162.7k +162,743
65 GREAT POINT PARTNERS LLC 0.83% of their portfolio Greenwich, CT 380,000380.0k $4.2m $4.2m 0.83% New
66 ALGERT GLOBAL LLC 0.17% of their portfolio SAN FRANCISCO, CA 330,425330.4k $3.7m $3.7m 0.17% Added +52.1k +52,073
67 NEUBERGER BERMAN GROUP LLC 0.00% of their portfolio NEW YORK, NY 325,055325.1k $3.6m $3.6m 0.00% Added +14.8k +14,819
68 Ergoteles LLC 0.14% of their portfolio NEW YORK, NY 322,144322.1k $3.6m $3.6m 0.14% Added +112.7k +112,678
69 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio BALA CYNWYD, PA 316,471316.5k $3.5m $3.5m 0.01% Added +198.9k +198,883
70 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 315,959316.0k $3.5m $3.5m 0.00% Added +30 +30
71 Integral Health Asset Management, LLC 0.70% of their portfolio New York, NY 305,000305.0k $3.4m $3.4m 0.70% Reduced -22.0k -22,000
72 BANK OF MONTREAL /CAN/ 0.00% of their portfolio TORONTO, A6 300,836300.8k $3.4m $3.4m 0.00% Added +11.4k +11,420
73 CREDIT SUISSE AG/ 0.00% of their portfolio ZURICH, V8 291,414291.4k $3.2m $3.2m 0.00% Added +15.7k +15,662
74 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 287,714287.7k $3.2m $3.2m 0.00% Reduced -5.4k -5,433
75 Faithward Advisors, LLC 0.76% of their portfolio LANCASTER, PA 287,050287.1k $3.4m $3.4m 0.76% Reduced -28.8k -28,756
76 BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio PARIS, I0 283,781283.8k $3.1m $3.1m 0.01% Added +143.0k +142,974
77 STRS OHIO 0.00% of their portfolio COLUMBUS, OH 273,300273.3k $3.0m $3.0m 0.00% Added +217.2k +217,200
78 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 271,402271.4k $3.0m $3.0m 0.00% Added +21.7k +21,731
79 UBS Group AG 0.00% of their portfolio ZURICH, V8 270,247270.2k $3.0m $3.0m 0.00% Reduced -306.1k -306,104
80 SEI INVESTMENTS CO 0.01% of their portfolio OAKS, PA 268,467268.5k $3.0m $3.0m 0.01% Reduced -45.6k -45,614
81 Trexquant Investment LP 0.08% of their portfolio STAMFORD, CT 267,931267.9k $3.0m $3.0m 0.08% Added +129.4k +129,447
82 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 264,202264.2k $2.9m $2.9m 0.00% Reduced -21.1k -21,133
83 Lombard Odier Asset Management (Switzerland) SA 0.25% of their portfolio PETIT-LANCY, V8 261,592261.6k $2.9m $2.9m 0.25% New
84 Saturn V Capital Management LP 2.14% of their portfolio AUSTIN, TX 258,288258.3k $2.9m $2.9m 2.14% Reduced -307.9k -307,891
85 Allianz Asset Management GmbH 0.01% of their portfolio MUNICH, 2M 257,828257.8k $2.9m $2.9m 0.01% Added +10.1k +10,121
86 Hudson Bay Capital Management LP 0.02% of their portfolio STAMFORD, CT 250,000250.0k $2.8m $2.8m 0.02% Added +125.0k +125,000
87 Cubist Systematic Strategies, LLC 0.03% of their portfolio STAMFORD, CT 243,707243.7k $2.7m $2.7m 0.03% Added +172.8k +172,844
88 Legal & General Group Plc 0.00% of their portfolio London, X0 243,132243.1k $2.7m $2.7m 0.00% Reduced -108.5k -108,499
89 SILVERCREST ASSET MANAGEMENT GROUP LLC 0.02% of their portfolio NEW YORK, NY 238,896238.9k $2.6m $2.6m 0.02% Reduced -189 -189
90 DekaBank Deutsche Girozentrale 0.01% of their portfolio FRANKFURT, 2M 217,700217.7k $2.3m $2.3m 0.01% Unchanged
91 WEDGE CAPITAL MANAGEMENT L L P/NC 0.04% of their portfolio CHARLOTTE, NC 217,454217.5k $2.4m $2.4m 0.04% Reduced -11.4k -11,426
92 TRANSCEND CAPITAL ADVISORS, LLC 0.25% of their portfolio MADISON, NJ 216,459216.5k $2.4m $2.4m 0.25% Added +773 +773
93 Mirae Asset Global Investments Co., Ltd. 0.01% of their portfolio SEOUL, M5 210,049210.0k $2.3m $2.3m 0.01% Added +23.9k +23,937
94 FIRST TRUST ADVISORS LP 0.00% of their portfolio Wheaton, IL 206,269206.3k $2.3m $2.3m 0.00% Reduced -9.8k -9,779
95 HRT FINANCIAL LP 0.03% of their portfolio NEW YORK, NY 204,695204.7k $2.3m $2.3m 0.03% Reduced -86.0k -85,981
96 Qube Research & Technologies Ltd 0.01% of their portfolio LONDON, X0 204,119204.1k $2.3m $2.3m 0.01% Added +139.8k +139,829
97 MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC 0.03% of their portfolio New York, NY 195,141195.1k $2.2m $2.2m 0.03% Reduced -9.0k -8,996
98 STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio MADISON, WI 194,374194.4k $2.2m $2.2m 0.01% Reduced -17.1k -17,058
99 State of New Jersey Common Pension Fund D 0.01% of their portfolio TRENTON, NJ 177,756177.8k $2.0m $2.0m 0.01% Reduced -22.0k -22,032
100 Jump Financial, LLC 0.08% of their portfolio Chicago, IL 167,647167.6k $1.9m $1.9m 0.08% New