Vault-13

ALPINE IMMUNE SCIENCES INC NVLS

COM · Common Stock · CUSIP 02083G100

89 institutional holders +12 vs Q2 2023
45,924,84145.9m shares reported held*
$525.8mreported value*
17 new 34 added 21 reduced 5 sold out net bought ≈ $102.2m (+8.9m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $11.45. Options: 3 managers hold calls ($20.6k notional), 1 hold puts ($0).

Trends to Q3 2023

Institutional holders

Managers reporting a position, each quarter

050100Q3 22: 70Q4 22: 64Q1 23: 61Q2 23: 77Q3 23: 8989Q3 22Q4 22Q1 23Q2 23Q3 23
Numbers
QuarterHolders
Q3 202270
Q4 202264
Q1 202361
Q2 202377
Q3 202389

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q4 22: 40 bought or addedQ4 22: 24 cut or sold outQ4 22Q1 23: 31 bought or addedQ1 23: 20 cut or sold outQ1 23Q2 23: 52 bought or addedQ2 23: 14 cut or sold outQ2 23Q3 23: 51 bought or addedQ3 23: 26 cut or sold outQ3 23
Numbers
QuarterBought or addedCut or sold out
Q4 20224024
Q1 20233120
Q2 20235214
Q3 20235126

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$20k$40k$60kQ4 22 calls: $8.1kQ4 22 puts: $735Q4 22P/C 0.09Q1 23 calls: $0Q1 23 puts: $0Q1 23P/C —Q2 23 calls: $51.6kQ2 23 puts: $0Q2 23P/C 0.00Q3 23 calls: $20.6kQ3 23 puts: $0Q3 23P/C 0.00
Numbers
QuarterCallsPutsP/C
Q4 2022$8.1k$7350.09
Q1 2023$0$0—
Q2 2023$51.6k$00.00
Q3 2023$20.6k$00.00

Biggest buyers

Decheng Capital Management III (Cayman), LLC New +6,708,288+6.7m
Cormorant Asset Management, LP New +1,900,000+1.9m
PRICE T ROWE ASSOCIATES INC /MD/ Added +1,374,704+1.4m
Woodline Partners LP Added +801,213+801.2k
Ghost Tree Capital, LLC Added +316,700+316.7k
Invesco Ltd. New +217,136+217.1k
Nan Fung Group Holdings Ltd New +182,280+182.3k
TWO SIGMA ADVISERS, LP Added +159,700+159.7k
ExodusPoint Capital Management, LP Added +154,216+154.2k
CHARLES SCHWAB INVESTMENT MANAGEMENT INC Added +147,976+148.0k

Biggest sellers

Omega Fund Management, LLC Reduced -1,875,880-1.9m
Avidity Partners Management LP Reduced -401,220-401.2k
GREAT POINT PARTNERS LLC Reduced -285,055-285.1k
Lynx1 Capital Management LP Reduced -265,858-265.9k
TCG Crossover Management, LLC Sold out -253,069-253.1k
FMR LLC Reduced -210,774-210.8k
Affinity Asset Advisors, LLC Sold out -118,891-118.9k
DEUTSCHE BANK AG\ Reduced -109,814-109.8k
HighVista Strategies LLC Reduced -50,426-50.4k
WESTWOOD HOLDINGS GROUP INC Sold out -43,799-43.8k

Biggest calls

CITADEL ADVISORS LLC Reduced $19.5k1.7k shares
GROUP ONE TRADING LLC New $1.1k100 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Holders, Q3 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Decheng Capital Management III (Cayman), LLC 25.63% of their portfolio Grand Cayman, E9 6,708,2886.7m $76.8m $76.8m 25.63% New
2 RA CAPITAL MANAGEMENT, L.P. 1.06% of their portfolio BOSTON, MA 4,691,1784.7m $53.7m $53.7m 1.06% Unchanged
3 ORBIMED ADVISORS LLC 1.00% of their portfolio New York, NY 4,081,5924.1m $46.7m $46.7m 1.00% Unchanged
4 GREAT POINT PARTNERS LLC 6.63% of their portfolio Greenwich, CT 3,078,6333.1m $35.3m $35.3m 6.63% Reduced -285.1k -285,055
5 Frazier Life Sciences Management, L.P. 2.27% of their portfolio PALO ALTO, CA 2,985,7573.0m $34.2m $34.2m 2.27% Unchanged
6 Paradigm Biocapital Advisors LP 1.89% of their portfolio NEW YORK, NY 2,421,7432.4m $27.7m $27.7m 1.89% Reduced -2.2k -2,218
7 Lynx1 Capital Management LP 18.21% of their portfolio DORADO, PR 2,404,6142.4m $27.5m $27.5m 18.21% Reduced -265.9k -265,858
8 BlackRock Inc. 0.00% of their portfolio New York, NY 2,351,9172.4m $26.9m $26.9m 0.00% Added +70.2k +70,225
9 Cormorant Asset Management, LP 1.27% of their portfolio BOSTON, MA 1,900,0001.9m $21.8m $21.8m 1.27% New
10 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 1,474,8791.5m $16.9m $16.9m 0.00% Added +70.9k +70,912
11 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 1,396,4441.4m $16.0m $16.0m 0.00% Added +1.4m +1,374,704
12 Commodore Capital LP 1.77% of their portfolio NEW YORK, NY 1,325,0001.3m $15.2m $15.2m 1.77% Unchanged
13 Artal Group S.A. 0.60% of their portfolio LUXEMBOURG, N4 1,193,0301.2m $13.7m $13.7m 0.60% Unchanged
14 Woodline Partners LP 0.14% of their portfolio San Francisco, CA 1,038,7771.0m $11.9m $11.9m 0.14% Added +801.2k +801,213
15 Vivo Capital, LLC 1.15% of their portfolio Palo Alto, CA 914,913914.9k $10.5m $10.5m 1.15% Unchanged
16 Octagon Capital Advisors LP 1.51% of their portfolio NEW YORK, NY 750,000750.0k $8.6m $8.6m 1.51% Unchanged
17 Ghost Tree Capital, LLC 3.68% of their portfolio NEW YORK, NY 664,132664.1k $7.6m $7.6m 3.68% Added +316.7k +316,700
18 Avidity Partners Management LP 0.30% of their portfolio DALLAS, TX 657,280657.3k $7.5m $7.5m 0.30% Reduced -401.2k -401,220
19 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 628,925628.9k $7.2m $7.2m 0.00% Added +11.0k +10,951
20 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 605,545605.5k $6.9m $6.9m 0.00% Added +32.7k +32,703
21 FMR LLC 0.00% of their portfolio BOSTON, MA 464,812464.8k $5.3m $5.3m 0.00% Reduced -210.8k -210,774
22 Tri Locum Partners LP 1.15% of their portfolio NEW YORK, NY 314,029314.0k $3.6m $3.6m 1.15% Reduced -18.0k -17,963
23 RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio NEW YORK, NY 288,194288.2k $3.3m $3.3m 0.01% Reduced -31.1k -31,100
24 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 270,424270.4k $3.1m $3.1m 0.00% Added +12.9k +12,900
25 TWO SIGMA ADVISERS, LP 0.01% of their portfolio NEW YORK, NY 246,075246.1k $2.8m $2.8m 0.01% Added +159.7k +159,700
26 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 234,256234.3k $2.7m $2.7m 0.00% Added +148.0k +147,976
27 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 217,136217.1k $2.5m $2.5m 0.00% New
28 ExodusPoint Capital Management, LP 0.03% of their portfolio NEW YORK, NY 217,055217.1k $2.5m $2.5m 0.03% Added +154.2k +154,216
29 TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio NEW YORK, NY 190,589190.6k $2.2m $2.2m 0.01% Added +132.6k +132,561
30 Walleye Capital LLC 0.03% of their portfolio NEW YORK, NY 186,273186.3k $2.1m $2.1m 0.03% Added +21.6k +21,600
31 Nan Fung Group Holdings Ltd 1.69% of their portfolio KAI TAK, K3 182,280182.3k $2.1m $2.1m 1.69% New
32 SPHERA FUNDS MANAGEMENT LTD. 0.49% of their portfolio TEL AVIV, L3 180,000180.0k $2.1m $2.1m 0.49% Reduced -20.0k -20,000
33 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 167,308167.3k $1.9m $1.9m 0.00% Added +25.8k +25,809
34 Omega Fund Management, LLC 1.62% of their portfolio Boston, MA 153,700153.7k $1.8m $1.8m 1.62% Reduced -1.9m -1,875,880
35 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 93,38593.4k $1.1m $1.1m 0.00% Reduced -292 -292
36 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 92,72392.7k $1.1m $1.1m 0.00% Added +1.2k +1,216
37 Schonfeld Strategic Advisors LLC 0.01% of their portfolio NEW YORK, NY 90,93790.9k $1.0m $1.0m 0.01% Added +78.0k +78,037
38 Soleus Capital Management, L.P. 0.10% of their portfolio GREENWICH, CT 88,07388.1k $1.0m $1.0m 0.10% Unchanged
39 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 82,92682.9k $949.5k $949.5k 0.00% Reduced -33.2k -33,249
40 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 66,44566.4k $760.8k $760.8k 0.00% Added +10.7k +10,670
41 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 53,47353.5k $612.3k $612.3k 0.00% Added +3.3k +3,269
42 D. E. Shaw & Co., Inc. 0.00% of their portfolio New York, NY 48,63148.6k $556.8k $556.8k 0.00% New
43 Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio VANCOUVER, A1 45,47545.5k $520.7k $520.7k 0.00% Reduced -1.1k -1,118
44 Swiss National Bank 0.00% of their portfolio ZURICH, V8 42,20042.2k $483.2k $483.2k 0.00% New
45 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 41,40341.4k $474.1k $474.1k 0.00% Added +2.0k +1,977
46 HighVista Strategies LLC 0.21% of their portfolio BOSTON, MA 39,86139.9k $456.4k $456.4k 0.21% Reduced -50.4k -50,426
47 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 39,73139.7k $454.9k $454.9k 0.00% New
48 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 31,30931.3k $358.5k $358.5k 0.00% Added +5.0k +4,960
49 Trexquant Investment LP 0.01% of their portfolio STAMFORD, CT 28,57828.6k $327.2k $327.2k 0.01% Reduced -14.2k -14,195
50 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 28,38328.4k $325.0k $325.0k 0.00% Added +14.9k +14,900
51 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 28,17428.2k $322.6k $322.6k 0.00% Reduced -25.5k -25,549
52 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 23,99324.0k $274.7k $274.7k 0.00% Added +13.4k +13,434
53 Legal & General Group Plc 0.00% of their portfolio London, X0 22,71522.7k $260.1k $260.1k 0.00% Added +19.2k +19,223
54 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 22,19722.2k $254.2k $254.2k 0.00% New
55 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 21,30021.3k $243.9k $243.9k 0.00% Added +3.4k +3,385
56 ALGERT GLOBAL LLC 0.01% of their portfolio SAN FRANCISCO, CA 20,01020.0k $229.1k $229.1k 0.01% New
57 UBS Group AG 0.00% of their portfolio ZURICH, V8 19,04719.0k $218.1k $218.1k 0.00% Reduced -26.8k -26,803
58 Driehaus Capital Management LLC 0.00% of their portfolio Chicago, IL 18,63618.6k $213.4k $213.4k 0.00% New
59 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 18,50018.5k $211.8k $211.8k 0.00% Added +2.7k +2,680
60 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 18,19818.2k $208.4k $208.4k 0.00% New
61 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 17,51117.5k $200.5k $200.5k 0.00% Reduced -109.8k -109,814
62 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 17,15317.2k $196.4k $196.4k 0.00% Added +72 +72
63 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 16,81816.8k $192.6k $192.6k 0.00% Unchanged
64 AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio New York, NY 15,84215.8k $181.4k $181.4k 0.00% Added +563 +563
65 CREDIT SUISSE AG/ 0.00% of their portfolio ZURICH, V8 15,20915.2k $174.1k $174.1k 0.00% New
66 MOORE CAPITAL MANAGEMENT, LP 0.00% of their portfolio NEW YORK, NY 13,74413.7k $157.4k $157.4k 0.00% Reduced -100 -100
67 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 13,51813.5k $154.8k $154.8k 0.00% Added +5.0k +5,029
68 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 13,50213.5k $154.6k $154.6k 0.00% Added +366 +366
69 Hikari Power Ltd 0.01% of their portfolio TOKYO, M0 12,44512.4k $142.0k $142.0k 0.01% Unchanged
70 Western Wealth Management, LLC 0.01% of their portfolio GOLDEN, CO 12,00012.0k $137.4k $137.4k 0.01% Unchanged
71 Qube Research & Technologies Ltd 0.00% of their portfolio LONDON, X0 10,07010.1k $115.3k $115.3k 0.00% New
72 SG Americas Securities, LLC 0.00% of their portfolio NEW YORK, NY 9,9279.9k $114.0k $114.0k 0.00% New
73 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 9,6349.6k $110.3k $110.3k 0.00% Added +4.2k +4,155
74 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 9,1269.1k $104.5k $104.5k 0.00% Added +2.8k +2,801
75 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 7,0357.0k $80.6k $80.6k 0.00% Reduced -5.6k -5,646
76 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 6,3236.3k $72.0k $72.0k 0.00% Added +3.7k +3,681
77 AMALGAMATED BANK 0.00% of their portfolio NEW YORK, NY 3,6563.7k $42.0k $42.0k 0.00% Unchanged
78 Ameritas Investment Partners, Inc. 0.00% of their portfolio LINCOLN, NE 2,6212.6k $30.0k $30.0k 0.00% Unchanged
79 Dorsey Wright & Associates 0.01% of their portfolio PASADENA, CA 2,2732.3k $26.0k $26.0k 0.01% Reduced -78 -78
80 Metropolitan Life Insurance Co/NY 0.00% of their portfolio New York, NY 1,7431.7k $20.0k $20.0k 0.00% Unchanged
81 China Universal Asset Management Co., Ltd. 0.00% of their portfolio SHANGHAI, F4 1,2691.3k $14.5k $14.5k 0.00% Added +640 +640
82 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 1,0731.1k $12.3k $12.3k 0.00% Added +40 +40
83 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 670670 $7.7k $7.7k 0.00% Reduced -9.6k -9,606
84 Aquatic Capital Management LLC 0.00% of their portfolio CHICAGO, IL 200200 $2.0k $2.0k 0.00% New
85 Allspring Global Investments Holdings, LLC 0.00% of their portfolio CHARLOTTE, NC 176176 $2.0k $2.0k 0.00% New
86 NewEdge Advisors, LLC 0.00% of their portfolio NEW ORLEANS, LA 125125 $1.4k $1.4k 0.00% New
87 Daiwa Securities Group Inc. 0.00% of their portfolio CHIYODA-KU,TOKYO, M0 8585 $1.0k $1.0k 0.00% Unchanged
88 NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio ST. LOUIS, MO 1212 $137 $137 0.00% Unchanged
89 CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio BIRMINGHAM, AL 00 $0 $0 0.00% Unchanged