Vault-13

AKERO THERAPEUTICS INC AKRO

COM · Common Stock · CUSIP 00973Y108

259 institutional holders +17 vs Q1 2025
91,915,88091.9m shares reported held*
$4.9bnreported value*
53 new 88 added 86 reduced 38 sold out net bought ≈ $300.2m (+5.6m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($12.9m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $53.36. Options: 23 managers hold calls ($100.1m notional), 13 hold puts ($48.2m).

Trends to Q2 2025

Institutional holders

Managers reporting a position, each quarter

0100200300Q3 22: 146Q4 22: 162Q1 23: 157Q2 23: 159Q3 23: 183Q4 23: 158Q1 24: 174Q2 24: 154Q3 24: 169Q4 24: 192Q1 25: 242Q2 25: 259259Q3 22Q2 23Q1 24Q4 24Q2 25
Numbers
QuarterHolders
Q3 2022146
Q4 2022162
Q1 2023157
Q2 2023159
Q3 2023183
Q4 2023158
Q1 2024174
Q2 2024154
Q3 2024169
Q4 2024192
Q1 2025242
Q2 2025259

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q3 23: 115 bought or addedQ3 23: 50 cut or sold outQ4 23: 81 bought or addedQ4 23: 99 cut or sold outQ4 23Q1 24: 111 bought or addedQ1 24: 66 cut or sold outQ2 24: 76 bought or addedQ2 24: 87 cut or sold outQ2 24Q3 24: 78 bought or addedQ3 24: 74 cut or sold outQ4 24: 90 bought or addedQ4 24: 69 cut or sold outQ4 24Q1 25: 166 bought or addedQ1 25: 73 cut or sold outQ2 25: 141 bought or addedQ2 25: 124 cut or sold outQ2 25
Numbers
QuarterBought or addedCut or sold out
Q3 202311550
Q4 20238199
Q1 202411166
Q2 20247687
Q3 20247874
Q4 20249069
Q1 202516673
Q2 2025141124

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$50m$100m$150mQ3 24 calls: $8.5mQ3 24 puts: $18.6mQ3 24P/C 2.18Q4 24 calls: $17.2mQ4 24 puts: $16.3mQ4 24P/C 0.95Q1 25 calls: $51.2mQ1 25 puts: $36.6mQ1 25P/C 0.71Q2 25 calls: $100.1mQ2 25 puts: $48.2mQ2 25P/C 0.48
Numbers
QuarterCallsPutsP/C
Q3 2024$8.5m$18.6m2.18
Q4 2024$17.2m$16.3m0.95
Q1 2025$51.2m$36.6m0.71
Q2 2025$100.1m$48.2m0.48

Biggest buyers

Avoro Capital Advisors LLC New +3,500,000+3.5m
Point72 Asset Management, L.P. Added +2,202,589+2.2m
Woodline Partners LP Added +1,986,614+2.0m
Holocene Advisors, LP New +1,075,642+1.1m
BANK OF AMERICA CORP /DE/ Added +1,059,860+1.1m
Bellevue Group AG Added +734,606+734.6k
Pictet Asset Management Holding SA Added +671,922+671.9k
READYSTATE ASSET MANAGEMENT LP Added +540,423+540.4k
GENERAL ATLANTIC, L.P. Added +500,000+500.0k
BARCLAYS PLC Added +410,253+410.3k

Biggest sellers

WELLINGTON MANAGEMENT GROUP LLP Reduced -2,526,294-2.5m
RTW INVESTMENTS, LP Reduced -1,941,779-1.9m
SG Americas Securities, LLC Reduced -1,150,442-1.2m
CITADEL ADVISORS LLC Reduced -739,648-739.6k
LORD, ABBETT & CO. LLC Sold out -527,004-527.0k
VOLORIDGE INVESTMENT MANAGEMENT, LLC Sold out -501,485-501.5k
BlackRock, Inc. Reduced -475,612-475.6k
JANUS HENDERSON GROUP PLC Reduced -330,092-330.1k
PRICE T ROWE ASSOCIATES INC /MD/ Reduced -307,766-307.8k
Rheos Capital Works Inc. Sold out -276,000-276.0k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $28.8m540.2k shares
Point72 Asset Management, L.P. New $26.7m500.0k shares
Caption Management, LLC Added $7.5m140.0k shares
JANE STREET GROUP, LLC Added $6.7m125.9k shares
SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC New $4.3m80.0k shares
CITADEL ADVISORS LLC Added $4.0m74.3k shares
SIMPLEX TRADING, LLC Added $3.8m70.9k shares
GROUP ONE TRADING LLC Added $3.2m60.7k shares
Ikarian Capital, LLC New $2.4m44.4k shares
Centiva Capital, LP New $2.1m40.0k shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $17.4m325.2k shares
Caption Management, LLC Added $12.3m229.7k shares
CITADEL ADVISORS LLC Added $6.4m119.4k shares
Exome Asset Management LLC New $3.1m58.6k shares
JANE STREET GROUP, LLC Reduced $2.5m47.3k shares
CITIGROUP INC Reduced $1.4m27.0k shares
SIMPLEX TRADING, LLC Reduced $1.2m22.8k shares
Hunting Hill Global Capital, LLC New $1.1m20.0k shares
GROUP ONE TRADING LLC Reduced $1.0m19.1k shares
NOMURA HOLDINGS INC New $875.1k16.4k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
GENERAL ATLANTIC, L.P. 13G · passive investor filed 2025-05-15 8.4% 6.8m 2025-05-15

Fell to 5% or below in the last year: JANUS HENDERSON GROUP PLC (4.1%, 2026-02-17), RTW INVESTMENTS, LP (0.0%, 2026-02-17), Deep Track Capital, LP (0.0%, 2026-02-13), WELLINGTON MANAGEMENT GROUP LLP (0.0%, 2026-02-10), PRICE T ROWE ASSOCIATES INC /MD/ (4.8%, 2025-11-14)

Holders, Q2 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 JANUS HENDERSON GROUP PLC 0.18% of their portfolio LONDON, X0 6,738,5566.7m $359.5m $359.5m 0.18% Reduced -330.1k -330,092
2 BlackRock, Inc. 0.01% of their portfolio New York, NY 5,779,4125.8m $308.4m $308.4m 0.01% Reduced -475.6k -475,612
3 GENERAL ATLANTIC, L.P. 8.43% of their portfolio New York, NY 5,733,9895.7m $306.0m $306.0m 8.43% Added +500.0k +500,000
4 RTW INVESTMENTS, LP 4.16% of their portfolio NEW YORK, NY 5,477,5615.5m $292.3m $292.3m 4.16% Reduced -1.9m -1,941,779
5 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 4,529,6284.5m $241.7m $241.7m 0.00% Added +299.0k +298,984
6 PRICE T ROWE ASSOCIATES INC /MD/ 0.03% of their portfolio BALTIMORE, MD 4,509,3254.5m $240.6m $240.6m 0.03% Reduced -307.8k -307,766
7 Avoro Capital Advisors LLC 3.27% of their portfolio NEW YORK, NY 3,500,0003.5m $186.8m $186.8m 3.27% New
8 WELLINGTON MANAGEMENT GROUP LLP 0.03% of their portfolio Boston, MA 3,409,9463.4m $182.0m $182.0m 0.03% Reduced -2.5m -2,526,294
9 Deep Track Capital, LP 5.22% of their portfolio GREENWICH, CT 3,042,5983.0m $162.4m $162.4m 5.22% Reduced -167.7k -167,672
10 STATE STREET CORP 0.01% of their portfolio BOSTON, MA 2,745,5642.7m $146.5m $146.5m 0.01% Added +250.8k +250,821
11 Point72 Asset Management, L.P. 0.34% of their portfolio STAMFORD, CT 2,710,9292.7m $144.7m $144.7m 0.34% Added +2.2m +2,202,589
12 Woodline Partners LP 0.70% of their portfolio San Francisco, CA 2,467,3502.5m $131.7m $131.7m 0.70% Added +2.0m +1,986,614
13 UBS Group AG 0.02% of their portfolio ZURICH, V8 2,028,8872.0m $108.3m $108.3m 0.02% Reduced -127.5k -127,519
14 Bellevue Group AG 2.33% of their portfolio ZURICH, V8 1,985,2722.0m $105.9m $105.9m 2.33% Added +734.6k +734,606
15 ALKEON CAPITAL MANAGEMENT LLC 0.48% of their portfolio New York, NY 1,850,9341.9m $98.8m $98.8m 0.48% Added +300.0k +300,000
16 GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio BOSTON, MA 1,722,4051.7m $91.9m $91.9m 0.01% Reduced -26.8k -26,789
17 ALLIANCEBERNSTEIN L.P. 0.03% of their portfolio NASHVILLE, TN 1,536,2001.5m $82.0m $82.0m 0.03% Added +284.8k +284,831
18 MARSHALL WACE, LLP 0.09% of their portfolio LONDON, X0 1,418,2151.4m $75.7m $75.7m 0.09% Reduced -189.6k -189,627
19 BANK OF AMERICA CORP /DE/ 0.01% of their portfolio CHARLOTTE, NC 1,320,4611.3m $70.5m $70.5m 0.01% Added +1.1m +1,059,860
20 Logos Global Management LP 8.55% of their portfolio San Francisco, CA 1,200,0001.2m $64.0m $64.0m 8.55% Unchanged
21 CITADEL ADVISORS LLC 0.05% of their portfolio MIAMI, FL 1,169,6821.2m $62.4m $62.4m 0.05% Reduced -739.6k -739,648
22 Holocene Advisors, LP 0.14% of their portfolio New York, NY 1,075,6421.1m $57.4m $57.4m 0.14% New
23 Pictet Asset Management Holding SA 0.05% of their portfolio CAROUGE, V8 986,633986.6k $52.8m $52.8m 0.05% Added +671.9k +671,922
24 FMR LLC 0.00% of their portfolio BOSTON, MA 931,926931.9k $49.7m $49.7m 0.00% Reduced -77.2k -77,201
25 PERCEPTIVE ADVISORS LLC 1.83% of their portfolio NEW YORK, NY 915,887915.9k $48.9m $48.9m 1.83% Added +122.9k +122,927
26 Redmile Group, LLC 4.40% of their portfolio LARKSPUR, CA 774,311774.3k $41.3m $41.3m 4.40% Reduced -165.0k -164,966
27 GOLDMAN SACHS GROUP INC 0.01% of their portfolio NEW YORK, NY 765,741765.7k $40.9m $40.9m 0.01% Added +277.3k +277,349
28 Long Focus Capital Management, LLC 2.48% of their portfolio SAN JUAN, PR 720,000720.0k $38.4m $38.4m 2.48% Reduced -9.5k -9,504
29 SILVERARC CAPITAL MANAGEMENT, LLC 7.80% of their portfolio BOSTON, MA 713,811713.8k $38.1m $38.1m 7.80% Reduced -6.2k -6,181
30 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 693,256693.3k $37.0m $37.0m 0.00% Reduced -109.6k -109,598
31 READYSTATE ASSET MANAGEMENT LP 1.42% of their portfolio CHICAGO, IL 640,923640.9k $34.2m $34.2m 1.42% Added +540.4k +540,423
32 Rock Springs Capital Management LP 2.13% of their portfolio Baltimore, MD 640,526640.5k $34.2m $34.2m 2.13% Reduced -32.2k -32,233
33 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 634,326634.3k $33.8m $33.8m 0.00% Reduced -22.4k -22,407
34 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio SAN FRANCISCO, CA 614,266614.3k $32.8m $32.8m 0.01% Added +32.0k +32,012
35 DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio AUSTIN, TX 573,688573.7k $30.6m $30.6m 0.01% Added +47.0k +47,046
36 Sofinnova Investments, Inc. 1.99% of their portfolio Menlo Park, CA 548,788548.8k $29.3m $29.3m 1.99% Added +38.8k +38,768
37 LOOMIS SAYLES & CO L P 0.04% of their portfolio BOSTON, MA 540,788540.8k $28.9m $28.9m 0.04% Added +51.9k +51,850
38 BARCLAYS PLC 0.01% of their portfolio LONDON, X0 533,416533.4k $28.5m $28.5m 0.01% Added +410.3k +410,253
39 EcoR1 Capital, LLC 1.39% of their portfolio San Francisco, CA 440,000440.0k $23.5m $23.5m 1.39% Unchanged
40 Vivo Capital, LLC 2.37% of their portfolio Palo Alto, CA 434,689434.7k $23.2m $23.2m 2.37% Added +233.5k +233,521
41 VOYA INVESTMENT MANAGEMENT LLC 0.02% of their portfolio ATLANTA, GA 417,423417.4k $22.3m $22.3m 0.02% Added +252.5k +252,481
42 Aberdeen Group plc 0.04% of their portfolio EDINBURGH, X0 391,600391.6k $20.9m $20.9m 0.04% Reduced -15.1k -15,100
43 PRINCIPAL FINANCIAL GROUP INC 0.01% of their portfolio DES MOINES, IA 390,174390.2k $20.8m $20.8m 0.01% Added +133.1k +133,149
44 Hudson Bay Capital Management LP 0.14% of their portfolio STAMFORD, CT 386,523386.5k $20.6m $20.6m 0.14% Added +84.6k +84,573
45 SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC 0.76% of their portfolio Boston, MA 366,997367.0k $19.6m $19.6m 0.76% Reduced -213.0k -213,003
46 Frazier Life Sciences Management, L.P. 0.78% of their portfolio PALO ALTO, CA 366,784366.8k $19.6m $19.6m 0.78% New
47 Nuveen, LLC 0.01% of their portfolio CHARLOTTE, NC 366,769366.8k $19.6m $19.6m 0.01% Added +58.4k +58,443
48 Jain Global LLC 0.29% of their portfolio NEW YORK, NY 345,372345.4k $18.4m $18.4m 0.29% Added +222.5k +222,475
49 DEUTSCHE BANK AG\ 0.01% of their portfolio FRANKFURT AM MAIN, 2M 341,998342.0k $18.2m $18.2m 0.01% Added +107.9k +107,868
50 University of Wisconsin Foundation 19.61% of their portfolio MADISON, WI 328,504328.5k $17.5m $17.5m 19.61% Unchanged
51 BAKER BROS. ADVISORS LP 0.17% of their portfolio NEW YORK, NY 324,630324.6k $17.3m $17.3m 0.17% Reduced -224.1k -224,083
52 Siren, L.L.C. 0.88% of their portfolio New York, NY 318,647318.6k $17.0m $17.0m 0.88% New
53 MILLENNIUM MANAGEMENT LLC 0.02% of their portfolio NEW YORK, NY 314,989315.0k $16.8m $16.8m 0.02% Added +84.1k +84,125
54 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 313,493313.5k $16.7m $16.7m 0.00% Reduced -18.9k -18,890
55 FRED ALGER MANAGEMENT, LLC 0.07% of their portfolio NEW YORK, NY 310,569310.6k $16.6m $16.6m 0.07% Reduced -204.8k -204,755
56 Yiheng Capital Management, L.P. 5.79% of their portfolio SAN FRANCISCO, CA 299,791299.8k $16.0m $16.0m 5.79% Reduced -60.0k -60,000
57 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.03% of their portfolio Boston, MA 295,000295.0k $15.7m $15.7m 0.03% Added +100.0k +100,000
58 EMERALD ADVISERS, LLC 0.57% of their portfolio LEOLA, PA 291,692291.7k $15.6m $15.6m 0.57% Reduced -2.7k -2,710
59 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 273,445273.4k $14.6m $14.6m 0.00% Added +194.0k +193,978
60 PFM Health Sciences, LP 1.23% of their portfolio SAN FRANCISCO, CA 266,167266.2k $14.2m $14.2m 1.23% New
61 Foresite Capital Management VI LLC 7.35% of their portfolio WEST HOLLYWOOD, CA 244,900244.9k $13.1m $13.1m 7.35% Reduced -120.1k -120,100
62 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 237,683237.7k $12.7m $12.7m 0.00% Added +25.0k +25,018
63 B Group, Inc. 10.71% of their portfolio DALLAS, TX 232,446232.4k $12.4m $12.4m 10.71% Reduced -10.1k -10,054
64 Propel Bio Management, LLC 14.82% of their portfolio Los Angeles, CA 228,884228.9k $12.2m $12.2m 14.82% Unchanged
65 Eagle Health Investments LP 2.98% of their portfolio Greenwich, CT 226,400226.4k $12.1m $12.1m 2.98% Unchanged
66 Ikarian Capital, LLC 3.88% of their portfolio DALLAS, TX 220,000220.0k $11.7m $11.7m 3.88% Reduced -25.0k -25,000
67 ORBIMED ADVISORS LLC 0.28% of their portfolio New York, NY 211,300211.3k $11.3m $11.3m 0.28% Added +31.4k +31,400
68 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.02% of their portfolio BALA CYNWYD, PA 207,754207.8k $11.1m $11.1m 0.02% Added +27.4k +27,364
69 EVENTIDE ASSET MANAGEMENT, LLC 0.19% of their portfolio Boston, MA 200,000200.0k $10.7m $10.7m 0.19% Reduced -534 -534
70 Rhenman & Partners Asset Management AB 1.33% of their portfolio Stockholm, V7 197,600197.6k $10.5m $10.5m 1.33% Added +105.1k +105,100
71 TD Asset Management Inc 0.01% of their portfolio Toronto, A6 191,448191.4k $10.2m $10.2m 0.01% Reduced -17.4k -17,400
72 Ensign Peak Advisors, Inc 0.02% of their portfolio SALT LAKE CITY, UT 188,409188.4k $10.1m $10.1m 0.02% Added +33.4k +33,365
73 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 167,305167.3k $8.9m $8.9m 0.00% Added +50.2k +50,184
74 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 161,565161.6k $8.6m $8.6m 0.00% Added +51.7k +51,656
75 SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio London, X0 149,431149.4k $8.0m $8.0m 0.01% Added +32.8k +32,824
76 Simplify Asset Management Inc. 0.47% of their portfolio Las Vegas, NV 145,609145.6k $7.8m $7.8m 0.47% Unchanged
77 Schonfeld Strategic Advisors LLC 0.06% of their portfolio NEW YORK, NY 141,306141.3k $7.5m $7.5m 0.06% Reduced -172.6k -172,625
78 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio Toronto, A6 138,834138.8k $7.4m $7.4m 0.01% Reduced -12.5k -12,456
79 EMERALD MUTUAL FUND ADVISERS TRUST 0.44% of their portfolio LEOLA, PA 136,297136.3k $7.3m $7.3m 0.44% Reduced -70.7k -70,738
80 Russell Investments Group, Ltd. 0.01% of their portfolio Seattle, WA 134,939134.9k $7.2m $7.2m 0.01% Reduced -23.3k -23,336
81 Avidity Partners Management LP 1.43% of their portfolio DALLAS, TX 134,000134.0k $7.2m $7.2m 1.43% Added +77.0k +77,000
82 STEMPOINT CAPITAL LP 2.01% of their portfolio NEW YORK, NY 116,779116.8k $6.2m $6.2m 2.01% Reduced -39.4k -39,406
83 First Turn Management, LLC 1.14% of their portfolio DEL MAR, CA 114,554114.6k $6.1m $6.1m 1.14% New
84 NAN FUNG TRINITY (HK) LTD 0.71% of their portfolio CENTRAL, HONG KONG, K3 110,650110.7k $5.9m $5.9m 0.71% New
85 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 107,438107.4k $5.7m $5.7m 0.00% Reduced -3.2k -3,249
86 Swiss National Bank 0.00% of their portfolio ZURICH, V8 106,400106.4k $5.7m $5.7m 0.00% Added +11.7k +11,700
87 GREAT POINT PARTNERS LLC 3.60% of their portfolio Greenwich, CT 103,848103.8k $5.5m $5.5m 3.60% New
88 Balyasny Asset Management L.P. 0.01% of their portfolio Chicago, IL 96,37196.4k $5.1m $5.1m 0.01% New
89 Rafferty Asset Management, LLC 0.02% of their portfolio New York, NY 93,12893.1k $5.0m $5.0m 0.02% Added +19.0k +19,047
90 PRUDENTIAL FINANCIAL INC 0.01% of their portfolio NEWARK, NJ 86,49086.5k $4.6m $4.6m 0.01% Added +48.1k +48,055
91 JENNISON ASSOCIATES LLC 0.00% of their portfolio NEW YORK, NY 76,86376.9k $4.1m $4.1m 0.00% Added +63.7k +63,685
92 Corient Private Wealth LP 0.01% of their portfolio MIAMI, FL 73,55373.6k $3.9m $3.9m 0.01% New
93 Soleus Capital Management, L.P. 0.27% of their portfolio GREENWICH, CT 72,00072.0k $3.8m $3.8m 0.27% Reduced -45.0k -45,000
94 AXA S.A. 0.01% of their portfolio PARIS, I0 70,98771.0k $3.8m $3.8m 0.01% New
95 J. Goldman & Co LP 0.11% of their portfolio NEW YORK, NY 65,62865.6k $3.5m $3.5m 0.11% Added +36.3k +36,302
96 BOOTHBAY FUND MANAGEMENT, LLC 0.10% of their portfolio NEW YORK, NY 63,56663.6k $3.4m $3.4m 0.10% Reduced -9.1k -9,100
97 Legal & General Group Plc 0.00% of their portfolio London, X0 60,87560.9k $3.2m $3.2m 0.00% Added +10.4k +10,376
98 HighVista Strategies LLC 1.18% of their portfolio BOSTON, MA 59,99360.0k $3.2m $3.2m 1.18% Added +35.9k +35,926
99 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 56,45156.5k $3.0m $3.0m 0.00% Added +9.8k +9,810
100 PICTON MAHONEY ASSET MANAGEMENT 0.04% of their portfolio Toronto, A6 56,28656.3k $3.0m $3.0m 0.04% Added +22.7k +22,675