Vault-13

JADE BIOSCIENCES INC JBIO

COM NEW · Common Stock · CUSIP 008064206

74 institutional holders
31,528,08431.5m shares reported held*
96.6% of all shares outstanding*
$315.0mreported value*

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($71.1k this quarter). Holder counts are more reliable. Shares outstanding: 32.6m as of 2025-08-08, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $9.99. Options: 1 managers hold calls ($0 notional), 5 hold puts ($1.5m).

Trends to Q2 2025

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$500k$1m$1.5m$2mQ3 24 calls: $0Q3 24 puts: $0Q3 24P/C —Q4 24 calls: $0Q4 24 puts: $0Q4 24P/C —Q1 25 calls: $0Q1 25 puts: $0Q1 25P/C —Q2 25 calls: $0Q2 25 puts: $1.5mQ2 25P/C —
Numbers
QuarterCallsPutsP/C
Q3 2024$0$0—
Q4 2024$0$0—
Q1 2025$0$0—
Q2 2025$0$1.5m—

Biggest buyers

FMR LLC New +4,835,383+4.8m
Fairmount Funds Management LLC New +3,220,368+3.2m
Venrock Adviser, LLC New +3,220,364+3.2m
Deep Track Capital, LP New +2,509,301+2.5m
VANGUARD GROUP INC New +1,807,582+1.8m
Frazier Life Sciences Management, L.P. New +1,772,116+1.8m
BlackRock, Inc. New +1,714,348+1.7m
Versant Venture Management, LLC New +1,525,820+1.5m
RTW INVESTMENTS, LP New +1,449,273+1.4m
Driehaus Capital Management LLC New +1,255,798+1.3m

Biggest sellers

None

Biggest calls

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP New $582.4k58.3k shares
Persistent Asset Partners Ltd New $452.2k12.4k shares
SIMPLEX TRADING, LLC New $258.0k25.9k shares
GROUP ONE TRADING LLC New $231.8k23.2k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. New $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
Fairmount Funds Management LLC 13D · may seek influence no change · filed 2026-06-09 20.0% no change 14.1m≈ $310.7m 2026-06-09
FMR LLC 13G · institution new · filed 2025-06-06 14.7% new 4.7m≈ $105.2m 2025-06-06
Janus Henderson Group Ltd. 13G · institution +4.3 pts · filed 2026-07-08 10.6% +4.3 pts 6.3m≈ $139.4m 2026-07-08
Venrock Healthcare Capital Partners III, L.P. 13G · passive investor -1.6 pts · filed 2026-08-14 8.3% -1.6 pts 5.1m≈ $114.3m 2026-08-14
RA CAPITAL MANAGEMENT, L.P. 13G · passive investor +2.9 pts · filed 2025-10-16 7.0% +2.9 pts 3.2m≈ $71.4m 2025-10-16
FRANKLIN TEMPLETON INC 13G · institution new · filed 2026-10-28 6.0% new 3.8m≈ $84.6m 2026-10-28
BlackRock, Inc. 13G · institution +0.5 pts · filed 2026-10-27 5.2% +0.5 pts 3.3m≈ $73.8m 2026-10-27
Paradigm Biocapital Advisors LP 13G · passive investor new · filed 2026-07-17 5.1% new 3.1m≈ $69.0m 2026-07-17
Bellevue Group AG 13G · institution -1.8 pts · filed 2026-08-14 5.0% -1.8 pts 3.1m≈ $67.9m 2026-08-14

Fell to 5% or below in the last year: Sofinnova Venture Partners X, L.P. (0.3%, 2026-03-05), Deep Track Capital, LP (0.0%, 2026-02-13), VANGUARD GROUP INC (4.2%, 2026-01-30), Frazier Life Sciences Public Fund, L.P. (4.2%, 2025-11-14)

Insider purchases and sales in Q2 2025

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
10010Q3 23: 0 buyingQ3 23: 3 sellingQ4 23: 0 buyingQ4 23: 5 sellingQ4 23Q1 24: 0 buyingQ1 24: 5 sellingQ2 24: 1 buyingQ2 24: 6 sellingQ2 24Q3 24: 0 buyingQ3 24: 0 sellingQ4 24: 0 buyingQ4 24: 0 sellingQ4 24Q1 25: 0 buyingQ1 25: 0 sellingQ2 25: 1 buyingQ2 25: 0 sellingQ2 25
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q3 20230—3$790.0k$790.0k
Q4 20230—5$1.2m$1.2m
Q1 20240—5$3.2m$3.2m
Q2 20241$1.5m6$3.3m$3.0m
Q3 20240—0——
Q4 20240—0——
Q1 20250—0——
Q2 20251$44.4k0——
DateInsiderTradeSharesPrice ValueTheir holding
2025-05-16 Frohlich Tom Chief Executive Officer, director Bought 6,000 $7.40 $44.4k6.0k shares new

Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).

Holders, Q2 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 FMR LLC 0.00% of their portfolio BOSTON, MA 4,835,3834.8m $48.3m $48.3m 0.00% New
2 Fairmount Funds Management LLC 4.17% of their portfolio WEST CONSHOHOCKEN, PA 3,220,3683.2m $32.2m $32.2m 4.17% New
3 Venrock Adviser, LLC 2.41% of their portfolio NEW YORK, NY 3,220,3643.2m $32.2m $32.2m 2.41% New
4 Deep Track Capital, LP 0.81% of their portfolio GREENWICH, CT 2,509,3012.5m $25.1m $25.1m 0.81% New
5 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 1,807,5821.8m $18.1m $18.1m 0.00% New
6 Frazier Life Sciences Management, L.P. 0.71% of their portfolio PALO ALTO, CA 1,772,1161.8m $17.7m $17.7m 0.71% New
7 BlackRock, Inc. 0.00% of their portfolio New York, NY 1,714,3481.7m $17.1m $17.1m 0.00% New
8 Versant Venture Management, LLC 18.56% of their portfolio San Francisco, CA 1,525,8201.5m $15.2m $15.2m 18.56% New
9 RTW INVESTMENTS, LP 0.21% of their portfolio NEW YORK, NY 1,449,2731.4m $14.5m $14.5m 0.21% New
10 Driehaus Capital Management LLC 0.10% of their portfolio Chicago, IL 1,255,7981.3m $12.5m $12.5m 0.10% New
11 Avidity Partners Management LP 2.26% of their portfolio DALLAS, TX 1,127,1861.1m $11.3m $11.3m 2.26% New
12 RA CAPITAL MANAGEMENT, L.P. 0.18% of their portfolio BOSTON, MA 1,062,3261.1m $10.6m $10.6m 0.18% New
13 Soleus Capital Management, L.P. 0.55% of their portfolio GREENWICH, CT 796,744796.7k $8.0m $8.0m 0.55% New
14 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 676,431676.4k $6.8m $6.8m 0.00% New
15 Logos Global Management LP 0.83% of their portfolio San Francisco, CA 625,000625.0k $6.2m $6.2m 0.83% New
16 DEERFIELD MANAGEMENT COMPANY, L.P. 0.10% of their portfolio New York, NY 531,163531.2k $5.3m $5.3m 0.10% New
17 ORBIMED ADVISORS LLC 0.13% of their portfolio New York, NY 531,163531.2k $5.3m $5.3m 0.13% New
18 SAMSARA BIOCAPITAL, LLC 1.09% of their portfolio PALO ALTO, CA 531,163531.2k $5.3m $5.3m 1.09% New
19 GREAT POINT PARTNERS LLC 3.24% of their portfolio Greenwich, CT 498,054498.1k $5.0m $5.0m 3.24% New
20 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 318,771318.8k $3.2m $3.2m 0.00% New
21 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 274,830274.8k $2.7m $2.7m 0.00% New
22 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 228,092228.1k $2.3m $2.3m 0.00% New
23 Sofinnova Investments, Inc. 0.07% of their portfolio Menlo Park, CA 107,391107.4k $1.1m $1.1m 0.07% New
24 Woodline Partners LP 0.01% of their portfolio San Francisco, CA 106,270106.3k $1.1m $1.1m 0.01% New
25 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 103,255103.3k $1.0m $1.0m 0.00% New
26 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 78,39378.4k $783.1k $783.1k 0.00% New
27 Affinity Asset Advisors, LLC 0.10% of their portfolio NEW YORK, NY 65,31765.3k $652.5k $652.5k 0.10% New
28 TCG Crossover Management, LLC 0.07% of their portfolio PALO ALTO, CA 64,02364.0k $639.6k $639.6k 0.07% New
29 Nuveen, LLC 0.00% of their portfolio CHARLOTTE, NC 60,12860.1k $600.7k $600.7k 0.00% New
30 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 49,77349.8k $497.2k $497.2k 0.00% New
31 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 44,57044.6k $445.2k $445.2k 0.00% New
32 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 39,22939.2k $391.9k $391.9k 0.00% New
33 XTX Topco Ltd 0.01% of their portfolio LONDON, X0 25,75225.8k $257.3k $257.3k 0.01% New
34 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 25,61425.6k $255.9k $255.9k 0.00% New
35 INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio WEST PALM BEACH, FL 22,99523.0k $229.7k $229.7k 0.00% New
36 Quantinno Capital Management LP 0.00% of their portfolio NEW YORK, NY 21,98622.0k $219.6k $219.6k 0.00% New
37 UBS Group AG 0.00% of their portfolio ZURICH, V8 21,03821.0k $210.2k $210.2k 0.00% New
38 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 20,83320.8k $208.1k $208.1k 0.00% New
39 MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio CAUSEWAY BAY, K3 17,75717.8k $177.4k $177.4k 0.00% New
40 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 16,25616.3k $163.0k $163.0k 0.00% New
41 DELTEC ASSET MANAGEMENT LLC 0.03% of their portfolio New York, NY 15,75615.8k $157.4k $157.4k 0.03% New
42 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 15,36715.4k $153.5k $153.5k 0.00% New
43 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 14,35014.3k $143.4k $143.4k 0.00% New
44 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 12,14312.1k $121.3k $121.3k 0.00% New
45 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 12,05412.1k $120.4k $120.4k 0.00% New
46 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 11,42011.4k $114.1k $114.1k 0.00% New
47 Corient Private Wealth LP 0.00% of their portfolio MIAMI, FL 10,13310.1k $101.2k $101.2k 0.00% New
48 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 7,3827.4k $74.0k $74.0k 0.00% New
49 Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio TRENTON, NJ 7,1137.1k $71.1k $71.1k 0.00% New
50 GROUP ONE TRADING LLC 0.00% of their portfolio CHICAGO, IL 5,2685.3k $52.6k $52.6k 0.00% New
51 STRS OHIO 0.00% of their portfolio COLUMBUS, OH 4,9004.9k $49.0k $49.0k 0.00% New
52 Ameritas Investment Partners, Inc. 0.00% of their portfolio LINCOLN, NE 3,3123.3k $33.1k $33.1k 0.00% New
53 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 3,2223.2k $32.2k $32.2k 0.00% New
54 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 3,1433.1k $31.4k $31.4k 0.00% New
55 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 3,0893.1k $30.9k $30.9k 0.00% New
56 Legal & General Group Plc 0.00% of their portfolio London, X0 2,9543.0k $29.4k $29.4k 0.00% New
57 Sterling Capital Management LLC 0.00% of their portfolio CHARLOTTE, NC 876876 $8.8k $8.8k 0.00% New
58 PNC Financial Services Group, Inc. 0.00% of their portfolio Pittsburgh, PA 339339 $3.4k $3.4k 0.00% New
59 GAMMA Investing LLC 0.00% of their portfolio FOSTER CITY, CA 127127 $1.3k $1.3k 0.00% New
60 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 122122 $1.2k $1.2k 0.00% New
61 CWM, LLC 0.00% of their portfolio OMAHA, NE 120120 $1.0k $1.0k 0.00% New
62 Glenmede Investment Management, LP 0.00% of their portfolio PHILADELPHIA, PA 5353 $529 $529 0.00% First filing
63 ROTHSCHILD INVESTMENT LLC 0.00% of their portfolio CHICAGO, IL 3030 $300 $300 0.00% New
64 Farther Finance Advisors, LLC 0.00% of their portfolio SAN FRANCISCO, CA 1616 $160 $160 0.00% New
65 PRINCIPAL SECURITIES, INC. 0.00% of their portfolio DES MOINES, IA 1313 $130 $130 0.00% New
66 AMALGAMATED BANK 0.00% of their portfolio NEW YORK, NY 99 $0 $0 0.00% New
67 EverSource Wealth Advisors, LLC 0.00% of their portfolio BIRMINGHAM, AL 77 $70 $70 0.00% New
68 Avion Wealth 0.00% of their portfolio THE WOODLANDS, TX 77 $0 $0 0.00% New
69 Capital Advisors, Ltd. LLC 0.00% of their portfolio SHAKER HEIGHTS, OH 66 $0 $0 0.00% New
70 SBI Securities Co., Ltd. 0.00% of their portfolio TOKYO, M0 44 $40 $40 0.00% New
71 Arax Advisory Partners 0.00% of their portfolio NEW YORK, NY 33 $30 $30 0.00% New
72 JONES FINANCIAL COMPANIES LLLP 0.00% of their portfolio DES PERES, MO 22 $18 $18 0.00% New
73 ASSETMARK, INC 0.00% of their portfolio CONCORD, CA 11 $10 $10 0.00% New
74 CONCOURSE FINANCIAL GROUP SECURITIES, INC. — of their portfolio BIRMINGHAM, AL 00 $0 $0 — New