ACADIA PHARMACEUTICALS INC ACAD
COM · Common Stock · CUSIP 004225108 · ISIN US0042251084
Pharmaceutical company, which developed Nuplazid, based in San Diego, California.
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersSan Diego, CA
- Founded1993
- Websiteacadia-pharm.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($5.6m this quarter). Holder counts are more reliable. Shares outstanding: 162.6m as of 2023-04-26, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $18.90. Options: 10 managers hold calls ($10.9m notional), 12 hold puts ($4.5m).
Trends to Q1 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 223 |
| Q4 2022 | 227 |
| Q1 2023 | 233 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 97 | 102 |
| Q1 2023 | 112 | 96 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $11.2m | $7.4m | 0.66 |
| Q4 2022 | $11.3m | $4.0m | 0.35 |
| Q1 2023 | $10.9m | $4.5m | 0.41 |
Biggest buyers
| FMR LLC | Added | +6.4m |
| RTW INVESTMENTS, LP | Added | +4.6m |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | New | +1.2m |
| MORGAN STANLEY | Added | +1.2m |
| D. E. Shaw & Co., Inc. | Added | +681.2k |
| Man Group plc | New | +676.8k |
| PICTET ASSET MANAGEMENT SA | Added | +577.7k |
| MILLENNIUM MANAGEMENT LLC | Added | +549.7k |
| Woodline Partners LP | New | +430.9k |
| VANGUARD GROUP INC | Added | +399.0k |
Biggest sellers
| STATE STREET CORP | Reduced | -2.2m |
| BRAIDWELL LP | Sold out | -1.5m |
| Man Group plc | Sold out | -955.7k |
| Bain Capital Life Sciences Investors, LLC | Sold out | -701.4k |
| NOMURA HOLDINGS INC | Reduced | -562.2k |
| JPMORGAN CHASE & CO | Reduced | -510.7k |
| Ally Bridge Group (NY) LLC | Sold out | -474.7k |
| Point72 Asset Management, L.P. | Reduced | -456.4k |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | Reduced | -433.1k |
| WELLINGTON MANAGEMENT GROUP LLP | Reduced | -399.3k |
Biggest calls
| GROUP ONE TRADING LLC | Reduced | $5.1m272.7k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $1.8m95.4k shares |
| CITIGROUP INC | Added | $937.2k49.8k shares |
| JANE STREET GROUP, LLC | Reduced | $777.3k41.3k shares |
| CITADEL ADVISORS LLC | Reduced | $685.0k36.4k shares |
| SIMPLEX TRADING, LLC | Reduced | $530.0k28.2k shares |
| Parallax Volatility Advisers, L.P. | New | $508.1k27.0k shares |
| Belvedere Trading LLC | New | $263.5k14.0k shares |
| Walleye Trading LLC | Added | $239.0k12.7k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| CITIGROUP INC | Added | $937.2k49.8k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $798.0k42.4k shares |
| J. Goldman & Co LP | New | $762.2k40.5k shares |
| CITADEL ADVISORS LLC | Reduced | $651.2k34.6k shares |
| Parallax Volatility Advisers, L.P. | New | $508.1k27.0k shares |
| GROUP ONE TRADING LLC | Added | $297.4k15.8k shares |
| SIMPLEX TRADING, LLC | Reduced | $233.0k12.4k shares |
| JANE STREET GROUP, LLC | Reduced | $199.5k10.6k shares |
| Belvedere Trading LLC | New | $69.6k3.7k shares |
| Walleye Trading LLC | Reduced | $15.1k800 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BAKER BROS. ADVISORS LP 13D · may seek influence filed 2026-02-26 | 25.4% |
| BlackRock, Inc. 13G · institution filed 2025-02-07 | 11.9% |
| STATE STREET CORP 13G · institution new · filed 2026-08-07 | 5.3% |
| VANGUARD PORTFOLIO MANAGEMENT LLC 13G · institution new · filed 2026-04-28 | 5.2% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-26; now reported by VANGUARD PORTFOLIO MANAGEMENT LLC)
Insider purchases and sales in Q1 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2021 | 0 | — | 0 | — | — |
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 0 | — | 2 | $128.2k | — |
| Q1 2022 | 0 | — | 6 | $336.7k | — |
| Q2 2022 | 0 | — | 6 | $217.5k | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 2 | $93.1k | — |
| Q1 2023 | 0 | — | 6 | $427.7k | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2023-02-24 | DAVIS STEPHEN CEO, director | Sold | $72.3k3.9k shares |
| 2023-02-24 | KIM AUSTIN D. EVP,General Counsel, Secretary | Sold | $15.1k803 shares |
| 2023-02-24 | Schneyer Mark C. EVP, Chief Financial Officer | Sold | $10.8k577 shares |
| 2023-02-24 | Teehan Brendan EVP, COO, Head of Commercial | Sold | $8.7k461 shares |
| 2023-02-24 | Kihara James Principal Accounting Officer | Sold | $6.6k350 shares |
| 2023-01-12 | Brege Laura Director | Sold | $228.1k12.5k shares |
| 2023-01-09 | DAVIS STEPHEN CEO, director | Sold | $66.9k3.9k shares |
| 2023-01-09 | KIM AUSTIN D. EVP,General Counsel, Secretary | Sold | $10.1k589 shares |
| 2023-01-09 | Teehan Brendan EVP, COO, Head of Commercial | Sold | $9.1k532 shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2023
| Manager | Shares | Change |
|---|---|---|
| BAKER BROS. ADVISORS LP 4.29% of their portfolio | 41.9m $789.3m | Added +15.0k |
| FMR LLC 0.01% of their portfolio | 15.7m $295.3m | Added +6.4m |
| VANGUARD GROUP INC 0.01% of their portfolio | 13.7m $257.4m | Added +399.0k |
| BlackRock Inc. 0.01% of their portfolio | 9.9m $185.7m | Reduced -390.1k |
| RTW INVESTMENTS, LP 3.23% of their portfolio | 8.2m $155.1m | Added +4.6m |
| EcoR1 Capital, LLC 3.63% of their portfolio | 6.0m $112.8m | Unchanged |
| STATE STREET CORP 0.01% of their portfolio | 5.6m $105.1m | Reduced -2.2m |
| D. E. Shaw & Co., Inc. 0.15% of their portfolio | 4.9m $92.2m | Added +681.2k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio | 4.6m $85.6m | Added +271.7k |
| MORGAN STANLEY 0.01% of their portfolio | 3.9m $73.7m | Added +1.2m |
| FIRST TRUST ADVISORS LP 0.06% of their portfolio | 2.7m $51.1m | Reduced -167.9k |
| Palo Alto Investors LP 3.75% of their portfolio | 2.4m $45.3m | Added +29.4k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 2.4m $45.0m | Added +90.8k |
| NORGES BANK 0.01% of their portfolio | 2.0m $38.1m | Added +67.8k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.22% of their portfolio | 1.9m $35.4m | Added +243.2k |
| MILLENNIUM MANAGEMENT LLC 0.04% of their portfolio | 1.8m $33.0m | Added +549.7k |
| FRED ALGER MANAGEMENT, LLC 0.17% of their portfolio | 1.7m $32.5m | Added +263.0k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 1.6m $29.8m | Reduced -510.7k |
| EMERALD ADVISERS, LLC 1.35% of their portfolio | 1.5m $28.2m | Added +174.4k |
| JUPITER ASSET MANAGEMENT LTD 0.36% of their portfolio | 1.4m $25.7m | Added +277.6k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.05% of their portfolio | 1.2m $23.1m | New |
| EMERALD MUTUAL FUND ADVISERS TRUST 1.34% of their portfolio | 1.2m $22.7m | Added +158.6k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 1.2m $22.2m | Reduced -399.3k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 1.2m $22.0m | Added +39.4k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 979.7k $18.4m | Reduced -10.9k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 969.3k $18.2m | Reduced -2.5k |
| Finepoint Capital LP 6.59% of their portfolio | 916.4k $17.2m | Reduced -260.5k |
| RICE HALL JAMES & ASSOCIATES, LLC 0.95% of their portfolio | 887.1k $16.7m | Reduced -70.6k |
| PICTET ASSET MANAGEMENT SA 0.02% of their portfolio | 882.3k $16.6m | Added +577.7k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio | 872.0k $16.4m | Reduced -57.2k |
| Frazier Life Sciences Management, L.P. 1.17% of their portfolio | 857.3k $16.1m | Unchanged |
| PANAGORA ASSET MANAGEMENT INC 0.09% of their portfolio | 728.0k $13.7m | Added +47.4k |
| Man Group plc 0.05% of their portfolio | 676.8k $12.7m | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 661.6k $12.5m | Reduced -64.5k |
| Point72 Asset Management, L.P. 0.04% of their portfolio | 659.5k $12.4m | Reduced -456.4k |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.06% of their portfolio | 596.3k $11.2m | Reduced -433.1k |
| NORDEA INVESTMENT MANAGEMENT AB 0.02% of their portfolio | 581.3k $11.0m | Reduced -33.2k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 580.5k $10.9m | Added +57.2k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 572.2k $10.8m | Reduced -12.5k |
| FRONTIER CAPITAL MANAGEMENT CO LLC 0.10% of their portfolio | 534.1k $10.1m | Added +173.2k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 521.2k $9.8m | Added +21.2k |
| Connor, Clark & Lunn Investment Management Ltd. 0.05% of their portfolio | 498.2k $9.4m | Added +8.6k |
| Invesco Ltd. 0.00% of their portfolio | 474.0k $8.9m | Reduced -61.8k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 454.5k $8.6m | Added +271.3k |
| Woodline Partners LP 0.11% of their portfolio | 430.9k $8.1m | New |
| Walleye Capital LLC 0.16% of their portfolio | 418.8k $7.9m | Added +290.9k |
| NOMURA HOLDINGS INC 0.07% of their portfolio | 365.7k $6.9m | Reduced -562.2k |
| Rafferty Asset Management, LLC 0.04% of their portfolio | 332.4k $6.3m | Reduced -224.3k |
| Russell Investments Group, Ltd. 0.01% of their portfolio | 324.8k $6.1m | Added +88.0k |
| CITIGROUP INC 0.01% of their portfolio | 278.5k $5.2m | Added +23.7k |
| BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio | 269.1k $5.1m | Added +123.8k |
| Thrivent Financial for Lutherans 0.01% of their portfolio | 266.6k $5.0m | Added +184.5k |
| Cubist Systematic Strategies, LLC 0.05% of their portfolio | 264.2k $5.0m | Added +253.3k |
| Swiss National Bank 0.00% of their portfolio | 262.1k $4.9m | Reduced -31.0k |
| HRT FINANCIAL LP 0.06% of their portfolio | 257.2k $4.8m | New |
| VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 254.1k $4.8m | Reduced -250 |
| Polar Capital Holdings Plc 0.03% of their portfolio | 250.0k $4.7m | Reduced -250.0k |
| Birchview Capital, LP 3.68% of their portfolio | 249.4k $4.7m | Unchanged |
| SECTOR GAMMA AS 1.06% of their portfolio | 232.7k $4.4m | Added +46.9k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio | 230.3k $4.3m | Added +151.5k |
| Squarepoint Ops LLC 0.03% of their portfolio | 218.5k $4.1m | New |
| INTERNATIONAL BIOTECHNOLOGY TRUST PLC 1.13% of their portfolio | 216.0k $4.1m | Added +116.0k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio | 215.9k $4.1m | Reduced -289.2k |
| Hennion & Walsh Asset Management, Inc. 0.24% of their portfolio | 211.8k $4.0m | Added +3.0k |
| CREDIT SUISSE AG/ 0.00% of their portfolio | 204.8k $3.9m | Added +4.1k |
| Jump Financial, LLC 0.15% of their portfolio | 196.9k $3.7m | New |
| Soleus Capital Management, L.P. 0.44% of their portfolio | 190.0k $3.6m | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 179.2k $3.4m | Added +78.2k |
| Empire Life Investments Inc. 0.24% of their portfolio | 177.5k $3.3m | Added +1.7k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 173.8k $3.3m | Added +917 |
| PDT Partners, LLC 0.43% of their portfolio | 167.0k $3.1m | Added +137.3k |
| BARCLAYS PLC 0.00% of their portfolio | 165.7k $3.1m | Reduced -145.5k |
| CAPITAL FUND MANAGEMENT S.A. 0.06% of their portfolio | 160.8k $3.0m | Reduced -79.6k |
| MACQUARIE GROUP LTD 0.00% of their portfolio | 160.0k $3.0m | Unchanged |
| UBS Group AG 0.00% of their portfolio | 153.2k $2.9m | Reduced -214.1k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 152.2k $2.9m | Reduced -50.0k |
| SG Americas Securities, LLC 0.04% of their portfolio | 152.0k $2.9m | Added +137.9k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 151.4k $2.8m | Reduced -2.2k |
| ALGERT GLOBAL LLC 0.13% of their portfolio | 141.7k $2.7m | Reduced -32.9k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 130.2k $2.5m | Reduced -186.2k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 126.6k $2.4m | New |
| State of New Jersey Common Pension Fund D 0.01% of their portfolio | 122.4k $2.3m | Reduced -32.8k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio | 118.8k $2.2m | Reduced -3.1k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 118.4k $2.2m | Added +104.5k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 117.8k $2.2m | Reduced -197.9k |
| Legal & General Group Plc 0.00% of their portfolio | 117.1k $2.2m | Added +6.2k |
| TD Asset Management Inc 0.00% of their portfolio | 116.9k $2.2m | Added +13.6k |
| TWINBEECH CAPITAL LP 0.04% of their portfolio | 115.7k $2.2m | New |
| Trexquant Investment LP 0.06% of their portfolio | 109.2k $2.1m | Added +8.4k |
| ALPS ADVISORS INC 0.02% of their portfolio | 106.9k $2.0m | Reduced -2.8k |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 106.2k $2.0m | Added +95.1k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 103.7k $2.0m | Reduced -116.1k |
| Hudson Bay Capital Management LP 0.01% of their portfolio | 100.0k $1.9m | Reduced -100.0k |
| ExodusPoint Capital Management, LP 0.02% of their portfolio | 98.9k $1.9m | Reduced -368.0k |
| STRS OHIO 0.00% of their portfolio | 96.8k $1.8m | Added +39.2k |
| HUSSMAN STRATEGIC ADVISORS, INC. 0.27% of their portfolio | 93.0k $1.8m | New |
| DUALITY ADVISERS, LP 0.19% of their portfolio | 90.9k $1.7m | Added +6.2k |
| Erste Asset Management GmbH 0.03% of their portfolio | 90.6k $1.7m | Unchanged |
| Allspring Global Investments Holdings, LLC 0.00% of their portfolio | 89.0k $1.7m | Added +79.7k |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 78.6k $1.5m | Added +5.0k |