Vault-13

PROQR THRAPEUTICS N V PRQR

SHS EURO · Common Stock · CUSIP N71542109

70 institutional holders +1 vs Q1 2026
60,738,79960.7m shares reported held*
$113.0mreported value*
12 new 25 added 11 reduced 11 sold out net bought ≈ $47.7m (+25.7m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $1.86. Options: 1 managers hold calls ($63.6k notional), 0 hold puts (—).

Trends to Q2 2026

Institutional holders

Managers reporting a position, each quarter

050100Q3 22: 48Q4 22: 47Q1 23: 56Q2 23: 52Q3 23: 47Q4 23: 48Q1 24: 50Q2 24: 49Q3 24: 48Q4 24: 78Q1 25: 66Q2 25: 63Q3 25: 64Q4 25: 65Q1 26: 69Q2 26: 7070Q3 22Q3 23Q3 24Q3 25Q2 26
Numbers
QuarterHolders
Q3 202248
Q4 202247
Q1 202356
Q2 202352
Q3 202347
Q4 202348
Q1 202450
Q2 202449
Q3 202448
Q4 202478
Q1 202566
Q2 202563
Q3 202564
Q4 202565
Q1 202669
Q2 202670

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q3 24: 13 bought or addedQ3 24: 20 cut or sold outQ4 24: 51 bought or addedQ4 24: 14 cut or sold outQ4 24Q1 25: 24 bought or addedQ1 25: 37 cut or sold outQ2 25: 21 bought or addedQ2 25: 27 cut or sold outQ2 25Q3 25: 22 bought or addedQ3 25: 18 cut or sold outQ4 25: 30 bought or addedQ4 25: 18 cut or sold outQ4 25Q1 26: 23 bought or addedQ1 26: 22 cut or sold outQ2 26: 37 bought or addedQ2 26: 22 cut or sold outQ2 26
Numbers
QuarterBought or addedCut or sold out
Q3 20241320
Q4 20245114
Q1 20252437
Q2 20252127
Q3 20252218
Q4 20253018
Q1 20262322
Q2 20263722

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$50k$100k$150k$200kQ3 25 calls: $12.6kQ3 25 puts: $0Q3 25P/C 0.00Q4 25 calls: $155.7kQ4 25 puts: $0Q4 25P/C 0.00Q1 26 calls: $22.2kQ1 26 puts: $0Q1 26P/C 0.00Q2 26 calls: $63.6kQ2 26 puts: $0Q2 26P/C 0.00
Numbers
QuarterCallsPutsP/C
Q3 2025$12.6k$00.00
Q4 2025$155.7k$00.00
Q1 2026$22.2k$00.00
Q2 2026$63.6k$00.00

Biggest buyers

Aberdeen Group plc Added +5,615,542+5.6m
Woodline Partners LP New +3,277,143+3.3m
Affinity Asset Advisors, LLC Added +3,089,658+3.1m
ADAGE CAPITAL PARTNERS GP, L.L.C. Added +2,762,430+2.8m
HEIGHTS CAPITAL MANAGEMENT, INC New +2,762,430+2.8m
Ikarian Capital, LLC Added +1,933,701+1.9m
SPHERA FUNDS MANAGEMENT LTD. New +1,757,458+1.8m
Squadron Capital Management LLC New +1,511,496+1.5m
683 Capital Management, LLC New +1,393,067+1.4m
Eversept Partners, LP New +1,022,265+1.0m

Biggest sellers

Sio Capital Management, LLC Sold out -1,954,715-2.0m
Point72 Asset Management, L.P. Reduced -705,190-705.2k
Walleye Capital LLC Sold out -607,529-607.5k
NORTHERN TRUST CORP Sold out -291,314-291.3k
Monaco Asset Management SAM Reduced -174,316-174.3k
BANK OF AMERICA CORP /DE/ Reduced -127,070-127.1k
MARSHALL WACE, LLP Sold out -115,945-115.9k
Graham Capital Management, L.P. Sold out -91,553-91.6k
XTX Topco Ltd Sold out -77,287-77.3k
PLATINUM INVESTMENT MANAGEMENT LTD Reduced -76,086-76.1k

Biggest calls

SIMPLEX TRADING, LLC New $63.6k34.2k shares

Biggest puts

None

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
ELI LILLY & Co 13G · passive investor filed 2026-07-24 15.6% 22.0m≈ $33.6m 2026-07-24
VAN HERK INVESTMENTS B.V. 13D · may seek influence no change · filed 2026-07-29
Stated purposeItem 4 of the Schedule 13D is amended by adding the following: On July 27, 2026, the Reporting Persons filed a petition (the "Petition") with the Enterprise Chamber (Ondernemingskamer) of the Amsterdam Court of Appeal against the Issuer, pursuant to Article 2:345 of the Dutch Civil Code and including a request for immediate relief measures pursuant to Article 2:349a(2) of the Dutch Civil Code. The Petition requests that the Enterprise Chamber (i) order an investigation into the policies and conduct of affairs of the Issuer from May 22, 2024 to the present, based on alleged systematic deviations by the Issuer's board of directors from the Issuer's own governance framework and applicable governance standards, including with respect to the reappointment of certain directors, the composition… Full filing
10.9% no change 15.4m≈ $23.5m 2026-07-29
Aberdeen Group plc 13G · institution new · filed 2026-07-29 6.3% new 8.9m≈ $13.6m 2026-07-29
Adage Capital Management, L.P. 13G · institution -1.4 pts · filed 2025-08-12 6.3% -1.4 pts 6.6m≈ $12.3m 2025-08-12
Privium Fund Management B.V. 13G · passive investor no change · filed 2026-07-15 5.2% no change 5.5m≈ $10.3m 2026-07-15

Insider purchases and sales since 1 Apr 2026

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
202Q4 24: 0 buyingQ4 24: 0 sellingQ1 25: 0 buyingQ1 25: 0 sellingQ1 25Q2 25: 0 buyingQ2 25: 0 sellingQ3 25: 0 buyingQ3 25: 0 sellingQ3 25Q4 25: 0 buyingQ4 25: 0 sellingQ1 26: 0 buyingQ1 26: 0 sellingQ1 26Q2 26: 1 buyingQ2 26: 0 sellingQ3 26: 2 buyingQ3 26: 0 sellingQ3 26
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q4 20240—0——
Q1 20250—0——
Q2 20250—0——
Q3 20250—0——
Q4 20250—0——
Q1 20260—0——
Q2 20261$231.0k0——
Q3 20262$1.1m0——
DateInsiderTradeSharesPrice ValueTheir holding
2026-07-31 de Boer Daniel Anton Chief Executive Officer, director Bought 200,000 $1.77 $354.0k200.0k shares +67%
2026-07-17 Filius Bart Director Bought 150,000 $1.72 $258.0k150.0k shares +100%
2026-07-09 de Boer Daniel Anton Chief Executive Officer, director Bought 150,000 $1.74 $261.0k150.0k shares +100%
2026-07-07 de Boer Daniel Anton Chief Executive Officer, director Bought 150,000 $1.59 $238.5k150.0k shares new
2026-06-26 Filius Bart Director Bought 150,000 $1.54 $231.0k150.0k shares new

Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).

Holders, Q2 2026

#ManagerLocationShares Value% of their portfolioChangeShares change
1 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.02% of their portfolio Boston, MA 9,015,8979.0m $16.8m $16.8m 0.02% Added +2.8m +2,762,430
2 Aberdeen Group plc 0.02% of their portfolio EDINBURGH, X0 8,932,5078.9m $16.6m $16.6m 0.02% Added +5.6m +5,615,542
3 Affinity Asset Advisors, LLC 0.50% of their portfolio NEW YORK, NY 5,543,9365.5m $10.3m $10.3m 0.50% Added +3.1m +3,089,658
4 Privium Fund Management B.V. 1.89% of their portfolio AMSTERDAM, P7 5,520,0245.5m $10.3m $10.3m 1.89% Added +52.9k +52,875
5 Ikarian Capital, LLC 1.04% of their portfolio DALLAS, TX 3,425,9303.4m $6.4m $6.4m 1.04% Added +1.9m +1,933,701
6 Woodline Partners LP 0.02% of their portfolio San Francisco, CA 3,277,1433.3m $6.1m $6.1m 0.02% New
7 HEIGHTS CAPITAL MANAGEMENT, INC 1.19% of their portfolio SAN FRANCISCO, CA 2,762,4302.8m $5.1m $5.1m 1.19% New
8 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 1,767,2151.8m $3.3m $3.3m 0.00% Added +467.4k +467,440
9 SPHERA FUNDS MANAGEMENT LTD. 0.47% of their portfolio TEL AVIV, L3 1,757,4581.8m $3.3m $3.3m 0.47% New
10 Kynam Capital Management, LP 0.16% of their portfolio PRINCETON, NJ 1,566,3171.6m $2.9m $2.9m 0.16% Unchanged
11 DAFNA Capital Management LLC 0.54% of their portfolio LOS ANGELES, CA 1,530,3611.5m $2.8m $2.8m 0.54% Reduced -37.2k -37,200
12 Squadron Capital Management LLC 0.96% of their portfolio OAK BROOK, IL 1,511,4961.5m $2.8m $2.8m 0.96% New
13 683 Capital Management, LLC 0.24% of their portfolio NEW YORK, NY 1,393,0671.4m $2.6m $2.6m 0.24% New
14 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 1,184,3141.2m $2.2m $2.2m 0.00% Added +481.0k +480,991
15 PLATINUM INVESTMENT MANAGEMENT LTD 0.53% of their portfolio SYDNEY AUSTRALIA 2000, C3 1,159,4281.2m $2.2m $2.2m 0.53% Reduced -76.1k -76,086
16 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 1,138,7151.1m $2.1m $2.1m 0.00% Added +219.9k +219,858
17 Eversept Partners, LP 0.10% of their portfolio NEW YORK, NY 1,022,2651.0m $1.9m $1.9m 0.10% New
18 BOOTHBAY FUND MANAGEMENT, LLC 0.03% of their portfolio NEW YORK, NY 948,736948.7k $1.8m $1.8m 0.03% Added +593.5k +593,453
19 DIADEMA PARTNERS LP 0.61% of their portfolio MORRISTOWN, NJ 926,016926.0k $1.7m $1.7m 0.61% Added +745.9k +745,933
20 UBS Group AG 0.00% of their portfolio ZURICH, V8 639,243639.2k $1.2m $1.2m 0.00% Added +334.0k +333,979
21 NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 0.00% of their portfolio PHILADELPHIA, PA 620,000620.0k $1.2m $1.2m 0.00% Unchanged
22 M28 Capital Management LP 2.37% of their portfolio STAMFORD, CT 599,793599.8k $1.1m $1.1m 2.37% Unchanged
23 RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio ST. PETERSBURG, FL 571,073571.1k $1.1m $1.1m 0.00% Added +25.0k +24,994
24 Lynx1 Capital Management LP 0.11% of their portfolio DORADO, PR 521,413521.4k $969.8k $969.8k 0.11% Added +452.9k +452,927
25 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 455,104455.1k $846.5k $846.5k 0.00% Added +421.8k +421,815
26 STEMPOINT CAPITAL LP 0.14% of their portfolio NEW YORK, NY 431,054431.1k $801.8k $801.8k 0.14% New
27 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 275,631275.6k $512.7k $512.7k 0.00% Added +103.3k +103,282
28 Monaco Asset Management SAM 0.17% of their portfolio Monaco, O9 244,487244.5k $454.7k $454.7k 0.17% Reduced -174.3k -174,316
29 Persistent Asset Partners Ltd 0.14% of their portfolio HONG KONG, K3 236,454236.5k $439.8k $439.8k 0.14% Added +190.4k +190,387
30 Palo Alto Investors LP 0.05% of their portfolio PALO ALTO, CA 188,807188.8k $351.2k $351.2k 0.05% Unchanged
31 Burkehill Global Management, LP 0.01% of their portfolio NEW YORK, NY 176,243176.2k $327.8k $327.8k 0.01% New
32 GSA CAPITAL PARTNERS LLP 0.02% of their portfolio LONDON, X0 173,844173.8k $323.0k $323.0k 0.02% Added +59.6k +59,588
33 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 161,004161.0k $299.5k $299.5k 0.00% Reduced -33.2k -33,242
34 FRANKLIN STREET ADVISORS INC /NC 0.02% of their portfolio CHAPEL HILL, NC 150,000150.0k $279.0k $279.0k 0.02% Unchanged
35 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 108,762108.8k $202.3k $202.3k 0.00% Unchanged
36 OneDigital Investment Advisors LLC 0.00% of their portfolio OVERLAND PARK, KS 85,00085.0k $158.1k $158.1k 0.00% Unchanged
37 Quadrature Capital Ltd 0.00% of their portfolio LONDON, X0 84,80684.8k $157.7k $157.7k 0.00% Added +72.8k +72,771
38 RFG Advisory, LLC 0.00% of their portfolio BIRMINGHAM, AL 64,00064.0k $119.0k $119.0k 0.00% Added +45.0k +45,000
39 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 58,04058.0k $108.0k $108.0k 0.00% Reduced -127.1k -127,070
40 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 57,99758.0k $107.9k $107.9k 0.00% Reduced -26.9k -26,912
41 Point72 Asset Management, L.P. 0.00% of their portfolio STAMFORD, CT 50,65250.7k $94.2k $94.2k 0.00% Reduced -705.2k -705,190
42 Keating Financial Advisory Services, Inc. 0.01% of their portfolio MANHATTAN, KS 47,55247.6k $88.4k $88.4k 0.01% Added +27.0k +27,000
43 Velan Capital Investment Management LP 0.05% of their portfolio ALPHARETTA, GA 45,00045.0k $83.7k $83.7k 0.05% Unchanged
44 GUGGENHEIM CAPITAL LLC 0.00% of their portfolio CHICAGO, IL 39,95440.0k $74.3k $74.3k 0.00% Added +12.3k +12,310
45 Steward Partners Investment Advisory, LLC 0.00% of their portfolio STAMFORD, CT 35,24135.2k $65.5k $65.5k 0.00% Added +33.9k +33,941
46 Axiom Investment Management LLC 0.04% of their portfolio NEW YORK, NY 31,00031.0k $57.7k $57.7k 0.04% Reduced -2.0k -2,000
47 MOODY LYNN LIEBERSON & WALKER, LLC 0.00% of their portfolio BOSTON, MA 25,00025.0k $46.5k $46.5k 0.00% Unchanged
48 Vanguard Personalized Indexing Management, LLC 0.00% of their portfolio OAKLAND, CA 22,09522.1k $41.1k $41.1k 0.00% Added +2.7k +2,685
49 Mariner, LLC 0.00% of their portfolio Overland Park, KS 20,16920.2k $37.5k $37.5k 0.00% Unchanged
50 Verdad Advisers, LP 0.03% of their portfolio BOSTON, MA 19,10019.1k $35.5k $35.5k 0.03% New
51 NANO CAP NEW MILLENNIUM GROWTH FUND L P 0.03% of their portfolio STATEN ISLAND, NY 17,50017.5k $32.5k $32.5k 0.03% Added +7.5k +7,500
52 TWO SIGMA SECURITIES, LLC 0.00% of their portfolio NEW YORK, NY 16,01616.0k $29.8k $29.8k 0.00% New
53 Atom Investors LP 0.00% of their portfolio AUSTIN, TX 13,10713.1k $24.4k $24.4k 0.00% Unchanged
54 China Universal Asset Management Co., Ltd. 0.00% of their portfolio SHANGHAI, F4 12,50012.5k $23.2k $23.2k 0.00% Reduced -7.5k -7,500
55 Virtu Financial LLC 0.00% of their portfolio New York, NY 11,62611.6k $22.0k $22.0k 0.00% New
56 WETZEL INVESTMENT ADVISORS, INC. 0.01% of their portfolio INDIANAPOLIS, IN 10,50010.5k $19.5k $19.5k 0.01% New
57 TRUIST FINANCIAL CORP 0.00% of their portfolio CHARLOTTE, NC 10,00010.0k $18.6k $18.6k 0.00% Unchanged
58 ADAR1 Capital Management, LLC 0.00% of their portfolio AUSTIN, TX 10,00010.0k $18.6k $18.6k 0.00% Unchanged
59 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 4,0004.0k $7.4k $7.4k 0.00% Unchanged
60 BlackRock, Inc. 0.00% of their portfolio New York, NY 3,9453.9k $7.3k $7.3k 0.00% Unchanged
61 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 3,3053.3k $6.0k $6.0k 0.00% Added +3.0k +2,997
62 Hilton Head Capital Partners, LLC 0.00% of their portfolio HILTON HEAD ISLAND, SC 1,4041.4k $2.6k $2.6k 0.00% Unchanged
63 Farther Finance Advisors, LLC 0.00% of their portfolio SAN FRANCISCO, CA 1,0001.0k $1.9k $1.9k 0.00% Unchanged
64 PFS Partners, LLC 0.00% of their portfolio MINE HILL, NJ 1,0001.0k $1.9k $1.9k 0.00% Unchanged
65 SBI Securities Co., Ltd. 0.00% of their portfolio TOKYO, M0 515515 $958 $958 0.00% Unchanged
66 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 283283 $518 $518 0.00% Unchanged
67 SIMPLEX TRADING, LLC 0.00% of their portfolio CHICAGO, IL 271271 $504 $504 0.00% Reduced -24.6k -24,597
68 TD Waterhouse Canada Inc. 0.00% of their portfolio TORONTO, A6 4040 $70 $70 0.00% Unchanged
69 Medallion Wealth Advisors, LLC 0.00% of their portfolio FARMINGTON, CT 1010 $19 $19 0.00% Unchanged
70 Caitong International Asset Management Co., Ltd 0.00% of their portfolio HONG KONG, K3 44 $7 $7 0.00% Reduced -119 -119