UROGEN PHARMA LTD URGN
COM · Common Stock · CUSIP M96088105
- SectorHealth care
- IndustryPharmaceutical Preparations
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($79.1k this quarter). Holder counts are more reliable. Shares outstanding: 46.8m as of 2025-10-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $23.42. Options: 8 managers hold calls ($33.9m notional), 5 hold puts ($7.2m).
Trends to Q4 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 60 |
| Q4 2022 | 65 |
| Q1 2023 | 67 |
| Q2 2023 | 86 |
| Q3 2023 | 102 |
| Q4 2023 | 106 |
| Q1 2024 | 113 |
| Q2 2024 | 116 |
| Q3 2024 | 129 |
| Q4 2024 | 139 |
| Q1 2025 | 141 |
| Q2 2025 | 151 |
| Q3 2025 | 161 |
| Q4 2025 | 168 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2024 | 51 | 48 |
| Q2 2024 | 76 | 39 |
| Q3 2024 | 73 | 41 |
| Q4 2024 | 64 | 59 |
| Q1 2025 | 65 | 64 |
| Q2 2025 | 85 | 70 |
| Q3 2025 | 81 | 69 |
| Q4 2025 | 83 | 76 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2025 | $1.7m | $542.3k | 0.32 |
| Q2 2025 | $35.4m | $14.1m | 0.40 |
| Q3 2025 | $36.2m | $11.1m | 0.31 |
| Q4 2025 | $33.9m | $7.2m | 0.21 |
Biggest buyers
| AMERICAN CENTURY COMPANIES INC | New | +1.4m |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | New | +1.1m |
| MPM BIOIMPACT LLC | Added | +806.4k |
| FRONTIER CAPITAL MANAGEMENT CO LLC | New | +781.6k |
| SUPERSTRING CAPITAL MANAGEMENT LP | Added | +630.4k |
| J. Goldman & Co LP | New | +513.3k |
| Opaleye Management Inc. | New | +268.4k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +260.0k |
| Paradigm Biocapital Advisors LP | Added | +257.6k |
| SG Americas Securities, LLC | Added | +220.3k |
Biggest sellers
| TORONTO DOMINION BANK | Sold out | -3.2m |
| JPMORGAN CHASE & CO | Reduced | -922.8k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -849.8k |
| TANG CAPITAL MANAGEMENT LLC | Reduced | -650.0k |
| Soleus Capital Management, L.P. | Reduced | -529.0k |
| JANE STREET GROUP, LLC | Sold out | -328.4k |
| BNP PARIBAS FINANCIAL MARKETS | Reduced | -299.1k |
| Schonfeld Strategic Advisors LLC | Sold out | -297.9k |
| Kynam Capital Management, LP | Sold out | -282.4k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | Reduced | -252.0k |
Biggest calls
| Caption Management, LLC | Unchanged | $23.4m1.0m shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $3.9m166.9k shares |
| J. Goldman & Co LP | New | $2.0m84.0k shares |
| GROUP ONE TRADING LLC | Reduced | $1.7m73.0k shares |
| CITADEL ADVISORS LLC | Reduced | $1.3m55.9k shares |
| ADAR1 Capital Management, LLC | Unchanged | $936.8k40.0k shares |
| JANE STREET GROUP, LLC | Reduced | $419.2k17.9k shares |
| SIMPLEX TRADING, LLC | Reduced | $243.6k10.4k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $2.8m121.0k shares |
| JANE STREET GROUP, LLC | Reduced | $1.4m60.6k shares |
| SIMPLEX TRADING, LLC | Added | $1.4m59.4k shares |
| GROUP ONE TRADING LLC | Reduced | $887.6k37.9k shares |
| CITADEL ADVISORS LLC | Reduced | $667.5k28.5k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| TORONTO DOMINION BANK 13G · institution +1.3 pts · filed 2026-08-12 | 6.7% |
| BlackRock, Inc. 13G · institution +1.1 pts · filed 2026-10-27 | 6.3% |
| MORGAN STANLEY 13G · institution +3.6 pts · filed 2025-08-06 | 5.4% |
Fell to 5% or below in the last year: Paradigm Biocapital Advisors LP (3.5%, 2026-05-15), Cowen Financial Products LLC (0.0%, 2025-11-14)
Insider purchases and sales in Q4 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2024 | 0 | — | 2 | $307.2k | — |
| Q2 2024 | 0 | — | 1 | $67.4k | — |
| Q3 2024 | 0 | — | 2 | $31.1k | — |
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 2 | $132.9k | — |
| Q2 2025 | 0 | — | 1 | $38.0k | — |
| Q3 2025 | 0 | — | 2 | $465.1k | — |
| Q4 2025 | 0 | — | 2 | $287.1k | $250.0k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-11-19 | Schoenberg Mark Chief Medical Officer | Sold plan | $250.0k10.0k shares |
| 2025-10-08 | Degnan Chris Chief Financial Officer | Sold | $37.1k2.2k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2025
| Manager | Shares | Change |
|---|---|---|
| RTW INVESTMENTS, LP 1.07% of their portfolio | 4.5m $106.4m | Unchanged |
| Paradigm Biocapital Advisors LP 2.81% of their portfolio | 4.5m $104.8m | Added +257.6k |
| BlackRock, Inc. 0.00% of their portfolio | 2.6m $60.9m | Added +19.7k |
| MORGAN STANLEY 0.00% of their portfolio | 2.6m $60.0m | Added +34.5k |
| Jefferies Financial Group Inc. 0.42% of their portfolio | 2.2m $51.5m | Unchanged |
| SILVERARC CAPITAL MANAGEMENT, LLC 5.89% of their portfolio | 1.7m $40.7m | Added +161.5k |
| ACORN CAPITAL ADVISORS, LLC 11.49% of their portfolio | 1.4m $33.9m | Added +188.7k |
| SG Americas Securities, LLC 0.04% of their portfolio | 1.4m $32.3m | Added +220.3k |
| AMERICAN CENTURY COMPANIES INC 0.02% of their portfolio | 1.4m $31.8m | New |
| MENORA MIVTACHIM HOLDINGS LTD. 0.13% of their portfolio | 1.2m $27.0m | Unchanged |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.04% of their portfolio | 1.1m $26.3m | New |
| D. E. Shaw & Co., Inc. 0.02% of their portfolio | 962.6k $22.5m | Added +73.7k |
| MPM BIOIMPACT LLC 2.52% of their portfolio | 941.4k $22.0m | Added +806.4k |
| ORBIMED ADVISORS LLC 0.42% of their portfolio | 875.5k $20.5m | Added +186.5k |
| STATE STREET CORP 0.00% of their portfolio | 807.4k $18.9m | Reduced -12.0k |
| FRONTIER CAPITAL MANAGEMENT CO LLC 0.19% of their portfolio | 781.6k $18.3m | New |
| Migdal Insurance & Financial Holdings Ltd. 0.16% of their portfolio | 770.9k $18.1m | Unchanged |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 737.8k $17.3m | Added +135.5k |
| SUPERSTRING CAPITAL MANAGEMENT LP 9.01% of their portfolio | 718.4k $16.8m | Added +630.4k |
| TCG Crossover Management, LLC 0.56% of their portfolio | 717.3k $16.8m | Unchanged |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 619.0k $14.5m | Reduced -849.8k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 616.6k $14.4m | Added +260.0k |
| J. Goldman & Co LP 0.47% of their portfolio | 513.3k $12.0m | New |
| Woodline Partners LP 0.05% of their portfolio | 500.7k $11.7m | Added +194.4k |
| Boxer Capital Management, LLC 2.56% of their portfolio | 500.0k $11.7m | Reduced -75.0k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 475.2k $11.1m | Added +4.0k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 459.7k $10.8m | Added +34.8k |
| VANGUARD GROUP INC 0.00% of their portfolio | 439.8k $10.3m | Added +136.0k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.04% of their portfolio | 435.5k $10.2m | Reduced -252.0k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 366.7k $8.6m | Added +204.4k |
| TANG CAPITAL MANAGEMENT LLC 0.40% of their portfolio | 350.0k $8.2m | Reduced -650.0k |
| Nuveen, LLC 0.00% of their portfolio | 302.6k $7.1m | Reduced -204.9k |
| RICE HALL JAMES & ASSOCIATES, LLC 0.36% of their portfolio | 281.9k $6.6m | Added +22.7k |
| Opaleye Management Inc. 0.83% of their portfolio | 268.4k $6.3m | New |
| RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio | 244.3k $5.7m | Reduced -30.8k |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 241.2k $5.6m | Reduced -145.0k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 237.5k $5.6m | Reduced -23.9k |
| UBS Group AG 0.00% of their portfolio | 235.0k $5.5m | Added +54.6k |
| Atom Investors LP 0.44% of their portfolio | 234.4k $5.5m | Reduced -57.5k |
| Privium Fund Management B.V. 0.93% of their portfolio | 214.6k $5.0m | Added +18.0k |
| Parkman Healthcare Partners LLC 0.38% of their portfolio | 168.8k $4.0m | Reduced -233.8k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio | 162.7k $3.8m | Added +15.5k |
| Hennion & Walsh Asset Management, Inc. 0.13% of their portfolio | 161.9k $3.8m | Added +96.7k |
| Informed Momentum Co LLC 0.42% of their portfolio | 160.4k $3.8m | New |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 153.4k $3.6m | Reduced -50.8k |
| Soleus Capital Management, L.P. 0.15% of their portfolio | 150.0k $3.5m | Reduced -529.0k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 146.3k $3.4m | Reduced -922.8k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 136.0k $3.2m | Added +105.5k |
| HRT FINANCIAL LP 0.01% of their portfolio | 130.9k $3.1m | Reduced -2.8k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 128.6k $3.0m | Added +20.2k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 126.0k $3.0m | Added +736 |
| ADAR1 Capital Management, LLC 0.22% of their portfolio | 125.4k $2.9m | Added +90.4k |
| FMR LLC 0.00% of their portfolio | 123.6k $2.9m | Added +50.4k |
| ARK Investment Management LLC 0.02% of their portfolio | 121.5k $2.8m | Reduced -5.2k |
| Aisling Capital Management LP 0.53% of their portfolio | 108.0k $2.5m | New |
| Elmind Capital, LP 0.69% of their portfolio | 100.0k $2.3m | First filing |
| Bank of New York Mellon Corp 0.00% of their portfolio | 98.8k $2.3m | Added +3.5k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 91.0k $2.1m | Reduced -70 |
| OAK RIDGE INVESTMENTS LLC 0.12% of their portfolio | 85.2k $2.0m | Reduced -2.3k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 84.2k $2.0m | Reduced -41.8k |
| TD Asset Management Inc 0.00% of their portfolio | 80.2k $1.9m | Added +36.2k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 76.8k $1.8m | Reduced -6.8k |
| PANAGORA ASSET MANAGEMENT INC 0.01% of their portfolio | 74.1k $1.7m | Reduced -110.3k |
| TRUIST FINANCIAL CORP 0.00% of their portfolio | 72.3k $1.7m | Unchanged |
| ALGERT GLOBAL LLC 0.02% of their portfolio | 65.9k $1.5m | New |
| Annandale Capital, LLC 0.23% of their portfolio | 60.6k $1.4m | Reduced -10.0k |
| BARCLAYS PLC 0.00% of their portfolio | 57.7k $1.4m | Added +2.1k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 55.7k $1.3m | Added +19.7k |
| NEOS Investment Management LLC 0.01% of their portfolio | 53.6k $1.3m | Added +3.1k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 47.3k $1.1m | Added +43.9k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 45.8k $1.1m | Reduced -5.2k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.00% of their portfolio | 39.4k $922.4k | Added +18.0k |
| Coastal Bridge Advisors, LLC 0.06% of their portfolio | 37.0k $866.5k | Unchanged |
| MEITAV INVESTMENT HOUSE LTD 0.01% of their portfolio | 35.5k $831.7k | Added +4.0k |
| ExodusPoint Capital Management, LP 0.01% of their portfolio | 35.4k $828.9k | Added +18.9k |
| Focus Partners Wealth 0.00% of their portfolio | 35.3k $826.2k | New |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 35.0k $820.6k | Unchanged |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 31.6k $626.6k | Added +412 |
| DARK FOREST CAPITAL MANAGEMENT LP 0.03% of their portfolio | 31.5k $738.1k | New |
| Cetera Investment Advisers 0.00% of their portfolio | 30.1k $704.8k | Reduced -2.0k |
| HighVista Strategies LLC 0.17% of their portfolio | 28.0k $655.9k | Reduced -3.9k |
| Susquehanna Portfolio Strategies, LLC 0.01% of their portfolio | 27.4k $641.2k | New |
| Invesco Ltd. 0.00% of their portfolio | 27.1k $633.9k | Added +4.7k |
| Tidal Investments LLC 0.00% of their portfolio | 27.0k $631.7k | New |
| Palo Alto Investors LP 0.08% of their portfolio | 24.5k $573.8k | Unchanged |
| MML INVESTORS SERVICES, LLC 0.00% of their portfolio | 24.4k $570.6k | New |
| Quantinno Capital Management LP 0.00% of their portfolio | 23.5k $550.7k | Added +3.2k |
| Squarepoint Ops LLC 0.00% of their portfolio | 22.8k $534.7k | New |
| XTX Topco Ltd 0.01% of their portfolio | 22.5k $526.7k | Reduced -6.8k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 22.4k $525.7k | Reduced -321 |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 22.2k $520.2k | Added +7.0k |
| SIMPLEX TRADING, LLC 0.01% of their portfolio | 22.1k $517.8k | New |
| Allianz Asset Management GmbH 0.00% of their portfolio | 22.0k $515.2k | Unchanged |
| Kranot Hishtalmut Le Morim Tichoniim Havera Menahelet LTD 0.10% of their portfolio | 21.8k $511.1k | Unchanged |
| DIADEMA PARTNERS LP 0.30% of their portfolio | 21.8k $510.8k | Reduced -68.2k |
| Main Street Financial Solutions, LLC 0.04% of their portfolio | 21.0k $491.6k | Reduced -11.2k |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 20.6k $471.9k | Added +6.8k |
| Jump Financial, LLC 0.01% of their portfolio | 17.9k $419.2k | Reduced -86.0k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 17.2k $401.7k | Added +137 |
| Cinctive Capital Management LP 0.02% of their portfolio | 17.0k $397.9k | New |