ENTERA BIO LTD ENTX
SHS · Common Stock · CUSIP M40527109
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 45.9m as of 2025-11-10, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $1.94. Options: 1 managers hold calls ($14.7k notional), 0 hold puts (—).
Trends to Q4 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 10 |
| Q4 2022 | 13 |
| Q1 2023 | 10 |
| Q2 2023 | 13 |
| Q3 2023 | 13 |
| Q4 2023 | 11 |
| Q1 2024 | 16 |
| Q2 2024 | 16 |
| Q3 2024 | 18 |
| Q4 2024 | 15 |
| Q1 2025 | 19 |
| Q2 2025 | 20 |
| Q3 2025 | 22 |
| Q4 2025 | 22 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2024 | 10 | 3 |
| Q2 2024 | 7 | 8 |
| Q3 2024 | 6 | 4 |
| Q4 2024 | 7 | 7 |
| Q1 2025 | 8 | 3 |
| Q2 2025 | 9 | 6 |
| Q3 2025 | 9 | 8 |
| Q4 2025 | 9 | 8 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2025 | $53.5k | $170 | 0.00 |
| Q2 2025 | $950 | $0 | 0.00 |
| Q3 2025 | $40.9k | $0 | 0.00 |
| Q4 2025 | $14.7k | $0 | 0.00 |
Biggest buyers
| JANE STREET GROUP, LLC | Added | +43.5k |
| Schonfeld Strategic Advisors LLC | Added | +29.6k |
| HighTower Advisors, LLC | Added | +25.0k |
| RENAISSANCE TECHNOLOGIES LLC | Added | +19.6k |
| SUPERSTRING CAPITAL MANAGEMENT LP | New | +17.1k |
| Point72 Asset Management, L.P. | Added | +15.2k |
| GOLDMAN SACHS GROUP INC | New | +12.3k |
| GSA CAPITAL PARTNERS LLP | New | +11.9k |
| CITADEL ADVISORS LLC | Added | +252 |
Biggest sellers
| BESSEMER GROUP INC | Sold out | -140.8k |
| XTX Topco Ltd | Sold out | -10.8k |
| UBS Group AG | Reduced | -10.4k |
| BANK OF AMERICA CORP /DE/ | Reduced | -6.0k |
| Parkman Healthcare Partners LLC | Reduced | -5.7k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -2.3k |
| SIMPLEX TRADING, LLC | Sold out | -69 |
| SBI Securities Co., Ltd. | Sold out | -1 |
Biggest calls
| GROUP ONE TRADING LLC | Added | $14.7k7.6k shares |
Biggest puts
| None |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
BIOTECHNOLOGY VALUE FUND L P
13D · may seek influence
new · filed 2026-08-04
Stated purposeThe Reporting Persons purchased the securities reported owned herein based on the Reporting Persons' belief that such securities, when purchased, were undervalued and represented an attractive investment opportunity. Depending upon overall market conditions, other investment opportunities available to the Reporting Persons, and the availability of Shares at prices that would make the purchase or sale of Shares desirable, the Reporting Persons may endeavor to increase or decrease their position in the Issuer through, among other things, the purchase or sale of Shares on the open market or in private transactions or otherwise, on such terms and at such times as the Reporting Persons may deem advisable. April Securities Purchase Agreement and Registration Rights Agreement On April 1, 2026, … Full filing |
10.0% |
| OPKO HEALTH, INC. 13G · passive investor new · filed 2025-04-02 | 8.1% |
| TCG Crossover GP III, LLC 13G · passive investor new · filed 2026-08-04 | 7.1% |
| Vivo Opportunity Fund Holdings, L.P. 13G · passive investor new · filed 2026-08-04 | 6.9% |
Fell to 5% or below in the last year: Longitude Capital Partners V, LLC (4.6%, 2026-08-04), Seven Fleet Capital Management LP (4.1%, 2026-08-04)
Insider purchases and sales in Q4 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2024 | 1 | $15.3k | 0 | — | — |
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 1 | $19.9k | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-12-29 | Toledano Miranda Jayne Chief Executive Officer, director | Bought | $19.9k11.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2025
| Manager | Shares | Change |
|---|---|---|
| Knoll Capital Management, LLC 5.23% of their portfolio | 5.9m $11.4m | Unchanged |
| Point72 Asset Management, L.P. 0.00% of their portfolio | 1.2m $2.3m | Added +15.2k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 627.3k $1.2m | Unchanged |
| Schonfeld Strategic Advisors LLC 0.01% of their portfolio | 596.6k $1.2m | Added +29.6k |
| Parkman Healthcare Partners LLC 0.05% of their portfolio | 275.1k $533.6k | Reduced -5.7k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 148.7k $288.4k | Unchanged |
| Seven Fleet Capital Management LP 0.18% of their portfolio | 135.3k $262.5k | First filing |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 108.0k $209.5k | Added +19.6k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 74.1k $143.7k | Added +43.5k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 64.9k $125.9k | Reduced -2.3k |
| SIGNATURE ESTATE & INVESTMENT ADVISORS LLC 0.00% of their portfolio | 47.3k $91.8k | Unchanged |
| HighTower Advisors, LLC 0.00% of their portfolio | 43.1k $83.7k | Added +25.0k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 40.2k $78.0k | Added +252 |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 21.1k $41.0k | Unchanged |
| Gem Investment Advisors, LLC 0.04% of their portfolio | 19.1k $37.1k | First filing |
| SUPERSTRING CAPITAL MANAGEMENT LP 0.02% of their portfolio | 17.1k $33.3k | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 15.0k $29.1k | Reduced -6.0k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 12.3k $23.9k | New |
| GSA CAPITAL PARTNERS LLP 0.00% of their portfolio | 11.9k $23.0k | New |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 10.0k $19.4k | Unchanged |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 51 $99 | Unchanged |
| UBS Group AG 0.00% of their portfolio | 17 $33 | Reduced -10.4k |