CRISPR THERAPEUTICS AG CRSP
NAMEN AKT · Common Stock · CUSIP H17182108
Company in Basel, Switzerland
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersZug, Switzerland
- Founded2013
- Websitecrisprtx.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($15.1k this quarter). Holder counts are more reliable. Shares outstanding: 78.3m as of 2022-10-28, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $40.65. Options: 24 managers hold calls ($109.4m notional), 20 hold puts ($86.2m).
Trends to Q4 2022
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 437 |
| Q4 2022 | 398 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $223.2m | $212.7m | 0.95 |
| Q4 2022 | $109.4m | $86.2m | 0.79 |
Biggest buyers
| T. Rowe Price Investment Management, Inc. | Added | +752.1k |
| STATE STREET CORP | Added | +512.7k |
| BlackRock Inc. | Added | +283.2k |
| PEAK6 Investments LLC | New | +271.8k |
| RENAISSANCE TECHNOLOGIES LLC | Added | +193.3k |
| UBS Group AG | Added | +180.6k |
| CITADEL ADVISORS LLC | Added | +164.3k |
| Cubist Systematic Strategies, LLC | Added | +158.7k |
| DIMENSIONAL FUND ADVISORS LP | Added | +125.8k |
| ARMISTICE CAPITAL, LLC | Added | +112.0k |
Biggest sellers
| BANK OF AMERICA CORP /DE/ | Reduced | -1.0m |
| MACQUARIE GROUP LTD | Reduced | -797.5k |
| ARK Investment Management LLC | Reduced | -407.2k |
| FRONTIER CAPITAL MANAGEMENT CO LLC | Reduced | -263.0k |
| Sumitomo Mitsui Trust Group, Inc. | Reduced | -256.3k |
| Amova Asset Management Americas, Inc. | Reduced | -256.3k |
| GOLDMAN SACHS GROUP INC | Reduced | -248.7k |
| AXA S.A. | Sold out | -225.1k |
| Integral Health Asset Management, LLC | Sold out | -220.0k |
| CLOUGH CAPITAL PARTNERS L P | Reduced | -153.1k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $17.6m433.9k shares |
| CITADEL ADVISORS LLC | Reduced | $16.8m412.7k shares |
| Walleye Trading LLC | Added | $13.1m322.9k shares |
| JANE STREET GROUP, LLC | Reduced | $10.4m256.5k shares |
| GROUP ONE TRADING LLC | Reduced | $8.1m199.7k shares |
| SIMPLEX TRADING, LLC | Added | $7.2m178.1k shares |
| IMC-Chicago, LLC | Reduced | $6.8m166.4k shares |
| D. E. Shaw & Co., Inc. | Added | $6.0m148.4k shares |
| SG3 Management, LLC | Not comparable | $4.8m117.4k shares |
| CITIGROUP INC | Added | $3.3m80.0k shares |
Biggest puts
| CITADEL ADVISORS LLC | Added | $19.0m466.9k shares |
| PEAK6 Investments LLC | Reduced | $15.3m375.5k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $8.2m200.6k shares |
| GOLDMAN SACHS GROUP INC | Reduced | $6.8m166.7k shares |
| Squarepoint Ops LLC | Unchanged | $5.4m131.8k shares |
| Walleye Trading LLC | Reduced | $4.6m112.8k shares |
| D. E. Shaw & Co., Inc. | Added | $4.1m100.0k shares |
| GROUP ONE TRADING LLC | Reduced | $4.0m98.4k shares |
| JANE STREET GROUP, LLC | Reduced | $3.8m92.8k shares |
| SIMPLEX TRADING, LLC | Added | $3.1m75.8k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| ARK Investment Management LLC 13G · institution +1.0 pts · filed 2026-04-30 | 11.8% |
| BlackRock, Inc. 13G · institution +1.4 pts · filed 2026-07-27 | 8.3% |
| ORBIS INVESTMENT MANAGEMENT LTD 13G · institution -0.7 pts · filed 2026-08-14 | 5.6% |
| Capital World Investors 13G · institution new · filed 2026-05-14 | 5.1% |
Fell to 5% or below in the last year: Capital International Investors (1.2%, 2026-02-05)
Insider purchases and sales in Q4 2022
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2021 | 0 | — | 0 | — | — |
| Q2 2021 | 0 | — | 0 | — | — |
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 0 | — | 0 | — | — |
| Q1 2022 | 0 | — | 0 | — | — |
| Q2 2022 | 0 | — | 1 | $1.5m | — |
| Q3 2022 | 0 | — | 1 | $5.2m | — |
| Q4 2022 | 0 | — | 1 | $3.7m | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2022-12-28 | Kulkarni Samarth Chief Executive Officer, director | Sold | $1.0m25.0k shares |
| 2022-11-28 | Kulkarni Samarth Chief Executive Officer, director | Sold | $1.4m25.0k shares |
| 2022-10-26 | Kulkarni Samarth Chief Executive Officer, director | Sold | $1.4m25.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2022
| Manager | Shares | Change |
|---|---|---|
| ARK Investment Management LLC 2.76% of their portfolio | 7.8m $318.3m | Reduced -407.2k |
| Capital International Investors 0.06% of their portfolio | 5.4m $217.7m | Added +12.1k |
| Sumitomo Mitsui Trust Group, Inc. 0.13% of their portfolio | 4.0m $162.9m | Reduced -256.3k |
| Amova Asset Management Americas, Inc. 2.35% of their portfolio | 4.0m $162.9m | Reduced -256.3k |
| T. Rowe Price Investment Management, Inc. 0.09% of their portfolio | 3.0m $121.7m | Added +752.1k |
| BlackRock Inc. 0.00% of their portfolio | 2.6m $106.9m | Added +283.2k |
| FMR LLC 0.01% of their portfolio | 2.2m $88.8m | Added +37.9k |
| STATE STREET CORP 0.00% of their portfolio | 2.1m $84.6m | Added +512.7k |
| NEA Management Company, LLC 3.63% of their portfolio | 1.6m $64.5m | Reduced -2.1k |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.4m $58.6m | Added +6.9k |
| LOOMIS SAYLES & CO L P 0.10% of their portfolio | 1.2m $48.3m | Reduced -56.9k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio | 1.1m $45.6m | Reduced -64.6k |
| ARMISTICE CAPITAL, LLC 1.13% of their portfolio | 1.0m $42.1m | Added +112.0k |
| Bellevue Group AG 0.49% of their portfolio | 911.7k $37.1m | Reduced -16.6k |
| CREDIT SUISSE AG/ 0.04% of their portfolio | 852.9k $34.7m | Added +12.2k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 789.1k $32.1m | Added +24.4k |
| RENAISSANCE TECHNOLOGIES LLC 0.04% of their portfolio | 786.6k $32.0m | Added +193.3k |
| DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio | 774.8k $31.5m | Added +125.8k |
| NORGES BANK 0.01% of their portfolio | 715.4k $29.1m | Added +48.7k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 641.1k $26.1m | Added +19.0k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 589.6k $24.0m | Reduced -23.3k |
| FEDERATED HERMES, INC. 0.06% of their portfolio | 508.8k $20.7m | Unchanged |
| MORGAN STANLEY 0.00% of their portfolio | 507.8k $20.6m | Reduced -78.1k |
| Versant Venture Management, LLC 41.93% of their portfolio | 498.6k $20.3m | Unchanged |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 497.2k $20.2m | Reduced -248.7k |
| UBS Group AG 0.01% of their portfolio | 448.5k $18.2m | Added +180.6k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 426.5k $17.3m | Reduced -1.0m |
| BARCLAYS PLC 0.01% of their portfolio | 389.7k $15.8m | First filing |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 294.1k $12.0m | Reduced -1.9k |
| PEAK6 Investments LLC 0.61% of their portfolio | 271.8k $11.1m | New |
| BAILLIE GIFFORD & CO 0.01% of their portfolio | 263.4k $10.7m | Reduced -25.2k |
| CLOUGH CAPITAL PARTNERS L P 1.08% of their portfolio | 261.7k $10.6m | Reduced -153.1k |
| Allspring Global Investments Holdings, LLC 0.02% of their portfolio | 259.9k $10.6m | Reduced -9.1k |
| Valiant Capital Management, L.P. 2.23% of their portfolio | 229.0k $9.3m | Added +38.8k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 188.6k $7.7m | Reduced -10.1k |
| TD Asset Management Inc 0.01% of their portfolio | 181.8k $7.4m | Added +66.5k |
| Swiss National Bank 0.01% of their portfolio | 179.0k $7.3m | Added +4.5k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 169.9k $6.9m | Added +164.3k |
| Cubist Systematic Strategies, LLC 0.06% of their portfolio | 168.4k $6.8m | Added +158.7k |
| Squarepoint Ops LLC 0.04% of their portfolio | 166.4k $6.8m | Added +96.8k |
| Rafferty Asset Management, LLC 0.06% of their portfolio | 164.7k $6.7m | Added +61.2k |
| Mirae Asset Global Investments Co., Ltd. 0.02% of their portfolio | 163.6k $6.7m | Reduced -5.2k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 136.7k $5.6m | Reduced -3.0k |
| California Public Employees Retirement System 0.00% of their portfolio | 134.9k $5.5m | Reduced -12.8k |
| CAPITAL ADVISORS INC/OK 0.15% of their portfolio | 129.9k $5.3m | Added +1.6k |
| Invesco Ltd. 0.00% of their portfolio | 125.1k $5.1m | Reduced -1.1k |
| CITIGROUP INC 0.01% of their portfolio | 124.9k $5.1m | Added +8.4k |
| LAZARD ASSET MANAGEMENT LLC 0.01% of their portfolio | 122.4k $5.0m | Reduced -103.4k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 108.9k $4.4m | Reduced -9.5k |
| NORDEA INVESTMENT MANAGEMENT AB 0.01% of their portfolio | 102.0k $4.0m | Added +14.1k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 99.6k $4.0m | Reduced -34.8k |
| EFG Asset Management (North America) Corp. 0.85% of their portfolio | 94.3k $3.8m | Added +10.0k |
| VAN ECK ASSOCIATES CORP 0.01% of their portfolio | 93.3k $3.8m | Added +14.1k |
| BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio | 90.3k $3.7m | Added +29.1k |
| Rokos Capital Management LLP 0.35% of their portfolio | 87.5k $3.5m | Unchanged |
| Lombard Odier Asset Management (Switzerland) SA 0.27% of their portfolio | 83.4k $3.4m | Added +24.2k |
| GUGGENHEIM CAPITAL LLC 0.03% of their portfolio | 82.1k $3.3m | Added +4.4k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio | 81.9k $3.3m | Added +40.1k |
| Hudson Bay Capital Management LP 0.04% of their portfolio | 81.6k $3.3m | Added +66.6k |
| BLAIR WILLIAM & CO/IL 0.01% of their portfolio | 79.6k $3.2m | Reduced -3.1k |
| Thrivent Financial for Lutherans 0.01% of their portfolio | 78.8k $3.2m | Added +53.6k |
| CAPITAL INTERNATIONAL LTD /CA/ 0.22% of their portfolio | 78.3k $3.2m | Added +2.2k |
| LPL Financial LLC 0.00% of their portfolio | 77.9k $3.2m | Reduced -274 |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 75.9k $3.1m | Added +120 |
| SHELTON CAPITAL MANAGEMENT 0.32% of their portfolio | 74.8k $3.0m | Reduced -57.0k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio | 74.3k $3.0m | Reduced -598 |
| JANE STREET GROUP, LLC 0.01% of their portfolio | 70.6k $2.9m | Added +64.0k |
| OSAIC HOLDINGS, INC. 0.01% of their portfolio | 68.9k $2.8m | Added +17.9k |
| GREENWOOD CAPITAL ASSOCIATES LLC 0.43% of their portfolio | 65.0k $2.6m | Added +5.0k |
| AGF MANAGEMENT LTD 0.02% of their portfolio | 64.7k $2.6m | First filing |
| Balyasny Asset Management L.P. 0.01% of their portfolio | 64.6k $2.6m | Added +42.0k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 64.5k $2.6m | Added +1.2k |
| Slow Capital, Inc. 0.58% of their portfolio | 64.5k $2.6m | Added +20.3k |
| CAPITAL FUND MANAGEMENT S.A. 0.05% of their portfolio | 60.3k $2.4m | New |
| CAPITAL INTERNATIONAL SARL 0.17% of their portfolio | 58.5k $2.4m | Added +8.6k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 57.4k $2.3m | Reduced -47.0k |
| FRONTIER CAPITAL MANAGEMENT CO LLC 0.02% of their portfolio | 55.9k $2.3m | Reduced -263.0k |
| Jump Financial, LLC 0.12% of their portfolio | 55.2k $2.2m | New |
| Tekla Capital Management LLC 0.08% of their portfolio | 55.1k $2.2m | Unchanged |
| Legal & General Group Plc 0.00% of their portfolio | 55.1k $2.2m | Added +619 |
| State of New Jersey Common Pension Fund D 0.01% of their portfolio | 51.9k $2.1m | Added +3.4k |
| COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio | 51.1k $2.1m | Reduced -56.2k |
| Allianz Asset Management GmbH 0.00% of their portfolio | 50.6k $2.1m | Added +209 |
| Capital International, Inc./CA/ 0.04% of their portfolio | 49.2k $2.0m | Reduced -3.9k |
| Twin Tree Management, LP 0.06% of their portfolio | 47.6k $1.9m | Reduced -79.9k |
| GROUP ONE TRADING LLC 0.06% of their portfolio | 45.9k $1.9m | Added +39.1k |
| RAYMOND JAMES & ASSOCIATES 0.00% of their portfolio | 43.4k $1.8m | Added +6.2k |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 41.7k $1.7m | Reduced -70.4k |
| MACQUARIE GROUP LTD 0.00% of their portfolio | 39.9k $1.6m | Reduced -797.5k |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.01% of their portfolio | 37.0k $1.5m | New |
| McGuire Investment Group, LLC 0.32% of their portfolio | 35.8k $1.5m | Added +31.2k |
| West Family Investments, Inc. 0.49% of their portfolio | 35.5k $1.4m | Unchanged |
| INTERNATIONAL BIOTECHNOLOGY TRUST PLC 0.43% of their portfolio | 34.2k $1.4m | Unchanged |
| HERSHEY TRUST CO 0.01% of their portfolio | 33.8k $1.4m | Unchanged |
| B & T Capital Management DBA Alpha Capital Management 0.33% of their portfolio | 32.9k $1.3m | Added +2.8k |
| Walleye Capital LLC 0.03% of their portfolio | 32.4k $1.3m | New |
| ZEKE CAPITAL ADVISORS, LLC 0.08% of their portfolio | 31.3k $1.3m | Reduced -3.4k |
| Mitsubishi UFJ Trust & Banking Corp 0.00% of their portfolio | 31.0k $1.3m | Unchanged |
| Green Alpha Advisors, LLC 1.03% of their portfolio | 30.6k $1.2m | Added +3.2k |
| HighTower Advisors, LLC 0.00% of their portfolio | 30.5k $1.2m | Reduced -4.9k |