AC IMMUNE SA ACIU
SHS · Common Stock · CUSIP H00263105
- SectorHealth care
- IndustryPharmaceutical Preparations
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 101.7m as of 2025-12-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $3.14. Options: 6 managers hold calls ($1.1m notional), 3 hold puts ($118.7k).
Trends to Q4 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 35 |
| Q4 2022 | 38 |
| Q1 2023 | 35 |
| Q2 2023 | 32 |
| Q3 2023 | 29 |
| Q4 2023 | 33 |
| Q1 2024 | 38 |
| Q2 2024 | 46 |
| Q3 2024 | 44 |
| Q4 2024 | 46 |
| Q1 2025 | 43 |
| Q2 2025 | 43 |
| Q3 2025 | 40 |
| Q4 2025 | 42 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2024 | 23 | 11 |
| Q2 2024 | 21 | 22 |
| Q3 2024 | 13 | 25 |
| Q4 2024 | 21 | 21 |
| Q1 2025 | 19 | 22 |
| Q2 2025 | 21 | 15 |
| Q3 2025 | 17 | 19 |
| Q4 2025 | 19 | 17 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2025 | $88.9k | $42.5k | 0.48 |
| Q2 2025 | $812 | $93.2k | 114.75 |
| Q3 2025 | $293.3k | $86.7k | 0.30 |
| Q4 2025 | $1.1m | $118.7k | 0.11 |
Biggest buyers
| Point72 Asset Management, L.P. | New | +384.8k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | New | +375.6k |
| MARSHALL WACE, LLP | New | +186.7k |
| UBS Group AG | Added | +177.9k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | +125.8k |
| BlackRock, Inc. | Added | +90.3k |
| TWO SIGMA INVESTMENTS, LP | Added | +71.1k |
| ACADIAN ASSET MANAGEMENT LLC | Added | +51.5k |
| CITADEL ADVISORS LLC | Added | +51.0k |
| MILLENNIUM MANAGEMENT LLC | Added | +38.8k |
Biggest sellers
| DEUTSCHE BANK AG\ | Sold out | -253.4k |
| Assenagon Asset Management S.A. | Sold out | -189.9k |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -101.6k |
| TWO SIGMA ADVISERS, LP | Sold out | -20.9k |
| Private Advisor Group, LLC | Sold out | -16.6k |
| Banque Cantonale Vaudoise | Reduced | -10.5k |
| JPMORGAN CHASE & CO | Reduced | -5.8k |
| State of Tennessee, Department of Treasury | Sold out | -5.1k |
| WELLS FARGO & COMPANY/MN | Reduced | -4.2k |
| SIMPLEX TRADING, LLC | Sold out | -3.3k |
Biggest calls
| GROUP ONE TRADING LLC | New | $624.9k199.0k shares |
| CITADEL ADVISORS LLC | New | $158.6k50.5k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $120.6k38.4k shares |
| SIMPLEX TRADING, LLC | Added | $95.8k30.5k shares |
| Point72 Asset Management, L.P. | New | $87.6k27.9k shares |
| JANE STREET GROUP, LLC | New | $33.0k10.5k shares |
Biggest puts
| JANE STREET GROUP, LLC | New | $67.2k21.4k shares |
| CITADEL ADVISORS LLC | Reduced | $35.8k11.4k shares |
| SIMPLEX TRADING, LLC | New | $15.7k5.0k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Insider purchases and sales in Q4 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
None reported in Q4 2025.
Holders, Q4 2025
| Manager | Shares | Change |
|---|---|---|
| BVF INC/IL 2.10% of their portfolio | 19.8m $62.2m | Unchanged |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 1.0m $3.2m | Reduced -4.2k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 933.3k $2.9m | Added +38.8k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 668.9k $2.1m | Reduced -101.6k |
| BlackRock, Inc. 0.00% of their portfolio | 502.2k $1.6m | Added +90.3k |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 464.7k $1.4m | Added +51.5k |
| Point72 Asset Management, L.P. 0.00% of their portfolio | 384.8k $1.2m | New |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.00% of their portfolio | 375.6k $1.2m | New |
| NORTHERN TRUST CORP 0.00% of their portfolio | 282.0k $885.3k | Unchanged |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 213.5k $670.4k | Added +36.4k |
| UBS Group AG 0.00% of their portfolio | 194.3k $610.3k | Added +177.9k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 186.7k $586.3k | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 147.6k $463.5k | Added +125.8k |
| Dauntless Investment Group, LLC 1.34% of their portfolio | 115.7k $363.2k | Not comparable |
| Deeter Investments LLP 0.07% of their portfolio | 100.0k $314.0k | First filing |
| MORGAN STANLEY 0.00% of their portfolio | 94.3k $296.2k | Added +2.3k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 87.9k $276.0k | Added +71.1k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 71.2k $223.4k | Added +51.0k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 63.6k $199.7k | Unchanged |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 21.5k $67.4k | Added +15.6k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 18.6k $58.3k | Added +5.9k |
| China Universal Asset Management Co., Ltd. 0.00% of their portfolio | 16.4k $51.4k | Reduced -1.2k |
| SEI INVESTMENTS CO 0.00% of their portfolio | 15.9k $49.9k | Unchanged |
| EFG International AG 0.00% of their portfolio | 12.9k $40.5k | First filing |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 10.7k $33.6k | New |
| Quinn Opportunity Partners LLC 0.00% of their portfolio | 10.1k $31.7k | Unchanged |
| Silverberg Bernstein Capital Management LLC 0.02% of their portfolio | 10.0k $31.3k | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 8.7k $27.4k | Reduced -5.8k |
| Banque Cantonale Vaudoise 0.00% of their portfolio | 7.9k $25.0k | Reduced -10.5k |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 6.2k $19.4k | Added +2.9k |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 4.9k $15.3k | Added +997 |
| Leonteq Securities AG 0.00% of their portfolio | 3.0k $9.4k | New |
| CITIGROUP INC 0.00% of their portfolio | 2.8k $8.8k | Added +870 |
| BARCLAYS PLC 0.00% of their portfolio | 2.7k $8.5k | Reduced -2.6k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 2.5k $7.8k | Reduced -323 |
| GF FUND MANAGEMENT CO. LTD. 0.00% of their portfolio | 2.0k $6.2k | Reduced -188 |
| Rockefeller Capital Management L.P. 0.00% of their portfolio | 1.0k $3.1k | Unchanged |
| Activest Wealth Management 0.00% of their portfolio | 1.0k $3.1k | Unchanged |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 858 $2.0k | Reduced -950 |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 547 $1.7k | Reduced -1 |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 221 $693 | Reduced -30 |
| Strengthening Families & Communities, LLC 0.00% of their portfolio | 200 $628 | Unchanged |