PROTHENA CORP PLC PRTA
SHS · Common Stock · CUSIP G72800108
- SectorHealth care
- IndustryPharmaceutical Preparations
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($431.8k this quarter). Holder counts are more reliable. Shares outstanding: 53.8m as of 2025-07-25, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $6.07. Options: 12 managers hold calls ($6.7m notional), 8 hold puts ($6.3m).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 183 |
| Q4 2022 | 201 |
| Q1 2023 | 192 |
| Q2 2023 | 197 |
| Q3 2023 | 188 |
| Q4 2023 | 188 |
| Q1 2024 | 170 |
| Q2 2024 | 161 |
| Q3 2024 | 166 |
| Q4 2024 | 172 |
| Q1 2025 | 162 |
| Q2 2025 | 190 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 98 | 83 |
| Q4 2023 | 99 | 84 |
| Q1 2024 | 81 | 102 |
| Q2 2024 | 82 | 77 |
| Q3 2024 | 68 | 65 |
| Q4 2024 | 86 | 67 |
| Q1 2025 | 57 | 82 |
| Q2 2025 | 104 | 64 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $3.0m | $2.1m | 0.68 |
| Q4 2024 | $8.8m | $4.3m | 0.49 |
| Q1 2025 | $3.5m | $1.2m | 0.36 |
| Q2 2025 | $6.7m | $6.3m | 0.95 |
Biggest buyers
| ADAR1 Capital Management, LLC | New | +3.4m |
| CITADEL ADVISORS LLC | Added | +1.1m |
| ACADIAN ASSET MANAGEMENT LLC | New | +1.0m |
| VANGUARD GROUP INC | Added | +907.0k |
| Rangeley Capital, LLC | New | +715.4k |
| JACOBS LEVY EQUITY MANAGEMENT, INC | Added | +674.6k |
| FEDERATED HERMES, INC. | Added | +634.8k |
| Balyasny Asset Management L.P. | New | +575.8k |
| Trexquant Investment LP | New | +552.8k |
| Cubist Systematic Strategies, LLC | New | +501.8k |
Biggest sellers
| EcoR1 Capital, LLC | Sold out | -11.6m |
| WELLINGTON MANAGEMENT GROUP LLP | Reduced | -5.1m |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -3.4m |
| Siren, L.L.C. | Sold out | -1.3m |
| Boxer Capital Management, LLC | Sold out | -690.0k |
| Finepoint Capital LP | Sold out | -640.1k |
| STATE STREET CORP | Reduced | -516.4k |
| Palo Alto Investors LP | Reduced | -385.0k |
| JPMORGAN CHASE & CO | Reduced | -245.0k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | Reduced | -242.4k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $2.3m383.9k shares |
| SIMPLEX TRADING, LLC | Added | $1.1m187.2k shares |
| CITADEL ADVISORS LLC | Added | $965.7k159.1k shares |
| Ikarian Capital, LLC | Unchanged | $607.0k100.0k shares |
| DIADEMA PARTNERS LP | New | $607.0k100.0k shares |
| JANE STREET GROUP, LLC | Added | $341.1k56.2k shares |
| GROUP ONE TRADING LLC | Added | $248.9k41.0k shares |
| Walleye Capital LLC | New | $193.6k31.9k shares |
| BOOTHBAY FUND MANAGEMENT, LLC | Unchanged | $179.7k29.6k shares |
| Walleye Trading LLC | Reduced | $81.3k13.4k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $2.9m479.5k shares |
| SIMPLEX TRADING, LLC | Added | $980.0k161.5k shares |
| JANE STREET GROUP, LLC | New | $868.0k143.0k shares |
| Caption Management, LLC | New | $607.0k100.0k shares |
| GROUP ONE TRADING LLC | Added | $574.2k94.6k shares |
| CITADEL ADVISORS LLC | Added | $385.4k63.5k shares |
| Walleye Trading LLC | Reduced | $10.3k1.7k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution filed 2026-08-06 | 13.8% |
| SCULLY WILLIAM P 13G · passive investor +0.5 pts · filed 2026-05-11 | 10.3% |
| Fennell Todd W. 13G · passive investor +0.4 pts · filed 2026-08-19 | 10.2% |
| Rubric Capital Management LP 13G · institution +2.5 pts · filed 2026-05-15 | 9.3% |
| BlackRock, Inc. 13G · institution +1.2 pts · filed 2026-07-29 | 6.9% |
Fell to 5% or below in the last year: ADAR1 Capital Management, LLC (2.7%, 2025-11-14)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 0 | — | 7 | $4.6m | $4.6m |
| Q4 2023 | 0 | — | 3 | $981.2k | $981.2k |
| Q1 2024 | 0 | — | 1 | $170.0k | $170.0k |
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-05-06 | EcoR1 Capital, LLC 10% owner · See Note | Sold | $15.2m2.0m shares |
| 2025-05-05 | EcoR1 Capital, LLC 10% owner · See Note | Sold | $7.9m977.7k shares |
| 2025-05-02 | EcoR1 Capital, LLC 10% owner · See Note | Sold | $27.7m3.3m shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.00% of their portfolio | 7.9m $48.0m | Reduced -40.2k |
| BlackRock, Inc. 0.00% of their portfolio | 3.9m $23.9m | Reduced -102.9k |
| ADAR1 Capital Management, LLC 3.33% of their portfolio | 3.4m $20.5m | New |
| ARMISTICE CAPITAL, LLC 0.51% of their portfolio | 2.2m $13.6m | Added +40.0k |
| VANGUARD GROUP INC 0.00% of their portfolio | 2.2m $13.2m | Added +907.0k |
| Palo Alto Investors LP 1.65% of their portfolio | 1.3m $7.7m | Reduced -385.0k |
| FEDERATED HERMES, INC. 0.01% of their portfolio | 1.2m $7.2m | Added +634.8k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 1.1m $7.0m | Added +1.1m |
| ACADIAN ASSET MANAGEMENT LLC 0.01% of their portfolio | 1.0m $6.2m | New |
| STATE STREET CORP 0.00% of their portfolio | 1.0m $6.1m | Reduced -516.4k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 962.3k $5.8m | Added +99.2k |
| MORGAN STANLEY 0.00% of their portfolio | 953.3k $5.8m | Added +233.3k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 933.4k $5.7m | Reduced -81.3k |
| Rangeley Capital, LLC 5.45% of their portfolio | 715.4k $4.3m | New |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.02% of their portfolio | 693.2k $4.2m | Added +674.6k |
| Balyasny Asset Management L.P. 0.01% of their portfolio | 575.8k $3.5m | New |
| Trexquant Investment LP 0.04% of their portfolio | 552.8k $3.4m | New |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 528.3k $3.2m | Added +17.9k |
| Cubist Systematic Strategies, LLC 0.03% of their portfolio | 501.8k $3.0m | New |
| Rock Springs Capital Management LP 0.19% of their portfolio | 492.6k $3.0m | Unchanged |
| Granahan Investment Management, LLC 0.11% of their portfolio | 461.1k $2.8m | New |
| Birchview Capital, LP 2.72% of their portfolio | 451.0k $2.7m | Added +118.0k |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 414.8k $2.5m | New |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 391.5k $2.4m | Added +373.7k |
| Mariner, LLC 0.00% of their portfolio | 386.7k $2.3m | Added +32.1k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 334.6k $2.0m | Reduced -39.1k |
| NORDEA INVESTMENT MANAGEMENT AB 0.00% of their portfolio | 311.6k $1.9m | Added +3.6k |
| Schonfeld Strategic Advisors LLC 0.01% of their portfolio | 307.3k $1.9m | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 275.1k $1.7m | Reduced -44.5k |
| Prosight Management, LP 0.40% of their portfolio | 267.8k $1.6m | Reduced -140.3k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 211.9k $1.3m | Added +207.6k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 210.9k $1.3m | Added +79.0k |
| GSA CAPITAL PARTNERS LLP 0.09% of their portfolio | 210.6k $1.3m | New |
| Squarepoint Ops LLC 0.00% of their portfolio | 209.2k $1.3m | New |
| MONIMUS CAPITAL MANAGEMENT, LP 1.01% of their portfolio | 206.5k $1.3m | New |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 201.4k $1.2m | Added +185.4k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 170.6k $1.0m | Added +118.1k |
| DCF Advisers, LLC 0.46% of their portfolio | 156.5k $950.0k | Reduced -38.5k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 151.5k $919.9k | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 148.3k $900.5k | Added +2.3k |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 139.8k $848.6k | New |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 139.3k $845.5k | Reduced -242.4k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 127.0k $770.6k | Reduced -245.0k |
| Nuveen, LLC 0.00% of their portfolio | 122.2k $741.5k | Reduced -27.8k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 117.5k $712.9k | Reduced -15.2k |
| BARCLAYS PLC 0.00% of their portfolio | 115.8k $703.2k | Added +32.5k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 107.8k $654.6k | Reduced -5.1m |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 104.0k $631.3k | New |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 96.2k $583.9k | Added +95.0k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 92.0k $558.1k | Added +14.7k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 90.2k $547.5k | Reduced -149.7k |
| Duncan Williams Asset Management, LLC 0.17% of their portfolio | 88.3k $536.2k | Unchanged |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 87.6k $531.7k | Added +40.8k |
| Hennion & Walsh Asset Management, Inc. 0.02% of their portfolio | 86.2k $523.0k | Added +8.5k |
| PINNACLE ASSOCIATES LTD 0.01% of their portfolio | 74.1k $449.7k | Reduced -26.2k |
| Susquehanna Portfolio Strategies, LLC 0.01% of their portfolio | 71.7k $435.0k | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 71.0k $432.0k | Reduced -3.4m |
| Monaco Asset Management SAM 0.16% of their portfolio | 70.0k $424.9k | New |
| Caption Management, LLC 0.04% of their portfolio | 65.1k $395.2k | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 63.0k $382.4k | Reduced -3.1k |
| UBS Group AG 0.00% of their portfolio | 60.7k $368.2k | Reduced -183.8k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 60.0k $364.0k | Added +25.1k |
| Quantinno Capital Management LP 0.00% of their portfolio | 59.6k $361.9k | New |
| ExodusPoint Capital Management, LP 0.00% of their portfolio | 58.9k $358.0k | Added +17.6k |
| NORGES BANK 0.00% of their portfolio | 57.5k $348.7k | Unchanged |
| Swiss National Bank 0.00% of their portfolio | 56.5k $343.0k | Reduced -12.2k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 56.1k $340.4k | Added +36.3k |
| SG Americas Securities, LLC 0.00% of their portfolio | 51.9k $315.0k | Reduced -20.6k |
| Creative Planning 0.00% of their portfolio | 50.6k $307.0k | Added +39.9k |
| Quinn Opportunity Partners LLC 0.03% of their portfolio | 50.0k $303.5k | New |
| CITIGROUP INC 0.00% of their portfolio | 49.3k $299.3k | Reduced -16.5k |
| ALGERT GLOBAL LLC 0.01% of their portfolio | 48.1k $292.3k | New |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 46.8k $284.3k | Added +37.3k |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 46.0k $282.3k | Added +33.0k |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.00% of their portfolio | 44.4k $269.3k | Added +548 |
| SIMPLEX TRADING, LLC 0.01% of their portfolio | 43.3k $262.0k | New |
| Man Group plc 0.00% of their portfolio | 42.8k $259.5k | Added +25.8k |
| Covestor Ltd 0.15% of their portfolio | 42.3k $257.0k | Added +42.3k |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO 0.00% of their portfolio | 42.2k $255.9k | New |
| PDT Partners, LLC 0.01% of their portfolio | 41.3k $250.6k | Reduced -109.0k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 41.2k $250.2k | Reduced -4.7k |
| Engineers Gate Manager LP 0.00% of their portfolio | 41.0k $248.7k | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 39.6k $240.4k | Reduced -56.2k |
| Thrivent Financial for Lutherans 0.00% of their portfolio | 38.6k $234.0k | Unchanged |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC 0.01% of their portfolio | 37.6k $228.2k | Reduced -37.2k |
| Invesco Ltd. 0.00% of their portfolio | 36.9k $223.9k | Reduced -753 |
| Graham Capital Management, L.P. 0.01% of their portfolio | 34.0k $206.6k | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 33.2k $201.8k | Unchanged |
| DARK FOREST CAPITAL MANAGEMENT LP 0.01% of their portfolio | 32.9k $199.5k | Added +11.8k |
| GROUP ONE TRADING LLC 0.01% of their portfolio | 32.3k $195.8k | New |
| Focused Wealth Management, Inc 0.02% of their portfolio | 32.1k $195.0k | Unchanged |
| RBF Capital, LLC 0.01% of their portfolio | 29.2k $177.2k | Unchanged |
| ALPS ADVISORS INC 0.00% of their portfolio | 29.0k $176.2k | Reduced -8.9k |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 28.0k $170.0k | New |
| Cambridge Investment Research Advisors, Inc. 0.00% of their portfolio | 27.3k $166.0k | Added +17.1k |
| SHERBROOKE PARK ADVISERS LLC 0.07% of their portfolio | 27.2k $165.2k | New |
| MetLife Investment Management, LLC 0.00% of their portfolio | 25.4k $154.2k | Unchanged |
| Purkiss Capital Advisors LLC 0.08% of their portfolio | 24.9k $151.2k | Added +3.3k |
| EDGEWOOD MANAGEMENT LLC 0.00% of their portfolio | 24.1k $146.0k | Unchanged |
| Point72 (DIFC) Ltd 0.01% of their portfolio | 23.9k $145.4k | New |