CRESCENT BIOPHARMA INC. CBIO
COM · Common Stock · CUSIP G2545C104
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersWaltham, MA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 37.1m as of 2026-07-27, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $18.00.
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q2 2025 | 31 |
| Q3 2025 | 41 |
| Q4 2025 | 56 |
| Q1 2026 | 60 |
| Q2 2026 | 80 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2025 | 22 | 13 |
| Q4 2025 | 37 | 15 |
| Q1 2026 | 31 | 19 |
| Q2 2026 | 48 | 26 |
Biggest buyers
| Logos Global Management LP | Added | +1.4m |
| BlackRock, Inc. | Added | +1.2m |
| Remedium Capital Partners, LLC | New | +361.2k |
| AMERIPRISE FINANCIAL INC | New | +302.6k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +280.4k |
| STATE STREET CORP | Added | +276.5k |
| JENNISON ASSOCIATES LLC | Added | +225.5k |
| VANGUARD PORTFOLIO MANAGEMENT LLC | New | +188.8k |
| STEMPOINT CAPITAL LP | New | +182.4k |
| Balyasny Asset Management L.P. | Added | +152.9k |
Biggest sellers
| Deep Track Capital, LP | Sold out | -453.7k |
| Alyeska Investment Group, L.P. | Sold out | -264.0k |
| GOLDMAN SACHS GROUP INC | Sold out | -228.5k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Sold out | -213.6k |
| Hudson Bay Capital Management LP | Sold out | -88.9k |
| SILVERARC CAPITAL MANAGEMENT, LLC | Reduced | -71.4k |
| Stonepine Capital Management, LLC | Reduced | -45.0k |
| VANGUARD CAPITAL MANAGEMENT LLC | Reduced | -33.6k |
| ADAR1 Capital Management, LLC | Reduced | -32.0k |
| JPMORGAN CHASE & CO | Reduced | -32.0k |
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
Fairmount Funds Management LLC
13D · may seek influence
-2.0 pts · filed 2026-07-20
Stated purposeItem 4 of the Statement is hereby amended and supplemented as follows: Fund II purchased the Ordinary Shares and Pre-funded Warrants referenced in Item 3 for investment purposes. Lock-Up Agreement In connection with the Company's underwritten public offering of Ordinary Shares and Pre-Funded Warrants that closed on July 16, 2026, the Reporting Persons entered into a customary lock-up letter agreement (the "Lock-Up Agreement") with Jefferies LLC and TD Securities (USA) LLC acting as the Representatives (collectively, the "Representatives") of the underwiters party to to an underwriting agreement with the Company. Pursuant to the Lock-Up Agreement, the Reporting Persons agreed to refrain from selling shares of the Company's securities without the consent of the Representatives, and other… Full filing |
16.5% |
| FMR LLC 13G · institution filed 2026-02-05 | 15.0% |
| BIOTECHNOLOGY VALUE FUND L P 13G · passive investor filed 2025-08-14 | 10.0% |
| Venrock Healthcare Capital Partners III, L.P. 13G · passive investor filed 2026-02-17 | 9.5% |
| ForGrowth III PA B.V. 13G · passive investor new · filed 2025-12-11 | 6.1% |
| BlackRock, Inc. 13G · institution new · filed 2026-10-27 | 5.6% |
| Vestal Point Capital, LP 13G · institution new · filed 2026-02-17 | 5.4% |
Fell to 5% or below in the last year: TANG CAPITAL MANAGEMENT LLC (4.2%, 2026-05-15)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 1 | $18.2m | 0 | — | — |
| Q1 2026 | 0 | — | 0 | — | — |
| Q2 2026 | 0 | — | 7 | $1.2m | $1.2m |
| Q3 2026 | 1 | $12.4m | 7 | $285.5k | $285.5k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-09-18 | Brumm Joshua T Chief Executive Officer, director | Sold plan | $131.0k7.8k shares |
| 2026-09-18 | McNeill Jonathan President and COO | Sold plan | $64.1k3.8k shares |
| 2026-09-16 | Brumm Joshua T Chief Executive Officer, director | Sold plan | $28.8k1.6k shares |
| 2026-09-16 | McNeill Jonathan President and COO | Sold plan | $13.1k731 shares |
| 2026-09-16 | Pinkas Jan Chief Scientific Officer | Sold plan | $11.8k658 shares |
| 2026-09-16 | Im Ellie Eunkyung Chief Medical Officer | Sold plan | $11.2k623 shares |
| 2026-09-16 | Bispham Barbara Harlin Officer | Sold plan | $11.1k620 shares |
| 2026-09-16 | Scalzo Richard William Chief Financial Officer | Sold plan | $10.2k568 shares |
| 2026-09-16 | Lynch Ryan Officer | Sold plan | $4.3k240 shares |
| 2026-07-16 | Harwin Peter Evan +3 Director · By Fairmount Healthcare Fund II L.P. | Bought | $12.4m853.5k shares |
| 2026-06-22 | Brumm Joshua T Chief Executive Officer, director | Sold plan | $761.1k42.3k shares |
| 2026-06-22 | McNeill Jonathan President and COO | Sold plan | $369.7k20.5k shares |
| 2026-06-22 | Pinkas Jan Chief Scientific Officer | Sold plan | $23.2k1.3k shares |
| 2026-06-22 | Im Ellie Eunkyung Chief Medical Officer | Sold plan | $21.9k1.2k shares |
| 2026-06-22 | Bispham Barbara Harlin Officer | Sold plan | $21.9k1.2k shares |
| 2026-06-22 | Scalzo Richard William Chief Financial Officer | Sold plan | $20.0k1.1k shares |
| 2026-06-22 | Lynch Ryan Officer | Sold plan | $8.4k465 shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.00% of their portfolio | 4.1m $74.4m | Unchanged |
| BVF INC/IL 1.27% of their portfolio | 2.7m $49.5m | Unchanged |
| Fairmount Funds Management LLC 3.27% of their portfolio | 2.7m $49.5m | Unchanged |
| Venrock Adviser, LLC 1.16% of their portfolio | 2.1m $38.4m | Unchanged |
| Logos Global Management LP 1.47% of their portfolio | 1.9m $34.2m | Added +1.4m |
| FCPM III SERVICES B.V. 4.02% of their portfolio | 1.7m $30.2m | Unchanged |
| Balyasny Asset Management L.P. 0.05% of their portfolio | 1.7m $29.9m | Added +152.9k |
| Vestal Point Capital, LP 0.69% of their portfolio | 1.6m $29.3m | Added +130.0k |
| Opaleye Management Inc. 2.15% of their portfolio | 1.3m $23.7m | Added +6.7k |
| BlackRock, Inc. 0.00% of their portfolio | 1.3m $22.9m | Added +1.2m |
| TANG CAPITAL MANAGEMENT LLC 0.95% of their portfolio | 1.2m $20.9m | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 767.8k $13.8m | Reduced -33.6k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 403.9k $7.3m | Added +80.3k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 384.6k $6.9m | Added +280.4k |
| JENNISON ASSOCIATES LLC 0.00% of their portfolio | 378.5k $6.8m | Added +225.5k |
| RTW INVESTMENTS, LP 0.06% of their portfolio | 372.9k $6.7m | Unchanged |
| NEXTBio Capital Management LP 3.09% of their portfolio | 372.9k $6.7m | Unchanged |
| Remedium Capital Partners, LLC 1.44% of their portfolio | 361.2k $6.5m | New |
| STATE STREET CORP 0.00% of their portfolio | 315.6k $5.7m | Added +276.5k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 302.6k $5.4m | New |
| Point72 Asset Management, L.P. 0.01% of their portfolio | 300.0k $5.4m | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 275.6k $5.0m | Reduced -28.0k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 214.3k $3.9m | Added +13.5k |
| PERCEPTIVE ADVISORS LLC 0.06% of their portfolio | 206.9k $3.7m | Unchanged |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 188.8k $3.4m | New |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 186.9k $3.4m | Added +71.0k |
| STEMPOINT CAPITAL LP 0.57% of their portfolio | 182.4k $3.3m | New |
| UBS Group AG 0.00% of their portfolio | 175.2k $3.2m | Added +92.5k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 138.8k $2.5m | Added +121.5k |
| Exome Asset Management LLC 1.42% of their portfolio | 127.8k $2.3m | Reduced -25.4k |
| SECTORAL ASSET MANAGEMENT INC 1.52% of their portfolio | 121.3k $2.2m | New |
| Woodline Partners LP 0.01% of their portfolio | 94.5k $1.7m | Added +20.5k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 75.2k $1.4m | Added +25.8k |
| Burkehill Global Management, LP 0.05% of their portfolio | 74.0k $1.3m | Unchanged |
| Blackstone Inc. 0.00% of their portfolio | 62.6k $1.1m | Not comparable |
| SILVERARC CAPITAL MANAGEMENT, LLC 0.12% of their portfolio | 59.1k $1.1m | Reduced -71.4k |
| Y-Intercept (Hong Kong) Ltd 0.02% of their portfolio | 50.8k $914.8k | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 50.3k $904.6k | New |
| Nuveen, LLC 0.00% of their portfolio | 47.6k $857.3k | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 45.8k $824.0k | New |
| Stonepine Capital Management, LLC 0.55% of their portfolio | 40.0k $720.0k | Reduced -45.0k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 25.8k $464.8k | Reduced -3.5k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 25.5k $458.8k | New |
| MOORE CAPITAL MANAGEMENT, LP 0.01% of their portfolio | 25.0k $450.0k | Unchanged |
| Squarepoint Ops LLC 0.00% of their portfolio | 24.2k $435.0k | New |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 22.8k $410.5k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 19.7k $354.6k | New |
| ADAR1 Capital Management, LLC 0.02% of their portfolio | 18.3k $328.9k | Reduced -32.0k |
| Virtus Investment Advisers, LLC 0.08% of their portfolio | 18.3k $328.6k | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 17.8k $319.6k | Reduced -7.1k |
| MORGAN STANLEY 0.00% of their portfolio | 17.7k $318.6k | Reduced -879 |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 14.6k $262.8k | New |
| BANK OF MONTREAL /CAN/ 0.00% of their portfolio | 13.8k $247.8k | New |
| MetLife Investment Management, LLC 0.00% of their portfolio | 12.8k $230.0k | New |
| Invesco Ltd. 0.00% of their portfolio | 11.7k $211.2k | New |
| Persistent Asset Partners Ltd 0.06% of their portfolio | 11.0k $197.4k | New |
| XTX Topco Ltd 0.00% of their portfolio | 10.6k $190.2k | New |
| CITIGROUP INC 0.00% of their portfolio | 10.1k $182.5k | Reduced -10.0k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 9.9k $178.2k | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 9.0k $162.4k | Reduced -32.0k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 7.6k $136.8k | New |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 6.4k $114.6k | New |
| BARCLAYS PLC 0.00% of their portfolio | 4.5k $80.3k | Reduced -25.7k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 3.3k $59.5k | Reduced -12.4k |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 2.7k $48.9k | Reduced -755 |
| Legal & General Group Plc 0.00% of their portfolio | 2.1k $37.7k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 1.8k $31.7k | New |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 1.7k $31.1k | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 681 $12.0k | Added +630 |
| US BANCORP \DE\ 0.00% of their portfolio | 403 $7.3k | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 297 $5.3k | New |
| Parallel Advisors, LLC 0.00% of their portfolio | 264 $4.8k | Unchanged |
| Allworth Financial LP 0.00% of their portfolio | 161 $2.9k | Unchanged |
| Sterling Capital Management LLC 0.00% of their portfolio | 76 $1.4k | New |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 68 $1.2k | Unchanged |
| Fortitude Family Office, LLC 0.00% of their portfolio | 40 $720 | Unchanged |
| Quarry LP 0.00% of their portfolio | 29 $522 | New |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 26 $468 | Unchanged |
| Caitong International Asset Management Co., Ltd 0.00% of their portfolio | 21 $378 | Added +17 |
| NATIONAL BANK OF CANADA /FI/ 0.00% of their portfolio | 3 $54 | New |