ZENTALIS PHARMACEUTICALS INC ZNTL
COM · Common Stock · CUSIP 98943L107
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersSan Diego, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 70.9m as of 2026-03-20, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $2.33. Options: 3 managers hold calls ($971.3k notional), 3 hold puts ($138.3k).
Trends to Q1 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 120 |
| Q4 2022 | 105 |
| Q1 2023 | 110 |
| Q2 2023 | 134 |
| Q3 2023 | 137 |
| Q4 2023 | 120 |
| Q1 2024 | 142 |
| Q2 2024 | 145 |
| Q3 2024 | 136 |
| Q4 2024 | 142 |
| Q1 2025 | 133 |
| Q2 2025 | 118 |
| Q3 2025 | 99 |
| Q4 2025 | 86 |
| Q1 2026 | 102 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2024 | 79 | 64 |
| Q3 2024 | 69 | 73 |
| Q4 2024 | 82 | 56 |
| Q1 2025 | 59 | 75 |
| Q2 2025 | 54 | 81 |
| Q3 2025 | 41 | 56 |
| Q4 2025 | 34 | 49 |
| Q1 2026 | 53 | 38 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2025 | $0 | $73.2k | — |
| Q3 2025 | $65.1k | $112.0k | 1.72 |
| Q4 2025 | $27.1k | $0 | 0.00 |
| Q1 2026 | $971.3k | $138.3k | 0.14 |
Biggest buyers
| Squadron Capital Management LLC | New | +3.6m |
| TWO SIGMA INVESTMENTS, LP | Added | +1.5m |
| Qube Research & Technologies Ltd | Added | +619.6k |
| MILLENNIUM MANAGEMENT LLC | Added | +616.7k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | +560.9k |
| GOLDMAN SACHS GROUP INC | Added | +344.5k |
| CDC Financial, Inc. | New | +283.8k |
| DIMENSIONAL FUND ADVISORS LP | Added | +175.8k |
| MARSHALL WACE, LLP | Added | +144.9k |
| Hudson Bay Capital Management LP | New | +117.1k |
Biggest sellers
| TWO SIGMA ADVISERS, LP | Sold out | -1.5m |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -945.6k |
| GSA CAPITAL PARTNERS LLP | Reduced | -549.2k |
| UBS Group AG | Reduced | -518.9k |
| MORGAN STANLEY | Reduced | -453.4k |
| Woodline Partners LP | Reduced | -264.6k |
| XTX Topco Ltd | Reduced | -254.2k |
| BANK OF AMERICA CORP /DE/ | Reduced | -235.0k |
| CITADEL ADVISORS LLC | Reduced | -232.2k |
| Stonepine Capital Management, LLC | Reduced | -194.6k |
Biggest calls
| Squadron Capital Management LLC | New | $936.0k400.0k shares |
| CITADEL ADVISORS LLC | New | $30.4k13.0k shares |
| SIMPLEX TRADING, LLC | New | $4.9k2.1k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $106.0k45.3k shares |
| CITADEL ADVISORS LLC | New | $26.2k11.2k shares |
| SIMPLEX TRADING, LLC | New | $6.1k2.6k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| WALTERS GROUP 13G · passive investor -0.9 pts · filed 2026-08-19 | 18.8% |
| Walters William T 13G · passive investor +0.8 pts · filed 2025-01-31 | 9.9% |
| 5AM Opportunities II (GP), LLC 13G · passive investor new · filed 2025-12-30 | 6.4% |
| Squadron Capital Management LLC 13G · passive investor new · filed 2026-03-03 | 5.1% |
Fell to 5% or below in the last year: BlackRock, Inc. (4.1%, 2026-10-27), BARCLAYS PLC (3.2%, 2026-08-13), Matrix Capital Management Company, LP (0.0%, 2026-01-02)
Insider purchases and sales in Q1 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2024 | 0 | — | 2 | $157.3k | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 1 | $5.1k | $5.1k |
| Q1 2025 | 4 | $223.1k | 3 | $65.4k | — |
| Q2 2025 | 1 | $29.4k | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 0 | — | 0 | — | — |
| Q1 2026 | 0 | — | 3 | $134.7k | $105.4k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-02-10 | Vultaggio Vincent PAO and PFO | Sold plan | $16.7k6.9k shares |
| 2026-02-09 | Vultaggio Vincent PAO and PFO | Sold plan | $8.1k3.4k shares |
| 2026-02-09 | EASTLAND JULIA MARIE CEO & President, director | Sold | $2.1k889 shares |
| 2026-02-09 | Bruns Ingmar Chief Medical Officer | Sold | $801335 shares |
| 2026-02-06 | Vultaggio Vincent PAO and PFO | Sold plan | $72.8k30.0k shares |
| 2026-02-06 | EASTLAND JULIA MARIE CEO & President, director | Sold | $19.1k7.9k shares |
| 2026-02-06 | Bruns Ingmar Chief Medical Officer | Sold | $7.2k3.0k shares |
| 2026-02-03 | Vultaggio Vincent PAO and PFO | Sold plan | $1.4k556 shares |
| 2026-02-02 | Vultaggio Vincent PAO and PFO | Sold plan | $6.5k2.5k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2026
| Manager | Shares | Change |
|---|---|---|
| 5AM Venture Management, LLC 2.56% of their portfolio | 3.9m $9.2m | Unchanged |
| Squadron Capital Management LLC 3.40% of their portfolio | 3.6m $8.5m | New |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 3.0m $6.9m | Added +1.5m |
| ACADIAN ASSET MANAGEMENT LLC 0.01% of their portfolio | 2.8m $6.7m | Reduced -1.0k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 2.3m $5.4m | First filing |
| RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio | 1.9m $4.5m | Reduced -945.6k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 1.7m $4.1m | Reduced -232.2k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 1.5m $3.5m | Reduced -176.3k |
| Opaleye Management Inc. 0.44% of their portfolio | 1.4m $3.3m | Added +11.8k |
| Decheng Capital LLC 0.47% of their portfolio | 1.3m $3.1m | Unchanged |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 1.3m $3.0m | Added +616.7k |
| BlackRock, Inc. 0.00% of their portfolio | 1.3m $3.0m | Added +19.9k |
| Ishara Investments LP 2.91% of their portfolio | 1.2m $2.9m | Reduced -90.0k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 1.1m $2.6m | Reduced -235.0k |
| PRIMECAP MANAGEMENT CO/CA/ 0.00% of their portfolio | 957.4k $2.2m | Unchanged |
| Pfizer Inc 0.84% of their portfolio | 953.8k $2.0m | Unchanged |
| Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio | 792.0k $1.9m | Added +4.9k |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 637.1k $1.5m | Added +619.6k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 621.0k $1.5m | Added +31.9k |
| GSA CAPITAL PARTNERS LLP 0.09% of their portfolio | 620.4k $1.5m | Reduced -549.2k |
| Almitas Capital LLC 0.32% of their portfolio | 610.1k $1.4m | Unchanged |
| BARCLAYS PLC 0.00% of their portfolio | 591.2k $1.4m | Added +22.8k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 571.3k $1.3m | Added +560.9k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 490.3k $1.1m | Added +17.2k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 471.4k $1.1m | Added +52.1k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 462.7k $1.1m | Added +344.5k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 392.6k $918.8k | Added +144.9k |
| Peapod Lane Capital LLC 0.68% of their portfolio | 366.9k $834.6k | Reduced -82.0k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 360.6k $843.8k | First filing |
| MORGAN STANLEY 0.00% of their portfolio | 350.2k $819.5k | Reduced -453.4k |
| XTX Topco Ltd 0.01% of their portfolio | 322.5k $754.7k | Reduced -254.2k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 304.5k $712.5k | First filing |
| Creative Planning 0.00% of their portfolio | 285.0k $666.9k | Added +25.0k |
| FMR LLC 0.00% of their portfolio | 283.9k $664.4k | Added +40.6k |
| CDC Financial, Inc. 0.55% of their portfolio | 283.8k $664.0k | New |
| Anfield Capital Management, LLC 0.18% of their portfolio | 274.5k $642.4k | Added +31.9k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 272.0k $634.3k | Added +175.8k |
| Stonepine Capital Management, LLC 0.55% of their portfolio | 269.1k $629.7k | Reduced -194.6k |
| Woodline Partners LP 0.00% of their portfolio | 266.0k $622.5k | Reduced -264.6k |
| STATE STREET CORP 0.00% of their portfolio | 249.7k $584.3k | Reduced -22.1k |
| SEI INVESTMENTS CO 0.00% of their portfolio | 191.6k $448.2k | Added +24.5k |
| UBS Group AG 0.00% of their portfolio | 155.7k $364.3k | Reduced -518.9k |
| Quarry LP 0.07% of their portfolio | 150.0k $351.0k | Added +18.0k |
| ADAR1 Capital Management, LLC 0.02% of their portfolio | 144.6k $338.4k | Added +64.6k |
| PANAGORA ASSET MANAGEMENT INC 0.00% of their portfolio | 139.7k $326.9k | Added +53.0k |
| Invesco Ltd. 0.00% of their portfolio | 125.8k $294.3k | Reduced -62.8k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 118.2k $276.6k | Added +25.3k |
| Hudson Bay Capital Management LP 0.00% of their portfolio | 117.1k $274.1k | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 113.1k $242.1k | Reduced -71.9k |
| BARR E S & CO 0.01% of their portfolio | 110.0k $257.4k | Added +52.5k |
| Seven Fleet Capital Management LP 0.08% of their portfolio | 110.0k $257.4k | New |
| SIMPLEX TRADING, LLC 0.01% of their portfolio | 98.6k $230.6k | New |
| Point72 Asset Management, L.P. 0.00% of their portfolio | 94.9k $222.0k | Reduced -5.4k |
| Graham Capital Management, L.P. 0.01% of their portfolio | 92.4k $216.3k | Added +1.5k |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 0.00% of their portfolio | 78.7k $207.1k | Reduced -51.7k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 77.3k $180.9k | Unchanged |
| CITIGROUP INC 0.00% of their portfolio | 77.3k $180.8k | New |
| 49 WEALTH MANAGEMENT, LLC 0.01% of their portfolio | 66.4k $155.4k | Reduced -4.5k |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 65.5k $153.3k | Added +30.9k |
| COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio | 61.4k $143.7k | Unchanged |
| HRT FINANCIAL LP 0.00% of their portfolio | 52.2k $122.0k | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 51.1k $119.5k | New |
| RBF Capital, LLC 0.01% of their portfolio | 50.0k $117.0k | Reduced -110.0k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 48.6k $113.7k | Added +35.7k |
| OMERS ADMINISTRATION Corp 0.00% of their portfolio | 47.7k $111.6k | New |
| Brevan Howard Capital Management LP 0.00% of their portfolio | 47.1k $110.1k | New |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 34.8k $81.5k | Unchanged |
| Quadrature Capital Ltd 0.00% of their portfolio | 33.3k $78.0k | Reduced -104.2k |
| Private Advisor Group, LLC 0.00% of their portfolio | 31.5k $73.6k | New |
| Squarepoint Ops LLC 0.00% of their portfolio | 30.7k $71.8k | Reduced -77.0k |
| Headlands Technologies LLC 0.01% of their portfolio | 29.9k $70.0k | New |
| Regency Capital Management Inc.\DE 0.03% of their portfolio | 29.5k $69.0k | Unchanged |
| State of Wyoming 0.01% of their portfolio | 28.5k $66.6k | New |
| Carson Advisory Inc. 0.03% of their portfolio | 23.3k $54.5k | Reduced -200 |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 22.9k $53.6k | Added +3.0k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 22.7k $53.1k | Reduced -23.3k |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.00% of their portfolio | 22.4k $52.5k | Reduced -28.6k |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 21.7k $50.8k | First filing |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 20.9k $48.8k | Reduced -3.7k |
| Schonfeld Strategic Advisors LLC 0.00% of their portfolio | 20.6k $48.2k | New |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 20.4k $47.7k | New |
| Sivia Capital Partners, LLC 0.01% of their portfolio | 20.0k $46.8k | Unchanged |
| Birchview Capital, LP 0.02% of their portfolio | 17.5k $41.0k | Added +503 |
| EVERGREEN CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 16.9k $39.6k | Unchanged |
| Catalyst Funds Management Pty Ltd 0.01% of their portfolio | 16.7k $39.1k | New |
| CTC Alternative Strategies, Ltd. 0.07% of their portfolio | 12.5k $29.2k | New |
| Shay Capital LLC 0.00% of their portfolio | 10.7k $24.9k | Unchanged |
| Cornerstone Wealth Management, LLC 0.00% of their portfolio | 10.2k $23.8k | New |
| CWM, LLC 0.00% of their portfolio | 5.4k $12.6k | Reduced -3.2k |
| EverSource Wealth Advisors, LLC 0.00% of their portfolio | 1.7k $4.0k | Added +55 |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 1.5k $3.4k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 1.1k $2.7k | New |
| Wilmington Savings Fund Society, FSB 0.00% of their portfolio | 1.0k $2.3k | Unchanged |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 387 $906 | Unchanged |
| Fortitude Family Office, LLC 0.00% of their portfolio | 209 $489 | New |
| HighMark Wealth Management LLC 0.00% of their portfolio | 130 $304 | Unchanged |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 98 $0 | Reduced -12.6k |
| Silicon Valley Capital Partners 0.00% of their portfolio | 84 $197 | New |
| Optiver Holding B.V. 0.00% of their portfolio | 44 $103 | Unchanged |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 27 $63 | Unchanged |