ZENTALIS PHARMACEUTICALS INC ZNTL
COM · Common Stock · CUSIP 98943L107
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersSan Diego, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 72.3m as of 2025-11-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $1.51. Options: 2 managers hold calls ($65.1k notional), 4 hold puts ($112.0k).
Trends to Q3 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 120 |
| Q4 2022 | 105 |
| Q1 2023 | 110 |
| Q2 2023 | 134 |
| Q3 2023 | 137 |
| Q4 2023 | 120 |
| Q1 2024 | 142 |
| Q2 2024 | 145 |
| Q3 2024 | 136 |
| Q4 2024 | 142 |
| Q1 2025 | 133 |
| Q2 2025 | 118 |
| Q3 2025 | 99 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2023 | 61 | 68 |
| Q1 2024 | 78 | 51 |
| Q2 2024 | 79 | 64 |
| Q3 2024 | 69 | 73 |
| Q4 2024 | 82 | 56 |
| Q1 2025 | 59 | 75 |
| Q2 2025 | 54 | 81 |
| Q3 2025 | 41 | 56 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q4 2024 | $228.8k | $222.3k | 0.97 |
| Q1 2025 | $30.7k | $187.9k | 6.12 |
| Q2 2025 | $0 | $73.2k | — |
| Q3 2025 | $65.1k | $112.0k | 1.72 |
Biggest buyers
| CITADEL ADVISORS LLC | Added | +1.6m |
| JPMORGAN CHASE & CO | Added | +895.7k |
| BANK OF AMERICA CORP /DE/ | Added | +835.5k |
| RENAISSANCE TECHNOLOGIES LLC | Added | +795.8k |
| UBS Group AG | Added | +403.2k |
| Stonepine Capital Management, LLC | Added | +344.8k |
| MORGAN STANLEY | Added | +310.2k |
| XTX Topco Ltd | Added | +283.8k |
| TWO SIGMA INVESTMENTS, LP | Added | +270.3k |
| Creative Planning | Added | +229.7k |
Biggest sellers
| MILLENNIUM MANAGEMENT LLC | Reduced | -2.6m |
| Opaleye Management Inc. | Reduced | -1.6m |
| Almitas Capital LLC | Reduced | -684.6k |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD | Reduced | -516.7k |
| GOLDMAN SACHS GROUP INC | Reduced | -516.6k |
| BlackRock, Inc. | Reduced | -492.2k |
| Man Group plc | Sold out | -406.3k |
| AQR CAPITAL MANAGEMENT LLC | Reduced | -328.0k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | Reduced | -257.1k |
| Cubist Systematic Strategies, LLC | Reduced | -249.7k |
Biggest calls
| SIMPLEX TRADING, LLC | New | $64.0k43.0k shares |
| GROUP ONE TRADING LLC | New | $1.1k700 shares |
Biggest puts
| CITADEL ADVISORS LLC | Added | $49.8k33.0k shares |
| SIMPLEX TRADING, LLC | Unchanged | $24.0k16.0k shares |
| GROUP ONE TRADING LLC | Reduced | $22.5k14.9k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $15.7k10.4k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| WALTERS GROUP 13G · passive investor -0.9 pts · filed 2026-08-19 | 18.8% |
| Walters William T 13G · passive investor +0.8 pts · filed 2025-01-31 | 9.9% |
| 5AM Opportunities II (GP), LLC 13G · passive investor new · filed 2025-12-30 | 6.4% |
| Squadron Capital Management LLC 13G · passive investor new · filed 2026-03-03 | 5.1% |
Fell to 5% or below in the last year: BlackRock, Inc. (4.1%, 2026-10-27), BARCLAYS PLC (3.2%, 2026-08-13), Matrix Capital Management Company, LP (0.0%, 2026-01-02)
Insider purchases and sales in Q3 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2023 | 2 | $219.4k | 3 | $432.6k | $432.6k |
| Q1 2024 | 0 | — | 4 | $332.7k | — |
| Q2 2024 | 0 | — | 2 | $157.3k | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 1 | $5.1k | $5.1k |
| Q1 2025 | 4 | $223.1k | 3 | $65.4k | — |
| Q2 2025 | 1 | $29.4k | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
None reported in Q3 2025.
Holders, Q3 2025
| Manager | Shares | Change |
|---|---|---|
| Matrix Capital Management Company, LP 19.75% of their portfolio | 14.0m $21.1m | Unchanged |
| VANGUARD GROUP INC 0.00% of their portfolio | 2.9m $4.4m | Added +19.8k |
| ACADIAN ASSET MANAGEMENT LLC 0.01% of their portfolio | 2.8m $4.3m | Added +46.1k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 2.3m $3.5m | Added +795.8k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 2.1m $3.1m | Added +1.6m |
| TANG CAPITAL MANAGEMENT LLC 0.09% of their portfolio | 1.6m $2.3m | Unchanged |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 1.5m $2.3m | Added +835.5k |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 1.5m $2.2m | Added +185.3k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 1.4m $2.2m | Added +895.7k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 1.4m $2.1m | Added +211.2k |
| MORGAN STANLEY 0.00% of their portfolio | 1.4m $2.1m | Added +310.2k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 1.4m $2.1m | Added +270.3k |
| Decheng Capital LLC 0.35% of their portfolio | 1.3m $2.0m | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 1.2m $1.9m | Reduced -492.2k |
| Balyasny Asset Management L.P. 0.00% of their portfolio | 1.2m $1.8m | Added +214.7k |
| GSA CAPITAL PARTNERS LLP 0.14% of their portfolio | 1.1m $1.6m | Reduced -55.7k |
| PRIMECAP MANAGEMENT CO/CA/ 0.00% of their portfolio | 962.6k $1.5m | Reduced -65.0k |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD 4.69% of their portfolio | 961.5k $1.5m | Reduced -516.7k |
| Pfizer Inc 0.33% of their portfolio | 953.8k $1.4m | Unchanged |
| Almitas Capital LLC 0.16% of their portfolio | 914.6k $1.4m | Reduced -684.6k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 902.5k $1.4m | Reduced -2.6m |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.00% of their portfolio | 700.6k $1.1m | Reduced -157.0k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 645.6k $974.9k | Reduced -18.4k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 589.2k $890.2k | Reduced -28.9k |
| Peapod Lane Capital LLC 0.76% of their portfolio | 565.4k $853.9k | Added +6.2k |
| XTX Topco Ltd 0.04% of their portfolio | 548.6k $828.4k | Added +283.8k |
| UBS Group AG 0.00% of their portfolio | 532.7k $804.3k | Added +403.2k |
| Woodline Partners LP 0.00% of their portfolio | 530.6k $801.2k | Unchanged |
| 5AM Venture Management, LLC 0.27% of their portfolio | 490.0k $739.9k | Unchanged |
| Stonepine Capital Management, LLC 0.56% of their portfolio | 453.8k $685.2k | Added +344.8k |
| Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio | 380.8k $575.0k | Added +66.0k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 345.2k $521.2k | Reduced -516.6k |
| Opaleye Management Inc. 0.07% of their portfolio | 316.6k $478.0k | Reduced -1.6m |
| STATE STREET CORP 0.00% of their portfolio | 271.8k $410.4k | Unchanged |
| Creative Planning 0.00% of their portfolio | 260.0k $392.6k | Added +229.7k |
| FMR LLC 0.00% of their portfolio | 203.3k $307.0k | Added +18.6k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 201.1k $303.7k | Added +55.3k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 185.0k $279.4k | Reduced -150.9k |
| Invesco Ltd. 0.00% of their portfolio | 173.6k $262.2k | Added +17.9k |
| SEI INVESTMENTS CO 0.00% of their portfolio | 167.1k $252.3k | Unchanged |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 0.00% of their portfolio | 166.3k $257.8k | Reduced -7.7k |
| BARCLAYS PLC 0.00% of their portfolio | 161.5k $243.8k | Added +161.5k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 158.9k $240.0k | Reduced -14.5k |
| Graham Capital Management, L.P. 0.01% of their portfolio | 152.1k $229.7k | Added +116.7k |
| Walleye Capital LLC 0.00% of their portfolio | 120.4k $181.9k | Reduced -9.4k |
| Quarry LP 0.04% of their portfolio | 108.8k $164.2k | Added +3.8k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 107.0k $161.5k | Reduced -328.0k |
| PANAGORA ASSET MANAGEMENT INC 0.00% of their portfolio | 97.9k $147.8k | New |
| NORTHERN TRUST CORP 0.00% of their portfolio | 94.1k $142.1k | Reduced -29.3k |
| RBF Capital, LLC 0.01% of their portfolio | 80.0k $120.8k | Unchanged |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 77.3k $116.7k | Unchanged |
| Anfield Capital Management, LLC 0.03% of their portfolio | 71.4k $107.8k | Unchanged |
| Cubist Systematic Strategies, LLC 0.00% of their portfolio | 70.6k $106.6k | Reduced -249.7k |
| COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio | 61.0k $92.0k | Unchanged |
| Quadrature Capital Ltd 0.00% of their portfolio | 60.7k $92.2k | Added +8.2k |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 56.6k $85.5k | Added +24.5k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 52.6k $79.4k | Reduced -38.6k |
| Catalyst Funds Management Pty Ltd 0.01% of their portfolio | 51.4k $77.6k | Added +24.6k |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.00% of their portfolio | 51.1k $77.1k | Unchanged |
| ADAR1 Capital Management, LLC 0.01% of their portfolio | 50.0k $75.5k | Unchanged |
| ALGERT GLOBAL LLC 0.00% of their portfolio | 48.5k $73.2k | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 42.0k $63.4k | Reduced -257.1k |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 41.1k $62.1k | Added +1.4k |
| BARR E S & CO 0.00% of their portfolio | 40.0k $60.4k | Unchanged |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 34.8k $52.6k | Unchanged |
| IEQ CAPITAL, LLC 0.00% of their portfolio | 34.2k $51.6k | Reduced -52.1k |
| Carson Advisory Inc. 0.03% of their portfolio | 32.1k $48.4k | Added +2.5k |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO 0.00% of their portfolio | 31.9k $48.2k | Reduced -4.8k |
| SG Americas Securities, LLC 0.00% of their portfolio | 31.6k $48.0k | Added +8.2k |
| BLUEFIN CAPITAL MANAGEMENT, LLC 0.02% of their portfolio | 31.3k $47.2k | New |
| HRT FINANCIAL LP 0.00% of their portfolio | 30.4k $45.0k | Reduced -83.4k |
| Regency Capital Management Inc.\DE 0.02% of their portfolio | 29.5k $44.5k | Unchanged |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 29.4k $44.4k | Added +12.3k |
| 49 WEALTH MANAGEMENT, LLC 0.00% of their portfolio | 28.2k $42.6k | Added +6.6k |
| Voleon Capital Management LP 0.00% of their portfolio | 27.2k $41.0k | New |
| Point72 Asia (Singapore) Pte. Ltd. 0.01% of their portfolio | 23.9k $36.0k | Reduced -35.6k |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 21.6k $32.6k | Added +2.7k |
| Squarepoint Ops LLC 0.00% of their portfolio | 21.3k $32.2k | Reduced -25.1k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 20.6k $31.1k | Unchanged |
| Acorn Wealth Advisors, LLC 0.01% of their portfolio | 20.0k $30.2k | Unchanged |
| Birchview Capital, LP 0.02% of their portfolio | 17.0k $25.7k | Unchanged |
| EVERGREEN CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 16.9k $25.5k | Unchanged |
| Harvest Investment Services, LLC 0.00% of their portfolio | 14.2k $21.5k | Reduced -11.3k |
| Engineers Gate Manager LP 0.00% of their portfolio | 13.6k $20.6k | Added +598 |
| CWM, LLC 0.00% of their portfolio | 13.1k $20.0k | Reduced -15.5k |
| HIGHLINE WEALTH PARTNERS LLC 0.00% of their portfolio | 12.0k $18.1k | Added +5.0k |
| CAPTRUST FINANCIAL ADVISORS 0.00% of their portfolio | 10.5k $15.8k | Reduced -1.4k |
| EverSource Wealth Advisors, LLC 0.00% of their portfolio | 2.6k $3.9k | Added +243 |
| Clearstead Advisors, LLC 0.00% of their portfolio | 1.1k $1.7k | Reduced -946 |
| Wilmington Savings Fund Society, FSB 0.00% of their portfolio | 1.0k $1.5k | Unchanged |
| CITIGROUP INC 0.00% of their portfolio | 906 $1.4k | Reduced -18.5k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 422 $1.0k | Reduced -4.5k |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 387 $584 | Unchanged |
| HighMark Wealth Management LLC 0.00% of their portfolio | 130 $196 | Unchanged |
| Covestor Ltd 0.00% of their portfolio | 52 $0 | Unchanged |
| Optiver Holding B.V. 0.00% of their portfolio | 44 $66 | New |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 28 $42 | Added +1 |
| IFP Advisors, Inc 0.00% of their portfolio | 24 $36 | Reduced -11 |
| Caitong International Asset Management Co., Ltd 0.00% of their portfolio | 1 $2 | Reduced -2.7k |