ZENTALIS PHARMACEUTICALS INC ZNTL
COM · Common Stock · CUSIP 98943L107
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersSan Diego, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($73.2k this quarter). Holder counts are more reliable. Shares outstanding: 71.8m as of 2025-03-21, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $1.59. Options: 4 managers hold calls ($30.7k notional), 5 hold puts ($187.9k).
Trends to Q1 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 120 |
| Q4 2022 | 105 |
| Q1 2023 | 110 |
| Q2 2023 | 134 |
| Q3 2023 | 137 |
| Q4 2023 | 120 |
| Q1 2024 | 142 |
| Q2 2024 | 145 |
| Q3 2024 | 136 |
| Q4 2024 | 142 |
| Q1 2025 | 133 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2023 | 92 | 38 |
| Q3 2023 | 69 | 52 |
| Q4 2023 | 61 | 68 |
| Q1 2024 | 78 | 51 |
| Q2 2024 | 79 | 64 |
| Q3 2024 | 69 | 73 |
| Q4 2024 | 82 | 56 |
| Q1 2025 | 59 | 75 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2024 | $262.0k | $48.4k | 0.18 |
| Q3 2024 | $351.6k | $430.9k | 1.23 |
| Q4 2024 | $228.8k | $222.3k | 0.97 |
| Q1 2025 | $30.7k | $187.9k | 6.12 |
Biggest buyers
| MILLENNIUM MANAGEMENT LLC | Added | +2.1m |
| ACADIAN ASSET MANAGEMENT LLC | Added | +1.6m |
| TANG CAPITAL MANAGEMENT LLC | New | +1.5m |
| BANK OF AMERICA CORP /DE/ | Added | +914.1k |
| Peapod Lane Capital LLC | New | +558.4k |
| GSA CAPITAL PARTNERS LLP | Added | +397.8k |
| AQR CAPITAL MANAGEMENT LLC | Added | +396.2k |
| RENAISSANCE TECHNOLOGIES LLC | Added | +286.7k |
| FEDERATED HERMES, INC. | Added | +258.5k |
| Opaleye Management Inc. | Added | +217.5k |
Biggest sellers
| EVENTIDE ASSET MANAGEMENT, LLC | Sold out | -4.5m |
| CITADEL ADVISORS LLC | Reduced | -3.1m |
| MPM BIOIMPACT LLC | Sold out | -1.1m |
| Verition Fund Management LLC | Reduced | -1.1m |
| Integral Health Asset Management, LLC | Sold out | -1.1m |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -910.2k |
| MORGAN STANLEY | Reduced | -619.2k |
| GOLDMAN SACHS GROUP INC | Reduced | -461.7k |
| Boxer Capital Management, LLC | Sold out | -450.0k |
| Decheng Capital LLC | Reduced | -318.3k |
Biggest calls
| GROUP ONE TRADING LLC | Added | $14.2k8.9k shares |
| CITADEL ADVISORS LLC | Added | $12.6k7.9k shares |
| SIMPLEX TRADING, LLC | Reduced | $4.0k2.9k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| GROUP ONE TRADING LLC | Added | $111.3k70.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $49.1k30.9k shares |
| CITADEL ADVISORS LLC | Added | $18.4k11.6k shares |
| SIMPLEX TRADING, LLC | Added | $9.0k5.8k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| WALTERS GROUP 13G · passive investor -0.9 pts · filed 2026-08-19 | 18.8% |
| Walters William T 13G · passive investor +0.8 pts · filed 2025-01-31 | 9.9% |
| 5AM Opportunities II (GP), LLC 13G · passive investor new · filed 2025-12-30 | 6.4% |
| Squadron Capital Management LLC 13G · passive investor new · filed 2026-03-03 | 5.1% |
Fell to 5% or below in the last year: BlackRock, Inc. (4.1%, 2026-10-27), BARCLAYS PLC (3.2%, 2026-08-13), Matrix Capital Management Company, LP (0.0%, 2026-01-02)
Insider purchases and sales in Q1 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2023 | 0 | — | 2 | $3.1m | $3.1m |
| Q3 2023 | 0 | — | 1 | $125.2k | $125.2k |
| Q4 2023 | 2 | $219.4k | 3 | $432.6k | $432.6k |
| Q1 2024 | 0 | — | 4 | $332.7k | — |
| Q2 2024 | 0 | — | 2 | $157.3k | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 1 | $5.1k | $5.1k |
| Q1 2025 | 4 | $223.1k | 3 | $65.4k | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-02-06 | Bruns Ingmar Chief Medical Officer | Bought | $45.6k20.0k shares |
| 2025-02-03 | Lackner Mark Chief Scientific Officer | Sold | $24.6k14.4k shares |
| 2025-02-03 | Paul Andrea Chief Legal Officer | Sold | $22.6k13.2k shares |
| 2025-02-03 | Vultaggio Vincent PAO and Interim PFO | Sold | $4.5k2.6k shares |
| 2025-01-31 | Skvarka Jan Director | Bought | $103.2k60.0k shares |
| 2025-01-31 | EASTLAND JULIA MARIE CEO & President, director | Bought | $49.3k28.5k shares |
| 2025-01-31 | Walker Luke Nathaniel Director | Bought | $25.0k14.2k shares |
| 2025-01-02 | Lackner Mark Chief Scientific Officer | Sold | $13.8k4.4k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2025
| Manager | Shares | Change |
|---|---|---|
| Matrix Capital Management Company, LP 6.39% of their portfolio | 14.0m $22.2m | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 4.2m $6.7m | Reduced -8.6k |
| VANGUARD GROUP INC 0.00% of their portfolio | 3.3m $5.2m | Reduced -10.6k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 3.1m $4.9m | Added +2.1m |
| ACADIAN ASSET MANAGEMENT LLC 0.01% of their portfolio | 2.7m $4.2m | Added +1.6m |
| Decheng Capital LLC 0.90% of their portfolio | 2.0m $3.2m | Reduced -318.3k |
| Opaleye Management Inc. 0.70% of their portfolio | 2.0m $3.2m | Added +217.5k |
| Almitas Capital LLC 0.90% of their portfolio | 1.7m $2.7m | Added +84.0k |
| TANG CAPITAL MANAGEMENT LLC 0.13% of their portfolio | 1.5m $2.4m | New |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.4m $2.2m | Added +42.7k |
| STATE STREET CORP 0.00% of their portfolio | 1.3m $2.1m | Added +30.8k |
| PRIMECAP MANAGEMENT CO/CA/ 0.00% of their portfolio | 1.3m $2.0m | Reduced -256.0k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 1.1m $1.8m | Added +914.1k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 1.1m $1.8m | Reduced -121.7k |
| MORGAN STANLEY 0.00% of their portfolio | 1.1m $1.7m | Reduced -619.2k |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD 6.49% of their portfolio | 961.5k $1.5m | Unchanged |
| Pfizer Inc 0.30% of their portfolio | 953.8k $1.5m | Unchanged |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 842.6k $1.3m | Reduced -47.1k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 826.0k $1.3m | Added +286.7k |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 752.5k $1.2m | Added +258.5k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 746.5k $1.2m | Reduced -113.2k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 619.3k $984.7k | Added +396.2k |
| Peapod Lane Capital LLC 1.00% of their portfolio | 558.4k $887.9k | New |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 549.3k $873.4k | Reduced -67.5k |
| GSA CAPITAL PARTNERS LLP 0.08% of their portfolio | 542.0k $862.0k | Added +397.8k |
| Woodline Partners LP 0.01% of their portfolio | 530.6k $843.6k | Unchanged |
| Nuveen, LLC 0.00% of their portfolio | 507.5k $807.0k | First filing |
| 5AM Venture Management, LLC 0.29% of their portfolio | 490.0k $779.1k | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 486.5k $773.5k | Reduced -10.9k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 462.3k $735.1k | Reduced -22.4k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 456.4k $725.7k | Reduced -461.7k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 447.4k $711.5k | Reduced -57.6k |
| Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio | 361.2k $574.4k | Added +16.2k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.00% of their portfolio | 349.0k $554.9k | Added +116.9k |
| Walleye Capital LLC 0.01% of their portfolio | 341.4k $542.8k | Added +147.7k |
| Creative Planning 0.00% of their portfolio | 236.5k $376.1k | Added +196.4k |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 0.00% of their portfolio | 234.1k $372.2k | Added +34.0k |
| SEI INVESTMENTS CO 0.00% of their portfolio | 202.4k $321.8k | Added +167.1k |
| FMR LLC 0.00% of their portfolio | 182.2k $289.7k | Reduced -119 |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC 0.00% of their portfolio | 159.8k $254.1k | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 156.1k $248.2k | Reduced -6.8k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 152.3k $242.2k | Reduced -22.7k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 152.3k $242.1k | Added +92.2k |
| Invesco Ltd. 0.00% of their portfolio | 149.5k $237.7k | Added +98.6k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 148.8k $236.6k | Reduced -174.7k |
| UBS Group AG 0.00% of their portfolio | 141.9k $225.7k | Reduced -41.7k |
| Graham Capital Management, L.P. 0.01% of their portfolio | 124.8k $198.4k | Added +66.9k |
| XTX Topco Ltd 0.01% of their portfolio | 124.4k $197.8k | Added +1.4k |
| ALGERT GLOBAL LLC 0.00% of their portfolio | 122.3k $194.5k | Added +71.2k |
| Verition Fund Management LLC 0.00% of their portfolio | 122.3k $194.4k | Reduced -1.1m |
| Quarry LP 0.05% of their portfolio | 120.0k $190.8k | Added +66.5k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 109.5k $174.2k | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 105.7k $168.0k | Added +61.7k |
| Man Group plc 0.00% of their portfolio | 101.0k $160.6k | New |
| IEQ CAPITAL, LLC 0.00% of their portfolio | 93.9k $149.3k | Added +78.8k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 84.5k $134.4k | Reduced -7.7k |
| Cubist Systematic Strategies, LLC 0.00% of their portfolio | 78.2k $124.4k | Reduced -102.0k |
| Anfield Capital Management, LLC 0.04% of their portfolio | 71.4k $113.5k | Reduced -57.9k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 71.1k $113.0k | Reduced -3.1m |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 70.8k $112.6k | First filing |
| Thrivent Financial for Lutherans 0.00% of their portfolio | 70.6k $112.0k | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 69.7k $111.0k | Reduced -910.2k |
| EXCHANGE TRADED CONCEPTS, LLC 0.00% of their portfolio | 67.4k $107.2k | Added +21.9k |
| COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio | 60.7k $96.0k | Reduced -3.3k |
| Stonepine Capital Management, LLC 0.09% of their portfolio | 60.0k $95.4k | New |
| BARCLAYS PLC 0.00% of their portfolio | 59.6k $94.8k | Reduced -57.8k |
| ALPS ADVISORS INC 0.00% of their portfolio | 55.0k $87.5k | Reduced -2.6k |
| Virtus Investment Advisers, LLC 0.02% of their portfolio | 52.4k $83.4k | New |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.00% of their portfolio | 51.1k $81.2k | New |
| Squarepoint Ops LLC 0.00% of their portfolio | 49.1k $78.1k | Reduced -1.7k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 46.9k $74.6k | Added +14.8k |
| 49 WEALTH MANAGEMENT, LLC 0.01% of their portfolio | 45.5k $72.4k | Added +18.9k |
| State of Wyoming 0.01% of their portfolio | 45.2k $71.8k | Added +10.5k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 42.8k $68.1k | Unchanged |
| CITIGROUP INC 0.00% of their portfolio | 40.6k $64.6k | Reduced -4.9k |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 40.3k $64.0k | Added +12.2k |
| BARR E S & CO 0.00% of their portfolio | 40.0k $63.6k | New |
| CWM, LLC 0.00% of their portfolio | 39.7k $63.0k | Added +34.9k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 35.4k $56.2k | Added +758 |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 34.8k $55.4k | Reduced -320 |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 34.6k $55.0k | Reduced -22.5k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 34.2k $54.4k | Added +1.5k |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 32.0k $50.8k | Added +19.1k |
| Alpine Global Management, LLC 0.01% of their portfolio | 30.2k $48.0k | New |
| Carson Advisory Inc. 0.03% of their portfolio | 29.6k $47.0k | Added +4.9k |
| Regency Capital Management Inc.\DE 0.03% of their portfolio | 29.5k $46.9k | Unchanged |
| Corebridge Financial, Inc. 0.00% of their portfolio | 28.0k $44.5k | Reduced -415 |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 24.9k $39.5k | Reduced -9.2k |
| Harvest Investment Services, LLC 0.01% of their portfolio | 24.8k $39.4k | Reduced -23.9k |
| SG Americas Securities, LLC 0.00% of their portfolio | 24.1k $38.0k | Reduced -32.3k |
| BANK OF MONTREAL /CAN/ 0.00% of their portfolio | 23.5k $37.3k | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 22.9k $36.4k | Reduced -105.3k |
| ZACKS INVESTMENT MANAGEMENT 0.00% of their portfolio | 22.3k $35.5k | Unchanged |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 22.3k $35.4k | Reduced -175 |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 21.9k $34.8k | Unchanged |
| Cerity Partners LLC 0.00% of their portfolio | 20.5k $32.6k | Added +7.6k |
| Dynamic Technology Lab Private Ltd 0.00% of their portfolio | 19.8k $31.0k | Added +2.3k |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 18.7k $29.7k | Reduced -800 |
| Point72 Asia (Singapore) Pte. Ltd. 0.01% of their portfolio | 18.1k $28.8k | Added +990 |
| Birchview Capital, LP 0.02% of their portfolio | 17.0k $27.0k | Reduced -17.0k |