ZAI LAB LTD ZLAB
ADR · ADR · CUSIP 98887Q104 · ISIN US98887Q1040
Zai Lab is an innovative, research-based, commercial stage biopharmaceutical company based in China and the U.S. focused on bringing transformative medicines for cancer, autoimmune and infectious diseases to patients in China and around the world.
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersShanghai, People's Republic of China
- Websitezailaboratory.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($2.6m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $34.97. Options: 6 managers hold calls ($6.1m notional), 8 hold puts ($7.3m).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 171 |
| Q4 2022 | 167 |
| Q1 2023 | 162 |
| Q2 2023 | 139 |
| Q3 2023 | 123 |
| Q4 2023 | 125 |
| Q1 2024 | 118 |
| Q2 2024 | 106 |
| Q3 2024 | 105 |
| Q4 2024 | 133 |
| Q1 2025 | 162 |
| Q2 2025 | 157 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 50 | 81 |
| Q4 2023 | 50 | 63 |
| Q1 2024 | 61 | 57 |
| Q2 2024 | 49 | 61 |
| Q3 2024 | 51 | 50 |
| Q4 2024 | 78 | 44 |
| Q1 2025 | 95 | 62 |
| Q2 2025 | 81 | 96 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $5.5m | $17.2m | 3.15 |
| Q4 2024 | $2.9m | $12.6m | 4.33 |
| Q1 2025 | $4.4m | $11.8m | 2.67 |
| Q2 2025 | $6.1m | $7.3m | 1.20 |
Biggest buyers
| RTW INVESTMENTS, LP | Added | +2.4m |
| Frazier Life Sciences Management, L.P. | Added | +958.1k |
| Clearbridge Investments, LLC | Added | +732.4k |
| NAN FUNG TRINITY (HK) LTD | New | +270.0k |
| ORBIMED ADVISORS LLC | New | +231.0k |
| STEMPOINT CAPITAL LP | Added | +224.0k |
| Point72 Asset Management, L.P. | Added | +164.2k |
| RENAISSANCE TECHNOLOGIES LLC | Added | +148.4k |
| HSBC HOLDINGS PLC | Added | +133.3k |
| Qube Research & Technologies Ltd | New | +97.3k |
Biggest sellers
| PRINCIPAL FINANCIAL GROUP INC | Reduced | -2.8m |
| MORGAN STANLEY | Reduced | -2.3m |
| WELLINGTON MANAGEMENT GROUP LLP | Reduced | -2.3m |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -2.1m |
| Mirae Asset Global Investments Co., Ltd. | Reduced | -2.1m |
| JANUS HENDERSON GROUP PLC | Reduced | -1.6m |
| RA CAPITAL MANAGEMENT, L.P. | Sold out | -1.3m |
| Allianz Asset Management GmbH | Reduced | -952.4k |
| Connor, Clark & Lunn Investment Management Ltd. | Reduced | -621.7k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | Reduced | -380.7k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $3.3m94.5k shares |
| CITADEL ADVISORS LLC | Added | $965.2k27.6k shares |
| JANE STREET GROUP, LLC | Added | $961.7k27.5k shares |
| SIMPLEX TRADING, LLC | Reduced | $671.0k19.2k shares |
| GROUP ONE TRADING LLC | Reduced | $160.9k4.6k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| JANE STREET GROUP, LLC | Reduced | $3.1m89.4k shares |
| Jefferies Financial Group Inc. | Unchanged | $1.6m45.6k shares |
| CITADEL ADVISORS LLC | Reduced | $940.7k26.9k shares |
| WOLVERINE TRADING, LLC | Unchanged | $753.9k21.7k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $594.5k17.0k shares |
| GROUP ONE TRADING LLC | Added | $220.3k6.3k shares |
| SIMPLEX TRADING, LLC | Reduced | $41.0k1.2k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| RTW INVESTMENTS, LP 13G · institution +4.2 pts · filed 2026-02-17 | 6.3% |
| Qiming Venture Partners IV, L.P. 13G · exempt (held before listing) filed 2025-08-12 | 6.0% |
| TCG Crossover GP II, LLC 13G · passive investor new · filed 2026-06-11 | 5.3% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor new · filed 2026-04-06 | 5.2% |
Fell to 5% or below in the last year: Qiming Corporate GP IV, Ltd (4.4%, 2026-02-13; now reported by Qiming Venture Partners IV, L.P.)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 0 | — | 0 | — | — |
| Q4 2023 | 1 | $254.2k | 1 | $4.2k | — |
| Q1 2024 | 1 | $62.5k | 4 | $1.1m | $235.1k |
| Q2 2024 | 1 | $64.2k | 6 | $1.2m | $213.3k |
| Q3 2024 | 0 | — | 8 | $647.2k | $279.3k |
| Q4 2024 | 0 | — | 2 | $212.0k | — |
| Q1 2025 | 0 | — | 5 | $7.8m | $7.8m |
| Q2 2025 | 0 | — | 7 | $10.2m | $6.5m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-06-30 | Du Ying Chairperson & CEO, director · American Depositary Shares | Sold | $245.7k6.9k shares |
| 2025-06-26 | Du Ying Chairperson & CEO, director · American Depositary Shares | Sold | $855.2k23.7k shares |
| 2025-06-26 | Edmondson Frazor Titus III Chief Legal Officer · American Depositary Shares | Sold | $212.3k5.9k shares |
| 2025-06-26 | Chen Yajing Chief Financial Officer · American Depositary Shares | Sold | $96.6k2.7k shares |
| 2025-06-20 | Lis William Director · American Depositary Shares | Sold plan | $492.7k13.8k shares |
| 2025-06-02 | Chen Yajing Chief Financial Officer · American Depositary Shares | Sold plan | $288.5k9.6k shares |
| 2025-05-14 | Du Ying Chairperson & CEO, director · American Depositary Shares | Sold plan | $1.3m46.4k shares |
| 2025-05-13 | Du Ying Chairperson & CEO, director · American Depositary Shares | Sold plan | $1.4m50.0k shares |
| 2025-05-12 | Du Ying Chairperson & CEO, director · American Depositary Shares | Sold plan | $1.5m50.0k shares |
| 2025-05-09 | Du Ying Chairperson & CEO, director · American Depositary Shares | Sold plan | $1.5m50.0k shares |
| 2025-05-09 | Morrison Scott W Director · American Depositary Shares | Sold | $715.2k23.8k shares |
| 2025-04-04 | Smiley Joshua L Officer · American Depositary Shares | Sold | $111.1k3.4k shares |
| 2025-04-04 | Amado Rafael Officer · American Depositary Shares | Sold | $100.3k3.0k shares |
| 2025-04-04 | Du Ying Chairperson & CEO, director · American Depositary Shares | Sold | $97.5k2.9k shares |
| 2025-04-04 | Edmondson Frazor Titus III Chief Legal Officer · American Depositary Shares | Sold | $62.0k1.9k shares |
| 2025-04-04 | Chen Yajing Chief Financial Officer · American Depositary Shares | Sold | $30.6k924 shares |
| 2025-04-02 | Smiley Joshua L Officer · American Depositary Shares | Sold | $421.3k11.7k shares |
| 2025-04-02 | Amado Rafael Officer · American Depositary Shares | Sold | $270.6k7.5k shares |
| 2025-04-02 | Du Ying Chairperson & CEO, director · American Depositary Shares | Sold | $208.4k5.8k shares |
| 2025-04-02 | Chen Yajing Chief Financial Officer · American Depositary Shares | Sold | $189.5k5.3k shares |
| 2025-04-02 | Edmondson Frazor Titus III Chief Legal Officer · American Depositary Shares | Sold | $156.8k4.4k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.01% of their portfolio | 6.2m $216.7m | Reduced -180.7k |
| Capital World Investors 0.03% of their portfolio | 6.0m $211.1m | Added +27.8k |
| RTW INVESTMENTS, LP 2.76% of their portfolio | 5.5m $193.6m | Added +2.4m |
| Clearbridge Investments, LLC 0.11% of their portfolio | 4.0m $140.3m | Added +732.4k |
| JANUS HENDERSON GROUP PLC 0.04% of their portfolio | 2.2m $76.8m | Reduced -1.6m |
| BAMCO INC /NY/ 0.15% of their portfolio | 1.6m $55.5m | Reduced -241.7k |
| WELLINGTON MANAGEMENT GROUP LLP 0.01% of their portfolio | 1.4m $48.2m | Reduced -2.3m |
| Frazier Life Sciences Management, L.P. 1.83% of their portfolio | 1.3m $45.7m | Added +958.1k |
| Woodline Partners LP 0.22% of their portfolio | 1.2m $42.0m | Unchanged |
| Allianz Asset Management GmbH 0.04% of their portfolio | 932.0k $32.6m | Reduced -952.4k |
| Rock Springs Capital Management LP 1.90% of their portfolio | 871.4k $30.5m | Reduced -33.2k |
| ADAR1 Capital Management, LLC 4.83% of their portfolio | 850.4k $29.7m | Reduced -90.4k |
| MPM BIOIMPACT LLC 4.51% of their portfolio | 745.1k $26.1m | Reduced -88.6k |
| JENNISON ASSOCIATES LLC 0.01% of their portfolio | 592.3k $20.7m | Reduced -120.0k |
| C WorldWide Group Holding A/S 0.24% of their portfolio | 510.0k $17.8m | Added +50.0k |
| BlackRock, Inc. 0.00% of their portfolio | 455.3k $15.9m | Reduced -60.0k |
| B Group, Inc. 12.08% of their portfolio | 400.0k $14.0m | Unchanged |
| Connor, Clark & Lunn Investment Management Ltd. 0.05% of their portfolio | 387.4k $13.5m | Reduced -621.7k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 366.2k $12.8m | Reduced -16.3k |
| XY Capital Ltd 8.74% of their portfolio | 362.6k $12.7m | Added +57.2k |
| MORGAN STANLEY 0.00% of their portfolio | 289.1k $10.1m | Reduced -2.3m |
| D. E. Shaw & Co., Inc. 0.01% of their portfolio | 279.7k $9.8m | Reduced -28.3k |
| NAN FUNG TRINITY (HK) LTD 1.13% of their portfolio | 270.0k $9.4m | New |
| Point72 Asset Management, L.P. 0.02% of their portfolio | 252.4k $8.8m | Added +164.2k |
| STEMPOINT CAPITAL LP 2.82% of their portfolio | 250.4k $8.8m | Added +224.0k |
| UBS Group AG 0.00% of their portfolio | 241.7k $8.5m | Reduced -151.5k |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 239.2k $8.4m | Added +60.5k |
| Candriam S.C.A. 0.05% of their portfolio | 238.9k $8.4m | Reduced -2.0k |
| RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio | 232.9k $8.1m | Added +148.4k |
| ORBIMED ADVISORS LLC 0.20% of their portfolio | 231.0k $8.1m | New |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 189.9k $6.6m | Added +63.9k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 174.5k $6.1m | Added +35.6k |
| Hennion & Walsh Asset Management, Inc. 0.24% of their portfolio | 168.1k $5.9m | Reduced -19.7k |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 158.3k $5.5m | Added +133.3k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 153.0k $5.4m | Reduced -2.1m |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 149.7k $5.2m | Reduced -82.8k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 146.0k $5.1m | Reduced -16.7k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 144.3k $5.0m | Added +70.7k |
| STATE STREET CORP 0.00% of their portfolio | 138.7k $4.9m | Added +1.1k |
| SUPERSTRING CAPITAL MANAGEMENT LP 5.88% of their portfolio | 134.9k $4.7m | Reduced -160.1k |
| Privium Fund Management B.V. 1.00% of their portfolio | 132.2k $4.6m | Unchanged |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 104.5k $3.7m | Reduced -2.8m |
| Tower Research Capital LLC (TRC) 0.10% of their portfolio | 104.5k $3.7m | Added +79.6k |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 97.3k $3.4m | New |
| DCF Advisers, LLC 1.53% of their portfolio | 91.0k $3.2m | Added +1.0k |
| CANADA PENSION PLAN INVESTMENT BOARD 0.00% of their portfolio | 87.5k $3.1m | Reduced -175.0k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 85.2k $3.0m | Reduced -80.8k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 84.0k $2.9m | Added +83.2k |
| Legal & General Group Plc 0.00% of their portfolio | 81.8k $2.9m | Reduced -534 |
| Mirae Asset Global Investments Co., Ltd. 0.01% of their portfolio | 77.9k $2.7m | Reduced -2.1m |
| Cubist Systematic Strategies, LLC 0.03% of their portfolio | 74.2k $2.6m | Reduced -19.5k |
| Jump Financial, LLC 0.03% of their portfolio | 66.0k $2.3m | New |
| AXA S.A. 0.01% of their portfolio | 65.8k $2.3m | Unchanged |
| ALPS ADVISORS INC 0.01% of their portfolio | 60.8k $2.1m | Reduced -15.5k |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 60.1k $2.1m | Added +21.9k |
| NEOS Investment Management LLC 0.03% of their portfolio | 58.8k $2.1m | Reduced -5.4k |
| Tema ETFs LLC 0.55% of their portfolio | 58.8k $2.1m | Reduced -5.4k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 56.5k $2.0m | Reduced -2.0k |
| Schonfeld Strategic Advisors LLC 0.01% of their portfolio | 56.5k $2.0m | New |
| KEYSTONE INVESTORS PTE LTD 0.40% of their portfolio | 55.2k $1.9m | New |
| Orion Porfolio Solutions, LLC 0.01% of their portfolio | 48.4k $1.7m | Added +12.2k |
| Invesco Ltd. 0.00% of their portfolio | 47.6k $1.7m | Reduced -6.9k |
| LMR Partners LLP 0.02% of their portfolio | 44.1k $1.5m | Reduced -18.4k |
| MML INVESTORS SERVICES, LLC 0.00% of their portfolio | 43.7k $1.5m | Added +15.9k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 37.4k $1.3m | Added +23.6k |
| WealthPlan Investment Management, LLC 0.09% of their portfolio | 36.8k $1.3m | Reduced -2.6k |
| DekaBank Deutsche Girozentrale 0.00% of their portfolio | 36.6k $1.3m | Unchanged |
| LPL Financial LLC 0.00% of their portfolio | 31.9k $1.1m | Added +7.6k |
| Balyasny Asset Management L.P. 0.00% of their portfolio | 30.8k $1.1m | Reduced -265.5k |
| BANK OF MONTREAL /CAN/ 0.00% of their portfolio | 29.8k $1.0m | Added +6.8k |
| GSA CAPITAL PARTNERS LLP 0.07% of their portfolio | 27.5k $963.0k | New |
| MARSHALL WACE, LLP 0.00% of their portfolio | 24.5k $855.2k | Reduced -3.5k |
| US BANCORP \DE\ 0.00% of their portfolio | 24.4k $854.6k | Added +6.1k |
| TD Asset Management Inc 0.00% of their portfolio | 24.1k $843.8k | Reduced -271.6k |
| Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio | 24.0k $840.9k | Added +23.5k |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO 0.00% of their portfolio | 23.8k $833.0k | Added +1.7k |
| BAROMETER CAPITAL MANAGEMENT INC. 0.23% of their portfolio | 23.6k $825.3k | Added +6.3k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio | 22.7k $793.8k | Reduced -68.8k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 22.2k $775.1k | Reduced -15.6k |
| Alberta Investment Management Corp 0.01% of their portfolio | 22.0k $769.3k | Reduced -174.3k |
| OPPENHEIMER ASSET MANAGEMENT INC. 0.01% of their portfolio | 22.0k $768.4k | Added +5.3k |
| Legacy Wealth Asset Management, LLC 0.20% of their portfolio | 22.0k $768.2k | Reduced -317 |
| M&T Bank Corp 0.00% of their portfolio | 21.8k $763.2k | Reduced -305 |
| HRT FINANCIAL LP 0.00% of their portfolio | 21.7k $759.0k | New |
| Penserra Capital Management LLC 0.01% of their portfolio | 21.0k $733.0k | Reduced -46.2k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 20.4k $712.1k | Reduced -380.7k |
| SECTORAL ASSET MANAGEMENT INC 0.37% of their portfolio | 15.8k $553.9k | Reduced -14.1k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 15.6k $544.6k | Unchanged |
| Erste Asset Management GmbH 0.00% of their portfolio | 15.1k $524.6k | Unchanged |
| PEAK6 LLC 0.01% of their portfolio | 15.0k $524.5k | Added +7.5k |
| Cerity Partners LLC 0.00% of their portfolio | 14.3k $499.0k | Added +2.7k |
| Marks Group Wealth Management, Inc 0.05% of their portfolio | 14.3k $498.4k | Added +3.9k |
| Walleye Capital LLC 0.00% of their portfolio | 13.9k $487.8k | Reduced -8.3k |
| Vanguard Personalized Indexing Management, LLC 0.00% of their portfolio | 11.8k $412.1k | New |
| China Universal Asset Management Co., Ltd. 0.04% of their portfolio | 11.6k $406.6k | Reduced -917 |
| NJ State Employees Deferred Compensation Plan 0.05% of their portfolio | 11.3k $395.2k | Unchanged |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 11.2k $393.3k | Added +3.1k |
| TRUIST FINANCIAL CORP 0.00% of their portfolio | 10.4k $363.3k | Added +3.8k |
| Virtus Investment Advisers, LLC 0.12% of their portfolio | 10.3k $361.2k | Reduced -3.1k |
| National Philanthropic Trust 0.00% of their portfolio | 10.0k $349.7k | Unchanged |