Vault-13

VYNE THERAPEUTICS INC

COM · CUSIP 92941V308

43 institutional holders +10 vs Q3 2025
9,180,2509.2m shares reported held*
$5.3mreported value*
10 new 11 added 8 reduced 3 sold out net bought ≈ $1.6m (+2.8m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $0.58.

Trends to Q4 2025

Institutional holders

Managers reporting a position, each quarter

0204060Q1 23: 22Q2 23: 20Q3 23: 21Q4 23: 33Q1 24: 31Q2 24: 31Q3 24: 33Q4 24: 35Q1 25: 38Q2 25: 45Q3 25: 33Q4 25: 4343Q1 23Q4 23Q3 24Q2 25Q4 25
Numbers
QuarterHolders
Q1 202322
Q2 202320
Q3 202321
Q4 202333
Q1 202431
Q2 202431
Q3 202433
Q4 202435
Q1 202538
Q2 202545
Q3 202533
Q4 202543

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
40040Q1 24: 13 bought or addedQ1 24: 12 cut or sold outQ2 24: 14 bought or addedQ2 24: 11 cut or sold outQ2 24Q3 24: 7 bought or addedQ3 24: 12 cut or sold outQ4 24: 16 bought or addedQ4 24: 14 cut or sold outQ4 24Q1 25: 21 bought or addedQ1 25: 11 cut or sold outQ2 25: 23 bought or addedQ2 25: 18 cut or sold outQ2 25Q3 25: 15 bought or addedQ3 25: 24 cut or sold outQ4 25: 21 bought or addedQ4 25: 11 cut or sold outQ4 25
Numbers
QuarterBought or addedCut or sold out
Q1 20241312
Q2 20241411
Q3 2024712
Q4 20241614
Q1 20252111
Q2 20252318
Q3 20251524
Q4 20252111

Biggest buyers

Anson Funds Management LP New +1,274,386+1.3m
Shay Capital LLC Added +1,131,772+1.1m
Nantahala Capital Management, LLC New +1,000,000+1.0m
ADAR1 Capital Management, LLC New +253,791+253.8k
ACADIAN ASSET MANAGEMENT LLC Added +192,078+192.1k
VANGUARD GROUP INC Added +124,162+124.2k
TWO SIGMA ADVISERS, LP Added +106,500+106.5k
GEODE CAPITAL MANAGEMENT, LLC Added +88,030+88.0k
XTX Topco Ltd New +79,040+79.0k
UBS Group AG Added +57,189+57.2k

Biggest sellers

BAKER BROS. ADVISORS LP Sold out -851,353-851.4k
ACORN CAPITAL ADVISORS, LLC Reduced -585,147-585.1k
BRIDGEWAY CAPITAL MANAGEMENT, LLC Sold out -76,958-77.0k
JANE STREET GROUP, LLC Reduced -74,764-74.8k
CORSAIR CAPITAL MANAGEMENT, L.P. Sold out -50,000-50.0k
BOOTHBAY FUND MANAGEMENT, LLC Reduced -25,088-25.1k
Ikarian Capital, LLC Reduced -25,088-25.1k
MORGAN STANLEY Reduced -868-868
TWO SIGMA INVESTMENTS, LP Reduced -788-788
JPMORGAN CHASE & CO Reduced -146-146

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
Nantahala Capital Management, LLC 13G · institution new · filed 2026-05-15 6.0% new 2.0m≈ $1.3m 2026-05-15

Holders, Q4 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Shay Capital LLC 0.15% of their portfolio NEW YORK, NY 1,624,3491.6m $942.3k $942.3k 0.15% Added +1.1m +1,131,772
2 Anson Funds Management LP 0.10% of their portfolio DALLAS, TX 1,274,3861.3m $739.3k $739.3k 0.10% New
3 Nantahala Capital Management, LLC 0.03% of their portfolio NEW CANAAN, CT 1,000,0001.0m $580.1k $580.1k 0.03% New
4 Deeter Investments LLP 0.13% of their portfolio AUSTIN, TX 1,000,0001.0m $580.1k $580.1k 0.13% First filing
5 T3 Companies, LLC 0.70% of their portfolio NEW YORK, NY 945,000945.0k $548.2k $548.2k 0.70% First filing
6 ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio Boston, MA 638,492638.5k $370.0k $370.0k 0.00% Added +192.1k +192,078
7 KVP Capital Advisors, LP 0.30% of their portfolio SAN FRANCISCO, CA 500,551500.6k $290.4k $290.4k 0.30% First filing
8 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 314,545314.5k $182.4k $182.4k 0.00% Added +124.2k +124,162
9 Ikarian Capital, LLC 0.02% of their portfolio DALLAS, TX 264,912264.9k $153.7k $153.7k 0.02% Reduced -25.1k -25,088
10 ADAR1 Capital Management, LLC 0.01% of their portfolio AUSTIN, TX 253,791253.8k $147.2k $147.2k 0.01% New
11 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 225,152225.2k $130.6k $130.6k 0.00% Added +88.0k +88,030
12 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 220,000220.0k $127.6k $127.6k 0.00% Reduced -788 -788
13 TWO SIGMA ADVISERS, LP 0.00% of their portfolio NEW YORK, NY 163,100163.1k $94.6k $94.6k 0.00% Added +106.5k +106,500
14 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 100,341100.3k $58.2k $58.2k 0.00% Added +42.6k +42,578
15 Rangeley Capital, LLC 0.05% of their portfolio NEW CANAAN, CT 100,000100.0k $58.0k $58.0k 0.05% Added +50.0k +50,000
16 BOOTHBAY FUND MANAGEMENT, LLC 0.00% of their portfolio NEW YORK, NY 81,37181.4k $47.2k $47.2k 0.00% Reduced -25.1k -25,088
17 XTX Topco Ltd 0.00% of their portfolio LONDON, X0 79,04079.0k $45.9k $45.9k 0.00% New
18 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 72,35672.4k $42.0k $42.0k 0.00% Reduced -74.8k -74,764
19 UBS Group AG 0.00% of their portfolio ZURICH, V8 62,76162.8k $36.4k $36.4k 0.00% Added +57.2k +57,189
20 GSA CAPITAL PARTNERS LLP 0.00% of their portfolio LONDON, X0 53,96154.0k $31.0k $31.0k 0.00% Added +18.0k +18,040
21 BlackRock, Inc. 0.00% of their portfolio New York, NY 44,40544.4k $25.8k $25.8k 0.00% Unchanged
22 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 30,52630.5k $17.7k $17.7k 0.00% New
23 Virtu Financial LLC 0.00% of their portfolio New York, NY 25,32725.3k $15.0k $15.0k 0.00% New
24 FNY Investment Advisers, LLC 0.00% of their portfolio NEW YORK, NY 25,00025.0k $14.0k $14.0k 0.00% New
25 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 23,11023.1k $13.4k $13.4k 0.00% Unchanged
26 COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio WALTHAM, MA 18,29818.3k $10.6k $10.6k 0.00% Unchanged
27 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 15,76515.8k $9.1k $9.1k 0.00% Unchanged
28 Harvest Investment Services, LLC 0.00% of their portfolio Oakbrook Terrace, IL 11,05911.1k $6.4k $6.4k 0.00% Unchanged
29 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 3,5673.6k $2.1k $2.1k 0.00% Reduced -30 -30
30 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 2,4412.4k $1.0k $1.0k 0.00% Added +1 +1
31 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 1,6771.7k $973 $973 0.00% Added +145 +145
32 ACORN CAPITAL ADVISORS, LLC 0.00% of their portfolio NEW YORK, NY 1,4251.4k $827 $827 0.00% Reduced -585.1k -585,147
33 MB, LEVIS & ASSOCIATES, LLC 0.00% of their portfolio CENTER VALLEY, PA 1,0411.0k $604 $604 0.00% Unchanged
34 NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 0.00% of their portfolio MILWAUKEE, WI 800800 $464 $464 0.00% New
35 Hurley Capital, LLC 0.00% of their portfolio NEW YORK, NY 561561 $325 $325 0.00% New
36 CWM, LLC 0.00% of their portfolio OMAHA, NE 500500 $0 $0 0.00% Unchanged
37 Centerpoint Advisors, LLC 0.00% of their portfolio NEEDHAM, MA 350350 $0 $0 0.00% Unchanged
38 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 146146 $85 $85 0.00% Reduced -146 -146
39 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 6565 $38 $38 0.00% Unchanged
40 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 4343 $25 $25 0.00% Reduced -868 -868
41 Truvestments Capital LLC 0.00% of their portfolio SARASOTA, FL 2525 $15 $15 0.00% Unchanged
42 NFSG Corp 0.00% of their portfolio BOCA RATON, FL 1010 $6 $6 0.00% Unchanged
43 Motiv8 Investments LLC 0.00% of their portfolio PORT ST. LUCIE, FL 11 $0 $0 0.00% New