Vault-13

VENTYX BIOSCIENCES INC VTYX

COM · Common Stock · CUSIP 92332V107

127 institutional holders +22 vs Q3 2022
44,461,71944.5m shares reported held*
$1.5bnreported value*
37 new 52 added 22 reduced 15 sold out net bought ≈ $127.0m (+3.9m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($487.3k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $32.75. Options: 6 managers hold calls ($1.6m notional), 3 hold puts ($98.2k).

Trends to Q4 2022

Institutional holders

Managers reporting a position, each quarter

050100150Q3 22: 105Q4 22: 127127Q3 22Q4 22
Numbers
QuarterHolders
Q3 2022105
Q4 2022127

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$1m$2m$3mQ3 22 calls: $2.0mQ3 22 puts: $2.3mQ3 22P/C 1.14Q4 22 calls: $1.6mQ4 22 puts: $98.2kQ4 22P/C 0.06
Numbers
QuarterCallsPutsP/C
Q3 2022$2.0m$2.3m1.14
Q4 2022$1.6m$98.2k0.06

Biggest buyers

Capital International Investors New +2,114,744+2.1m
LORD, ABBETT & CO. LLC Added +1,949,036+1.9m
Avidity Partners Management LP New +1,285,000+1.3m
PRICE T ROWE ASSOCIATES INC /MD/ Added +1,120,232+1.1m
ADAGE CAPITAL PARTNERS GP, L.L.C. Added +1,021,245+1.0m
TCG Crossover Management, LLC New +787,231+787.2k
ORBIMED ADVISORS LLC Added +700,000+700.0k
BlackRock Inc. Added +588,360+588.4k
Jefferies Financial Group Inc. New +470,026+470.0k
Holocene Advisors, LP New +417,235+417.2k

Biggest sellers

Third Point LLC Reduced -3,312,834-3.3m
venBio Partners LLC Reduced -1,550,000-1.6m
Darwin Global Management, Ltd. Sold out -1,401,123-1.4m
JANUS HENDERSON GROUP PLC Reduced -1,165,306-1.2m
Logos Global Management LP Reduced -740,664-740.7k
Redmile Group, LLC Reduced -470,026-470.0k
Venrock Adviser, LLC Sold out -207,925-207.9k
FMR LLC Reduced -201,325-201.3k
WELLINGTON MANAGEMENT GROUP LLP Reduced -187,172-187.2k
Maven Securities LTD Sold out -150,000-150.0k

Biggest calls

SIMPLEX TRADING, LLC Added $757.0k23.1k shares
CITADEL ADVISORS LLC Added $701.7k21.4k shares
HAP Trading, LLC New $79.0k12.6k shares
COWEN AND COMPANY, LLC New $77.8k12.4k shares
Cutler Group LLC / CA Reduced $2.0k700 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

CITADEL ADVISORS LLC Reduced $49.2k1.5k shares
SIMPLEX TRADING, LLC Reduced $49.0k1.5k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
NSV Investments I, L.P. 13D · may seek influence filed 2025-03-12
Stated purposeItem 4 of the Schedule 13D is hereby amended and supplemented by adding the following at the end of Item 4: On March 10, 2025, NSV Investments I, L.P., which holds certain shares beneficially owned by the Reporting Persons, authorized the distribution of 1,735,306 shares of Common Stock to its limited partners (the "NSV I Distribution"). Full filing
 7.6% 5.4m 2025-03-12
Mohan Raju 13D · may seek influence no change · filed 2026-01-09
Stated purposeOn January 7, 2026, the Issuer entered into an Agreement and Plan of Merger (the "Merger Agreement") with Eli Lilly and Company, an Indiana corporation ("Parent"), and Parent's wholly owned subsidiary, RYLS Merger Corporation, a Delaware corporation ("Merger Sub"), pursuant to which, subject to satisfaction or waiver of the conditions therein, Merger Sub will merge with and into the Issuer (the "Merger"), with the Issuer surviving as a wholly owned subsidiary of Parent. Pursuant to the Merger Agreement, and upon the terms and subject to the conditions thereof, at the effective time of the Merger (the "Effective Time"), each share of the Issuer's common stock, par value $0.0001 per share (the "Common Stock") issued and outstanding immediately prior to the Effective Time, will be converted … Full filing
 6.0% no change 4.4m 2026-01-09
NSV Partners III LP 13D · may seek influence filed 2025-04-01
Stated purposeItem 4 of the Schedule 13D is hereby amended and supplemented by adding the following at the end of Item 4: On March 28, 2025, NSV Investments I, L.P., which holds certain shares beneficially owned by the Reporting Persons, authorized the distribution of 1,335,450 shares of Common Stock to its limited partners (the "Distribution"). Full filing
 5.7% 4.1m 2025-04-01
VANGUARD GROUP INC 13G · institution new · filed 2025-10-31 5.3% new 3.8m 2025-10-31

Fell to 5% or below in the last year: TANG CAPITAL MANAGEMENT LLC (0.0%, 2026-05-15), GLAZER CAPITAL, LLC (0.0%, 2026-05-14), Affinity Asset Advisors, LLC (0.0%, 2026-05-14), Subramaniam Somu (0.0%, 2026-03-05), MORGAN STANLEY (0.3%, 2026-02-06), Point72 Asset Management, L.P. (4.5%, 2025-11-14)

Holders, Q4 2022

#ManagerLocationShares Value% of their portfolioChangeShares change
1 CITADEL ADVISORS LLC 0.14% of their portfolio MIAMI, FL 3,767,3433.8m $123.5m $123.5m 0.14% Added +296.2k +296,179
2 LORD, ABBETT & CO. LLC 0.22% of their portfolio JERSEY CITY, NJ 3,686,8143.7m $120.9m $120.9m 0.22% Added +1.9m +1,949,036
3 venBio Partners LLC 35.19% of their portfolio SAN FRANCISCO, CA 3,461,5363.5m $113.5m $113.5m 35.19% Reduced -1.6m -1,550,000
4 Capital International Investors 0.02% of their portfolio Los Angeles, CA 2,114,7442.1m $69.3m $69.3m 0.02% New
5 BlackRock Inc. 0.00% of their portfolio New York, NY 1,969,8632.0m $64.6m $64.6m 0.00% Added +588.4k +588,360
6 PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio BALTIMORE, MD 1,805,5741.8m $59.2m $59.2m 0.01% Added +1.1m +1,120,232
7 FMR LLC 0.01% of their portfolio BOSTON, MA 1,694,4871.7m $55.6m $55.6m 0.01% Reduced -201.3k -201,325
8 RTW INVESTMENTS, LP 1.04% of their portfolio NEW YORK, NY 1,551,7781.6m $50.9m $50.9m 1.04% Unchanged
9 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 1,496,1711.5m $49.1m $49.1m 0.00% Added +392.2k +392,218
10 JANUS HENDERSON GROUP PLC 0.03% of their portfolio LONDON, X0 1,463,7721.5m $48.0m $48.0m 0.03% Reduced -1.2m -1,165,306
11 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.11% of their portfolio Boston, MA 1,421,2451.4m $46.6m $46.6m 0.11% Added +1.0m +1,021,245
12 Vivo Capital, LLC 4.92% of their portfolio Palo Alto, CA 1,303,2941.3m $42.7m $42.7m 4.92% Reduced -52.6k -52,567
13 Avidity Partners Management LP 0.98% of their portfolio DALLAS, TX 1,285,0001.3m $42.1m $42.1m 0.98% New
14 PICTET ASSET MANAGEMENT SA 0.06% of their portfolio GENEVA 73, V8 1,227,9721.2m $40.3m $40.3m 0.06% Added +156.0k +155,989
15 Cormorant Asset Management, LP 2.38% of their portfolio BOSTON, MA 1,080,6431.1m $35.4m $35.4m 2.38% Added +300.0k +299,997
16 Driehaus Capital Management LLC 0.49% of their portfolio Chicago, IL 1,012,3201.0m $33.2m $33.2m 0.49% Added +3.2k +3,217
17 Third Point LLC 0.55% of their portfolio NEW YORK, NY 1,000,0001.0m $32.8m $32.8m 0.55% Reduced -3.3m -3,312,834
18 ORBIMED ADVISORS LLC 0.58% of their portfolio New York, NY 925,000925.0k $30.3m $30.3m 0.58% Added +700.0k +700,000
19 Redmile Group, LLC 1.20% of their portfolio LARKSPUR, CA 894,974895.0k $29.3m $29.3m 1.20% Reduced -470.0k -470,026
20 Boxer Capital, LLC 1.47% of their portfolio San Diego, CA 850,000850.0k $27.9m $27.9m 1.47% Unchanged
21 TCG Crossover Management, LLC 4.56% of their portfolio PALO ALTO, CA 787,231787.2k $25.8m $25.8m 4.56% New
22 QIMING U.S. VENTURES MANAGEMENT, LLC 32.37% of their portfolio BELLEVUE, WA 746,370746.4k $24.5m $24.5m 32.37% Unchanged
23 Logos Global Management LP 2.52% of their portfolio San Francisco, CA 657,016657.0k $21.5m $21.5m 2.52% Reduced -740.7k -740,664
24 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 610,273610.3k $20.0m $20.0m 0.00% Reduced -187.2k -187,172
25 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 552,006552.0k $18.1m $18.1m 0.00% Added +111.1k +111,063
26 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 509,414509.4k $16.7m $16.7m 0.00% Added +100.5k +100,452
27 Jefferies Financial Group Inc. 0.26% of their portfolio NEW YORK, NY 470,026470.0k $15.4m $15.4m 0.26% New
28 Holocene Advisors, LP 0.08% of their portfolio New York, NY 417,235417.2k $13.7m $13.7m 0.08% New
29 GREAT POINT PARTNERS LLC 2.72% of their portfolio Greenwich, CT 400,695400.7k $13.1m $13.1m 2.72% Added +130.7k +130,728
30 EcoR1 Capital, LLC 0.40% of their portfolio San Francisco, CA 400,000400.0k $13.1m $13.1m 0.40% Unchanged
31 Point72 Asset Management, L.P. 0.05% of their portfolio STAMFORD, CT 379,300379.3k $12.4m $12.4m 0.05% New
32 Matrix Capital Management Company, LP 0.21% of their portfolio Portsmouth, NH 335,000335.0k $11.0m $11.0m 0.21% Unchanged
33 AMERICAN CENTURY COMPANIES INC 0.01% of their portfolio KANSAS CITY, MO 296,088296.1k $9.7m $9.7m 0.01% Reduced -2.1k -2,090
34 ACUTA CAPITAL PARTNERS, LLC 4.65% of their portfolio REDWOOD CITY, CA 290,500290.5k $7.6m $7.6m 4.65% Added +110.5k +110,500
35 Affinity Asset Advisors, LLC 3.62% of their portfolio NEW YORK, NY 240,623240.6k $7.9m $7.9m 3.62% Added +70.6k +70,623
36 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 216,066216.1k $7.1m $7.1m 0.00% Added +32.1k +32,130
37 Integral Health Asset Management, LLC 1.55% of their portfolio New York, NY 210,000210.0k $6.9m $6.9m 1.55% Added +110.0k +110,000
38 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 199,773199.8k $6.6m $6.6m 0.00% Added +39.3k +39,311
39 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 192,933192.9k $6.3m $6.3m 0.00% Added +123.9k +123,882
40 MONTANOVA CAPITAL, LLC 0.26% of their portfolio New York, NY 186,400186.4k $6.1m $6.1m 0.26% Unchanged
41 Nantahala Capital Management, LLC 0.47% of their portfolio NEW CANAAN, CT 158,033158.0k $5.2m $5.2m 0.47% Added +41.4k +41,400
42 HighTower Advisors, LLC 0.01% of their portfolio CHICAGO, IL 152,712152.7k $5.0m $5.0m 0.01% Added +131 +131
43 Walleye Capital LLC 0.09% of their portfolio NEW YORK, NY 124,792124.8k $4.1m $4.1m 0.09% Added +98.4k +98,392
44 Woodline Partners LP 0.05% of their portfolio San Francisco, CA 120,013120.0k $3.9m $3.9m 0.05% Reduced -8.7k -8,650
45 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 119,214119.2k $3.9m $3.9m 0.00% Added +36.4k +36,449
46 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 110,387110.4k $3.6m $3.6m 0.00% Added +29.9k +29,942
47 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 108,703108.7k $3.6m $3.6m 0.00% Added +88.4k +88,407
48 D. E. Shaw & Co., Inc. 0.00% of their portfolio New York, NY 88,35988.4k $2.9m $2.9m 0.00% Reduced -84.4k -84,371
49 Moody Aldrich Partners LLC 0.53% of their portfolio MARBLEHEAD, MA 79,25079.2k $2.6m $2.6m 0.53% New
50 TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio NEW YORK, NY 76,16976.2k $2.5m $2.5m 0.01% Reduced -15.2k -15,226
51 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 72,53372.5k $2.4m $2.4m 0.00% New
52 Soleus Capital Management, L.P. 0.32% of their portfolio GREENWICH, CT 69,00069.0k $2.3m $2.3m 0.32% New
53 Informed Momentum Co LLC 0.44% of their portfolio SOLANA BEACH, CA 64,92764.9k $2.1m $2.1m 0.44% Reduced -18.3k -18,311
54 Squarepoint Ops LLC 0.01% of their portfolio NEW YORK, NY 61,96762.0k $2.0m $2.0m 0.01% New
55 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 53,73053.7k $1.8m $1.8m 0.00% Added +43.0k +42,965
56 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 46,32946.3k $1.5m $1.5m 0.00% Added +22.1k +22,086
57 Global IMC LLC 0.39% of their portfolio SOLANA BEACH, CA 46,18946.2k $1.5m $1.5m 0.39% Reduced -26.0k -26,028
58 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 41,08041.1k $1.4m $1.4m 0.00% Added +13.1k +13,120
59 Swiss National Bank 0.00% of their portfolio ZURICH, V8 40,90040.9k $1.3m $1.3m 0.00% New
60 ALPS ADVISORS INC 0.01% of their portfolio Denver, CO 38,39138.4k $1.3m $1.3m 0.01% New
61 Jump Financial, LLC 0.06% of their portfolio Chicago, IL 35,07035.1k $1.1m $1.1m 0.06% New
62 ADVISORY RESEARCH INC 0.10% of their portfolio CHICAGO, IL 33,60033.6k $1.1m $1.1m 0.10% Added +1.9k +1,874
63 HighVista Strategies LLC 0.65% of their portfolio BOSTON, MA 33,25633.3k $1.1m $1.1m 0.65% New
64 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 30,83630.8k $1.0m $1.0m 0.00% Added +14.6k +14,596
65 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 30,42030.4k $997.0k $997.0k 0.00% Added +2.5k +2,464
66 TWO SIGMA ADVISERS, LP 0.00% of their portfolio NEW YORK, NY 30,00030.0k $983.7k $983.7k 0.00% Added +22.0k +22,000
67 FRED ALGER MANAGEMENT, LLC 0.01% of their portfolio NEW YORK, NY 28,29028.3k $927.6k $927.6k 0.01% Added +16.4k +16,411
68 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 26,60026.6k $872.2k $872.2k 0.00% Added +11.4k +11,400
69 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 24,68424.7k $809.4k $809.4k 0.00% Added +15.8k +15,832
70 Birchview Capital, LP 0.51% of their portfolio BURLINGTON, VT 22,00022.0k $721.0k $721.0k 0.51% Reduced -23.0k -23,000
71 Cheyne Capital Management (UK) LLP 1.16% of their portfolio LONDON, X0 20,03520.0k $656.9k $656.9k 1.16% New
72 Callan Capital, LLC 0.08% of their portfolio LA JOLLA, CA 19,18019.2k $628.9k $628.9k 0.08% New
73 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 17,01517.0k $557.9k $557.9k 0.00% New
74 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 16,95317.0k $556.0k $556.0k 0.00% Added +4.7k +4,705
75 SEI INVESTMENTS CO 0.00% of their portfolio OAKS, PA 16,06616.1k $526.8k $526.8k 0.00% Added +4.5k +4,452
76 Carnegie Investment Counsel 0.02% of their portfolio PEPPER PIKE, OH 15,70815.7k $515.1k $515.1k 0.02% New
77 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 15,46515.5k $507.1k $507.1k 0.00% Reduced -4.3k -4,287
78 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 15,30015.3k $501.7k $501.7k 0.00% New
79 DekaBank Deutsche Girozentrale 0.00% of their portfolio FRANKFURT, 2M 15,00015.0k $494.0k $494.0k 0.00% Unchanged
80 Connective Portfolio Management, LLC 1.05% of their portfolio NEW YORK, NY 15,00015.0k $491.9k $491.9k 1.05% New
81 US BANCORP \DE\ 0.00% of their portfolio MINNEAPOLIS, MN 14,19914.2k $465.6k $465.6k 0.00% New
82 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 13,08113.1k $428.9k $428.9k 0.00% Added +3.1k +3,116
83 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 13,02613.0k $427.1k $427.1k 0.00% Unchanged
84 Janney Montgomery Scott LLC 0.00% of their portfolio PHILADELPHIA, PA 12,95713.0k $425.0k $425.0k 0.00% Reduced -7.9k -7,927
85 CREDIT SUISSE AG/ 0.00% of their portfolio ZURICH, V8 12,86612.9k $421.9k $421.9k 0.00% Added +12.7k +12,739
86 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 12,84312.8k $421.1k $421.1k 0.00% Added +1.4k +1,433
87 AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio New York, NY 11,79511.8k $386.8k $386.8k 0.00% Added +1.2k +1,154
88 PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio DES MOINES, IA 11,58311.6k $379.8k $379.8k 0.00% New
89 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 10,83510.8k $355.3k $355.3k 0.00% First filing
90 GLENMEDE TRUST CO NA 0.00% of their portfolio PHILADELPHIA, PA 10,39010.4k $340.7k $340.7k 0.00% New
91 MYDA Advisors LLC 0.24% of their portfolio WOODMERE, NY 10,00010.0k $327.9k $327.9k 0.24% New
92 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 9,3499.3k $306.6k $306.6k 0.00% Added +563 +563
93 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 8,6548.7k $283.8k $283.8k 0.00% Added +1.8k +1,755
94 SG Americas Securities, LLC 0.00% of their portfolio NEW YORK, NY 7,9758.0k $262.0k $262.0k 0.00% Added +4.2k +4,192
95 ProShare Advisors LLC 0.00% of their portfolio BETHESDA, MD 7,8937.9k $258.8k $258.8k 0.00% New
96 Legal & General Group Plc 0.00% of their portfolio London, X0 7,3827.4k $242.1k $242.1k 0.00% Added +4.7k +4,689
97 Freemont Management S.A. 0.04% of their portfolio VAUD, V8 7,1077.1k $233.0k $233.0k 0.04% New
98 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 6,8006.8k $223.0k $223.0k 0.00% Added +1.0k +1,000
99 Moors & Cabot, Inc. 0.02% of their portfolio BOSTON, MA 6,6006.6k $216.4k $216.4k 0.02% Added +600 +600
100 Avestar Capital, LLC 0.05% of their portfolio New York, NY 6,4696.5k $212.1k $212.1k 0.05% New