VAXCYTE INC PCVX
COM · Common Stock · CUSIP 92243G108 · ISIN US92243G1085
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersSan Carlos, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($2.0m this quarter). Holder counts are more reliable. Shares outstanding: 130.9m as of 2025-10-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $46.14. Options: 7 managers hold calls ($6.3m notional), 6 hold puts ($10.8m).
Trends to Q4 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 126 |
| Q4 2022 | 199 |
| Q1 2023 | 190 |
| Q2 2023 | 199 |
| Q3 2023 | 204 |
| Q4 2023 | 225 |
| Q1 2024 | 253 |
| Q2 2024 | 267 |
| Q3 2024 | 329 |
| Q4 2024 | 324 |
| Q1 2025 | 317 |
| Q2 2025 | 297 |
| Q3 2025 | 287 |
| Q4 2025 | 296 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2024 | 150 | 94 |
| Q2 2024 | 151 | 102 |
| Q3 2024 | 208 | 108 |
| Q4 2024 | 185 | 151 |
| Q1 2025 | 181 | 159 |
| Q2 2025 | 189 | 150 |
| Q3 2025 | 137 | 146 |
| Q4 2025 | 137 | 151 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2025 | $14.1m | $9.8m | 0.69 |
| Q2 2025 | $12.0m | $5.4m | 0.45 |
| Q3 2025 | $20.9m | $4.3m | 0.20 |
| Q4 2025 | $6.3m | $10.8m | 1.70 |
Biggest buyers
| T. Rowe Price Investment Management, Inc. | Added | +9.7m |
| Caligan Partners LP | New | +1.7m |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Added | +1.4m |
| FMR LLC | Added | +1.3m |
| Polar Capital Holdings Plc | Added | +1.3m |
| Deep Track Capital, LP | Added | +1.0m |
| WELLINGTON MANAGEMENT GROUP LLP | Added | +933.5k |
| Soleus Capital Management, L.P. | New | +609.0k |
| EVENTIDE ASSET MANAGEMENT, LLC | Added | +537.8k |
| FEDERATED HERMES, INC. | Added | +505.3k |
Biggest sellers
| JPMORGAN CHASE & CO | Reduced | -2.0m |
| RA CAPITAL MANAGEMENT, L.P. | Reduced | -1.2m |
| ROYAL BANK OF CANADA | Reduced | -939.8k |
| D. E. Shaw & Co., Inc. | Reduced | -659.7k |
| COMERICA BANK | Reduced | -653.3k |
| BAKER BROS. ADVISORS LP | Sold out | -640.9k |
| Point72 Asset Management, L.P. | Reduced | -535.2k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -524.7k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | Sold out | -519.7k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -513.1k |
Biggest calls
| Nantahala Capital Management, LLC | New | $1.6m35.2k shares |
| Caption Management, LLC | Reduced | $1.4m30.0k shares |
| CITADEL ADVISORS LLC | Reduced | $1.3m27.3k shares |
| GOLDMAN SACHS GROUP INC | New | $1.2m25.1k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $659.8k14.3k shares |
| JANE STREET GROUP, LLC | Reduced | $226.1k4.9k shares |
| SIMPLEX TRADING, LLC | Reduced | $4.6k100 shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $4.3m93.3k shares |
| Caption Management, LLC | New | $2.8m60.0k shares |
| CITADEL ADVISORS LLC | Added | $2.1m44.9k shares |
| JANE STREET GROUP, LLC | Added | $1.3m28.3k shares |
| SIMPLEX TRADING, LLC | Added | $295.3k6.4k shares |
| GROUP ONE TRADING LLC | Reduced | $4.6k100 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution +3.0 pts · filed 2026-08-06 | 14.4% |
| Janus Henderson Group Ltd. 13G · institution +12.0 pts · filed 2026-08-11 | 12.1% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor -1.0 pts · filed 2026-05-15 | 8.9% |
| T. Rowe Price Investment Management, Inc. 13G · institution +2.2 pts · filed 2026-02-17 | 8.6% |
| BlackRock, Inc. 13G · institution filed 2025-04-17 | 7.6% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.0% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q4 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2024 | 0 | — | 6 | $13.0m | $13.0m |
| Q2 2024 | 0 | — | 5 | $7.6m | $7.6m |
| Q3 2024 | 0 | — | 6 | $10.3m | $10.3m |
| Q4 2024 | 0 | — | 4 | $21.4m | $21.4m |
| Q1 2025 | 0 | — | 4 | $5.1m | $5.1m |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 0 | — | 2 | $1.0m | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-12-31 | Dhaliwal Harpreet S. Chief Technical Ops Officer | Sold | $454.9k9.7k shares |
| 2025-12-23 | Cowan Elvia SVP, FINANCE | Sold | $557.0k11.6k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2025
| Manager | Shares | Change |
|---|---|---|
| T. Rowe Price Investment Management, Inc. 0.33% of their portfolio | 18.0m $829.6m | Added +9.7m |
| FMR LLC 0.03% of their portfolio | 13.8m $638.3m | Added +1.3m |
| JANUS HENDERSON GROUP PLC 0.28% of their portfolio | 13.4m $617.7m | Added +283.0k |
| VANGUARD GROUP INC 0.01% of their portfolio | 12.2m $562.6m | Reduced -126.5k |
| RA CAPITAL MANAGEMENT, L.P. 5.07% of their portfolio | 10.7m $494.8m | Reduced -1.2m |
| BlackRock, Inc. 0.01% of their portfolio | 10.2m $472.8m | Added +290.4k |
| WELLINGTON MANAGEMENT GROUP LLP 0.05% of their portfolio | 6.0m $275.3m | Added +933.5k |
| STATE STREET CORP 0.01% of their portfolio | 5.0m $229.8m | Added +194.1k |
| Paradigm Biocapital Advisors LP 5.03% of their portfolio | 4.1m $187.7m | Added +283.3k |
| Deep Track Capital, LP 4.21% of their portfolio | 4.0m $184.6m | Added +1.0m |
| D. E. Shaw & Co., Inc. 0.13% of their portfolio | 3.6m $167.5m | Reduced -659.7k |
| WESTFIELD CAPITAL MANAGEMENT CO LP 0.68% of their portfolio | 3.5m $163.3m | Reduced -193.0k |
| Kynam Capital Management, LP 8.78% of their portfolio | 2.9m $134.8m | Reduced -149.3k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 2.9m $132.3m | Reduced -17.7k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.12% of their portfolio | 1.7m $79.6m | Added +1.4m |
| Caligan Partners LP 7.20% of their portfolio | 1.7m $78.7m | New |
| Polar Capital Holdings Plc 0.35% of their portfolio | 1.7m $77.2m | Added +1.3m |
| Pivotal bioVenture Partners Investment Advisor LLC 24.48% of their portfolio | 1.4m $63.3m | Unchanged |
| MAVERICK CAPITAL LTD 0.67% of their portfolio | 1.4m $62.5m | Added +64.7k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 1.3m $59.7m | Added +423 |
| NORGES BANK 0.01% of their portfolio | 1.2m $56.7m | Not comparable |
| Eversept Partners, LP 3.10% of their portfolio | 1.2m $55.3m | Reduced -224.3k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio | 1.2m $54.2m | Reduced -513.1k |
| UBS Group AG 0.01% of their portfolio | 1.1m $50.5m | Added +246.0k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 1.1m $50.1m | Reduced -2.0m |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 1.1m $49.7m | Added +102.7k |
| NORTHERN TRUST CORP 0.01% of their portfolio | 1.0m $47.7m | Reduced -39.2k |
| Aberdeen Group plc 0.07% of their portfolio | 979.8k $45.2m | Added +257.0k |
| EVENTIDE ASSET MANAGEMENT, LLC 0.66% of their portfolio | 917.1k $42.3m | Added +537.8k |
| NOVO HOLDINGS A/S 3.28% of their portfolio | 916.2k $42.3m | Unchanged |
| Pictet Asset Management Holding SA 0.04% of their portfolio | 881.4k $40.7m | Reduced -148.2k |
| Capital Research Global Investors 0.01% of their portfolio | 843.0k $38.9m | Unchanged |
| MORGAN STANLEY 0.00% of their portfolio | 835.4k $38.5m | Added +50.9k |
| Saturn V Capital Management LP 6.77% of their portfolio | 798.9k $36.9m | Added +10.5k |
| Trails Edge Capital Partners, LP 8.41% of their portfolio | 737.5k $34.0m | First filing |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 701.6k $32.4m | Added +66.6k |
| JENNISON ASSOCIATES LLC 0.02% of their portfolio | 677.6k $31.3m | Reduced -493.3k |
| Logos Global Management LP 2.00% of their portfolio | 650.0k $30.0m | Added +25.0k |
| Soleus Capital Management, L.P. 1.19% of their portfolio | 609.0k $28.1m | New |
| BROWN ADVISORY INC 0.04% of their portfolio | 566.9k $26.2m | Reduced -110.1k |
| VICTORY CAPITAL MANAGEMENT INC 0.01% of their portfolio | 549.5k $25.4m | Added +234.6k |
| Assenagon Asset Management S.A. 0.04% of their portfolio | 544.7k $25.1m | Added +324.8k |
| Ensign Peak Advisors, Inc 0.04% of their portfolio | 527.7k $24.3m | Reduced -1.2k |
| FEDERATED HERMES, INC. 0.04% of their portfolio | 523.5k $24.2m | Added +505.3k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.59% of their portfolio | 497.7k $23.0m | Added +369.0k |
| EcoR1 Capital, LLC 0.95% of their portfolio | 450.0k $20.8m | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 449.4k $20.7m | Added +9.8k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 424.3k $19.6m | Reduced -524.7k |
| Spruce Street Capital LP 6.10% of their portfolio | 400.4k $18.5m | First filing |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 389.0k $17.9m | Reduced -9.1k |
| Ikarian Capital, LLC 2.26% of their portfolio | 378.7k $17.5m | Added +67.0k |
| TD Asset Management Inc 0.01% of their portfolio | 363.7k $16.8m | Reduced -34.7k |
| AMERICAN CENTURY COMPANIES INC 0.01% of their portfolio | 357.3k $16.5m | Added +13.3k |
| DEUTSCHE BANK AG\ 0.01% of their portfolio | 342.9k $15.8m | Reduced -54.9k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 336.1k $15.5m | Added +37 |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 326.6k $15.1m | Added +120.8k |
| ADAR1 Capital Management, LLC 1.09% of their portfolio | 315.6k $14.6m | Added +102.6k |
| Nuveen, LLC 0.00% of their portfolio | 307.2k $14.2m | Reduced -177.4k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 305.2k $14.1m | Reduced -69.7k |
| Artisan Partners Limited Partnership 0.02% of their portfolio | 304.0k $14.0m | New |
| BARCLAYS PLC 0.01% of their portfolio | 296.2k $13.7m | Reduced -97.7k |
| Elmind Capital, LP 3.97% of their portfolio | 291.5k $13.4m | First filing |
| JANE STREET GROUP, LLC 0.02% of their portfolio | 279.6k $12.9m | Reduced -64.1k |
| TANG CAPITAL MANAGEMENT LLC 0.63% of their portfolio | 275.0k $12.7m | Reduced -25.0k |
| Woodline Partners LP 0.05% of their portfolio | 274.7k $12.7m | Added +27.8k |
| University of Wisconsin Foundation 9.58% of their portfolio | 247.0k $11.4m | New |
| Alyeska Investment Group, L.P. 0.03% of their portfolio | 244.8k $11.3m | Unchanged |
| CITIGROUP INC 0.01% of their portfolio | 241.9k $11.2m | Reduced -71.2k |
| Swiss National Bank 0.01% of their portfolio | 230.4k $10.6m | Added +5.3k |
| Qube Research & Technologies Ltd 0.01% of their portfolio | 207.1k $9.6m | Reduced -346.8k |
| C WorldWide Group Holding A/S 0.16% of their portfolio | 195.0k $9.0m | Unchanged |
| SEGALL BRYANT & HAMILL, LLC 0.12% of their portfolio | 193.4k $8.9m | Added +8.6k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 191.8k $8.8m | Added +163.4k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 185.9k $8.5m | Reduced -3.4k |
| Point72 Asset Management, L.P. 0.01% of their portfolio | 161.6k $7.5m | Reduced -535.2k |
| RHUMBLINE ADVISERS 0.01% of their portfolio | 150.9k $7.0m | Reduced -32.3k |
| SILVERARC CAPITAL MANAGEMENT, LLC 0.99% of their portfolio | 148.8k $6.9m | Reduced -165.6k |
| California Public Employees Retirement System 0.00% of their portfolio | 144.6k $6.7m | Reduced -11 |
| NAN FUNG TRINITY (HK) LTD 0.52% of their portfolio | 142.9k $6.6m | Added +38.7k |
| Invesco Ltd. 0.00% of their portfolio | 141.2k $6.5m | Reduced -37.9k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 134.1k $6.2m | Added +8.0k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 133.9k $6.2m | Reduced -1.3k |
| Rafferty Asset Management, LLC 0.02% of their portfolio | 133.8k $6.2m | Reduced -15.7k |
| READYSTATE ASSET MANAGEMENT LP 0.27% of their portfolio | 131.6k $6.1m | New |
| Cormorant Asset Management, LP 0.33% of their portfolio | 125.0k $5.8m | Reduced -50.0k |
| Legal & General Group Plc 0.00% of their portfolio | 120.3k $5.6m | Reduced -10.1k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.01% of their portfolio | 116.8k $5.4m | Reduced -5.0k |
| HighVista Strategies LLC 1.36% of their portfolio | 114.0k $5.3m | Added +27.2k |
| HRT FINANCIAL LP 0.02% of their portfolio | 114.0k $5.3m | Reduced -84 |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 111.3k $5.1m | Added +3.7k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio | 110.9k $5.1m | Added +1.4k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 108.4k $5.0m | Reduced -28.4k |
| Creative Planning 0.00% of their portfolio | 102.7k $4.7m | Added +22.4k |
| NEXTBio Capital Management LP 2.58% of their portfolio | 95.5k $4.4m | First filing |
| Jump Financial, LLC 0.05% of their portfolio | 89.8k $4.1m | Reduced -101.9k |
| TWINBEECH CAPITAL LP 0.26% of their portfolio | 78.2k $3.6m | Reduced -149.8k |
| BANQUE PICTET & CIE SA 0.03% of their portfolio | 71.8k $3.3m | Reduced -3.0k |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.01% of their portfolio | 70.1k $3.2m | Added +36.0k |
| Man Group plc 0.01% of their portfolio | 68.9k $3.2m | Reduced -176.0k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio | 68.3k $3.2m | Reduced -8.3k |