VAXCYTE INC PCVX
COM · Common Stock · CUSIP 92243G108 · ISIN US92243G1085
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersSan Carlos, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($9.6m this quarter). Holder counts are more reliable. Shares outstanding: 79.0m as of 2022-11-03, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $47.95. Options: 13 managers hold calls ($25.1m notional), 11 hold puts ($15.6m).
Trends to Q4 2022
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 126 |
| Q4 2022 | 199 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $13.9m | $13.6m | 0.97 |
| Q4 2022 | $25.1m | $15.6m | 0.62 |
Biggest buyers
| Capital Research Global Investors | Added | +2.3m |
| VANGUARD GROUP INC | Added | +2.2m |
| WELLINGTON MANAGEMENT GROUP LLP | Added | +1.8m |
| BlackRock Inc. | Added | +1.6m |
| JENNISON ASSOCIATES LLC | New | +1.4m |
| RA CAPITAL MANAGEMENT, L.P. | Added | +1.3m |
| FMR LLC | Added | +1.3m |
| STATE STREET CORP | Added | +1.2m |
| PERCEPTIVE ADVISORS LLC | New | +1.2m |
| Avidity Partners Management LP | Added | +986.7k |
Biggest sellers
| JANUS HENDERSON GROUP PLC | Reduced | -3.1m |
| Abingworth LLP | Reduced | -2.1m |
| TPG GP A, LLC | Reduced | -2.1m |
| Medicxi Ventures Management (Jersey) Ltd | Reduced | -430.2k |
| NATIONAL BANK OF CANADA /FI/ | Reduced | -400.0k |
| Ghost Tree Capital, LLC | Reduced | -200.0k |
| STATE OF WISCONSIN INVESTMENT BOARD | Reduced | -185.3k |
| Frazier Life Sciences Management, L.P. | Reduced | -150.0k |
| Point72 Asset Management, L.P. | Reduced | -120.2k |
| NOVO HOLDINGS A/S | Reduced | -98.7k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $8.5m176.6k shares |
| CITADEL ADVISORS LLC | Reduced | $7.9m165.4k shares |
| JANE STREET GROUP, LLC | New | $2.7m55.3k shares |
| GROUP ONE TRADING LLC | New | $1.6m34.2k shares |
| Caption Management, LLC | New | $1.4m30.0k shares |
| J. Goldman & Co LP | Reduced | $1.3m27.0k shares |
| Parallax Volatility Advisers, L.P. | New | $920.6k19.2k shares |
| CITIGROUP INC | Unchanged | $297.3k6.2k shares |
| Walleye Trading LLC | New | $220.6k4.6k shares |
| Walleye Capital LLC | New | $124.7k2.6k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $6.1m128.0k shares |
| Caption Management, LLC | New | $5.3m110.0k shares |
| SIMPLEX TRADING, LLC | New | $2.1m43.4k shares |
| Parallax Volatility Advisers, L.P. | Added | $1.1m23.7k shares |
| Walleye Trading LLC | New | $594.6k12.4k shares |
| Walleye Capital LLC | New | $201.4k4.2k shares |
| GROUP ONE TRADING LLC | New | $129.5k2.7k shares |
| CITADEL ADVISORS LLC | Reduced | $43.2k900 shares |
| Cutler Group LLC / CA | New | $15.0k3.0k shares |
| HAP Trading, LLC | New | $1.0k35.0k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution +3.0 pts · filed 2026-08-06 | 14.4% |
| Janus Henderson Group Ltd. 13G · institution +12.0 pts · filed 2026-08-11 | 12.1% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor -1.0 pts · filed 2026-05-15 | 8.9% |
| T. Rowe Price Investment Management, Inc. 13G · institution +2.2 pts · filed 2026-02-17 | 8.6% |
| BlackRock, Inc. 13G · institution filed 2025-04-17 | 7.6% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.0% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q4 2022
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2021 | 0 | — | 0 | — | — |
| Q2 2021 | 0 | — | 0 | — | — |
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 0 | — | 4 | $1.4m | — |
| Q1 2022 | 0 | — | 5 | $1.5m | — |
| Q2 2022 | 0 | — | 5 | $1.6m | — |
| Q3 2022 | 0 | — | 5 | $3.9m | — |
| Q4 2022 | 0 | — | 3 | $1.1m | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2022-12-12 | Lukatch Heath Director | Sold | $14.7k335 shares |
| 2022-11-10 | Lukatch Heath Director | Sold | $200.0k4.3k shares |
| 2022-10-26 | Fairman Jeff VP, Research · By Fairman Family Trust | Sold | $400.0k10.0k shares |
| 2022-10-26 | Lukatch Heath Director | Sold | $153.0k4.0k shares |
| 2022-10-24 | Lukatch Heath Director | Sold | $105.9k3.0k shares |
| 2022-10-17 | Wassil Jim Chief Operating Officer | Sold | $72.0k2.8k shares |
| 2022-10-11 | Fairman Jeff VP, Research · By Fairman Family Trust | Sold | $127.5k5.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2022
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.05% of their portfolio | 10.2m $487.6m | Added +1.3m |
| VANGUARD GROUP INC 0.01% of their portfolio | 6.6m $317.1m | Added +2.2m |
| JANUS HENDERSON GROUP PLC 0.20% of their portfolio | 6.0m $286.5m | Reduced -3.1m |
| RA CAPITAL MANAGEMENT, L.P. 5.70% of their portfolio | 5.9m $280.9m | Added +1.3m |
| BlackRock Inc. 0.01% of their portfolio | 5.1m $244.8m | Added +1.6m |
| WELLINGTON MANAGEMENT GROUP LLP 0.03% of their portfolio | 3.5m $169.2m | Added +1.8m |
| STATE STREET CORP 0.01% of their portfolio | 3.2m $151.9m | Added +1.2m |
| Capital Research Global Investors 0.04% of their portfolio | 2.8m $134.5m | Added +2.3m |
| Abingworth LLP 31.54% of their portfolio | 2.0m $96.8m | Reduced -2.1m |
| Avidity Partners Management LP 1.81% of their portfolio | 1.6m $77.5m | Added +986.7k |
| Medicxi Ventures Management (Jersey) Ltd 29.35% of their portfolio | 1.5m $69.9m | Reduced -430.2k |
| JENNISON ASSOCIATES LLC 0.07% of their portfolio | 1.4m $68.2m | New |
| Frazier Life Sciences Management, L.P. 4.17% of their portfolio | 1.4m $67.0m | Reduced -150.0k |
| BRAIDWELL LP 2.19% of their portfolio | 1.4m $65.3m | First filing |
| ORBIMED ADVISORS LLC 1.18% of their portfolio | 1.3m $61.5m | Added +565.2k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 1.3m $60.0m | Added +356.6k |
| MILLENNIUM MANAGEMENT LLC 0.06% of their portfolio | 1.2m $58.5m | Added +433.2k |
| TPG GP A, LLC 1.12% of their portfolio | 1.2m $57.1m | Reduced -2.1m |
| PERCEPTIVE ADVISORS LLC 1.62% of their portfolio | 1.2m $56.1m | New |
| D. E. Shaw & Co., Inc. 0.08% of their portfolio | 972.3k $46.6m | New |
| FRED ALGER MANAGEMENT, LLC 0.23% of their portfolio | 877.3k $42.1m | New |
| CITADEL ADVISORS LLC 0.05% of their portfolio | 851.9k $40.8m | Added +19.0k |
| Driehaus Capital Management LLC 0.59% of their portfolio | 830.8k $39.8m | Added +247.2k |
| GREAT POINT PARTNERS LLC 7.93% of their portfolio | 800.0k $38.4m | Added +200.0k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.09% of their portfolio | 795.0k $38.1m | Added +695.0k |
| NOVO HOLDINGS A/S 2.17% of their portfolio | 725.0k $34.8m | Reduced -98.7k |
| Kynam Capital Management, LP 5.17% of their portfolio | 703.4k $33.7m | Added +4.8k |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.69% of their portfolio | 700.0k $33.6m | New |
| Pivotal bioVenture Partners Investment Advisor LLC 14.45% of their portfolio | 693.0k $33.2m | Reduced -83.0k |
| PICTET ASSET MANAGEMENT SA 0.05% of their portfolio | 666.5k $32.0m | New |
| NORTHERN TRUST CORP 0.01% of their portfolio | 659.3k $31.6m | Added +175.4k |
| Vivo Capital, LLC 3.20% of their portfolio | 579.5k $27.8m | Added +175.0k |
| Polar Asset Management Partners Inc. 0.38% of their portfolio | 555.9k $26.7m | Added +200.2k |
| RENAISSANCE TECHNOLOGIES LLC 0.03% of their portfolio | 522.0k $25.0m | Added +428.8k |
| T. Rowe Price Investment Management, Inc. 0.02% of their portfolio | 511.4k $24.5m | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 488.5k $23.4m | Added +143.3k |
| NATIONAL BANK OF CANADA /FI/ 0.06% of their portfolio | 485.5k $23.3m | Reduced -400.0k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 399.4k $19.1m | Reduced -88.5k |
| Soleus Capital Management, L.P. 2.67% of their portfolio | 387.9k $18.6m | Added +52.3k |
| Cormorant Asset Management, LP 1.05% of their portfolio | 325.0k $15.6m | New |
| MARSHALL WACE, LLP 0.04% of their portfolio | 322.6k $15.5m | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 307.6k $14.8m | Added +128.1k |
| Point72 Asset Management, L.P. 0.05% of their portfolio | 302.6k $14.5m | Reduced -120.2k |
| TANG CAPITAL MANAGEMENT LLC 2.09% of their portfolio | 300.0k $14.4m | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 296.6k $14.2m | Added +190.2k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 284.5k $13.6m | Added +37.2k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 256.4k $12.3m | Added +66.9k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 252.9k $12.1m | Added +72.8k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.07% of their portfolio | 251.2k $12.0m | New |
| Ikarian Capital, LLC 4.97% of their portfolio | 250.0k $12.0m | New |
| Woodline Partners LP 0.16% of their portfolio | 250.0k $12.0m | Added +53.6k |
| Ensign Peak Advisors, Inc 0.03% of their portfolio | 248.5k $11.9m | Added +145.0k |
| Invesco Ltd. 0.00% of their portfolio | 220.2k $10.6m | Added +184.2k |
| TWO SIGMA INVESTMENTS, LP 0.03% of their portfolio | 200.2k $9.6m | New |
| Rafferty Asset Management, LLC 0.08% of their portfolio | 190.3k $9.1m | Added +96.9k |
| Eversept Partners, LP 0.83% of their portfolio | 178.5k $8.6m | New |
| Opaleye Management Inc. 2.95% of their portfolio | 177.0k $8.5m | Reduced -13.0k |
| Maven Securities LTD 1.68% of their portfolio | 175.0k $8.4m | New |
| Commodore Capital LP 1.25% of their portfolio | 173.5k $8.3m | New |
| MOORE CAPITAL MANAGEMENT, LP 0.23% of their portfolio | 172.5k $8.3m | Added +28.5k |
| MORGAN STANLEY 0.00% of their portfolio | 168.1k $8.1m | Added +125.6k |
| Ghost Tree Capital, LLC 3.28% of their portfolio | 160.0k $7.7m | Reduced -200.0k |
| Parkman Healthcare Partners LLC 2.02% of their portfolio | 158.0k $7.6m | New |
| Schonfeld Strategic Advisors LLC 0.06% of their portfolio | 157.1k $7.5m | Added +134.1k |
| Cubist Systematic Strategies, LLC 0.06% of their portfolio | 149.1k $7.2m | Added +117.9k |
| ACUTA CAPITAL PARTNERS, LLC 4.26% of their portfolio | 144.5k $6.9m | Added +59.5k |
| Walleye Capital LLC 0.15% of their portfolio | 143.2k $6.9m | Added +84.0k |
| NORGES BANK 0.00% of their portfolio | 125.9k $6.0m | Not comparable |
| Swiss National Bank 0.00% of their portfolio | 125.7k $6.0m | Added +42.7k |
| Nicholas Investment Partners, LP 0.52% of their portfolio | 123.3k $5.9m | New |
| UBS Group AG 0.00% of their portfolio | 122.7k $5.9m | Added +122.6k |
| CITIGROUP INC 0.01% of their portfolio | 118.8k $5.7m | Reduced -36.7k |
| Caption Management, LLC 0.95% of their portfolio | 117.3k $5.6m | Added +58.7k |
| BARCLAYS PLC 0.00% of their portfolio | 113.9k $5.5m | First filing |
| Tri Locum Partners LP 2.41% of their portfolio | 113.5k $5.4m | Added +34.1k |
| Pier Capital, LLC 0.87% of their portfolio | 111.2k $5.3m | New |
| RHUMBLINE ADVISERS 0.01% of their portfolio | 91.8k $4.4m | Added +23.6k |
| SILVERARC CAPITAL MANAGEMENT, LLC 1.37% of their portfolio | 83.1k $4.0m | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio | 73.9k $3.5m | Added +22.5k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 73.7k $3.5m | Added +28.5k |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 67.7k $3.2m | Added +11.7k |
| Informed Momentum Co LLC 0.64% of their portfolio | 64.8k $3.1m | New |
| PURA VIDA INVESTMENTS, LLC 0.49% of their portfolio | 61.5k $3.0m | New |
| SECTORAL ASSET MANAGEMENT INC 0.56% of their portfolio | 60.0k $2.9m | New |
| Affinity Asset Advisors, LLC 1.32% of their portfolio | 60.0k $2.9m | New |
| NISA INVESTMENT ADVISORS, LLC 0.02% of their portfolio | 56.7k $2.7m | Added +55.8k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 55.2k $2.6m | Added +18.3k |
| ALPS ADVISORS INC 0.02% of their portfolio | 53.6k $2.6m | Added +21.2k |
| State of New Jersey Common Pension Fund D 0.01% of their portfolio | 52.7k $2.5m | New |
| STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio | 52.1k $2.5m | Reduced -185.3k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 51.7k $2.5m | Added +17.1k |
| Jump Financial, LLC 0.13% of their portfolio | 51.6k $2.5m | New |
| BAKER BROS. ADVISORS LP 0.01% of their portfolio | 48.9k $2.3m | New |
| BOOTHBAY FUND MANAGEMENT, LLC 0.07% of their portfolio | 45.9k $2.2m | New |
| Alyeska Investment Group, L.P. 0.02% of their portfolio | 45.0k $2.2m | Reduced -7.1k |
| CREDIT SUISSE AG/ 0.00% of their portfolio | 43.0k $2.1m | Added +13.6k |
| Altium Capital Management LLC 1.05% of their portfolio | 43.0k $2.1m | New |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 42.8k $2.1m | Added +22.2k |
| TWO SIGMA ADVISERS, LP 0.01% of their portfolio | 42.0k $2.0m | New |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 41.4k $2.0m | Added +26.9k |