UNICYCIVE THERAPEUTICS INC UNCY
COM NEW · Common Stock · CUSIP 90466Y202
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersMountain View, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 27.9m as of 2026-08-12, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $4.70. Options: 8 managers hold calls ($8.2m notional), 5 hold puts ($3.6m).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q2 2025 | 21 |
| Q3 2025 | 30 |
| Q4 2025 | 35 |
| Q1 2026 | 51 |
| Q2 2026 | 80 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2025 | 22 | 4 |
| Q4 2025 | 14 | 8 |
| Q1 2026 | 27 | 14 |
| Q2 2026 | 59 | 18 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $0 | $0 | — |
| Q4 2025 | $341.6k | $0 | 0.00 |
| Q1 2026 | $1.1m | $3.5m | 3.11 |
| Q2 2026 | $8.2m | $3.6m | 0.44 |
Biggest buyers
| Nantahala Capital Management, LLC | Added | +1.9m |
| BlackRock, Inc. | Added | +1.4m |
| MARSHALL WACE, LLP | Added | +392.9k |
| STATE STREET CORP | Added | +370.1k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +360.3k |
| J. Goldman & Co LP | New | +327.3k |
| Diametric Capital, LP | Added | +293.8k |
| VANGUARD CAPITAL MANAGEMENT LLC | Added | +260.1k |
| DIADEMA PARTNERS LP | Added | +197.6k |
| CITIGROUP INC | Added | +182.7k |
Biggest sellers
| Vivo Capital, LLC | Reduced | -1.2m |
| MILLENNIUM MANAGEMENT LLC | Reduced | -1.1m |
| GREAT POINT PARTNERS LLC | Sold out | -796.6k |
| Integral Health Asset Management, LLC | Sold out | -225.0k |
| CITADEL ADVISORS LLC | Reduced | -175.7k |
| BNP PARIBAS FINANCIAL MARKETS | Reduced | -115.8k |
| MORGAN STANLEY | Reduced | -78.5k |
| JANE STREET GROUP, LLC | Reduced | -61.1k |
| ACUTA CAPITAL PARTNERS, LLC | Sold out | -58.0k |
| HRT FINANCIAL LP | Sold out | -41.5k |
Biggest calls
| DIADEMA PARTNERS LP | New | $3.7m792.6k shares |
| Caption Management, LLC | New | $2.0m420.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $1.6m334.8k shares |
| CITADEL ADVISORS LLC | Added | $433.8k92.5k shares |
| GROUP ONE TRADING LLC | New | $164.2k35.0k shares |
| SIMPLEX TRADING, LLC | Added | $159.0k33.9k shares |
| JANE STREET GROUP, LLC | Reduced | $138.4k29.5k shares |
| Persistent Asset Partners Ltd | New | $62.9k2.0k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $1.5m314.8k shares |
| JANE STREET GROUP, LLC | Added | $839.0k178.9k shares |
| CITADEL ADVISORS LLC | Added | $692.7k147.7k shares |
| SIMPLEX TRADING, LLC | Added | $443.7k94.6k shares |
| GROUP ONE TRADING LLC | Added | $181.5k38.7k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Nantahala Capital Management, LLC 13G · institution no change · filed 2026-08-14 | 10.0% |
| Vivo Opportunity Fund Holdings, L.P. 13G · passive investor no change · filed 2026-08-14 | 10.0% |
| BIOTECHNOLOGY VALUE FUND L P 13G · passive investor filed 2025-08-14 | 10.0% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor no change · filed 2026-05-15 | 9.9% |
| BlackRock, Inc. 13G · institution new · filed 2026-07-30 | 5.3% |
Fell to 5% or below in the last year: INTEGRATED CORE STRATEGIES (US) LLC (1.0%, 2026-07-08), Octagon Capital Advisors LP (4.7%, 2026-02-10), GREAT POINT PARTNERS LLC (4.5%, 2025-11-14)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
None reported since 1 Apr 2026.
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| Nantahala Capital Management, LLC 0.40% of their portfolio | 2.8m $13.1m | Added +1.9m |
| BlackRock, Inc. 0.00% of their portfolio | 1.4m $6.6m | Added +1.4m |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 1.1m $5.0m | Added +260.1k |
| Octagon Capital Advisors LP 0.43% of their portfolio | 1.0m $4.7m | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 564.0k $2.6m | Added +360.3k |
| Vivo Capital, LLC 0.24% of their portfolio | 550.0k $2.6m | Reduced -1.2m |
| MARSHALL WACE, LLP 0.00% of their portfolio | 547.9k $2.6m | Added +392.9k |
| Logos Global Management LP 0.10% of their portfolio | 473.6k $2.2m | Unchanged |
| STATE STREET CORP 0.00% of their portfolio | 450.2k $2.1m | Added +370.1k |
| Diametric Capital, LP 0.19% of their portfolio | 374.1k $1.8m | Added +293.8k |
| J. Goldman & Co LP 0.05% of their portfolio | 327.3k $1.5m | New |
| DIADEMA PARTNERS LP 0.50% of their portfolio | 303.7k $1.4m | Added +197.6k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 271.5k $1.3m | Reduced -1.1m |
| Dauntless Investment Group, LLC 1.74% of their portfolio | 214.0k $1.0m | Added +66.9k |
| CITIGROUP INC 0.00% of their portfolio | 182.7k $856.6k | Added +182.7k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 181.9k $853.3k | Added +146.0k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 169.2k $793.5k | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 160.0k $750.6k | Reduced -39.2k |
| Jump Financial, LLC 0.01% of their portfolio | 153.0k $717.6k | New |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 149.0k $698.6k | Added +47.9k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 145.3k $681.5k | Added +118.2k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 143.1k $678.0k | Unchanged |
| Caption Management, LLC 0.02% of their portfolio | 110.0k $515.9k | New |
| MORGAN STANLEY 0.00% of their portfolio | 109.6k $514.2k | Reduced -78.5k |
| Seven Fleet Capital Management LP 0.09% of their portfolio | 103.4k $521.1k | Added +47.7k |
| CANTOR FITZGERALD, L. P. 0.00% of their portfolio | 100.0k $469.0k | Added +25.0k |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 95.0k $445.6k | New |
| Persistent Asset Partners Ltd 0.13% of their portfolio | 90.2k $422.9k | Added +63.3k |
| Scientech Research LLC 0.28% of their portfolio | 74.5k $349.4k | New |
| UBS Group AG 0.00% of their portfolio | 69.4k $325.4k | Added +49.9k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 61.2k $286.9k | Reduced -175.7k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 54.8k $257.2k | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 52.8k $247.7k | New |
| Nuveen, LLC 0.00% of their portfolio | 47.8k $224.3k | New |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 40.4k $189.6k | Added +34.6k |
| BARCLAYS PLC 0.00% of their portfolio | 39.0k $182.9k | Reduced -11.0k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 31.6k $148.4k | Added +2.1k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 29.3k $137.4k | New |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 27.7k $130.0k | Added +15.5k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 24.3k $113.8k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 22.1k $103.5k | New |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 21.6k $101.2k | New |
| Chicago Partners Investment Group LLC 0.00% of their portfolio | 21.4k $116.9k | Reduced -368 |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 20.0k $95.0k | New |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 0.00% of their portfolio | 19.9k $103.9k | New |
| MetLife Investment Management, LLC 0.00% of their portfolio | 15.5k $72.9k | New |
| SEI INVESTMENTS CO 0.00% of their portfolio | 14.8k $69.2k | New |
| Invesco Ltd. 0.00% of their portfolio | 13.2k $61.9k | New |
| Virtu Financial LLC 0.00% of their portfolio | 11.6k $54.0k | Reduced -14.7k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 11.3k $52.8k | New |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 11.2k $52.4k | Reduced -61.1k |
| XTX Topco Ltd 0.00% of their portfolio | 10.6k $49.7k | Reduced -12.0k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 10.1k $78.0k | New |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 7.9k $36.9k | Unchanged |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 7.2k $33.8k | New |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 6.5k $30.5k | New |
| STRS OHIO 0.00% of their portfolio | 4.8k $22.5k | New |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 3.7k $17.5k | Reduced -115.8k |
| GABLES CAPITAL MANAGEMENT INC. 0.01% of their portfolio | 3.0k $14.1k | New |
| Legal & General Group Plc 0.00% of their portfolio | 2.4k $11.1k | New |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 2.3k $10.8k | New |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 2.2k $10.4k | New |
| Rockefeller Capital Management L.P. 0.00% of their portfolio | 2.1k $9.8k | Added +500 |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 2.0k $9.2k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 1.8k $8.4k | New |
| Integrated Wealth Concepts LLC 0.00% of their portfolio | 1.0k $4.7k | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 793 $4.0k | Added +416 |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 634 $3.0k | New |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 557 $2.6k | Unchanged |
| FIDUCIARY FINANCIAL ADVISORS 0.00% of their portfolio | 500 $2.3k | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 336 $1.6k | New |
| TFC Financial Management, Inc. 0.00% of their portfolio | 300 $1.4k | Unchanged |
| Larson Financial Group LLC 0.00% of their portfolio | 200 $938 | New |
| FMR LLC 0.00% of their portfolio | 197 $925 | New |
| Sterling Capital Management LLC 0.00% of their portfolio | 135 $633 | New |
| HARBOUR INVESTMENTS, INC. 0.00% of their portfolio | 100 $469 | Unchanged |
| Fortitude Family Office, LLC 0.00% of their portfolio | 75 $352 | Unchanged |
| Caitong International Asset Management Co., Ltd 0.00% of their portfolio | 52 $244 | Added +47 |
| Bogart Wealth, LLC 0.00% of their portfolio | 6 $28 | Unchanged |
| DANSKE BANK A/S 0.00% of their portfolio | 1 $5 | Unchanged |